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1. Building genetic medicine
: breast cancer, technology, and the comparative politics of health care
by Parthasarathy, Shobita
2007, 1, MIT Press Books, ISBN 0262162423, Volume 1, x, 271
Genetic screaning | United States | prevention & control | Social aspects | Breast Neoplasms | Genetic screening | Diagnostic use | Great Britain | Cross-Cultural Comparison | Delivery of Health Care | General Science | BRCA genes | Breast | Diagnosis | Ovarian Neoplasms | Cancer | Health Sciences | breast cancer; ovarian cancer; health care; Britain; United States
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2. Full Text Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2
by Oza, Amit M and Tinker, Anna V and Oaknin, Ana and Shapira-Frommer, Ronnie and McNeish, Iain A and Swisher, Elizabeth M and Ray-Coquard, Isabelle and Bell-McGuinn, Katherine and Coleman, Robert L and O'Malley, David M and Leary, Alexandra and Chen, Lee-may and Provencher, Diane and Ma, Ling and Brenton, James D and Konecny, Gottfried E and Castro, Cesar M and Giordano, Heidi and Maloney, Lara and Goble, Sandra and Lin, Kevin K and Sun, James and Raponi, Mitch and Rolfe, Lindsey and Kristeleit, Rebecca S
Gynecologic oncology, ISSN 0090-8258, 11/2017, Volume 147, Issue 2, pp. 267 - 275
Ovarian carcinoma | Rucaparib | Somatic, germline BRCA mutation | PARP inhibitor | Oncology | Life Sciences & Biomedicine | Obstetrics & Gynecology | Science & Technology | Neoplasms, Glandular and Epithelial - pathology | Humans | Middle Aged | Ovarian Neoplasms - pathology | Poly(ADP-ribose) Polymerase Inhibitors - adverse effects | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | Ovarian Neoplasms - genetics | BRCA1 Protein - genetics | Neoplasms, Glandular and Epithelial - genetics | Indoles - adverse effects | Neoplasm Grading | Neoplasms, Glandular and Epithelial - drug therapy | Aged, 80 and over | Carcinoma, Ovarian Epithelial | Genes, BRCA2 | Germ-Line Mutation | Adult | Female | Indoles - therapeutic use | Aged | Genes, BRCA1 | Ovarian Neoplasms - drug therapy | BRCA2 Protein - genetics | Care and treatment | Genetic aspects | Carcinoma | Safety and security measures | Analysis | Cancer | Index Medicus
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3. Breast cancer gene research and medical practices
: transnational perspectives in the time of BRCA
by Gibbon, Sahra, editor of compilation
2014, Genetics and society, ISBN 9780415824064, xxii, 225
BRCA genes | Breast | Genetic aspects | Tumor markers | Cancer | Anthropology | Cultural & Social | Sociology | Social Science | Health & Medical Anthropology | Anthropology - Soc Sci | New Genetics | Sociology of Science & Technology | Gender Studies | Medicine - Sociology | Bioethics | Genetics - Sociology | Medical Sociology | Sociology & Social Policy | Genetic screening
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4. Full Text PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies
by Lee, J-m and Ledermann, J.A and Kohn, E.C
Annals of oncology, ISSN 0923-7534, 01/2014, Volume 25, Issue 1, pp. 32 - 40
brca-like cancers | brca1/2 mutation | parp inhibitor | brca1/2 mutation-associated cancers | Parp inhibitor | Brca1/2 mutation | Brca1/2 mutation-associated cancers | Brca-like cancers | Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Tumors | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerases - metabolism | Animals | Neoplasms - genetics | Humans | Antineoplastic Agents - pharmacology | Clinical Trials as Topic | Mutation | Poly (ADP-Ribose) Polymerase-1 | Poly(ADP-ribose) Polymerase Inhibitors | BRCA2 Protein - genetics | Neoplasms - drug therapy | Index Medicus | brca1 | 2 mutation | Reviews | 2 mutation-associated cancers
