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1. Full Text Airway Responsiveness in Mild to Moderate Childhood Asthma: Sex Influences on the Natural History
by Tantisira, Kelan G and Colvin, Ryan and Tonascia, James and Strunk, Robert C and Weiss, Scott T and Fuhlbrigge, Anne L and Childhood Asthma Management Program Research Group and Childhood Asthma Management Progra and Childhood Asthma Management Program Research Group
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 08/2008, Volume 178, Issue 4, pp. 325 - 331
Rationale: Airway responsiveness is a prognostic marker for asthma symptoms in later life. Objectives: To evaluate characteristics responsible for persistence... 
Bronchoconstriction | FEV | Methacholine | YOUNG-ADULTS | MANAGEMENT PROGRAM | RISK-FACTORS | BRONCHIAL RESPONSIVENESS | SERUM IGE | LUNG-FUNCTION | PULMONARY-FUNCTION | bronchoconstriction | PC20 | RESPIRATORY SYSTEM | INHALED HISTAMINE | FEV1 | RESPIRATORY SYMPTOMS | methacholine | VITAL CAPACITY | CRITICAL CARE MEDICINE | Prognosis | Prospective Studies | Age Factors | Bronchodilator Agents - administration & dosage | Follow-Up Studies | Forced Expiratory Volume - drug effects | Humans | Bronchial Provocation Tests | Child, Preschool | Male | Puberty - physiology | Vital Capacity - drug effects | Bronchial Hyperreactivity - physiopathology | Female | Child | Methacholine Chloride | Asthma - epidemiology | Bronchoconstriction - physiology | Asthma - physiopathology | Double-Blind Method | Forced Expiratory Volume - physiology | Nedocromil - administration & dosage | Disease Progression | Sex Ratio | Vital Capacity - physiology | Adolescent | Least-Squares Analysis | Bronchial Hyperreactivity - epidemiology | Anti-Asthmatic Agents - administration & dosage | Budesonide - administration & dosage | Cohort Studies | Index Medicus | Abridged Index Medicus | A. Asthma and Allergy
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2. Full Text Airway responsiveness to methacholine and incidence of COPD: An international prospective cohort study
by Marcon, Alessandro and Locatelli, Francesca and Keidel, Dirk and Beckmeyer-Borowko, Anna B and Cerveri, Isa and Dharmage, Shyamali C and Fuertes, Elaine and Garcia-Aymerich, Judith and Heinrich, Joachim and Imboden, Medea and Janson, Christer and Johannessen, Ane and Leynaert, Bénédicte and Pascual Erquicia, Silvia and Pesce, Giancarlo and Schaffner, Emmanuel and Svanes, Cecilie and Urrutia, Isabel and Jarvis, Deborah and Probst-Hensch, Nicole M and Accordini, Simone and Ageing Lungs European Cohorts ALEC and Ageing Lungs in European Cohorts (ALEC) study and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för medicinska vetenskaper and Lung- allergi- och sömnforskning
Thorax, ISSN 0040-6376, 09/2018, Volume 73, Issue 9, pp. 825 - 832
Background It has been debated, but not yet established, whether increased airway responsiveness can predict COPD. Recognising this link may help in... 
COPD epidemiology | asthma | clinical epidemiology | POPULATION | OBSTRUCTIVE PULMONARY-DISEASE | BRONCHIAL HYPERRESPONSIVENESS | RESPIRATORY SYSTEM | LUNG-FUNCTION | ADULTS | OVERLAP SYNDROME | ASTHMA | RESPIRATORY-HEALTH-SURVEY | SAPALDIA | DECLINE | Pulmonary Disease, Chronic Obstructive - diagnosis | Prospective Studies | Humans | Middle Aged | Bronchial Provocation Tests | Male | Pulmonary Disease, Chronic Obstructive - epidemiology | Incidence | Forced Expiratory Volume | Young Adult | Adult | Female | Methacholine Chloride | Outdoor air quality | Studies | Disease | Population | Chronic obstructive pulmonary disease | Health risk assessment | Epidemiology | Asthma | Index Medicus | Respiratory organs diseases | Malalties de l'aparell respiratori | copd epidemiology | Chronic Obstructive Pulmonary Disease | 2313 | 1506 | Clinical Medicine | Lungmedicin och allergi | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Respiratory Medicine and Allergy
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3. Full Text Childhood Asthma and Increased Airway Responsiveness: A Relationship That Begins in Infancy
by Turner, Stephen W and Young, Sally and Goldblatt, Jack and Landau, Louis I and Le Souef, Peter N
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 01/2009, Volume 179, Issue 2, pp. 98 - 104
Rationale Asthma is associated with increased airway responsiveness (AR), but the age when this relationship becomes established is not clear. The present... 
