Journal of Biological Chemistry, ISSN 0021-9258, 12/2000, Volume 275, Issue 50, pp. 39523 - 39528
In developing ovarian follicles, the regulation of cell proliferation and differentiation is tightly coordinated, Precisely how this coordination is achieved...
GROWTH FACTOR-BETA | AROMATASE-ACTIVITY | INDUCED DIFFERENTIATION | TGF-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOLLICLE-STIMULATING-HORMONE | RAT GRANULOSA-CELLS | HOMOLOG GDF-9B | FOLLICULOGENESIS | BOVINE ACTIVIN | ESTROUS-CYCLE | Immunohistochemistry | Humans | RNA, Messenger - metabolism | Recombinant Fusion Proteins - metabolism | Dose-Response Relationship, Drug | In Situ Hybridization | Growth Differentiation Factor 9 | Cell Division | Female | Cell Differentiation | Ovarian Follicle - metabolism | Recombinant Proteins - metabolism | Cell Line | Follicle Stimulating Hormone - metabolism | Oocytes - metabolism | Electrophoresis, Polyacrylamide Gel | Intercellular Signaling Peptides and Proteins | Cells, Cultured | Glutathione Transferase - metabolism | Rats | Reverse Transcriptase Polymerase Chain Reaction | Plasmids - metabolism | Rats, Sprague-Dawley | Blotting, Western | Bone Morphogenetic Protein 15 | Animals | Mitosis - drug effects | Growth Substances - physiology | Progesterone - metabolism | Sheep | Granulosa Cells | Growth Substances - metabolism
GROWTH FACTOR-BETA | AROMATASE-ACTIVITY | INDUCED DIFFERENTIATION | TGF-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOLLICLE-STIMULATING-HORMONE | RAT GRANULOSA-CELLS | HOMOLOG GDF-9B | FOLLICULOGENESIS | BOVINE ACTIVIN | ESTROUS-CYCLE | Immunohistochemistry | Humans | RNA, Messenger - metabolism | Recombinant Fusion Proteins - metabolism | Dose-Response Relationship, Drug | In Situ Hybridization | Growth Differentiation Factor 9 | Cell Division | Female | Cell Differentiation | Ovarian Follicle - metabolism | Recombinant Proteins - metabolism | Cell Line | Follicle Stimulating Hormone - metabolism | Oocytes - metabolism | Electrophoresis, Polyacrylamide Gel | Intercellular Signaling Peptides and Proteins | Cells, Cultured | Glutathione Transferase - metabolism | Rats | Reverse Transcriptase Polymerase Chain Reaction | Plasmids - metabolism | Rats, Sprague-Dawley | Blotting, Western | Bone Morphogenetic Protein 15 | Animals | Mitosis - drug effects | Growth Substances - physiology | Progesterone - metabolism | Sheep | Granulosa Cells | Growth Substances - metabolism
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2003, Volume 278, Issue 1, pp. 304 - 310
Bone morphogenetic protein-15 (BMP-15), an oocyte growth factor belonging to the transforming growth factor-β superfamily, has recently been shown to be...
I RECEPTORS | PATHWAYS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | GROWTH-DIFFERENTIATION FACTOR-9 | OOCYTES | OSTEOGENIC PROTEIN-1 | BETA SUPERFAMILY | IDENTIFICATION | EXPRESSION | ACTIVIN | Presenilin-1 | Receptors, Transforming Growth Factor beta - genetics | Nitriles - pharmacology | Humans | Activins - metabolism | Recombinant Fusion Proteins - metabolism | Granulosa Cells - drug effects | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Growth Differentiation Factor 9 | Bone Morphogenetic Protein Receptors, Type I | Female | Membrane Proteins - metabolism | Genes, Reporter | Protein-Serine-Threonine Kinases - metabolism | Thymidine - metabolism | Protein Structure, Tertiary | Butadienes - pharmacology | Follicle Stimulating Hormone - metabolism | Granulosa Cells - physiology | Receptors, Growth Factor | Cells, Cultured | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Rats | Activin Receptors, Type I - metabolism | Activin Receptors, Type I - genetics | Bone Morphogenetic Protein Receptors, Type II | Rats, Sprague-Dawley | Bone Morphogenetic Protein 15 | Animals | Receptors, Transforming Growth Factor beta - metabolism | Smad1 Protein | Progesterone - metabolism | Smad Proteins | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Trans-Activators - metabolism | Mitogen-Activated Protein Kinases - metabolism
I RECEPTORS | PATHWAYS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | GROWTH-DIFFERENTIATION FACTOR-9 | OOCYTES | OSTEOGENIC PROTEIN-1 | BETA SUPERFAMILY | IDENTIFICATION | EXPRESSION | ACTIVIN | Presenilin-1 | Receptors, Transforming Growth Factor beta - genetics | Nitriles - pharmacology | Humans | Activins - metabolism | Recombinant Fusion Proteins - metabolism | Granulosa Cells - drug effects | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Growth Differentiation Factor 9 | Bone Morphogenetic Protein Receptors, Type I | Female | Membrane Proteins - metabolism | Genes, Reporter | Protein-Serine-Threonine Kinases - metabolism | Thymidine - metabolism | Protein Structure, Tertiary | Butadienes - pharmacology | Follicle Stimulating Hormone - metabolism | Granulosa Cells - physiology | Receptors, Growth Factor | Cells, Cultured | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Rats | Activin Receptors, Type I - metabolism | Activin Receptors, Type I - genetics | Bone Morphogenetic Protein Receptors, Type II | Rats, Sprague-Dawley | Bone Morphogenetic Protein 15 | Animals | Receptors, Transforming Growth Factor beta - metabolism | Smad1 Protein | Progesterone - metabolism | Smad Proteins | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Trans-Activators - metabolism | Mitogen-Activated Protein Kinases - metabolism
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 2004, Volume 75, Issue 1, pp. 106 - 111
Hypergonadotropic ovarian failure is a common cause of female infertility. It is a heterogeneous disorder that, in the most severe forms, is a result of...
