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Nature Medicine, ISSN 1078-8956, 04/2010, Volume 16, Issue 4, pp. 438 - 445
Class Ia phosphoinositide 3-kinase (PI3K), an essential mediator of the metabolic actions of insulin, is composed of a catalytic (p110 alpha or p110 beta) and... 
MEDICINE, RESEARCH & EXPERIMENTAL | METABOLIC SYNDROME | PHOSPHATIDYLINOSITOL 3-KINASE | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | P85-ALPHA SUBUNIT | CELL BIOLOGY | SKELETAL-MUSCLE | MESSENGER-RNA | INSULIN-RESISTANCE | PURIFICATION METHOD | ADIPOSE-TISSUE | Insulin - physiology | Endoplasmic Reticulum - metabolism | Activating Transcription Factor 6 | Phosphatidylinositol 3-Kinases - metabolism | Cell Nucleus - physiology | X-Box Binding Protein 1 | Endoribonucleases - physiology | Gene Knockdown Techniques | Trans-Activators - physiology | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Membrane Proteins - physiology | Stress, Physiological - physiology | Cell Line | Unfolded Protein Response - drug effects | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Protein-Serine-Threonine Kinases - physiology | Liver - metabolism | Endoplasmic Reticulum - physiology | Regulatory Factor X Transcription Factors | Transcription Factors - metabolism | Animals | Tunicamycin - pharmacology | Liver - physiology | Phosphatidylinositol 3-Kinases - physiology | Mice | Apoptosis - physiology | Unfolded Protein Response - physiology | Transcription factors | Physiological aspects | Causes of | Insulin resistance | Genetic aspects | Research | Binding proteins | Protein kinases | Catalysis | Kinases | Metabolism | Protein folding | Insulin
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2012, Volume 287, Issue 4, pp. 2558 - 2567
Hepatic insulin resistance has been attributed to both increased endoplasmic reticulum (ER) stress and accumulation of intracellular lipids, specifically... 
GLUCOSE-HOMEOSTASIS | ENERGY-EXPENDITURE | MESSENGER-RNA | STEATOSIS | FATTY LIVER-DISEASE | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | DIET-INDUCED OBESITY | TRANSCRIPTION FACTOR | RECEPTOR SUBSTRATE-1 | Endoribonucleases - genetics | Phosphorylation | Endoplasmic Reticulum - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Insulin Receptor Substrate Proteins - metabolism | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Heat-Shock Proteins - genetics | Eukaryotic Initiation Factor-2 - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Insulin Receptor Substrate Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Endoplasmic Reticulum - genetics | Endoribonucleases - metabolism | Heat-Shock Proteins - metabolism | Liver - metabolism | Insulin Resistance | Protein-Serine-Threonine Kinases - genetics | Lipid Metabolism | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Mice, Knockout | Transcription Factors - metabolism | Animals | Endoplasmic Reticulum Stress | Eukaryotic Initiation Factor-2 - genetics | Mice | Liver Metabolism | ER Stress | Protein Kinase C (PKC) | Diacylglycerol | Glucose Metabolism | Ceramide | Metabolism | Gluconeogenesis
Journal Article
Journal Article
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Journal Article
Journal Article
Circulation, ISSN 0009-7322, 10/2007, Volume 116, Issue 16, pp. 1812 - 1820
Journal Article
Experimental Cell Research, ISSN 0014-4827, 08/2016, Volume 346, Issue 2, pp. 157 - 166
Journal Article
Circulation Research, ISSN 0009-7330, 07/2017, Volume 121, Issue 3, pp. 270 - 281
Journal Article