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Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 18, pp. 8202 - 8211
BET proteins are key epigenetic regulators that regulate transcription through binding to acetylated lysine (AcLys) residues of histones and transcription... 
PROTEIN-DEGRADATION | CHEMISTRY, MEDICINAL | BRD4
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2019, Volume 519, Issue 3, pp. 481 - 488
Ischemic stroke is a major cause of death and disability worldwide. Hyperneuroinflammation significantly contributes to ischemic stroke. Bromodomain-containing... 
Inflammation | Pyroptosis | Ischemic stroke | JQ1 | BRD4
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 10/2019
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 7, pp. 732 - 740
Journal Article
FEBS Letters, ISSN 0014-5793, 09/2019, Volume 593, Issue 18, pp. 2556 - 2565
Nuclear receptor‐binding SET domain 3 (NSD3) is a lysine methyltransferase that plays important roles in multiple biological activities; however; its potential... 
NSD3 | ANF | H3K27me2/3 | cardiomyocyte hypertrophy | H3K27ac | BRD4
Journal Article
Experimental Cell Research, ISSN 0014-4827, 10/2019, Volume 383, Issue 2, p. 111507
Fibrosis is a common pathology in renal disease. Hypertensive nephropathy (HN) is one of the most common secondary nephropathies that often progresses to... 
Epithelial-mesenchymal transition | Hypertensive nephropathy | Fibrosis | Brd4
Journal Article
Oncotarget, ISSN 1949-2553, 02/2018, Volume 9, Issue 14, pp. 11665 - 11676
We have recently reported that activation of Brd4 is associated with the presence of autophagy in NPMc+ and MLL AML cells. In order to determine the mechanisms... 
AML | Keap1 | Autophagy | Brd4
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2017, Volume 25, Issue 14, pp. 3677 - 3684
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 08/2019, Volume 24, Issue 17, p. 3096
We introduce SAR-by-Space, a concept to drastically accelerate structure-activity relationship (SAR) elucidation by synthesizing neighboring compounds that... 
bromodomains | chemical space | new chemical entities | BRD4 inhibitors
Journal Article
Biochimie, ISSN 0300-9084, 10/2019, Volume 165, pp. 100 - 107
High glucose (HG)-induced podocyte injury contributes to the pathogenesis of diabetic nephropathy, a severe complication of diabetes. Bromodomain-containing... 
Podocyte | Diabetic nephropathy | Nrf2 | BRD4 | High glucose | APOPTOSIS | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | NEPHROPATHY | INHIBITION | PATHWAY | ANTIOXIDANT | BROMODOMAIN PROTEIN BRD4 | MOLECULAR-MECHANISMS | Antioxidants | Glucose | RNA | Dextrose | Diabetic nephropathies
Journal Article
BBA - Gene Regulatory Mechanisms, ISSN 1874-9399, 09/2013, Volume 1829, Issue 9, pp. 937 - 945
The NF-κB family of transcription factors governs the cellular reaction to a variety of extracellular signals. Following stimulation, NF-κB activates genes... 
transcription elongation | NF-κB | DSIF | P-TEFb | Brd4 | Transcription elongation | RNA-POLYMERASE-II | CARBOXY-TERMINAL DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TATA-BINDING PROTEIN | NF-kappa B | BIOPHYSICS | IMMUNODEFICIENCY-VIRUS TRANSCRIPTION | MESSENGER-RNA | GENE-EXPRESSION | TRANSACTIVATION DOMAIN | SENSITIVITY-INDUCING FACTOR | BROMODOMAIN PROTEIN BRD4
Journal Article