WOMEN | CELLS | INCREASED OVULATION RATE | GENETICS & HEREDITY | INFERTILITY | SHEEP | GROWTH-DIFFERENTIATION FACTOR-9 | OOCYTES | SECRETION | REGION | Amino Acid Sequence | Genetic Predisposition to Disease | Chromosomes, Human, X - genetics | Humans | Intercellular Signaling Peptides and Proteins - genetics | Molecular Sequence Data | Amenorrhea - genetics | Mutation, Missense | Sequence Homology, Amino Acid | Bone Morphogenetic Protein 15 | Growth Differentiation Factor 9 | Pedigree | Karyotyping | Adolescent | Alleles | Ovary - abnormalities | Primary Ovarian Insufficiency - genetics | Adult | Female | Bone Morphogenetic Proteins - genetics | Granulosa Cells - pathology | Human genetics | Research | Report
WOMEN | CELLS | INCREASED OVULATION RATE | GENETICS & HEREDITY | INFERTILITY | SHEEP | GROWTH-DIFFERENTIATION FACTOR-9 | OOCYTES | SECRETION | REGION | Amino Acid Sequence | Genetic Predisposition to Disease | Chromosomes, Human, X - genetics | Humans | Intercellular Signaling Peptides and Proteins - genetics | Molecular Sequence Data | Amenorrhea - genetics | Mutation, Missense | Sequence Homology, Amino Acid | Bone Morphogenetic Protein 15 | Growth Differentiation Factor 9 | Pedigree | Karyotyping | Adolescent | Alleles | Ovary - abnormalities | Primary Ovarian Insufficiency - genetics | Adult | Female | Bone Morphogenetic Proteins - genetics | Granulosa Cells - pathology | Human genetics | Research | Report
Journal Article
Animal Reproduction Science, ISSN 0378-4320, 05/2018, Volume 192, pp. 69 - 77
Currently there is no contraceptive vaccine that can cause permanent sterility in mares. This study investigates the effect of vaccination against...
Contraceptive | Equine | Mare | BMP-15 | GDF-9 | INCREASED OVULATION RATE | AGRICULTURE, DAIRY & ANIMAL SCIENCE | HEMORRHAGIC ANOVULATORY FOLLICLES | SHEEP | BMP15 | GDF9 | REPRODUCTIVE BIOLOGY | GENES | MUTATIONS | ESTROUS-CYCLE | Animals | Ovary - immunology | Vaccines, Contraceptive - immunology | Growth Differentiation Factor 9 - immunology | Female | Immunization Schedule | Ovary - physiology | Horses - physiology | Bone Morphogenetic Protein 15 - immunology | Ovulation - immunology | Phosphates | Bone morphogenetic proteins | Contraceptives | Growth | Analysis | Vaccination
Contraceptive | Equine | Mare | BMP-15 | GDF-9 | INCREASED OVULATION RATE | AGRICULTURE, DAIRY & ANIMAL SCIENCE | HEMORRHAGIC ANOVULATORY FOLLICLES | SHEEP | BMP15 | GDF9 | REPRODUCTIVE BIOLOGY | GENES | MUTATIONS | ESTROUS-CYCLE | Animals | Ovary - immunology | Vaccines, Contraceptive - immunology | Growth Differentiation Factor 9 - immunology | Female | Immunization Schedule | Ovary - physiology | Horses - physiology | Bone Morphogenetic Protein 15 - immunology | Ovulation - immunology | Phosphates | Bone morphogenetic proteins | Contraceptives | Growth | Analysis | Vaccination
Journal Article
Journal of Physiology and Pharmacology, ISSN 0867-5910, 10/2017, Volume 68, Issue 5, pp. 683 - 691
Bone morphogenetic protein-15 (BMP-15), an oocyte-derived growth factor, has been shown to play integral roles in regulation of ovarian follicular function in...
