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Nature (London), ISSN 1476-4687, 12/2015, Volume 528, Issue 7582, pp. 422 - 426
Journal Article
Cancer cell, ISSN 1535-6108, 02/2007, Volume 11, Issue 2, pp. 103 - 105
Journal Article
Nature cell biology, ISSN 1476-4679, 07/2018, Volume 20, Issue 8, pp. 954 - 965
.... We identified two previously uncharacterized proteins, C2Oorf196 and FAM35A, whose inactivation confers strong PARP-inhibitor resistance... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Osteosarcoma - drug therapy | Mad2 Proteins - metabolism | Humans | Multiprotein Complexes | Ovarian Neoplasms - pathology | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | HEK293 Cells | Female | Bone Neoplasms - genetics | Ovarian Neoplasms - metabolism | Bone Neoplasms - drug therapy | BRCA1 Protein - deficiency | Telomere-Binding Proteins - metabolism | Ovarian Neoplasms - drug therapy | Osteosarcoma - metabolism | DNA-Binding Proteins | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinational DNA Repair | Tumor Suppressor p53-Binding Protein 1 - genetics | Cisplatin - pharmacology | Breast Neoplasms - drug therapy | Proteins - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Proteins - metabolism | Breast Neoplasms - pathology | Mad2 Proteins - genetics | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Cell Cycle Proteins | Osteosarcoma - pathology | Care and treatment | DNA | Cancer cells | Breast cancer | Genetic aspects | Research | Gene expression | Single-stranded DNA | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Inactivation | Proteins | Ribose | Null cells | Deoxyribonucleic acid--DNA | BRCA2 protein | CRISPR | Deactivation | BRCA1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Oligosaccharides | Double-strand break repair | Screens | Cisplatin | Inhibitors | Prostate | Viability | Tumors | Index Medicus | Telomere-Binding Proteins / metabolism | Osteosarcoma / genetics | Telomere-Binding Proteins / genetics | BRCA1 Protein / genetics | Cellular Biology | Genetics | Proteins / genetics | Osteosarcoma / drug therapy | Ovarian Neoplasms / genetics | Mad2 Proteins / genetics | Proteins / metabolism | Breast Neoplasms / drug therapy | Breast Neoplasms / metabolism | Tumor Suppressor p53-Binding Protein 1 / genetics | BRCA1 Protein / deficiency | Ovarian Neoplasms / metabolism | Mad2 Proteins / metabolism | Breast Neoplasms / pathology | Bone Neoplasms / genetics | Ovarian Neoplasms / pathology | Bone Neoplasms / pathology | Life Sciences | Bone Neoplasms / drug therapy | Ovarian Neoplasms / drug therapy | Osteosarcoma / metabolism | Biochemistry, Molecular Biology | Breast Neoplasms / genetics | Drug Resistance, Neoplasm / genetics | Osteosarcoma / pathology | Bone Neoplasms / metabolism | Poly(ADP-ribose) Polymerase Inhibitors / pharmacology | Cisplatin / pharmacology | Molecular biology | Tumor Suppressor p53-Binding Protein 1 / metabolism | Cancer
Journal Article
Molecular & cellular proteomics, ISSN 1535-9484, 05/2015, Volume 14, Issue 5, pp. 1419 - 1434
.... Small Ubiquitin-like Modifiers (SUMOs) are known to counteract replication stress, nevertheless, only a small number of relevant SUMO target proteins are known... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Adaptor Proteins, Signal Transducing - chemistry | Genomic Instability | Hydroxyurea - pharmacology | Nucleic Acid Synthesis Inhibitors - pharmacology | Humans | Molecular Sequence Data | Chromatin Assembly Factor-1 - metabolism | Trans-Activators - chemistry | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - genetics | BRCA1 Protein - metabolism | Chromatin Assembly Factor-1 - genetics | Endodeoxyribonucleases - metabolism | Trans-Activators - genetics | Carrier Proteins - chemistry | Lysine - metabolism | Osteoblasts - cytology | Nuclear Proteins - genetics | BRCA1 Protein - chemistry | Amino Acid Sequence | Gene Expression | Signal Transduction | Chromatin Assembly Factor-1 - chemistry | Small Ubiquitin-Related Modifier Proteins - metabolism | Osteoblasts - drug effects | DNA Replication | Nuclear Proteins - metabolism | Endodeoxyribonucleases - chemistry | Recombinant Fusion Proteins - chemistry | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Protein Interaction Mapping | BRCA1 Protein - genetics | Carrier Proteins - genetics | Endodeoxyribonucleases - genetics | Carrier Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Sumoylation | Trans-Activators - metabolism | DNA Damage | Adaptor Proteins, Signal Transducing - metabolism | Lysine - chemistry | Osteoblasts - metabolism | Index Medicus | Technological Innovation and Resources
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 07/2012, Volume 109, Issue 27, pp. E1839 - E1847
Journal Article
Nature structural & molecular biology, ISSN 1545-9985, 02/2013, Volume 20, Issue 3, pp. 317 - 325
The pathogenic sequelae of BRCA1 mutation in human and mouse cells are mitigated by concomitant deletion of 53BP1, which binds histone H4 dimethylated at Lys20... 
