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JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 06/2011, Volume 54, Issue 11, pp. 3827 - 3838
Epigenetic mechanisms of gene regulation have a profound role in normal development and disease processes. An integral part of this mechanism occurs through... 
HDL | CHEMISTRY, MEDICINAL | HUMAN BRD2 BROMODOMAIN | PROTEIN | RECOGNITION | STRUCTURAL BASIS | BINDING | ACETYLATED HISTONE H4 | INSIGHTS
Journal Article
EPILEPSIA, ISSN 0013-9580, 05/2019, Volume 60, Issue 5, pp. E31 - E36
Juvenile myoclonic epilepsy (JME) is a common syndrome of genetic generalized epilepsies (GGEs). Linkage and association studies suggest that the gene encoding... 
BRD2 | GENE | association analysis | genetic generalized epilepsy | DNA methylation | SUSCEPTIBILITY LOCI | LINKAGE | ASSOCIATION | juvenile myoclonic epilepsy | CLINICAL NEUROLOGY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2011, Volume 108, Issue 40, pp. 16669 - 16674
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 03/2019, Volume 18, Issue 3, pp. 1032 - 1042
DNA methylation is a critical epigenetic modification that is established and maintained across the genome by DNA methyltransferase enzymes (Dnmts). Altered... 
DNMT1 | Azacitidine | UHRF1 | Chemical knockdown | BRD2 | METHYLATION | RNA | 5-AZACYTIDINE | BIOCHEMICAL RESEARCH METHODS | CATENIN | DNA METHYLTRANSFERASE INHIBITORS | DAMAGE | PATHWAY | SRA DOMAIN | chemical knockdown | azacitidine
Journal Article
Cell Journal (Yakhteh), ISSN 2228-5806, 2017, Volume 19, Issue Suppl 1, pp. 1 - 8
Cancer cells have recently been shown to activate hundreds of normally silent tissue-restricted genes, including a specific subset associated with cancer... 
BRD3 | BRD2 | BRD4-NUT | iBET | Review | P-TEFb
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 07/2014, Volume 111, Issue 26, pp. E2721 - E2730
Journal Article
Cell Cycle, ISSN 1538-4101, 02/2013, Volume 12, Issue 3, pp. 452 - 462
The therapeutic potential of pharmacologic inhibition of bromodomain and extraterminal (BET) proteins has recently emerged in hematological malignancies and... 
I-BET151 | BRD2 | HIV | Tat | latency | MS417 | I-BET | JQ1 | P-TEFb | BRD4 | Latency | RNA-POLYMERASE-II | TRANSCRIPTION ELONGATION-FACTOR | DEPENDENT TRANSCRIPTION | HISTONE ACETYLATION | CELL BIOLOGY | IN-VITRO | T-CELL-ACTIVATION | POSTINTEGRATION LATENCY | NF-KAPPA-B | PCAF BROMODOMAIN | Transcription, Genetic - drug effects | Virus Latency | Humans | Positive Transcriptional Elongation Factor B - metabolism | Positive Transcriptional Elongation Factor B - genetics | Promoter Regions, Genetic - drug effects | Heterocyclic Compounds, 4 or More Rings - pharmacology | HIV-1 - physiology | RNA Interference | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | CD4-Positive T-Lymphocytes - virology | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Benzodiazepines - pharmacology | HIV-1 - drug effects | Jurkat Cells | tat Gene Products, Human Immunodeficiency Virus - genetics | HIV Infections - virology | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | HIV-1 - genetics | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Nuclear Proteins - antagonists & inhibitors | RNA, Small Interfering | tat Gene Products, Human Immunodeficiency Virus - metabolism | Report
Journal Article
Cell Reports, ISSN 2211-1247, 01/2018, Volume 22, Issue 3, pp. 796 - 808
BRD4 belongs to the bromodomain and extraterminal (BET) family of chromatin reader proteins that bind acetylated histones and regulate gene expression.... 
BRD2 | prostate cancer | TMPRSS2-ERG | gene fusion | genomic rearrangements | non-homologous end joining | NHEJ | DNA repair | CRPC | BRD4 | ANDROGEN RECEPTOR | METHYLATION | INHIBITION | CHROMATIN | RECOGNITION | STRUCTURAL BASIS | 53BP1 | COMPLEXES | ADAPTER | BET BROMODOMAIN PROTEINS | CELL BIOLOGY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2018, Volume 115, Issue 22, pp. E5086 - E5095
Competitive BET bromodomain inhibitors (BBIs) targeting BET proteins (BRD2, BRD3, BRD4, and BRDT) show promising preclinical activities against brain cancers.... 
BRD3 | E2F | BRD2 | Glioma | BRD4 | Proteins | Medical research | Physiological aspects | Medicine, Experimental | Genetic aspects | Genetic transcription | Research | Glioblastoma multiforme | Cell proliferation | Brain | Chromatin | Transcription | Brain cancer | Brain tumors | Glioblastoma | Exploration | Malignancy | Ribonucleic acid--RNA | Studies | Degradation | Organic chemistry | Bet protein | Biological Sciences | PNAS Plus | glioma
Journal Article
Current Opinion in Hematology, ISSN 1065-6251, 07/2019, Volume 26, Issue 4, pp. 273 - 280
PURPOSE OF REVIEWPharmacological inhibition of Bromodomain and Extra-Terminal (BET) domain proteins is a very exciting epigenetic therapeutic modality. Due to... 
SELECTIVE-INHIBITION | TARGET | BRD2 | lymphoma | TRANSCRIPTION | BET | bromodomain | DOSE-ESCALATION | MYC | CELL LYMPHOMA | OTX015 | DEGRADATION | BAY 1238097 | HEMATOLOGY | PHASE-I | Bromodomain and Extra-Terminal domain | BRD4 | Lymphomas | Dosage and administration | Enzyme inhibitors | Genetic transcription | Research | Drug therapy
Journal Article
Development (Cambridge), ISSN 0950-1991, 01/2018, Volume 145, Issue 1, pp. dev156232 - dev156232
Journal Article
Genes, Brain and Behavior, ISSN 1601-1848, 09/2014, Volume 13, Issue 7, pp. 702 - 712
Journal Article