Granulosa cells | Bone morphogenetic protein-15 | Progesterone | Cumulus extracellular matrix | Hyaluronic acid | Ovarian follicle | MAMMALIAN OVARY | ovarian follicle | PHYSIOLOGY | GRANULOSA-CELLS | PIG OOCYTES | progesterone | cumulus extracellular matrix | granulosa cells | bone morphogenetic protein-15 | hyaluronic acid | IN-VITRO MATURATION | MESSENGER-RNA | EXPANSION | GROWTH-DIFFERENTIATION FACTOR-9 | EXTRACELLULAR-MATRIX | RNA EXPRESSION | OOCYTE-CUMULUS COMPLEXES
Granulosa cells | Bone morphogenetic protein-15 | Progesterone | Cumulus extracellular matrix | Hyaluronic acid | Ovarian follicle | MAMMALIAN OVARY | ovarian follicle | PHYSIOLOGY | GRANULOSA-CELLS | PIG OOCYTES | progesterone | cumulus extracellular matrix | granulosa cells | bone morphogenetic protein-15 | hyaluronic acid | IN-VITRO MATURATION | MESSENGER-RNA | EXPANSION | GROWTH-DIFFERENTIATION FACTOR-9 | EXTRACELLULAR-MATRIX | RNA EXPRESSION | OOCYTE-CUMULUS COMPLEXES
Journal Article
Human Reproduction, ISSN 0268-1161, 06/2007, Volume 22, Issue 6, pp. 1526 - 1531
BACKGROUND Bone morphogenetic protein-15 (BMP-15) has been shown to influence oocyte maturation and quality. However, no relationship has been established...
IVF | Embryonic development | Bone morphogenetic protein-15 | Follicular fluid | Oocyte | STIMULATING-HORMONE | INCREASED OVULATION RATE | embryonic development | bone morphogenetic protein-15 | follicular fluid | BMP15 | OBSTETRICS & GYNECOLOGY | IN-VITRO | REPRODUCTIVE BIOLOGY | oocyte | GENE | CYTOPLASMIC MATURATION | GROWTH-DIFFERENTIATION FACTOR-9 | MUTATIONS | KIT-LIGAND | EXPRESSION | Intercellular Signaling Peptides and Proteins - analysis | Estradiol - analysis | Humans | Biomarkers - analysis | Male | Embryonic Development | Follicular Fluid - chemistry | Pregnancy | Sperm Injections, Intracytoplasmic | Bone Morphogenetic Protein 15 | Follicle Stimulating Hormone - analysis | Oocytes - physiology | Embryo, Mammalian - anatomy & histology | Growth Differentiation Factor 9 | Adult | Female | Cleavage Stage, Ovum - cytology
IVF | Embryonic development | Bone morphogenetic protein-15 | Follicular fluid | Oocyte | STIMULATING-HORMONE | INCREASED OVULATION RATE | embryonic development | bone morphogenetic protein-15 | follicular fluid | BMP15 | OBSTETRICS & GYNECOLOGY | IN-VITRO | REPRODUCTIVE BIOLOGY | oocyte | GENE | CYTOPLASMIC MATURATION | GROWTH-DIFFERENTIATION FACTOR-9 | MUTATIONS | KIT-LIGAND | EXPRESSION | Intercellular Signaling Peptides and Proteins - analysis | Estradiol - analysis | Humans | Biomarkers - analysis | Male | Embryonic Development | Follicular Fluid - chemistry | Pregnancy | Sperm Injections, Intracytoplasmic | Bone Morphogenetic Protein 15 | Follicle Stimulating Hormone - analysis | Oocytes - physiology | Embryo, Mammalian - anatomy & histology | Growth Differentiation Factor 9 | Adult | Female | Cleavage Stage, Ovum - cytology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2001, Volume 276, Issue 14, pp. 11387 - 11392
We have recently reported that oocyte-derived bone morphogenetic protein-15 (BMP-15) can directly modulate follicle-stimulating hormone (FSH) action in rat...
