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Journal Article
JOURNAL OF BIOMOLECULAR NMR, ISSN 0925-2738, 07/1994, Volume 4, Issue 4, pp. 463 - 482
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 2002, Volume 81, Issue 1, pp. 101 - 111
This study proposes a strategy to generate new anticancer therapy using hydrogel-based drug delivery systems to improve drug bioavailability and increase the... 
Cyclosporine A | Antibody-targeted HPMA-conjugates | Biodegradable HPMA-hydrogels | Doxorubicin | Pharmacokinetic | cyclosporine A | ENZYMATICALLY DEGRADABLE BONDS | SOLID TUMORS | INVITRO | antibody-targeted HPMA-conjugates | CHEMISTRY, MULTIDISCIPLINARY | CARCINOMA CELL-LINE | N-(2-HYDROXYPROPYL)METHACRYLAMIDE | INVIVO | COPOLYMER-BOUND ADRIAMYCIN | CO-POLYMERS | PHARMACOLOGY & PHARMACY | doxorubicin | biodegradable HPMA-hydrogels | pharmacokinetic | MONOCLONAL-ANTIBODIES | MULTIDRUG-RESISTANCE | Cyclosporine - pharmacology | Cross-Linking Reagents - pharmacology | Hydrogels - pharmacokinetics | Methacrylates - pharmacokinetics | Drug Implants - pharmacokinetics | Tumor Cells, Cultured - pathology | Leukemia P388 - pathology | Delayed-Action Preparations - pharmacology | Delayed-Action Preparations - pharmacokinetics | Cyclosporine - pharmacokinetics | Methacrylates - pharmacology | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cross-Linking Reagents - pharmacokinetics | Growth Inhibitors - pharmacology | Tumor Cells, Cultured - drug effects | Doxorubicin - pharmacokinetics | Drug Carriers - pharmacology | Drug Implants - pharmacology | Leukemia P388 - drug therapy | Animals | Drug Carriers - pharmacokinetics | Mice | Mice, Inbred BALB C | Hydrogels - pharmacology | Drug Delivery Systems - methods | Doxorubicin - pharmacology | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
Advanced Drug Delivery Reviews, ISSN 0169-409X, 2009, Volume 61, Issue 13, pp. 1149 - 1158
This paper reviews an early clinical experience with anthracycline (epirubicin; Epi or doxorubicin; Dox) containing an -(2-hydroyxypropyl)methacrylamide... 
CRP | Cancer patients | NK cells | Tumor markers | Immunostimulation | LAK | Doxorubicin–HPMA–HuIg | Anthracycline antibiotics | HuIg | Epirubicin–HPMA–autologous IgG | Polymeric drug | HPMA | Epirubicin-HPMA-autologous IgG | Doxorubicin-HPMA-HuIg | C-REACTIVE PROTEIN | BONE-MARROW | POLYMER-BOUND DRUGS | PERIPHERAL-BLOOD | BREAST-CANCER | CARCINOMA CELL-LINE | CYCLOSPORINE-A | PHARMACOLOGY & PHARMACY | ANTITUMOR IMMUNITY | MULTIDRUG-RESISTANCE | PHASE-I | Doxorubicin - therapeutic use | Polymethacrylic Acids - adverse effects | Humans | Middle Aged | Antibiotics, Antineoplastic - adverse effects | Immunoglobulins, Intravenous - administration & dosage | Polymethacrylic Acids - therapeutic use | Drug Resistance, Neoplasm | Epirubicin - administration & dosage | Drug Carriers - chemistry | Drug Delivery Systems | Neoplasm Metastasis | Immunoglobulin G - immunology | Polymethacrylic Acids - administration & dosage | Doxorubicin - analogs & derivatives | Adult | Female | Doxorubicin - administration & dosage | Hemangiosarcoma - drug therapy | Immunologic Factors - administration & dosage | Immunologic Factors - immunology | Treatment Outcome | Breast Neoplasms - drug therapy | Immunoglobulin G - administration & dosage | Acrylamides - chemistry | Antibiotics, Antineoplastic - administration & dosage | Biomarkers, Tumor - blood | Animals | Antibiotics, Antineoplastic - therapeutic use | Epirubicin - therapeutic use | Quality of Life | Immunoglobulins, Intravenous - immunology | Doxorubicin - adverse effects | Epirubicin - adverse effects | Drugs | Care and treatment | Anthracyclines | Drug delivery systems | C-reactive protein | Immunoglobulin G | Metastasis | CEA (Oncology) | Cancer | Vehicles | Index Medicus | Anthracycline
Journal Article
DRUG METABOLISM AND DISPOSITION, ISSN 0090-9556, 11/1991, Volume 19, Issue 6, pp. 1147 - 1151
The distribution and immunosuppressive activity of liposomal cyclosporine (L-CSA) when administered iv as single- and multiple-doses were compared with the... 
