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1. Full Text Analysis of IDH1-R132 mutation, BRAF V600 mutation and KIAA1549–BRAF fusion transcript status in central nervous system tumors supports pediatric tumor classification
by Gierke, Midea and Gierke, Midea and Sperveslage, Jan and Sperveslage, Jan and Schwab, David and Schwab, David and Beschorner, Rudi and Beschorner, Rudi and Ebinger, Martin and Ebinger, Martin and Schuhmann, Martin U and Schuhmann, Martin U and Schittenhelm, Jens and Schittenhelm, Jens
Journal of cancer research and clinical oncology, ISSN 0171-5216, 1/2016, Volume 142, Issue 1, pp. 89 - 100
BRAF V600E | Medicine & Public Health | Hematology | Glioma | IDH1 | Classification | KIAA1549 – BRAF | Oncology | Cancer Research | Internal Medicine | KIAA1549–BRAF | Life Sciences & Biomedicine | Science & Technology | Oncogene Proteins, Fusion - metabolism | Prognosis | Follow-Up Studies | Tissue Array Analysis | Humans | Middle Aged | Child, Preschool | Infant | Male | Immunoenzyme Techniques | Young Adult | Polymerase Chain Reaction | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Child | Infant, Newborn | Proto-Oncogene Proteins B-raf - metabolism | Central Nervous System Neoplasms - classification | Central Nervous System Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Mutation - genetics | Central Nervous System Neoplasms - pathology | Oncogene Proteins, Fusion - genetics | Proto-Oncogene Proteins B-raf - genetics | Adolescent | Isocitrate Dehydrogenase - metabolism | Aged | Biomarkers, Tumor - genetics | Neoplasm Staging | Immunohistochemistry | Pediatrics | Genetic aspects | Gene mutations | Gliomas | Analysis | Index Medicus
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2. Full Text Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma: long-term survival and safety analysis of a phase 3 study
by Long, G.V and Flaherty, K.T and Stroyakovskiy, D and Gogas, H and Levchenko, E and de Braud, F and Larkin, J and Garbe, C and Jouary, T and Hauschild, A and Chiarion-Sileni, V and Lebbe, C and Mandalà, M and Millward, M and Arance, A and Bondarenko, I and Haanen, J.B.A.G and Hansson, J and Utikal, J and Ferraresi, V and Mohr, P and Probachai, V and Schadendorf, D and Nathan, P and Robert, C and Ribas, A and Davies, M.A and Lane, S.R and Legos, J.J and Mookerjee, B and Grob, J-J
Annals of oncology, ISSN 0923-7534, 07/2017, Volume 28, Issue 7, pp. 1631 - 1639
trametinib | melanoma | durable outcomes | BRAF | metastatic | dabrafenib | Life Sciences & Biomedicine | Oncology | Science & Technology | Index Medicus | Medicin och hälsovetenskap
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3. Full Text Mutation‐specific antibody detects mutant BRAFV600E protein expression in human colon carcinomas
by Sinicrope, Frank A and Smyrk, Thomas C and Tougeron, David and Thibodeau, Stephen N and Singh, Shalini and Muranyi, Andrea and Shanmugam, Kandavel and Grogan, Thomas M and Alberts, Steven R and Shi, Qian
Cancer, ISSN 0008-543X, 08/2013, Volume 119, Issue 15, pp. 2765 - 2770
microsatellite instability | immunohistochemistry | BRAFV600E mutation | BRAFV600E protein | colon cancer | mutation | BRAF | protein | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Tumors | Colonic Neoplasms - genetics | Microsatellite Instability | Prognosis | Prospective Studies | Antibodies - chemistry | Humans | Middle Aged | Male | Immunohistochemistry - methods | Point Mutation | Proto-Oncogene Proteins B-raf - biosynthesis | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Antibodies - genetics | Female | Aged | Biomarkers, Tumor - genetics | Colonic Neoplasms - enzymology | Neoplasm Staging | Biomarkers, Tumor - biosynthesis | Care and treatment | Colon cancer | Gene mutations | Patient outcomes | Physiological aspects | Genetic aspects | Research | Diagnosis | Gene expression | Index Medicus | Abridged Index Medicus | MSI
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4. Full Text Prognostic implication of BRAF and TERT promoter mutation combination in papillary thyroid carcinoma—A meta‐analysis
by Vuong, Huy Gia and Altibi, Ahmed M.A and Duong, Uyen N.P and Hassell, Lewis