MAMMALIAN OVARY | CHAIN CLEAVAGE CYTOCHROME-P-450 | MESSENGER-RIBONUCLEIC-ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE OOCYTES | GROWTH-DIFFERENTIATION FACTOR-9 | CUMULUS CELLS | RAT GRANULOSA-CELLS | INDEPENDENT REGULATION | OVULATION RATE | HOMOLOG GDF-9B | Follicle Stimulating Hormone - metabolism | Intercellular Signaling Peptides and Proteins | Cells, Cultured | Rats | Rats, Sprague-Dawley | Receptors, FSH - antagonists & inhibitors | Granulosa Cells - metabolism | Bone Morphogenetic Protein 15 | Animals | Signal Transduction - drug effects | Growth Differentiation Factor 9 | Growth Substances - pharmacology | Female | Growth Substances - metabolism | Receptors, FSH - metabolism
MAMMALIAN OVARY | CHAIN CLEAVAGE CYTOCHROME-P-450 | MESSENGER-RIBONUCLEIC-ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE OOCYTES | GROWTH-DIFFERENTIATION FACTOR-9 | CUMULUS CELLS | RAT GRANULOSA-CELLS | INDEPENDENT REGULATION | OVULATION RATE | HOMOLOG GDF-9B | Follicle Stimulating Hormone - metabolism | Intercellular Signaling Peptides and Proteins | Cells, Cultured | Rats | Rats, Sprague-Dawley | Receptors, FSH - antagonists & inhibitors | Granulosa Cells - metabolism | Bone Morphogenetic Protein 15 | Animals | Signal Transduction - drug effects | Growth Differentiation Factor 9 | Growth Substances - pharmacology | Female | Growth Substances - metabolism | Receptors, FSH - metabolism
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2003, Volume 278, Issue 6, pp. 3713 - 3719
Bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9 (GDF-9) are members of the transforming growth factor-beta superfamily. Both...
Cell Line | Electrophoresis, Polyacrylamide Gel | Humans | Intercellular Signaling Peptides and Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Intercellular Signaling Peptides and Proteins - physiology | Bone Morphogenetic Protein 15 | Phenotype | Animals | Growth Differentiation Factor 9 | Female | Sheep | Intercellular Signaling Peptides and Proteins - secretion | Mutation | Ovary - metabolism
Cell Line | Electrophoresis, Polyacrylamide Gel | Humans | Intercellular Signaling Peptides and Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Intercellular Signaling Peptides and Proteins - physiology | Bone Morphogenetic Protein 15 | Phenotype | Animals | Growth Differentiation Factor 9 | Female | Sheep | Intercellular Signaling Peptides and Proteins - secretion | Mutation | Ovary - metabolism
Journal Article
Endocrinology, ISSN 0013-7227, 03/2012, Volume 153, Issue 3, pp. 1509 - 1518
Genetic studies have identified bone morphogenetic protein-15 (BMP15) as an essential regulator of female fertility in humans and in sheep. Oocyte-derived...
INCREASED OVULATION RATE | SMAD PROTEINS | BMP15 GENE | TRANSFORMING GROWTH-FACTOR-BETA-2 | I RECEPTOR | MUTATION | ENDOCRINOLOGY & METABOLISM | GROWTH-DIFFERENTIATION FACTOR-9 | INHIBIN-B PRODUCTION | FACTOR-BETA SUPERFAMILY | LUTEAL CELLS | Protein Structure, Tertiary | Humans | Gene Expression Regulation | Bone Morphogenetic Protein 15 - metabolism | Cercopithecus aethiops | Recombinant Fusion Proteins - chemistry | Bone Morphogenetic Protein Receptors, Type I - metabolism | Granulosa Cells - metabolism | Homozygote | Animals | Female | Cell Membrane - metabolism | COS Cells | Dimerization | Genes, Reporter | Granulosa Cells - cytology | Ovary - metabolism
INCREASED OVULATION RATE | SMAD PROTEINS | BMP15 GENE | TRANSFORMING GROWTH-FACTOR-BETA-2 | I RECEPTOR | MUTATION | ENDOCRINOLOGY & METABOLISM | GROWTH-DIFFERENTIATION FACTOR-9 | INHIBIN-B PRODUCTION | FACTOR-BETA SUPERFAMILY | LUTEAL CELLS | Protein Structure, Tertiary | Humans | Gene Expression Regulation | Bone Morphogenetic Protein 15 - metabolism | Cercopithecus aethiops | Recombinant Fusion Proteins - chemistry | Bone Morphogenetic Protein Receptors, Type I - metabolism | Granulosa Cells - metabolism | Homozygote | Animals | Female | Cell Membrane - metabolism | COS Cells | Dimerization | Genes, Reporter | Granulosa Cells - cytology | Ovary - metabolism
Journal Article
Fertility and Sterility, ISSN 0015-0282, 2010, Volume 94, Issue 1, pp. 261 - 267
Objective To evaluate the effect of growth differentiation factor-9 (GDF-9) and bone morphogenetic protein-15 (BMP-15) on the development of follicles among...
