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Cancer cell, ISSN 1535-6108, 02/2007, Volume 11, Issue 2, pp. 103 - 105
Journal Article
Cancer, ISSN 0008-543X, 05/2017, Volume 123, Issue 10, pp. 1721 - 1730
Journal Article
Nature cell biology, ISSN 1476-4679, 07/2018, Volume 20, Issue 8, pp. 954 - 965
.... We identified two previously uncharacterized proteins, C2Oorf196 and FAM35A, whose inactivation confers strong PARP-inhibitor resistance... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Osteosarcoma - drug therapy | Mad2 Proteins - metabolism | Humans | Multiprotein Complexes | Ovarian Neoplasms - pathology | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | HEK293 Cells | Female | Bone Neoplasms - genetics | Ovarian Neoplasms - metabolism | Bone Neoplasms - drug therapy | BRCA1 Protein - deficiency | Telomere-Binding Proteins - metabolism | Ovarian Neoplasms - drug therapy | Osteosarcoma - metabolism | DNA-Binding Proteins | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinational DNA Repair | Tumor Suppressor p53-Binding Protein 1 - genetics | Cisplatin - pharmacology | Breast Neoplasms - drug therapy | Proteins - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Proteins - metabolism | Breast Neoplasms - pathology | Mad2 Proteins - genetics | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Cell Cycle Proteins | Osteosarcoma - pathology | Care and treatment | DNA | Cancer cells | Breast cancer | Genetic aspects | Research | Gene expression | Single-stranded DNA | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Inactivation | Proteins | Ribose | Null cells | Deoxyribonucleic acid--DNA | BRCA2 protein | CRISPR | Deactivation | BRCA1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Oligosaccharides | Double-strand break repair | Screens | Cisplatin | Inhibitors | Prostate | Viability | Tumors | Index Medicus | Telomere-Binding Proteins / metabolism | Osteosarcoma / genetics | Telomere-Binding Proteins / genetics | BRCA1 Protein / genetics | Cellular Biology | Genetics | Proteins / genetics | Osteosarcoma / drug therapy | Ovarian Neoplasms / genetics | Mad2 Proteins / genetics | Proteins / metabolism | Breast Neoplasms / drug therapy | Breast Neoplasms / metabolism | Tumor Suppressor p53-Binding Protein 1 / genetics | BRCA1 Protein / deficiency | Ovarian Neoplasms / metabolism | Mad2 Proteins / metabolism | Breast Neoplasms / pathology | Bone Neoplasms / genetics | Ovarian Neoplasms / pathology | Bone Neoplasms / pathology | Life Sciences | Bone Neoplasms / drug therapy | Ovarian Neoplasms / drug therapy | Osteosarcoma / metabolism | Biochemistry, Molecular Biology | Breast Neoplasms / genetics | Drug Resistance, Neoplasm / genetics | Osteosarcoma / pathology | Bone Neoplasms / metabolism | Poly(ADP-ribose) Polymerase Inhibitors / pharmacology | Cisplatin / pharmacology | Molecular biology | Tumor Suppressor p53-Binding Protein 1 / metabolism | Cancer
Journal Article
Cancer, ISSN 0008-543X, 10/2017, Volume 123, Issue 20, pp. 3925 - 3932
... protein Hox‐B13 ( HOXB13 ) gene on chromosome 17 through linkage analysis. The HOXB13 G84E mutation typically occurs on a common haplotype consistent with a founder... 
prostate cancer | germline variants | multiple primary malignant neoplasms | genetic testing | gene panel | Life Sciences & Biomedicine | Oncology | Science & Technology | Humans | Middle Aged | Male | Mutation, Missense | Checkpoint Kinase 2 - genetics | Prostatic Neoplasms - genetics | DNA Mutational Analysis | Tumor Suppressor Proteins - genetics | Aged, 80 and over | Germ-Line Mutation | Adult | RNA Helicases - genetics | Neoplastic Syndromes, Hereditary - genetics | Neoplasms, Second Primary - genetics | Nuclear Proteins - genetics | Fanconi Anemia Complementation Group N Protein | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Genetic Predisposition to Disease | Neoplastic Syndromes, Hereditary - diagnosis | DNA-Binding Proteins - genetics | Fanconi Anemia Complementation Group Proteins | Sequence Analysis, DNA | Homeodomain Proteins - genetics | MutL Protein Homolog 1 - genetics | Age of Onset | Aged | Ataxia Telangiectasia Mutated Proteins - genetics | BRCA2 Protein - genetics | Care and treatment | Genetic aspects | Research | Gene mutations | Genetic variation | Prostate cancer | Fibroblast growth factor | Genes | DNA damage | Homology | Malignancy | Criteria | DNA repair | Genetic screening | Homeobox | DNA helicase | Proteins | Ataxia | Genetics | Deoxyribonucleic acid--DNA | Fibroblast growth factor receptor 3 | BRCA2 protein | CHK2 protein | Nucleotide sequence | BRCA1 protein | MLH1 protein | Health risks | Protein C | Breast cancer | Medical screening | Patients | Medical prognosis | Men | Ataxia telangiectasia mutated protein | Mutation | Prostate | Cancer | Fibroblast growth factor receptors | Index Medicus | Abridged Index Medicus
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 04/2017, Volume 35, Issue 10, pp. 1086 - 1095
Journal Article
Cell (Cambridge), ISSN 0092-8674, 11/2003, Volume 115, Issue 5, pp. 523 - 535
.... Here we identify a protein, EMSY, which binds BRCA2 within a region (exon 3) deleted in cancer. EMSY is capable of silencing the activation potential of BRCA2 exon 3, associates with chromatin regulators HP1... 