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5. Full Text Mutational Spectrum in a Worldwide Study of 29,700 Families with BRCA1 or BRCA2 Mutations
by Hamann, Ute and Huo, Dezheng and Solano, Angela R and teo, Soo-Hwang and Weitzel, Jeffrey N and Couch, Fergus J and Goldgar, David E and van Rensburg, Elizabeth J and McGuffog, Lesley and Agata, Simona and Anews, Lesley and Auerbach, Leo and Azzollini, Jacopo and Balmaña, Judith and Barile, Monica and Barrowdale, Daniel and Blanco, Amie M and Blazer, Kathleen R and Blok, Marinus J and Brewer, Carole and Buecher, Bruno and Chung, Wendy K and de la Hoya, Miguel and de Pauw, Antoine and Diez, Orland and Dworniczak, Bernd and Ehrencrona, Hans and Evans, D. Gareth and Feliubadaló, Lidia and Foretova, Lenka and Galvão, Henrique C. R and Ganz, Patricia A and Gauthier-Villars, Marion and Giannini, Giuseppe and Glendon, Gord and Godwin, Anew K and Gronwald, Jacek and Hahnen, Eric and Hogervorst, Frans B. L and Honisch, Ellen and Imyanitov, Evgeny N and Izatt, Louise and Izquierdo, Angel and Jakubowska, Anna and Janavicius, Ramunas and Jensen, Uffe Birk and Kast, Karin and Kim, Sung-Won and Lasa, Aiana and Lasset, Christine and Lázaro, Conxi and Lee, Annette and Lee, Min Hyuk and Lindor, Noralane M and Longy, Michel and Loud, Jennifer T and Lubinski, Jan and Machackova, Eva and Manoukian, Siranoush and Matrai, Zoltan and Mebirouk, Noura and Meijers-Heijboer, Hanne E. J and Mensenkamp, Arjen R and Miller, Austin and Moysich, Kirsten B and Musinsky, Jacob and Neuhausen, Susan L and Ngeow, Joanne and Niederacher, Dieter and Nielsen, Henriette Roed and Nussbaum, Robert L and Offit, Kenneth and Osorio, Ana and Papi, Laura and MSc, Ana Peixoto and Ba, Nisha Pradhan and Ramus, Susan J and Rudaitis, Vilius and Schmutzler, Rita Katharina and Senter, Leigha and Shah, Payal D and Side, Lucy E and Slavin, Thomas P and Snape, Katie and Southey, Melissa and Steinemann, Doris and Sutter, Christian and Thomas, Abigail and Thull, Darcy L and Tischkowitz, Marc and Toland, Amanda Ewart and Topka, Sabine and Trainer, Alison H and van der Hout, Annemieke H and van der Luijt, Rob B and Vega, Ana and von Wachenfeldt, Anna and Zidan, Jamal and Chenevix-Trench, Georgia and Antoniou, Antonis C and KConFab Investigators and HEBON and EMBRACE and GEMO Study Collaborators
Human mutation, ISSN 1059-7794, 2018, Volume 39, Issue 5, pp. 593 - 620
mutation | ethnicity | ovarian cancer | geography | breast cancer | BRCA1 | BRCA2 | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Geography | BRCA1 Protein - genetics | Internationality | Humans | Databases, Genetic | Family | Mutation - genetics | BRCA2 Protein - genetics | Genetic aspects | BRCA mutations | Genetic screening | Singers | Ovarian cancer | BRCA2 protein | Mutation | Genotyping | BRCA1 protein | Minority & ethnic groups | Index Medicus | Life Sciences | Genetics | Human genetics | Medicin och hälsovetenskap
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6. Full Text The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
by Helleday, Thomas
Molecular oncology, ISSN 1574-7891, 2011, Volume 5, Issue 4, pp. 387 - 393
Stalled replication fork | Homologous recombination | Poly(ADP-ribose) polymerase | Review | BRCA1 | Synthetic lethality | DNA double-strand breaks | BRCA2 | Cancer | Life Sciences & Biomedicine | Oncology | Science & Technology | Humans | DNA Replication | DNA Breaks, Double-Stranded | Poly(ADP-ribose) Polymerase Inhibitors | DNA Breaks, Single-Stranded | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerases - metabolism | Animals | BRCA2 Protein - metabolism | BRCA1 Protein - antagonists & inhibitors | BRCA2 Protein - antagonists & inhibitors | Neoplasms - genetics | Recombination, Genetic | BRCA1 Protein - metabolism | DNA Repair | Models, Genetic | Neoplasms - pathology | BRCA2 Protein - genetics | DNA | Analysis | BRCA2 protein | BRCA1 protein | DNA damage | Genes | Lethality | Roles | DNA repair | Base excision repair | Intermediates | Replication forks | DNA biosynthesis | Proteins | Councils | Ribose | Deoxyribonucleic acid--DNA | Tumors | Index Medicus | Reviews