Internal Medicine | Obstetrics and Gynecology | PCOS | follicular development | GDF-9 | BMP-15 | SMAD2 | SHEEP | FAILURE | HAMSTER | BMP15 | OBSTETRICS & GYNECOLOGY | WOMEN | REPRODUCTIVE BIOLOGY | GENES | FOLLICLE-STIMULATING-HORMONE | MUTATIONS | OVULATION RATE | Cumulus Cells - pathology | Polycystic Ovary Syndrome - metabolism | Oocytes - metabolism | Humans | Gene Expression Regulation | Sperm Injections, Intracytoplasmic - methods | Case-Control Studies | Growth Differentiation Factor 9 - biosynthesis | Cumulus Cells - metabolism | Growth Differentiation Factor 9 - antagonists & inhibitors | Bone Morphogenetic Protein 15 - genetics | Adult | Female | Bone Morphogenetic Protein 15 - biosynthesis | Polycystic Ovary Syndrome - pathology | Growth Differentiation Factor 9 - genetics
Internal Medicine | Obstetrics and Gynecology | PCOS | follicular development | GDF-9 | BMP-15 | SMAD2 | SHEEP | FAILURE | HAMSTER | BMP15 | OBSTETRICS & GYNECOLOGY | WOMEN | REPRODUCTIVE BIOLOGY | GENES | FOLLICLE-STIMULATING-HORMONE | MUTATIONS | OVULATION RATE | Cumulus Cells - pathology | Polycystic Ovary Syndrome - metabolism | Oocytes - metabolism | Humans | Gene Expression Regulation | Sperm Injections, Intracytoplasmic - methods | Case-Control Studies | Growth Differentiation Factor 9 - biosynthesis | Cumulus Cells - metabolism | Growth Differentiation Factor 9 - antagonists & inhibitors | Bone Morphogenetic Protein 15 - genetics | Adult | Female | Bone Morphogenetic Protein 15 - biosynthesis | Polycystic Ovary Syndrome - pathology | Growth Differentiation Factor 9 - genetics
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 09/2007, Volume 194, Issue 3, pp. 485 - 497
The bone morphogenetic protein 15 (Bmp15) and growth differentiation factor 9 (Gdf9) genes are two members of the transforming growth factor-beta superfamily....
INCREASED OVULATION RATE | SYNERGISTIC ROLES | MESSENGER-RNA | PROGESTERONE SECRETION | FOLLICULAR DEVELOPMENT | CHICKEN GRANULOSA | ENDOCRINOLOGY & METABOLISM | GERMINAL DISC REGION | GROWTH-DIFFERENTIATION FACTOR-9 | BETA SUPERFAMILY | GRANULOSA-CELL PROLIFERATION | Intercellular Signaling Peptides and Proteins - analysis | Ovary - chemistry | Humans | Granulosa Cells - secretion | Molecular Sequence Data | RNA, Messenger - analysis | Phosphoproteins - metabolism | Granulosa Cells - drug effects | Granulosa Cells - metabolism | Chickens - metabolism | Cattle | Growth Differentiation Factor 9 | Base Sequence | Female | Ovary - metabolism | Follicular Phase | Amino Acid Sequence | Progesterone - secretion | Gene Expression | Oocytes - metabolism | Oocytes - chemistry | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Rats | Zebrafish | Reverse Transcriptase Polymerase Chain Reaction | Bone Morphogenetic Protein 15 | Sequence Alignment | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Smad1 Protein - metabolism | Mice
INCREASED OVULATION RATE | SYNERGISTIC ROLES | MESSENGER-RNA | PROGESTERONE SECRETION | FOLLICULAR DEVELOPMENT | CHICKEN GRANULOSA | ENDOCRINOLOGY & METABOLISM | GERMINAL DISC REGION | GROWTH-DIFFERENTIATION FACTOR-9 | BETA SUPERFAMILY | GRANULOSA-CELL PROLIFERATION | Intercellular Signaling Peptides and Proteins - analysis | Ovary - chemistry | Humans | Granulosa Cells - secretion | Molecular Sequence Data | RNA, Messenger - analysis | Phosphoproteins - metabolism | Granulosa Cells - drug effects | Granulosa Cells - metabolism | Chickens - metabolism | Cattle | Growth Differentiation Factor 9 | Base Sequence | Female | Ovary - metabolism | Follicular Phase | Amino Acid Sequence | Progesterone - secretion | Gene Expression | Oocytes - metabolism | Oocytes - chemistry | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Rats | Zebrafish | Reverse Transcriptase Polymerase Chain Reaction | Bone Morphogenetic Protein 15 | Sequence Alignment | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Smad1 Protein - metabolism | Mice
Journal Article
Endocrinology, ISSN 0013-7227, 06/2008, Volume 149, Issue 6, pp. 2807 - 2815
Whereas mutations in the bmp15 gene cause infertility in ewes and women due to defects in folliculogenesis, most defects in female mice lacking bone...