DOMAIN | METHYLATION | METHYLTRANSFERASE | GENE | HISTONE H3 | CHROMO | TRANSCRIPTION | LYSINE 9 | PROTEINS | EXPRESSION | UMCG Approved | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Prognosis | Humans | DNA, Complementary - genetics | Molecular Sequence Data | Phylogeny | Breast Neoplasms - metabolism | Ovarian Neoplasms - genetics | Genes, Regulator - genetics | Neoplasm Proteins | Repressor Proteins - isolation & purification | Female | Ovarian Neoplasms - metabolism | DNA, Complementary - analysis | Base Sequence - genetics | Genetic Predisposition to Disease - genetics | Signal Transduction | Repressor Proteins - genetics | Exons - genetics | Chromosomes, Human, Pair 11 - genetics | Protein Structure, Tertiary - genetics | Chromosomal Proteins, Non-Histone - genetics | Nuclear Proteins | Carrier Proteins - genetics | Plant Proteins - genetics | Breast Neoplasms - genetics | Carcinoma - genetics | BRCA2 Protein - deficiency | Gene Amplification - genetics | Carcinoma - metabolism | Gene Silencing - physiology | BRCA2 Protein - genetics | Gene amplification | Analysis | Breast cancer | Genetic aspects | Research | Genetic regulation | Ovarian cancer | BS69 protein | HP1^b protein | EMSY protein | chromosome 11 | BRCA2 gene | HP1b protein | Index Medicus
Journal Article
Nature structural & molecular biology, ISSN 1545-9985, 09/2010, Volume 17, Issue 10, pp. 1247 - 1254
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 10/2013, Volume 110, Issue 42, pp. 17041 - 17046
Breast Cancer Type 1 Susceptibility Protein (BRCA1)-deficient cells have compromised DNA repair and are sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors... 
Proteins | BRCA proteins | Platinum | DNA | Cell lines | Small interfering RNA | Cellular immunity | Breast cancer | Genetic mutation | Tumors | Cancer therapy | Homologous recombination | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | Ovarian Neoplasms - pathology | Ovarian Neoplasms - genetics | BRCA1 Protein - metabolism | Tumor Suppressor Proteins - genetics | Female | Antineoplastic Agents - pharmacology | HSP90 Heat-Shock Proteins - genetics | Ovarian Neoplasms - metabolism | Nuclear Proteins - genetics | Fanconi Anemia Complementation Group N Protein | Ovarian Neoplasms - drug therapy | Platinum - pharmacology | Protein Structure, Tertiary | Rad51 Recombinase - metabolism | Tumor Suppressor Proteins - metabolism | Rad51 Recombinase - genetics | Nuclear Proteins - metabolism | Cisplatin - pharmacology | Lactams, Macrocyclic - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Benzoquinones - pharmacology | BRCA1 Protein - genetics | Drug Resistance, Neoplasm - genetics | Poly(ADP-ribose) Polymerases - metabolism | BRCA2 Protein - metabolism | Poly(ADP-ribose) Polymerases - genetics | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Mutation | BRCA2 Protein - genetics | Drug Resistance, Neoplasm - drug effects | Gene mutations | Physiological aspects | Genetic aspects | Research | Binding proteins | Health aspects | Index Medicus | homologous recombination | Biological Sciences | cancer therapy
Journal Article
PLoS genetics, ISSN 1553-7390, 10/2009, Volume 5, Issue 10, pp. e1000680 - e1000680
Journal Article