Chromatin - metabolism | Humans | Histone Acetyltransferases - genetics | Molecular Sequence Data | Homologous Recombination | Intracellular Signaling Peptides and Proteins - metabolism | DNA Breaks, Double-Stranded | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | BRCA1 Protein - metabolism | Histone Acetyltransferases - metabolism | Acetylation | Lysine Acetyltransferase 5 | DNA Helicases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Amino Acid Sequence | ATPases Associated with Diverse Cellular Activities | Chromosomal Proteins, Non-Histone - metabolism | Magnetic Resonance Spectroscopy | Cells, Cultured | Histone Deacetylases - metabolism | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | BRCA1 Protein - genetics | Carrier Proteins - genetics | DNA Helicases - metabolism | Carrier Proteins - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Protein Conformation | Histones - metabolism | Tumor Suppressor p53-Binding Protein 1 | Chromatin - genetics | Care and treatment | Chromatin | BRCA mutations | Physiological aspects | Breast cancer | Genetic aspects | Research | Structure | Health aspects | Risk factors | Mutation | Molecular biology | DNA repair | DNA damage | Index Medicus | BRCA1 | 53BP1 | Homologous recombination | PARP inhibitors | TIP60
Journal Article
Biochemical journal, ISSN 1470-8728, 12/2011, Volume 441, Issue 2, pp. 523 - 540
...) proteins and 50 lysosomal hydrolases. Autophagosomes... 
Mitochondrion | Oxidative stress | Redox signalling | Neurodegeneration | Autophagy | Nitrative stress | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Kinases - metabolism | Transcription, Genetic - drug effects | Cardiovascular Diseases - physiopathology | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Reactive Nitrogen Species - metabolism | Humans | Oxidative Stress - physiology | Hydrogen Peroxide - pharmacology | Oncogene Proteins - metabolism | Nitric Oxide - physiology | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Parkinson Disease - physiopathology | Lysosomes - physiology | Protein Deglycase DJ-1 | Animals | Signal Transduction - physiology | TOR Serine-Threonine Kinases - physiology | Neoplasms - physiopathology | Index Medicus | neurodegeneration | AMPK, 5′-AMP-activated protein kinase | NBR1, neighbour of BRCA1 (breast cancer early-onset 1) | NGF, nerve growth factor | LC3, light chain 3 | NOX, NADPH oxidase | EM, electron microscopy | TOR, target of rapamycin | ULK, unc (unco-ordinated family member)-51-like kinase | mtDNA, mitochondrial DNA | mTOR, mammalian target of rapamycin | IKKβ, IκB kinase β | LRRK2, leucine-rich repeat kinase 2 | NAC, N-acetyl-L-cysteine | Nrf2, nuclear factor-erythroid 2-related factor 2 | PI3P, phosphatidylinositol 3-phosphate | autophagy | ECH, enoyl-CoA hydratase | BNIP3L, BNIP3-like | Drp1, dynamin-related protein 1 | tfLC3, tandem fluorescently tagged LC3 | NF-κB, nuclear factor κB | BAG, Bcl-2-associated athanogene | Keap1, Kelch-like ECH-associated protein 1 | PE, phosphatidylethanolamine | mitochondrion | 3-MA, 3-methyladenine | UCP, uncoupling protein | IκB, inhibitor of nuclear factor κB | FIP200, focal adhesion kinase family-interacting protein of 200 kDa | PI3K, phosphoinositide 3-kinase | HNE, 4-hydroxynonenal | Review | ALS, amyotrophic lateral sclerosis | redox signalling | ATG, AuTophaGy-related | adenovirus E18 19-kDa-interacting protein | Tzb, trastuzumab | mETC, mitochondrial electron-transport chain | Rubicon, RUN domain- and cysteine-rich domain-containing beclin-1-interacting protein | VDAC, voltage-dependent anion channel | IP3, inositol 1,4,5-trisphosphate | RFP, red fluorescent protein | ROS, reactive oxygen species | TNFα, tumour necrosis factor α | PINK1, PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced kinase 1 | GFP, green fluorescent protein | LAMP, lysosome-associated membrane protein | JNK1, c-Jun N-terminal kinase 1 | TAC, transverse aortic constriction | GABARAP, GABAA (γ-aminobutyric acid type A)-receptor-associated protein | HIF-1, hypoxia-inducible factor 1 | NOS, nitric oxide synthase | siRNA, small interfering RNA | SOD, superoxide dismutase | RLS, reactive lipid species | nitrative stress | RNS, reactive nitrogen species | ER, endoplasmic reticulum | TIGAR, TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator | Vps34, vacuolar protein sorting 34 | oxidative stress | BNIP, Bcl-2
Journal Article