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Nature, ISSN 0028-0836, 02/2013, Volume 494, Issue 7438, pp. 502 - 505
Mammalian telomeres repress DNA-damage activation at natural chromosome ends by recruiting specific inhibitors of the DNA-damage machinery that form a... 
UBIQUITINATION | RECOMBINATION | MAINTENANCE | COMPLEX | REPAIR | MAMMALIAN TELOMERES | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | CELL-CYCLE | PROTEINS | TRF2 | Tumor Suppressor Proteins - antagonists & inhibitors | Chromosomes, Mammalian - genetics | Protein Multimerization | Ubiquitin-Protein Ligases - antagonists & inhibitors | Telomeric Repeat Binding Protein 2 - chemistry | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Telomere - metabolism | Protein-Serine-Threonine Kinases - metabolism | Telomere - genetics | Protein Structure, Tertiary | Endopeptidases - metabolism | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Ataxia Telangiectasia Mutated Proteins | Endopeptidases - deficiency | Protein Transport | Animals | DNA Repair | Telomeric Repeat Binding Protein 2 - metabolism | Mice | DNA Damage | Enzyme Activation | Tumor Suppressor p53-Binding Protein 1 | Chromosomes, Mammalian - metabolism | Telomeres | Research | Binding proteins | Observations | Properties | DNA damage | Proteins | Enzymes | DNA methylation | Amino acids | Agreements | Telomerase | Chromosomes | Index Medicus | RNF168 | Brca1 | genomic stability | telomere | ATM | NHEJ
Journal Article
Cancer Cell, ISSN 1535-6108, 2007, Volume 11, Issue 2, pp. 103 - 105
Journal Article
Journal Article
Nature, ISSN 0028-0836, 12/2015, Volume 528, Issue 7582, pp. 422 - 426
Journal Article
Nature, ISSN 0028-0836, 12/2009, Volume 462, Issue 7275, pp. 935 - 939
Journal Article
Nature, ISSN 0028-0836, 2015, Volume 521, Issue 7553, pp. 541 - U308
Journal Article
Molecular and Cellular Proteomics, ISSN 1535-9476, 05/2015, Volume 14, Issue 5, pp. 1419 - 1434
Genotoxic agents can cause replication fork stalling in dividing cells because of DNA lesions, eventually leading to replication fork collapse when the damage... 
E3 LIGASE | PCNA | PATHWAY | HUMAN-CELLS | BIOCHEMICAL RESEARCH METHODS | REQUIRES | SUMO-1 CONJUGATION | NEDD8-ACTIVATING ENZYME | DNA-REPAIR | IDENTIFICATION | SIGNALING NETWORKS | Adaptor Proteins, Signal Transducing - chemistry | Genomic Instability | Hydroxyurea - pharmacology | Nucleic Acid Synthesis Inhibitors - pharmacology | Humans | Molecular Sequence Data | Chromatin Assembly Factor-1 - metabolism | Trans-Activators - chemistry | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - genetics | BRCA1 Protein - metabolism | Chromatin Assembly Factor-1 - genetics | Endodeoxyribonucleases - metabolism | Trans-Activators - genetics | Carrier Proteins - chemistry | Lysine - metabolism | Osteoblasts - cytology | Nuclear Proteins - genetics | BRCA1 Protein - chemistry | Amino Acid Sequence | Gene Expression | Signal Transduction | Chromatin Assembly Factor-1 - chemistry | Small Ubiquitin-Related Modifier Proteins - metabolism | Osteoblasts - drug effects | DNA Replication | Nuclear Proteins - metabolism | Endodeoxyribonucleases - chemistry | Recombinant Fusion Proteins - chemistry | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Protein Interaction Mapping | BRCA1 Protein - genetics | Carrier Proteins - genetics | Endodeoxyribonucleases - genetics | Carrier Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Sumoylation | Trans-Activators - metabolism | DNA Damage | Adaptor Proteins, Signal Transducing - metabolism | Lysine - chemistry | Osteoblasts - metabolism | Index Medicus | Technological Innovation and Resources
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 08/2007, Volume 67, Issue 15, pp. 7395 - 7405
Proteasome inhibitors sensitize tumor cells to DNA-damaging agents, including ionizing radiation (IR), and DNA crosslinking agents (melphalan and cisplatin)... 