Clinical endocrinology (Oxford), ISSN 0300-0664, 11/2017, Volume 87, Issue 5, pp. 411 - 417
BRAF V600E | meta‐analysis | papillary thyroid carcinoma | review | BRAF mutation | TERT promoter | meta-analysis | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Risk Assessment - methods | Thyroid Neoplasms - diagnosis | Thyroid Neoplasms - genetics | Carcinoma, Papillary - genetics | Prognosis | Telomerase - genetics | Proto-Oncogene Proteins B-raf - genetics | Humans | Mutation | Promoter Regions, Genetic - genetics | Carcinoma, Papillary - diagnosis | Thyroid Cancer, Papillary | Medical research | Carcinoma | Gene mutations | Analysis | Thyroid diseases | Medicine, Experimental | Genetic aspects | Cancer | Thyroid cancer | Risk groups | Papillary thyroid carcinoma | Genotypes | Tumors | Thyroid | Index Medicus
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5. Full Text Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody
by Capper, David and Preusser, Matthias and Habel, Antje and Sahm, Felix and Ackermann, Ulrike and Schindler, Genevieve and Pusch, Stefan and Mechtersheimer, Gunhild and Zentgraf, Hanswalter and von Deimling, Andreas
Acta neuropathologica, ISSN 0001-6322, 7/2011, Volume 122, Issue 1, pp. 11 - 19
V600E | Immunohistochemistry | Pathology | Neurosciences | Biomarker | Medicine & Public Health | Melanoma | BRAF | Mutation | Monoclonal antibody | Papillary thyroid carcinoma | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Predictive Value of Tests | Thyroid Neoplasms - diagnosis | Melanoma - diagnosis | Prognosis | Humans | Brain Neoplasms - metabolism | Carcinoma, Papillary - metabolism | Brain Neoplasms - secondary | Biomarkers, Tumor - metabolism | Female | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Brain Neoplasms - diagnosis | Mice, Inbred C57BL | Mutation - genetics | Carcinoma, Papillary - pathology | Melanoma - secondary | Immunohistochemistry - methods | Antibodies, Monoclonal - genetics | Animals | Proto-Oncogene Proteins B-raf - genetics | Biomarkers, Tumor - genetics | Mice | Carcinoma, Papillary - diagnosis | Thyroid Neoplasms - metabolism | Thyroid Neoplasms - pathology | Medical colleges | Sarcoma | Oncology, Experimental | Thyroid diseases | Amino acids | Metastasis | Research | Gene mutations | Analysis | Monoclonal antibodies | Genetic aspects | Cancer | Index Medicus
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6. Full Text Detection of the BRAF V600E Mutation in Colon Carcinoma: Critical Evaluation of the Imunohistochemical Approach
by Lasota, Jerzy and Kowalik, Artur and Wasag, Bartosz and Wang, Zeng-Feng and Felisiak-Golabek, Anna and Coates, Tiffany and Kopczynski, Janusz and Gozdz, Stanislaw and Miettinen, Markku
The American journal of surgical pathology, ISSN 0147-5185, 09/2014, Volume 38, Issue 9, pp. 1235 - 1241
BRAF V600 allele-specific PCR | BRAF V600E | BRAF V600 qPCR | the Cobas 4800 BRAF V600 mutation test | colon cancer | immunohistochemistry | Sanger sequencing | Pathology | Life Sciences & Biomedicine | Surgery | Science & Technology | Immunohistochemistry | Predictive Value of Tests | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | United States | Humans | Middle Aged | Male | DNA Mutational Analysis | DNA Mismatch Repair | Polymerase Chain Reaction | Poland | Adult | Female | Adenocarcinoma - genetics | Genetic Predisposition to Disease | Reproducibility of Results | Membrane Proteins - genetics | Adenocarcinoma - enzymology | Proto-Oncogene Proteins - genetics | Adenocarcinoma - secondary | Automation, Laboratory | Phenotype | Biopsy | GTP Phosphohydrolases - genetics | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Aged | Biomarkers, Tumor - genetics | Colonic Neoplasms - enzymology | Mutation | Index Medicus | the cobas® 4800 BRAF V600 Mutation Test
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7. Full Text NRAS mutations are more prevalent than KIT mutations in melanoma of the female urogenital tract—A study of 24 cases from the Netherlands
by van Engen-van Grunsven, Adriana C.H and Küsters-Vandevelde, Heidi V.N and De Hullu, Joanne and van Duijn, Lucette M and Rijntjes, Jos and Bovée, Judith V.M.G and Groenen, Patricia J.T.A and Blokx, Willeke A.M
