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Nature Structural & Molecular Biology, ISSN 1545-9993, 10/2010, Volume 17, Issue 10, pp. 1247 - 1254
Inherited mutations in human PALB2 are associated with a predisposition to breast and pancreatic cancers. PALB2's tumor-suppressing effect is thought to be... 
POLY(ADP-RIBOSE) POLYMERASE | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | HISTONE H2AX | FANCONI-ANEMIA | CELL BIOLOGY | RAD51 | BIOPHYSICS | IN-VIVO | SUSCEPTIBILITY GENE | D-LOOP FORMATION | DNA-REPAIR | Recombination, Genetic - physiology | DNA, Neoplasm - metabolism | Humans | Neoplasm Proteins - physiology | DNA Repair - physiology | Molecular Sequence Data | Structure-Activity Relationship | DNA Breaks, Double-Stranded | BRCA2 Protein - physiology | Breast Neoplasms - metabolism | Base Sequence | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Female | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Nucleic Acid Conformation | Fanconi Anemia Complementation Group N Protein | Peptide Fragments - metabolism | Neoplasm Proteins - chemistry | Nuclear Proteins - chemistry | Poly(ADP-ribose) Polymerase Inhibitors | Protein Interaction Mapping | Tumor Suppressor Proteins - physiology | Peptide Fragments - chemistry | Apoptosis Regulatory Proteins | Models, Biological | Rad51 Recombinase - chemistry | Rad51 Recombinase - physiology | BRCA2 Protein - chemistry | Nuclear Proteins - physiology | Poly (ADP-Ribose) Polymerase-1 | Breast cancer | Genetic aspects | Research | BRCA mutations | Ovarian cancer | Proteins | Mutation | Molecular biology | Prostate cancer | Index Medicus | homologous recombination | BRCA2 | PALB2
Journal Article
Cancer Cell, ISSN 1535-6108, 2007, Volume 11, Issue 2, pp. 103 - 105
Journal Article
Nature, ISSN 0028-0836, 12/2015, Volume 528, Issue 7582, pp. 422 - 426
Journal Article
ChemBioChem, ISSN 1439-4227, 02/2013, Volume 14, Issue 3, pp. 332 - 342
Journal Article
The FEBS Journal, ISSN 1742-464X, 08/2018, Volume 285, Issue 16, pp. 3026 - 3040
Journal Article
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 10/2010, Volume 17, Issue 10, pp. 1255 - 1259
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 42, pp. 17041 - 17046
Breast Cancer Type 1 Susceptibility Protein (BRCA1)-deficient cells have compromised DNA repair and are sensitive to poly(ADP-ribose) polymerase (PARP)... 
Proteins | BRCA proteins | Platinum | DNA | Cell lines | Small interfering RNA | Cellular immunity | Breast cancer | Genetic mutation | Tumors | Cancer therapy | Homologous recombination | cancer therapy | POLY(ADP-RIBOSE) POLYMERASE | CELLS | REPAIR | homologous recombination | TUMOR SUPPRESSION | 53BP1 | MULTIDISCIPLINARY SCIENCES | BREAST CANCERS | OVARIAN CARCINOMAS | MUTATIONS | CHEMOTHERAPY | Humans | Ovarian Neoplasms - pathology | Ovarian Neoplasms - genetics | BRCA1 Protein - metabolism | Tumor Suppressor Proteins - genetics | Female | Antineoplastic Agents - pharmacology | HSP90 Heat-Shock Proteins - genetics | Ovarian Neoplasms - metabolism | Nuclear Proteins - genetics | Fanconi Anemia Complementation Group N Protein | Ovarian Neoplasms - drug therapy | Platinum - pharmacology | Protein Structure, Tertiary | Rad51 Recombinase - metabolism | Tumor Suppressor Proteins - metabolism | Rad51 Recombinase - genetics | Nuclear Proteins - metabolism | Cisplatin - pharmacology | Lactams, Macrocyclic - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Benzoquinones - pharmacology | BRCA1 Protein - genetics | Drug Resistance, Neoplasm - genetics | Poly(ADP-ribose) Polymerases - metabolism | BRCA2 Protein - metabolism | Poly(ADP-ribose) Polymerases - genetics | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Mutation | BRCA2 Protein - genetics | Drug Resistance, Neoplasm - drug effects | Gene mutations | Physiological aspects | Genetic aspects | Research | Binding proteins | Health aspects | DNA polymerase | DNA repair | Cells | Index Medicus | Biological Sciences
Journal Article
Oncogene, ISSN 0950-9232, 10/2014, Volume 33, Issue 40, pp. 4803 - 4812
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2013, Volume 110, Issue 26, pp. 10640 - 10645
The RAD51 recombinase plays a central role in homologous recombination (HR), which is critical for repair of DNA double-strand breaks, maintenance of genomic... 
Proteins | Carrier proteins | DNA damage | DNA | Homologous recombination | Cell lines | Immunoblotting | Genetic mutation | DNA repair | Tumors | CELLS | RAD51 RECOMBINASE | INSTABILITY | MULTIDISCIPLINARY SCIENCES |