Infant | Child | Bronchial hyperreactivity | Longitudinal study | Asthma | PREDICTS | REDUCED LUNG-FUNCTION | BRONCHIAL HYPERRESPONSIVENESS | RISK | asthma | longitudinal study | SYMPTOMS | infant | CHILDREN | RESPIRATORY SYSTEM | COLD | BIRTH COHORT | bronchial hyperreactivity | child | LIFE | AGE | CRITICAL CARE MEDICINE | Asthma - diagnosis | Prevalence | Skin Tests | Humans | Respiratory Sounds - diagnosis | Risk Factors | Bronchial Provocation Tests | Bronchial Hyperreactivity - diagnosis | Male | Australia - epidemiology | Age of Onset | Bronchial Hyperreactivity - epidemiology | Female | Surveys and Questionnaires | Respiratory Function Tests | Longitudinal Studies | Infant, Newborn | Asthma - epidemiology | Cohort Studies | Index Medicus | Abridged Index Medicus
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4. Full Text TNF-α ( −308 G/A ) and CD14 ( −159T/C ) polymorphisms in the bronchial responsiveness of Korean children with asthma
by Hong, Soo-Jong, MD, PhD and Kim, Hyo-Bin, MD and Kang, Mi-Jin, BS and Lee, So-Yeon, MD and Kim, Ja-Hyung, MD and Kim, Bong-Seong, MD and Jang, Seong-Ok, BS and Shin, Hyung-Doo, PhD and Park, Choon-Sik, MD, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2007, Volume 119, Issue 2, pp. 398 - 404
Background TNF-α is a pivotal proinflammatory cytokine increased in asthmatic airways. The TNF-α gene family might be linked to asthma or bronchial... 
Allergy and Immunology | atopy | asthma | polymorphism | CD14 | bronchial hyperreactivity | Tumor necrosis factor α | POPULATION | PROMOTER POLYMORPHISM | TNF-ALPHA-308 | IMMUNOLOGY | GENE POLYMORPHISM | CHILDHOOD ASTHMA | TUMOR-NECROSIS-FACTOR | tumor necrosis factor alpha | ALLERGY | CD14 GENE | ASSOCIATION | SERUM TOTAL IGE | ATOPIC ASTHMA | Humans | Tumor Necrosis Factor-alpha - genetics | Adolescent | Alleles | Lipopolysaccharide Receptors - genetics | Female | Genotype | Male | Bronchial Hyperreactivity - genetics | Child | Asthma - genetics | Polymorphism, Genetic | Index Medicus | Abridged Index Medicus
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5. Full Text Asthma Remission: Predicting Future Airways Responsiveness using a miRNA Network
by McGeachie, Michael J., Ph.D and Davis, Joshua S., MD and Kho, Alvin T., Ph.D and Dahlin, Amber, Ph.D and Sordillo, Joanne E., Sc.D and Sun, Maoyun, Ph.D and Lu, Quan, Ph.D and Weiss, Scott T., MD and Tantisira, Kelan G., MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2017, Volume 140, Issue 2, pp. 598 - 600.e8
Capsule Summary A panel of circulating microRNAs can be used to predict airway hyperresponsiveness remission in growing children with asthma as they transition... 
Allergy and Immunology | ALLERGY | IMMUNOLOGY | Asthma - diagnosis | Genetic Predisposition to Disease | Prognosis | Genetic Association Studies | Area Under Curve | Humans | Gene Expression Regulation | Bronchial Hyperreactivity - diagnosis | Gene Regulatory Networks | Bronchial Hyperreactivity - genetics | Asthma - genetics | Phenotype | MicroRNAs - genetics | MicroRNA | Public health | Medical informatics | Asthma | Cdc42 protein | Biotechnology | CXCL12 protein | Smooth muscle | Myc protein | Kinases | Interleukin 1 | Janus kinase | Remission | Lipoprotein (low density) receptors | Aquaporin 3 | IRAK protein | MDM2 protein | Bone morphogenetic protein 2 | Bone morphogenetic protein receptor type II | DNMT1 protein | MiRNA | Data processing | Gene expression | Gelatinase A | Polymerase chain reaction | Ribonucleic acids | MicroRNAs | Quality control | Interleukin 10 | In vitro methods and tests | Chemokines | Hypertrophy | Matrilysin | Index Medicus | Abridged Index Medicus
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6. Full Text Predictive value of nonspecific bronchial responsiveness in occupational asthma
by Pralong, Jacques A., MD, MSc and Lemière, Catherine, MD, MSc and Rochat, Thierry, MD and L'Archevêque, Jocelyne, RT and Labrecque, Manon, MD, MSc and Cartier, André, MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 137, Issue 2, pp. 412 - 416
Background The diagnosis of occupational asthma (OA) can be challenging and needs a stepwise approach. However, the predictive value of the methacholine... 