INCREASED OVULATION RATE | GRANULOSA-CELLS | BMP15 GENE | ENDOCRINOLOGY & METABOLISM | FOLLICLE-STIMULATING-HORMONE | GROWTH-DIFFERENTIATION FACTOR-9 | SEQUENCE VARIANTS | VAGINAL CYTOLOGY | PREMATURE OVARIAN FAILURE | MUTATIONS | BMP-15 | Ovulation - genetics | Estrus | Humans | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Mice, Transgenic | Bone Morphogenetic Protein 15 | Fertility - genetics | Animals | Oocytes - physiology | Growth Differentiation Factor 9 | Ovarian Follicle - physiology | Polymerase Chain Reaction | Female | Mice | Ovulation - physiology
INCREASED OVULATION RATE | GRANULOSA-CELLS | BMP15 GENE | ENDOCRINOLOGY & METABOLISM | FOLLICLE-STIMULATING-HORMONE | GROWTH-DIFFERENTIATION FACTOR-9 | SEQUENCE VARIANTS | VAGINAL CYTOLOGY | PREMATURE OVARIAN FAILURE | MUTATIONS | BMP-15 | Ovulation - genetics | Estrus | Humans | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Mice, Transgenic | Bone Morphogenetic Protein 15 | Fertility - genetics | Animals | Oocytes - physiology | Growth Differentiation Factor 9 | Ovarian Follicle - physiology | Polymerase Chain Reaction | Female | Mice | Ovulation - physiology
Journal Article
Reproductive Biology and Endocrinology, ISSN 1477-7827, 12/2012, Volume 10, Issue 1, pp. 116 - 116
Background: The counselling of poor ovarian responders about the probability of pregnancy remains a puzzle for gynaecologists. The aim of this study was to...
Retrospective study | Poor response | BMP-15 | IVF-ET | Age | Oocyte | CELLS | QUALITY | BMP15 | REPRODUCTIVE BIOLOGY | HORMONE | RESERVE | ENDOCRINOLOGY & METABOLISM | FSH | IN-VITRO FERTILIZATION | EXPRESSION | Age Factors | Ovarian Follicle - anatomy & histology | Ovulation Induction | Humans | Treatment Outcome | Oocyte Retrieval | Follicular Fluid - chemistry | Pregnancy | Infertility, Female - physiopathology | Sperm Injections, Intracytoplasmic | Fertilization in Vitro | Embryo Transfer | Ovarian Follicle - physiology | Bone Morphogenetic Protein 15 - analysis | Adult | Female | Ovary - drug effects | Infertility, Female - therapy | Ovary - physiopathology | Fertilization in vitro, Human | Bone morphogenetic proteins | Maternal age | Embryo transplantation | Reproductive health | Medicine | Ultrasonic imaging | Womens health | Infertility | Reproductive technologies | Patients | Embryos
Retrospective study | Poor response | BMP-15 | IVF-ET | Age | Oocyte | CELLS | QUALITY | BMP15 | REPRODUCTIVE BIOLOGY | HORMONE | RESERVE | ENDOCRINOLOGY & METABOLISM | FSH | IN-VITRO FERTILIZATION | EXPRESSION | Age Factors | Ovarian Follicle - anatomy & histology | Ovulation Induction | Humans | Treatment Outcome | Oocyte Retrieval | Follicular Fluid - chemistry | Pregnancy | Infertility, Female - physiopathology | Sperm Injections, Intracytoplasmic | Fertilization in Vitro | Embryo Transfer | Ovarian Follicle - physiology | Bone Morphogenetic Protein 15 - analysis | Adult | Female | Ovary - drug effects | Infertility, Female - therapy | Ovary - physiopathology | Fertilization in vitro, Human | Bone morphogenetic proteins | Maternal age | Embryo transplantation | Reproductive health | Medicine | Ultrasonic imaging | Womens health | Infertility | Reproductive technologies | Patients | Embryos
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2011, Volume 338, Issue 1, pp. 1 - 9
This study investigates steady-state level of bone morphogenetic protein-15 (BMP-15) mRNA in caprine follicles, and the effects of BMP-15 on development of...