MULTIPLE-MYELOMA | CELLS | REPAIR | GENOMIC STABILITY | PROTEIN | ONCOLOGY | 53BP1 | IN-VIVO | DOUBLE-STRAND BREAKS | ATM | S-PHASE CHECKPOINT | Gamma Rays | Humans | Ovarian Neoplasms - pathology | Ubiquitin - metabolism | Ovarian Neoplasms - metabolism | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Rad51 Recombinase - metabolism | Tumor Suppressor Proteins - metabolism | Bortezomib | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | Cell Cycle Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | Blotting, Western | Proteasome Endopeptidase Complex - genetics | Leupeptins - pharmacology | Phosphorylation - radiation effects | BRCA1 Protein - antagonists & inhibitors | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Pyrazines - pharmacology | Proteasome Endopeptidase Complex - radiation effects | Fanconi Anemia Complementation Group D2 Protein - genetics | Tumor Suppressor Proteins - antagonists & inhibitors | Fanconi Anemia | Rad51 Recombinase - antagonists & inhibitors | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Flow Cytometry | BRCA1 Protein - metabolism | Tumor Suppressor Proteins - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Female | Nuclear Proteins - genetics | Rad51 Recombinase - genetics | RNA, Small Interfering - pharmacology | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Fanconi Anemia Complementation Group D2 Protein - antagonists & inhibitors | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | BRCA1 Protein - genetics | Fanconi Anemia Complementation Group D2 Protein - metabolism | DNA Repair | Nuclear Proteins - antagonists & inhibitors | Proteasome Inhibitors | DNA Damage - radiation effects | Microscopy, Fluorescence | Boronic Acids - pharmacology | Index Medicus
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 10/2014, Volume 1844, Issue 10, pp. 1808 - 1819
Human centrosomal proteins show a significant, 3.5 fold, bias to be both unstructured and coiled-coils with respect to generic human proteins, based on results... 
Coiled-coil | CD | NMR | Disordered regions | Peptides | Centrosome | INTRINSIC DISORDER | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | HELIX | BRCA1 | MOLECULAR INTERACTION DATABASE | BIOPHYSICS | AMINO-ACIDS | FUNCTIONAL-ANALYSIS | BINDING | WEB SERVER | AGGREGATION | Proteins | Oligomers | Medicine, Experimental | Medical research | Hydrogen-ion concentration | Protein-protein interactions
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2010, Volume 29, Issue 3, pp. 574 - 585
The Mre11/Rad50/Nbs1 (MRN) complex has a central function in facilitating activation of the ATM protein kinase at sites of DNA double‐strand breaks (DSBs).... 
MRN | checkpoints | ATM | DNA repair | 53BP1 | Checkpoints | DEPENDENT PHOSPHORYLATION | MRE11 COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | TELANGIECTASIA-LIKE DISORDER | S-PHASE CHECKPOINT | CELL BIOLOGY | BRCT PROTEIN 53BP1 | CLASS-SWITCH RECOMBINATION | DNA-DAMAGE-RESPONSE | ATAXIA-TELANGIECTASIA | IONIZING IRRADIATION | Phosphorylation | Protein Binding - genetics | Humans | Recombinant Fusion Proteins - physiology | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Multiprotein Complexes - metabolism | BRCA1 Protein - metabolism | DNA Repair Enzymes - metabolism | Protein Multimerization - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins - physiology | Tumor Suppressor Proteins - metabolism | Protein-Serine-Threonine Kinases - physiology | Cell Cycle Proteins - metabolism | Cells, Cultured | Nuclear Proteins - metabolism | Protein Structure, Tertiary - genetics | Ataxia Telangiectasia Mutated Proteins | Multiprotein Complexes - physiology | Tumor Suppressor Proteins - physiology | Animals | Recombinant Fusion Proteins - genetics | Mice | Tumor Suppressor p53-Binding Protein 1 | Enzyme Activation - genetics | Intracellular Signaling Peptides and Proteins - physiology | Cell Cycle Proteins - physiology | Protein Structure, Tertiary - physiology | Signal transduction | Kinases | Molecular biology | Substrates | Index Medicus
Journal Article