X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
science & technology (1586) 1586
humans (1554) 1554
life sciences & biomedicine (1426) 1426
female (995) 995
brca2 protein - genetics (812) 812
oncology (739) 739
breast cancer (708) 708
mutation (695) 695
brca2 protein - metabolism (596) 596
breast neoplasms - genetics (584) 584
brca1 protein - genetics (505) 505
brca2 protein (479) 479
dna repair (478) 478
cancer (470) 470
brca2 (467) 467
animals (458) 458
genetic aspects (397) 397
dna damage (377) 377
middle aged (370) 370
biochemistry & molecular biology (342) 342
genes, brca2 (334) 334
adult (332) 332
cell biology (326) 326
genes, brca1 (323) 323
brca1 (304) 304
research (296) 296
brca1 protein - metabolism (288) 288
genetic predisposition to disease (286) 286
skin and connective tissue diseases (280) 280
ovarian cancer (275) 275
breast neoplasms - metabolism (267) 267
ovarian neoplasms - genetics (267) 267
aged (266) 266
male (261) 261
cell line, tumor (255) 255
brca1 protein (253) 253
genetics & heredity (250) 250
homologous recombination (248) 248
mice (239) 239
proteins (239) 239
deoxyribonucleic acid--dna (236) 236
genes (215) 215
tumors (207) 207
endocrine system diseases (206) 206
risk factors (205) 205
breast neoplasms - pathology (203) 203
rad51 recombinase - metabolism (192) 192
gene expression (171) 171
dna (168) 168
gene mutations (165) 165
dna-binding proteins - metabolism (163) 163
science & technology - other topics (162) 162
multidisciplinary sciences (160) 160
analysis (159) 159
health aspects (154) 154
neoplasm proteins - genetics (142) 142
germ-line mutation (141) 141
genetics (137) 137
research article (137) 137
transcription factors - genetics (134) 134
cell cycle (131) 131
cell line (131) 131
protein binding (130) 130
dna-binding proteins - genetics (129) 129
immunohistochemistry (129) 129
gene expression regulation, neoplastic (127) 127
prognosis (125) 125
genomics (124) 124
dna repair - genetics (116) 116
genomes (115) 115
ovarian neoplasms - metabolism (115) 115
nuclear proteins - metabolism (111) 111
nuclear proteins - genetics (109) 109
dna breaks, double-stranded (108) 108
molecular sequence data (106) 106
medicine (105) 105
aged, 80 and over (104) 104
medicine & public health (103) 103
chemotherapy (102) 102
rad51 recombinase - genetics (102) 102
biology (101) 101
heterozygote (101) 101
pathology (100) 100
physiological aspects (100) 100
recombination, genetic (100) 100
care and treatment (98) 98
tumor suppressor protein p53 - metabolism (96) 96
brca2 protein - chemistry (94) 94
ovarian neoplasms - pathology (94) 94
neoplasms - genetics (93) 93
poly polymerase inhibitors (93) 93
genetic research (91) 91
tumor suppressor protein p53 - genetics (91) 91
antineoplastic agents - pharmacology (88) 88
amino acid sequence (87) 87
rad51 (87) 87
genomic instability (86) 86
poly polymerases - metabolism (86) 86
phenotype (84) 84
antineoplastic agents - therapeutic use (83) 83
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1802) 1802
Chinese (11) 11
Japanese (6) 6
Russian (5) 5
French (3) 3
Norwegian (2) 2
Polish (2) 2
Bulgarian (1) 1
Croatian (1) 1
Dutch (1) 1
German (1) 1
Hungarian (1) 1
Swedish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature (London), ISSN 1476-4687, 12/2015, Volume 528, Issue 7582, pp. 422 - 426
Journal Article
Cancer cell, ISSN 1535-6108, 02/2007, Volume 11, Issue 2, pp. 103 - 105
Journal Article
Nature cell biology, ISSN 1476-4679, 07/2018, Volume 20, Issue 8, pp. 954 - 965
