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Tumor, ISSN 1000-7431, 05/2018, Volume 38, Issue 5, pp. 491 - 497
Journal Article
Cancer Discovery, ISSN 2159-8274, 04/2012, Volume 2, Issue 4, pp. 344 - 355
The anti-diabetic drug metformin has anti-tumor activity in a variety of cancers because it blocks cell growth by inhibiting TORC1. Here we show that melanoma... 
melanoma | metformin | AMPK | BRAFV600E | VEGF
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 07/2016, Volume 117, Issue 7, pp. 1491 - 1496
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 09/2018, Volume 472, pp. 140 - 148
The involvement of alterations in , an essential mismatch repair component, in mutated papillary thyroid carcinoma (PTC) has been suggested to be associated... 
BRAFV600E | Prognosis | Papillary thyroid cancer | DNA repair | BRAF | Index Medicus
Journal Article
Pathology, ISSN 0031-3025, 12/2013, Volume 45, Issue 7, pp. 637 - 644
BRAF mutation has been shown in a large metaanalysis to be an independent prognostic marker for papillary thyroid carcinoma (PTC) with poorer survival and... 
prognostic factors | specific BRAFV600E mutation immunohistochemistry | lymph node recurrences | papillary thyroid carcinoma | BRAFv600e mutation | competitive PCR | Competitive PCR | Lymph node recurrences | Papillary thyroid carcinoma | Prognostic factors | Specific BRAFV600E mutation immunohistochemistry
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2018, Volume 28, Issue 14, pp. 2382 - 2390
Binding mode of compound with the BRAF kinase (PDB code: ). (A) 2D diagram of the interaction between compound and BRAF , (B) 3D models of compound binding... 
3D-QSAR | BRAFV600E | Inhibitors | Docking simulation | Bioassays | BRAF | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2015, Volume 23, Issue 1, pp. 46 - 54
To provide new therapeutic opportunities, a series of novel 4,5-dihydro-1 -pyrazole derivatives ( – ) containing thiazole moiety as potential V600E mutant BRAF... 
BRAFV600E inhibition | 4,5-Dihydro-1H-pyrazole | Molecular docking | Anticancer activity | inhibition | BRAF
Journal Article
Academic Radiology, ISSN 1076-6332, 02/2019, Volume 26, Issue 2, pp. 154 - 160
The purpose of this study was to evaluate the associations between BRAF mutation, the American College of Radiology (ACR) thyroid imaging, reporting and data... 
BRAFV600E mutation | Ultrasound | ACR TI-RADS | PTC | Hashimoto's thyroiditis
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 02/2016, Volume 17, Issue 2, pp. 199 - 207
The oncogenic mutation of BRAF V600E has been found in approximately 8% of all human cancers, including more than 60% of melanoma and 10% of colorectal... 
inhibitors | BRAFV600E | kinase | RAF | EBI-907 | BRAF | MAPK
Journal Article
by Ma B and Shi RL and Yang SW and Zhou L and Qu N and Liao T and Wang Y and Wang YL and Ji QH
OncoTargets and Therapy, ISSN 1178-6930, 04/2016, Volume 2016, Issue Issue 1, pp. 2255 - 2263
Ben Ma,1,2,* Rongliang Shi,1-3,* Shuwen Yang,1,2 Li Zhou,1,2 Ning Qu,1,2 Tian Liao,1,2 Yu Wang,1,2 Yulong Wang,1,2 Qinghai Ji1,2 1Department of Head and Neck... 
BRAFV600E | LNM | DUSP4/MKP2 | PTC
Journal Article
Cancer Research, ISSN 0008-5472, 09/2018, Volume 78, Issue 17, pp. 5038 - 5049
Regulatory T cells (Tregs) are critical mediators of immune suppression in established tumors, although little is known about their role in restraining immune... 
Index Medicus | self antigen | BRAFV600E | cancer immune surveillance | regulatory T cell | autochthonous tumorigenesis
Journal Article
Cancer Letters, ISSN 0304-3835, 11/2017, Volume 408, pp. 43 - 54
Vemurafenib, a BRAF inhibitor, elicits in ∼80% of BRAF -mutant melanoma patients a transient anti-tumor response which precedes the emergence of resistance. We... 
Vemurafenib | BRAFV600E melanoma cells | Tumor microenvironment | Acidosis | Everolimus | Trametinib | BRAF | melanoma cells | Index Medicus
Journal Article
Cancer Biology and Therapy, ISSN 1538-4047, 02/2016, Volume 17, Issue 2, pp. 199 - 207
Journal Article
European Thyroid Journal, ISSN 2235-0640, 10/2018, Volume 7, Issue 5, pp. 251 - 257
V600E (c.1799T>A) somatic mutation evaluation in fine needle aspiration biopsies (FNAB) is a powerful diagnostic tool in the settings of papillary thyroid... 
BRAFV600E | Prognosis | Papillary thyroid cancer | Prospective study
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 04/2018, Volume 110, Issue 4, pp. 362 - 370
Background: Precise risk stratification-based treatment of solitary intrathyroidal papillary thyroid cancer (SI-PTC) that is larger than 1.0 cm and 4.0 cm or... 
PATHOGENESIS | ADULT PATIENTS | TERT PROMOTER MUTATIONS | NODULES | BRAFV600E | BRAF(V600E) MUTATION | ONCOLOGY | RECURRENCE | COHORT | ASSOCIATION MANAGEMENT GUIDELINES | CARCINOMA | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2018, Volume 155, pp. 725 - 735
A series of novel selective BRAF inhibitory agents (Compound ) 5-(2,3-dihydrobenzo[ ][1,4]dioxane-6-yl)- ,3-diaryl-4,5-dihydro-1 -pyrazole-1-carbothioamides... 
Apoptosis induction | Dioxane | BRAFV600E | Selectivity | Triaryl pyrazoline | Antitumor | BRAF | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2018, Volume 155, pp. 210 - 228
Aiming to explore novel BRAF and VEGFR-2 dual inhibitors, a series of 1 -pyrazolo[3,4-d]pyrimidine derivatives were designed, synthesized and biologically... 
Tyrosine kinase | 1H-pyrazolo[3,4-d]pyrimidine | BRAFV600E | Dual inhibitor | VEGFR-2 | BRAF | Index Medicus
Journal Article
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