Allergy and Immunology | Bronchial responsiveness | methacholine challenge | occupational asthma | DIAGNOSIS | PROVOCATION TESTS | AIRWAY INFLAMMATION | WORKER | IMMUNOLOGY | HYPERRESPONSIVENESS | CHALLENGE | ALLERGY | ABSENCE | METHACHOLINE | Reproducibility of Results | Humans | Middle Aged | Risk Factors | Bronchial Provocation Tests | Male | Asthma, Occupational - diagnosis | Canada | Asthma, Occupational - physiopathology | Sensitivity and Specificity | Adult | Female | Retrospective Studies | Methacholine Chloride | Databases, Factual | Asthma | Laboratories | Molecular weight | Index Medicus | Abridged Index Medicus
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7. Full Text Effector CD8 + T cells mediate inflammation and airway hyper-responsiveness
by Swanson, Bradley J and Takeda, Katsuyuki and Gelfand, Erwin W and Miyahara, Satoko and Miyahara, Nobuaki and Dakhama, Azzeddine and Kodama, Taku and Ott, Vanessa L and Taube, Christian
Nature Medicine, ISSN 1078-8956, 08/2004, Volume 10, Issue 8, pp. 865 - 869
Allergic asthma is a complex syndrome characterized by airway obstruction, airway inflammation and airway hyper-responsiveness (AHR). Using a mouse model of... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERLEUKIN-13 | ASTHMA | MICE | IL-13 | LYMPHOCYTES | CELL BIOLOGY | T-Lymphocyte Subsets - immunology | Bronchial Hyperreactivity - immunology | Bronchoalveolar Lavage Fluid - immunology | Interleukin-13 - immunology | Adoptive Transfer | Alum Compounds | Flow Cytometry | Allergens - immunology | Mice, Mutant Strains | Bronchitis - immunology | Methacholine Chloride | Disease Models, Animal | Ovalbumin | Lung - pathology | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Cells, Cultured | Bronchitis - physiopathology | CD8 Antigens - immunology | Bronchial Hyperreactivity - pathology | Animals | Analysis of Variance | Mice | CD8-Positive T-Lymphocytes - immunology | Lung - immunology | Index Medicus
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8. Full Text Serum periostin levels correlate with airway hyper‐responsiveness to methacholine and mannitol in children with asthma
by Song, J.‐S and You, J.‐S and Jeong, S.‐I and Yang, S and Hwang, I.‐T and Im, Y.‐G and Baek, H.‐S and Kim, H.‐Y and Suh, D.‐I and Lee, H.‐B and Izuhara, K
Allergy, ISSN 0105-4538, 06/2015, Volume 70, Issue 6, pp. 674 - 681
BackgroundPeriostin is a matricellular protein, and its synthesis in airway epithelial cells and lung fibroblasts is induced by interleukin (IL)-4 and IL-13.... 