HUMAN-PLASMA | DRUG | RAT | PHARMACOKINETICS | INJECTION | INVITRO | BOUND CYCLOSPORINE | PHARMACOLOGY & PHARMACY | TOXICITY | LIPOPROTEINS | NEPHROTOXICITY
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 01/1995, Volume 9, Issue 1, pp. 63 - 72
The use of the immunosuppressant drug cyclosporin A (CsA) as a biochemical tool to study the signal transduction pathway in T cells has led to the discovery of... 
RAPAMYCIN | CYTOSOLIC BINDING-PROTEIN | CYCLOSPORINE A | CRYSTAL-STRUCTURE | NMR-SPECTROSCOPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | X-RAY STRUCTURE | FK506 | PEPTIDYL-PROLYL ISOMERASE | BOUND CONFORMATION | FKBP | CYCLOSPORINE-A | CIS-TRANS ISOMERASE | HUMAN CYCLOPHILIN-B | BIOLOGY | MOLECULAR-CLONING | CYCLOPHILIN
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 02/2009, Volume 155, Issue 2, pp. 239 - 248
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 08/1992, Volume 149, Issue 3, pp. 762 - 767
Concomitant administration of cyclosporin A (CsA) with Ag has been shown to augment the production of Ag-specific IgE in vivo. We demonstrate that addition of... 
RESPONSES | T-CELL CLONES | TOLERANCE | LYMPHOCYTES-B | IL-4 | ANTIBODY | RECEPTOR | INDUCTION | IMMUNOLOGY | BINDING PROTEIN | BOUND IGE
Journal Article
Journal Article
Haematologica, ISSN 0390-6078, 07/2006, Volume 91, Issue 7, pp. 992 - 993
Journal Article
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 12/1999, Volume 277, Issue 6, pp. 1087 - 1094
The use of cyclosporin A has contributed greatly to the success of organ transplantation. However, cyclosporin-associated side effects of hypertension,... 
Transcription | Heart disease | Immunotherapy | Liver | Very low-density lipoprotein | Sterol regulatory element-binding protein | TRIGLYCERIDE TRANSFER PROTEIN | PHYSIOLOGY | transcription | liver | ACCELERATED ATHEROSCLEROSIS | B MESSENGER-RNA | BOUND TRANSCRIPTION FACTOR | APOLIPOPROTEIN-B | LIPID ABNORMALITIES | ACID SYNTHESIS | RENAL-TRANSPLANT RECIPIENTS | RECEPTOR ACTIVITY | DISULFIDE-ISOMERASE | heart disease | very low-density lipoprotein | immunotherapy | ENDOCRINOLOGY & METABOLISM | sterol regulatory element-binding protein | Triglycerides - secretion | Gene Expression Regulation, Enzymologic - drug effects | Transcription, Genetic - drug effects | Apolipoproteins B - metabolism | Sterols - metabolism | Liver - enzymology | RNA, Messenger - analysis | Apolipoprotein B-100 | Apolipoprotein B-48 | Sterols - biosynthesis | Acetyl-CoA Carboxylase - genetics | Coronary Disease - metabolism | Female | Hyperlipoproteinemias - chemically induced | Fatty Acid Synthases - genetics | Fatty Acids - metabolism | Steroid Hydroxylases - genetics | Receptors, LDL - genetics | Cholesterol, VLDL - metabolism | Coronary Disease - chemically induced | Farnesyl-Diphosphate Farnesyltransferase - genetics | Liver - secretion | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Stearoyl-CoA Desaturase - genetics | Cytochrome P-450 Enzyme System | Immunotherapy - adverse effects | Leucine Zippers - genetics | Triglycerides - metabolism | Cholesterol, VLDL - secretion | Animals | Cyclosporine - adverse effects | Apolipoproteins B - secretion | Hyperlipoproteinemias - metabolism | Immunosuppressive Agents - adverse effects | Mice | Hydroxymethylglutaryl CoA Reductases - genetics | Sterol Regulatory Element Binding Protein 2 | Fatty Acids - biosynthesis | Lipase - genetics | Lipoproteins | Messenger RNA | Carrier proteins | Analysis | Causes of | Physiological aspects | Cyclosporine | Research | Heart diseases | Index Medicus
Journal Article