Preantral follicles | Activation | Growth | BMP-15 | Caprine | STIMULATING-HORMONE | PRIMORDIAL FOLLICLES | BONE-MORPHOGENETIC-PROTEIN-15 BMP15 | HOMOLOG GDF-9B | CELL BIOLOGY | BETA SUPERFAMILY MEMBERS | MESSENGER-RNA | FOLLICULAR DEVELOPMENT | ENDOCRINOLOGY & METABOLISM | GROWTH-DIFFERENTIATION FACTOR-9 | GRANULOSA-CELL FUNCTION | GROWTH-DIFFERENTIATION-FACTOR-9 COOPERATE | Cell Survival - drug effects | Microscopy, Electron, Transmission | Oocytes - growth & development | Ovarian Follicle - anatomy & histology | Ovarian Follicle - growth & development | Tissue Culture Techniques | Bone Morphogenetic Protein 15 - metabolism | Goats - growth & development | Ovarian Follicle - drug effects | Animals | Bone Morphogenetic Protein 15 - genetics | Oocytes - drug effects | Female | Transcription, Genetic | Bone Morphogenetic Protein 15 - pharmacology | Ovarian Follicle - metabolism | Bone morphogenetic proteins | Messenger RNA | Universities and colleges
Preantral follicles | Activation | Growth | BMP-15 | Caprine | STIMULATING-HORMONE | PRIMORDIAL FOLLICLES | BONE-MORPHOGENETIC-PROTEIN-15 BMP15 | HOMOLOG GDF-9B | CELL BIOLOGY | BETA SUPERFAMILY MEMBERS | MESSENGER-RNA | FOLLICULAR DEVELOPMENT | ENDOCRINOLOGY & METABOLISM | GROWTH-DIFFERENTIATION FACTOR-9 | GRANULOSA-CELL FUNCTION | GROWTH-DIFFERENTIATION-FACTOR-9 COOPERATE | Cell Survival - drug effects | Microscopy, Electron, Transmission | Oocytes - growth & development | Ovarian Follicle - anatomy & histology | Ovarian Follicle - growth & development | Tissue Culture Techniques | Bone Morphogenetic Protein 15 - metabolism | Goats - growth & development | Ovarian Follicle - drug effects | Animals | Bone Morphogenetic Protein 15 - genetics | Oocytes - drug effects | Female | Transcription, Genetic | Bone Morphogenetic Protein 15 - pharmacology | Ovarian Follicle - metabolism | Bone morphogenetic proteins | Messenger RNA | Universities and colleges
Journal Article
Endocrinology, ISSN 0013-7227, 12/2002, Volume 143, Issue 12, pp. 4938 - 4941
Bone morphogenetic protein-15 (BMP-15) has been known to be an oocyte-specific factor and regulate granulosa cell functions. Here, we report that BMP-15 is...
CELLS | RAT | DISCRETE STAGES | ENDOCRINOLOGY & METABOLISM | FOLLICLE-STIMULATING-HORMONE | FOLLISTATIN | EXPRESSION | BINDING | ACTIVIN | BETA | Transcription, Genetic - drug effects | Receptors, LHRH - genetics | Receptors, FSH - genetics | Ovary - chemistry | RNA, Messenger - analysis | Male | Pituitary Gland - chemistry | Pituitary Gland, Anterior - metabolism | Intercellular Signaling Peptides and Proteins - physiology | Growth Differentiation Factor 9 | Female | Bone Morphogenetic Proteins - pharmacology | Luteinizing Hormone - biosynthesis | Transforming Growth Factor beta | Luteinizing Hormone - secretion | Bone Morphogenetic Protein 6 | Cell Line | Gene Expression | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Rats | Follicle Stimulating Hormone - biosynthesis | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Bone Morphogenetic Protein 15 | Inhibin-beta Subunits - pharmacology | Animals | Follicle Stimulating Hormone - secretion | Activins - pharmacology | Intercellular Signaling Peptides and Proteins - pharmacology | Luteinizing Hormone, beta Subunit - genetics | Follicle Stimulating Hormone, beta Subunit - genetics | Mice | Bone Morphogenetic Protein 7 | Pituitary Gland - physiology
CELLS | RAT | DISCRETE STAGES | ENDOCRINOLOGY & METABOLISM | FOLLICLE-STIMULATING-HORMONE | FOLLISTATIN | EXPRESSION | BINDING | ACTIVIN | BETA | Transcription, Genetic - drug effects | Receptors, LHRH - genetics | Receptors, FSH - genetics | Ovary - chemistry | RNA, Messenger - analysis | Male | Pituitary Gland - chemistry | Pituitary Gland, Anterior - metabolism | Intercellular Signaling Peptides and Proteins - physiology | Growth Differentiation Factor 9 | Female | Bone Morphogenetic Proteins - pharmacology | Luteinizing Hormone - biosynthesis | Transforming Growth Factor beta | Luteinizing Hormone - secretion | Bone Morphogenetic Protein 6 | Cell Line | Gene Expression | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Rats | Follicle Stimulating Hormone - biosynthesis | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Bone Morphogenetic Protein 15 | Inhibin-beta Subunits - pharmacology | Animals | Follicle Stimulating Hormone - secretion | Activins - pharmacology | Intercellular Signaling Peptides and Proteins - pharmacology | Luteinizing Hormone, beta Subunit - genetics | Follicle Stimulating Hormone, beta Subunit - genetics | Mice | Bone Morphogenetic Protein 7 | Pituitary Gland - physiology
Journal Article
Comparative Biochemistry and Physiology, Part A, ISSN 1095-6433, 2009, Volume 153, Issue 1, pp. 83 - 87
Bone morphogenetic protein (BMP)-15 is a member of the transforming growth factor β (TGF-β) superfamily and is closely related to growth and differentiation...