.... We identified two previously uncharacterized proteins, C2Oorf196 and FAM35A, whose inactivation confers strong PARP-inhibitor resistance... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Osteosarcoma - drug therapy | Mad2 Proteins - metabolism | Humans | Multiprotein Complexes | Ovarian Neoplasms - pathology | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | HEK293 Cells | Female | Bone Neoplasms - genetics | Ovarian Neoplasms - metabolism | Bone Neoplasms - drug therapy | BRCA1 Protein - deficiency | Telomere-Binding Proteins - metabolism | Ovarian Neoplasms - drug therapy | Osteosarcoma - metabolism | DNA-Binding Proteins | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinational DNA Repair | Tumor Suppressor p53-Binding Protein 1 - genetics | Cisplatin - pharmacology | Breast Neoplasms - drug therapy | Proteins - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Proteins - metabolism | Breast Neoplasms - pathology | Mad2 Proteins - genetics | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Cell Cycle Proteins | Osteosarcoma - pathology | Care and treatment | DNA | Cancer cells | Breast cancer | Genetic aspects | Research | Gene expression | Single-stranded DNA | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Inactivation | Proteins | Ribose | Null cells | Deoxyribonucleic acid--DNA | BRCA2 protein | CRISPR | Deactivation | BRCA1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Oligosaccharides | Double-strand break repair | Screens | Cisplatin | Inhibitors | Prostate | Viability | Tumors | Index Medicus | Telomere-Binding Proteins / metabolism | Osteosarcoma / genetics | Telomere-Binding Proteins / genetics | BRCA1 Protein / genetics | Cellular Biology | Genetics | Proteins / genetics | Osteosarcoma / drug therapy | Ovarian Neoplasms / genetics | Mad2 Proteins / genetics | Proteins / metabolism | Breast Neoplasms / drug therapy | Breast Neoplasms / metabolism | Tumor Suppressor p53-Binding Protein 1 / genetics | BRCA1 Protein / deficiency | Ovarian Neoplasms / metabolism | Mad2 Proteins / metabolism | Breast Neoplasms / pathology | Bone Neoplasms / genetics | Ovarian Neoplasms / pathology | Bone Neoplasms / pathology | Life Sciences | Bone Neoplasms / drug therapy | Ovarian Neoplasms / drug therapy | Osteosarcoma / metabolism | Biochemistry, Molecular Biology | Breast Neoplasms / genetics | Drug Resistance, Neoplasm / genetics | Osteosarcoma / pathology | Bone Neoplasms / metabolism | Poly(ADP-ribose) Polymerase Inhibitors / pharmacology | Cisplatin / pharmacology | Molecular biology | Tumor Suppressor p53-Binding Protein 1 / metabolism | Cancer
Journal Article
Nature structural & molecular biology, ISSN 1545-9985, 09/2010, Volume 17, Issue 10, pp. 1247 - 1254
Journal Article
The EMBO journal, ISSN 1460-2075, 09/2009, Volume 28, Issue 21, pp. 3413 - 3427
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 10/2013, Volume 110, Issue 42, pp. 17041 - 17046
Breast Cancer Type 1 Susceptibility Protein (BRCA1)-deficient cells have compromised DNA repair and are sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors... 
Proteins | BRCA proteins | Platinum | DNA | Cell lines | Small interfering RNA | Cellular immunity | Breast cancer | Genetic mutation | Tumors | Cancer therapy | Homologous recombination | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | Ovarian Neoplasms - pathology | Ovarian Neoplasms - genetics | BRCA1 Protein - metabolism | Tumor Suppressor Proteins - genetics | Female | Antineoplastic Agents - pharmacology | HSP90 Heat-Shock Proteins - genetics | Ovarian Neoplasms - metabolism | Nuclear Proteins - genetics | Fanconi Anemia Complementation Group N Protein | Ovarian Neoplasms - drug therapy | Platinum - pharmacology | Protein Structure, Tertiary | Rad51 Recombinase - metabolism | Tumor Suppressor Proteins - metabolism | Rad51 Recombinase - genetics | Nuclear Proteins - metabolism | Cisplatin - pharmacology | Lactams, Macrocyclic - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Benzoquinones - pharmacology | BRCA1 Protein - genetics | Drug Resistance, Neoplasm - genetics | Poly(ADP-ribose) Polymerases - metabolism | BRCA2 Protein - metabolism | Poly(ADP-ribose) Polymerases - genetics | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Mutation | BRCA2 Protein - genetics | Drug Resistance, Neoplasm - drug effects | Gene mutations | Physiological aspects | Genetic aspects | Research | Binding proteins | Health aspects | DNA polymerase | DNA repair | Cells | Index Medicus | homologous recombination | Biological Sciences | cancer therapy
Journal Article