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7. Full Text Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells
by Dev, Harveer and Chiang, Ting-Wei Will and Lescale, Chloe and de Krijger, Inge and Martin, Alistair G and Pilger, Domenic and Coates, Julia and Sczaniecka-Clift, Matylda and Wei, Wenming and Ostermaier, Matthias and Herzog, Mareike and Lam, Jonathan and Shea, Abigail and Demir, Mukerrem and Wu, Qian and Yang, Fengtang and Fu, Beiyuan and Lai, Zhongwu and Balmus, Gabriel and Belotserkovskaya, Rimma and Serra, Violeta and O’Connor, Mark J and Bruna, Alejandra and Beli, Petra and Pellegrini, Luca and Caldas, Carlos and Deriano, Ludovic and Jacobs, Jacqueline J. L and Galanty, Yaron and Jackson, Stephen P
Nature cell biology, ISSN 1465-7392, 08/2018, Volume 20, Issue 8, pp. 954 - 965
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Osteosarcoma - drug therapy | Mad2 Proteins - metabolism | Humans | Multiprotein Complexes | Ovarian Neoplasms - pathology | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | HEK293 Cells | Female | Bone Neoplasms - genetics | Ovarian Neoplasms - metabolism | Bone Neoplasms - drug therapy | BRCA1 Protein - deficiency | Telomere-Binding Proteins - metabolism | Ovarian Neoplasms - drug therapy | Osteosarcoma - metabolism | DNA-Binding Proteins | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinational DNA Repair | Tumor Suppressor p53-Binding Protein 1 - genetics | Cisplatin - pharmacology | Breast Neoplasms - drug therapy | Proteins - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Proteins - metabolism | Breast Neoplasms - pathology | Mad2 Proteins - genetics | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Cell Cycle Proteins | Osteosarcoma - pathology | Care and treatment | DNA | Cancer cells | Breast cancer | Genetic aspects | Research | Gene expression | Single-stranded DNA | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Inactivation | Proteins | Ribose | Null cells | Deoxyribonucleic acid--DNA | BRCA2 protein | CRISPR | Deactivation | BRCA1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Oligosaccharides | Double-strand break repair | Screens | Cisplatin | Inhibitors | Prostate | Viability | Tumors | Index Medicus | Telomere-Binding Proteins / metabolism | Osteosarcoma / genetics | Telomere-Binding Proteins / genetics | BRCA1 Protein / genetics | Cellular Biology | Genetics | Proteins / genetics | Osteosarcoma / drug therapy | Ovarian Neoplasms / genetics | Mad2 Proteins / genetics | Proteins / metabolism | Breast Neoplasms / drug therapy | Breast Neoplasms / metabolism | Tumor Suppressor p53-Binding Protein 1 / genetics | BRCA1 Protein / deficiency | Ovarian Neoplasms / metabolism | Mad2 Proteins / metabolism | Breast Neoplasms / pathology | Bone Neoplasms / genetics | Ovarian Neoplasms / pathology | Bone Neoplasms / pathology | Life Sciences | Bone Neoplasms / drug therapy | Ovarian Neoplasms / drug therapy | Osteosarcoma / metabolism | Biochemistry, Molecular Biology | Breast Neoplasms / genetics | Drug Resistance, Neoplasm / genetics | Osteosarcoma / pathology | Bone Neoplasms / metabolism | Poly(ADP-ribose) Polymerase Inhibitors / pharmacology | Cisplatin / pharmacology | Molecular biology | Tumor Suppressor p53-Binding Protein 1 / metabolism | Cancer
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