Ovary | Zebrafish | BMP-15 | Oocyte maturation | INCREASED OVULATION RATE | PHYSIOLOGY | TGF-BETA | BMP15 GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH-DIFFERENTIATION-FACTOR-9 GDF9 | BONE-MORPHOGENETIC-PROTEIN-15 BMP15 | PREMATURE OVARIAN FAILURE | SPATIOTEMPORAL EXPRESSION | ZOOLOGY | MESSENGER-RNA | GROWTH-DIFFERENTIATION FACTOR-9 | MEMBRANE PROGESTIN RECEPTOR | Oogenesis | Animals | Bone Morphogenetic Protein 15 - chemistry | Oocytes - growth & development | Ovarian Follicle - growth & development | Zebrafish - metabolism | Bone Morphogenetic Protein 15 - metabolism | Female | Ovarian Follicle - metabolism | Zebrafish - growth & development
Ovary | Zebrafish | BMP-15 | Oocyte maturation | INCREASED OVULATION RATE | PHYSIOLOGY | TGF-BETA | BMP15 GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH-DIFFERENTIATION-FACTOR-9 GDF9 | BONE-MORPHOGENETIC-PROTEIN-15 BMP15 | PREMATURE OVARIAN FAILURE | SPATIOTEMPORAL EXPRESSION | ZOOLOGY | MESSENGER-RNA | GROWTH-DIFFERENTIATION FACTOR-9 | MEMBRANE PROGESTIN RECEPTOR | Oogenesis | Animals | Bone Morphogenetic Protein 15 - chemistry | Oocytes - growth & development | Ovarian Follicle - growth & development | Zebrafish - metabolism | Bone Morphogenetic Protein 15 - metabolism | Female | Ovarian Follicle - metabolism | Zebrafish - growth & development
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 01/2011, Volume 332, Issue 1-2, pp. 106 - 115
Oocyte-derived bone morphogenetic protein-15 (BMP15) is critical for the regulation of mammalian fertility. Previously we have found that a C-terminal His -tag...
Human | Granulosa cell | Bone morphogenetic protein | BMP15 | GRANULOSA-LUTEAL CELLS | PREMATURE OVARIAN FAILURE | INDIAN WOMEN | CELL BIOLOGY | MESSENGER-RNA | TRANSFORMING GROWTH-FACTOR-BETA-2 | ENDOCRINOLOGY & METABOLISM | GROWTH-DIFFERENTIATION FACTOR-9 | INHIBIN-B PRODUCTION | FACTOR-BETA SUPERFAMILY | OVULATION RATE | GROWTH-DIFFERENTIATION-FACTOR-9 COOPERATE | Luteal Cells - metabolism | Bone Morphogenetic Protein 15 - chemistry | Humans | Bone Morphogenetic Protein 15 - metabolism | Rats | Luteal Cells - cytology | Animals | Oocytes - physiology | Growth Differentiation Factor 9 - metabolism | Growth Differentiation Factor 9 - chemistry | Bone Morphogenetic Protein 15 - genetics | HEK293 Cells | Female | Growth Differentiation Factor 9 - genetics | Transforming Growth Factor beta - metabolism | Genes, Reporter | Stimulators | Control | Fertility | Rodents | Bones | Biochemistry | Flags | Recombinant
Human | Granulosa cell | Bone morphogenetic protein | BMP15 | GRANULOSA-LUTEAL CELLS | PREMATURE OVARIAN FAILURE | INDIAN WOMEN | CELL BIOLOGY | MESSENGER-RNA | TRANSFORMING GROWTH-FACTOR-BETA-2 | ENDOCRINOLOGY & METABOLISM | GROWTH-DIFFERENTIATION FACTOR-9 | INHIBIN-B PRODUCTION | FACTOR-BETA SUPERFAMILY | OVULATION RATE | GROWTH-DIFFERENTIATION-FACTOR-9 COOPERATE | Luteal Cells - metabolism | Bone Morphogenetic Protein 15 - chemistry | Humans | Bone Morphogenetic Protein 15 - metabolism | Rats | Luteal Cells - cytology | Animals | Oocytes - physiology | Growth Differentiation Factor 9 - metabolism | Growth Differentiation Factor 9 - chemistry | Bone Morphogenetic Protein 15 - genetics | HEK293 Cells | Female | Growth Differentiation Factor 9 - genetics | Transforming Growth Factor beta - metabolism | Genes, Reporter | Stimulators | Control | Fertility | Rodents | Bones | Biochemistry | Flags | Recombinant
Journal Article