airway hyperresponsiveness | asthma | children | periostin | RESPONSIVENESS | MATRIX PROTEIN | PHENOTYPES | IMMUNOLOGY | CLUSTER-ANALYSIS | ALLERGY | INFLAMMATION | EXHALED NITRIC-OXIDE | 1ST 6 YEARS | CLINICAL-SIGNIFICANCE | BRONCHIAL-ASTHMA | LIFE | Cell Adhesion Molecules - blood | Asthma - physiopathology | Humans | Respiratory Hypersensitivity - chemically induced | Bronchial Provocation Tests | Male | Case-Control Studies | Forced Expiratory Volume | Respiratory Hypersensitivity - blood | Asthma - blood | Adolescent | Mannitol | Respiratory Hypersensitivity - physiopathology | Female | Bronchoconstrictor Agents | Child | Methacholine Chloride | Asthma in children | Methacholine | Children | Proteins | Biomarkers | Asthma | Children & youth | Index Medicus
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9. Full Text IL‐33 drives airway hyper‐responsiveness through IL‐13‐mediated mast cell: airway smooth muscle crosstalk
by Kaur, D and Gomez, E and Doe, C and Berair, R and Woodman, L and Saunders, R and Hollins, F and Rose, F.R and Amrani, Y and May, R and Kearley, J and Humbles, A and Cohen, E.S and Brightling, C.E
Allergy, ISSN 0105-4538, 05/2015, Volume 70, Issue 5, pp. 556 - 567
BackgroundMast cell localization within the airway smooth muscle (ASM)-bundle plays an important role in the development of airway hyper-responsiveness (AHR).... 
33 | mast cells | ASM | IL-33 | IL-13 PRODUCTION | SEVERE ASTHMA | INTERLEUKIN-33 | INNATE LYMPHOID-CELLS | IMMUNOLOGY | THYMIC STROMAL LYMPHOPOIETIN | MURINE MODEL | ALLERGY | INFLAMMATION | IN-VIVO | EXPRESSION | PROMOTES | Immunohistochemistry | Mast Cells - immunology | Bronchial Hyperreactivity - immunology | Enzyme-Linked Immunosorbent Assay | Humans | Mice, Inbred C57BL | Middle Aged | Interleukin-13 - immunology | Muscle, Smooth - metabolism | Muscle, Smooth - immunology | Interleukin-33 - immunology | Receptor Cross-Talk - immunology | Animals | Flow Cytometry | Asthma - immunology | Fluorescent Antibody Technique | Polymerase Chain Reaction | Adult | Mice | Mice, Inbred BALB C | Histamine | Care and treatment | RNA | Analysis | Smooth muscle | Wounds and injuries | Asthma | Cytokines | Cells | Index Medicus | Original
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10. Full Text A multiscale, spatially distributed model of asthmatic airway hyper-responsiveness
by Politi, Antonio Z and Donovan, Graham M and Tawhai, Merryn H and Sanderson, Michael J and Lauzon, Anne-Marie and Bates, Jason H.T and Sneyd, James
Journal of Theoretical Biology, ISSN 0022-5193, 2010, Volume 266, Issue 4, pp. 614 - 624
We present a multiscale, spatially distributed model of lung and airway behaviour with the goal of furthering the understanding of airway hyper-responsiveness... 
Crossbridge | Tethering | Actin–myosin | Calcium | Smooth muscle cells | Actin-myosin | EXPIRATORY FLOW | VOLUME | SURFACE-TENSION | LUNG ELASTICITY | SMOOTH-MUSCLE | MECHANICS | BIOLOGY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | DYNAMICS | MYOSIN BINDING | SHEAR MODULUS | BRONCHIAL TREE | Bronchoconstriction - physiology | Asthma - physiopathology | Models, Biological | Bronchial Hyperreactivity - physiopathology | Humans | Muscle Contraction - physiology | Kinetics | Respiration | Pressure | Analysis | Models | Asthma | Index Medicus | smooth muscle cells | tethering | crossbridge | calcium | actin-myosin
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11. Full Text Jagged1 on Dendritic Cells and Notch on CD4+ T Cells Initiate Lung Allergic Responsiveness by Inducing IL-4 Production
by Okamoto, Masakazu and Matsuda, Hiroyuki and Joetham, Anthony and Lucas, Joseph J and Domenico, Joanne and Yasutomo, Koji and Takeda, Katsuyuki and Gelfand, Erwin W
The Journal of Immunology, ISSN 0022-1767, 09/2009, Volume 183, Issue 5, pp. 2995 - 3003
Jagged1, a Notch ligand, and Notch have been implicated in Th2 differentiation, but their role in initiating IL-4 production and Th2 differentiation in vivo... 