Gynecologic oncology, ISSN 0090-8258, 2014, Volume 134, Issue 1, pp. 10 - 14
Hematology, Oncology and Palliative Medicine | Obstetrics and Gynecology | MAPK pathway | Vaginal melanoma | NRAS | BRAF | Urogenital tract melanoma | KIT | Oncology | Life Sciences & Biomedicine | Obstetrics & Gynecology | Science & Technology | Melanoma - epidemiology | Exons | Humans | Middle Aged | Netherlands - epidemiology | Melanoma - enzymology | Genital Neoplasms, Female - epidemiology | Formaldehyde | MAP Kinase Signaling System | Paraffin Embedding | Melanoma - genetics | Aged, 80 and over | Adult | Female | Proto-Oncogene Proteins c-kit - genetics | Genital Neoplasms, Female - enzymology | Retrospective Studies | Tissue Fixation | Genital Neoplasms, Female - genetics | Membrane Proteins - genetics | Ureteral Neoplasms - genetics | Molecular Epidemiology | GTP Phosphohydrolases - genetics | Proto-Oncogene Proteins B-raf - genetics | Aged | Mutation | Genetic aspects | Melanoma | Index Medicus
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8. Full Text Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma
by Marimuthu, Adhirai and D'Andrea, Kurt and Lin, Paul S and Puzanov, Igor and Chapman, Paul B and Zhang, Jiazhong and Tsai, James and Ibrahim, Prabha N and Cho, Hanna and West, Brian L and Nathanson, Katherine L and Zhang, Kam Y. J and Zhang, Ying and Nolop, Keith and Schlessinger, Joseph and Grippo, Joseph and Shellooe, Rafe and Zhang, Chao and Flaherty, Keith T and Tsang, Garson and Powell, Ben and Kim, Kevin B and Wong, Bernice and Stumm, Michael and Ribas, Antoni and Spevak, Wayne and Higgins, Brian and Sosman, Jeffrey A and Artis, Dean R and Habets, Gaston and Hirth, Peter and Burton, Elizabeth A and Iyer, Raman and Su, Fei and Koehler, Astrid and Lee, Richard J and Bollag, Gideon and Nguyen, Hoa and McArthur, Grant A and Xu, Xiaowei
Nature (London), ISSN 0028-0836, 09/2010, Volume 467, Issue 7315, pp. 596 - 599
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Macaca fascicularis | Melanoma - enzymology | Substrate Specificity | Positron-Emission Tomography | Extracellular Signal-Regulated MAP Kinases - metabolism | Indoles - administration & dosage | Neoplasm Metastasis | Melanoma - genetics | Phosphorylation - drug effects | Mutant Proteins - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Sulfonamides - chemistry | Mutant Proteins - genetics | Models, Molecular | Rats | Mutant Proteins - metabolism | Melanoma - pathology | Mutation - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Indoles - adverse effects | MAP Kinase Signaling System - drug effects | Sulfonamides - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Mutant Proteins - chemistry | Alleles | Dogs | Sulfonamides - adverse effects | Indoles - therapeutic use | Indoles - chemistry | Sulfonamides - administration & dosage | Control | Gene mutations | Melanoma | Development and progression | Genetic aspects | Research | Health aspects | Protein kinases | Cancer | Proteins | Mutation | Kinases | Rodents | Index Medicus | targeted therapy | melanoma | BRAF | PLX4032 | biomarker | oncogene
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9. Full Text Melanoma: From mutations to medicine
by Tsao, Hensin and Chin, Lynda and Garraway, Levi A and Fisher, David E
Genes & development, ISSN 0890-9369, 06/2012, Volume 26, Issue 11, pp. 1131 - 1155
MITF pathway | BRAF | Melanoma | Genetics & Heredity | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Melanoma - diagnosis | Animals | Microphthalmia-Associated Transcription Factor - metabolism | Cell Cycle | Signal Transduction | Melanoma - genetics | Proto-Oncogene Proteins B-raf - genetics | Humans | Melanoma - drug therapy | Melanoma - pathology | Microphthalmia-Associated Transcription Factor - genetics | Proto-Oncogene Proteins B-raf - metabolism | Care and treatment | Cancer patients | Usage | Gene mutations | Medical care | Research | Genetic transcription | Health aspects | Cancer | Index Medicus | melanoma | Review
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