RESPONSES | TH2 DIFFERENTIATION | MEDIATED AIRWAY HYPERRESPONSIVENESS | INFLAMMATION | IN-VIVO | GATA3 EXPRESSION | ASTHMA | MICE | IMMUNOLOGY | GAMMA-SECRETASE | ANTIGEN | Eosinophilia - metabolism | Inflammation Mediators - administration & dosage | Bronchial Hyperreactivity - immunology | Coculture Techniques | Dendritic Cells - immunology | Male | Th2 Cells - immunology | Intercellular Signaling Peptides and Proteins - physiology | CD4-Positive T-Lymphocytes - immunology | Eosinophilia - pathology | Interleukin-4 - biosynthesis | Ovalbumin - toxicity | Membrane Proteins - physiology | Serrate-Jagged Proteins | Inflammation Mediators - metabolism | Bronchial Hyperreactivity - metabolism | Female | Lung - metabolism | Receptors, Notch - administration & dosage | Intercellular Signaling Peptides and Proteins - administration & dosage | Inflammation Mediators - physiology | Interleukin-4 - physiology | Dendritic Cells - metabolism | Th2 Cells - pathology | Jagged-1 Protein | Lung - pathology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Receptors, Notch - physiology | Interleukin-4 - deficiency | Th2 Cells - metabolism | Calcium-Binding Proteins - administration & dosage | Mice, Knockout | Membrane Proteins - administration & dosage | Bronchial Hyperreactivity - pathology | Animals | Ovalbumin - administration & dosage | CD4-Positive T-Lymphocytes - transplantation | Eosinophilia - immunology | Calcium-Binding Proteins - physiology | Mice | Dendritic Cells - transplantation | Lung - immunology | Index Medicus | Abridged Index Medicus
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12. Full Text Gender Differences in Murine Airway Responsiveness and Lipopolysaccharide-Induced Inflammation
by Card, Jeffrey W and Carey, Michelle A and Bradbury, J. Alyce and DeGraff, Laura M and Morgan, Daniel L and Moorman, Michael P and Flake, Gordon P and Zeldin, Darryl C
The Journal of Immunology, ISSN 0022-1767, 07/2006, Volume 177, Issue 1, pp. 621 - 630
The roles of gender and sex hormones in lung function and disease are complex and not completely understood. The present study examined the influence. of... 
RESPONSES | INHALED LIPOPOLYSACCHARIDE | TESTOSTERONE | ESTRADIOL | RATS | ESTROGEN | ACUTE LUNG INJURY | ASTHMA | SYNTHASE-DEFICIENT MICE | IMMUNOLOGY | HORMONES | Lung - pathology | Toll-Like Receptor 4 - biosynthesis | Bronchial Hyperreactivity - immunology | Lipopolysaccharides - administration & dosage | Mice, Inbred C57BL | Male | Respiratory Mechanics - immunology | Inflammation - immunology | Hypothermia - immunology | Sex Characteristics | Lung - enzymology | Cyclooxygenase 2 - biosynthesis | Bronchial Hyperreactivity - pathology | Animals | Bronchial Hyperreactivity - physiopathology | Female | Mice | Mice, Inbred BALB C | Respiratory Function Tests | Lung - immunology | Plethysmography | Inflammation - physiopathology | Index Medicus | Abridged Index Medicus
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13. Full Text Effects of small airway dysfunction on the clinical expression of asthma: a focus on asthma symptoms and bronchial hyper-responsiveness
by van der Wiel, E and Postma, D. S and van der Molen, T and Schiphof-Godart, L and ten Hacken, N. H. T and van den Berge, M
Allergy, ISSN 0105-4538, 12/2014, Volume 69, Issue 12, pp. 1681 - 1688
BackgroundThe small airways are an important site of inflammation in asthma. However, the relation between small airway dysfunction and clinical expression of... 
symptoms | bronchial hyper‐responsiveness | asthma | small airways | bronchial hyper‐reactivity | Small airways | Bronchial hyper-reactivity | Symptoms | Bronchial hyper-responsiveness | Asthma | bronchial hyper-reactivity | FORCED OSCILLATION | OFFICIAL STATEMENT | MODEL | IMMUNOLOGY | EUROPEAN RESPIRATORY SOCIETY | LUNG-VOLUMES | COMMUNITY | ALLERGY | WORKING PARTY STANDARDIZATION | INFLAMMATION | NITRIC-OXIDE | IMPULSE OSCILLOMETRY | bronchial hyper-responsiveness | Asthma - diagnosis | Severity of Illness Index | Asthma - physiopathology | Cross-Sectional Studies | Humans | Middle Aged | Bronchial Provocation Tests | Male | Dyspnea - physiopathology | Young Adult | Bronchial Hyperreactivity - physiopathology | Adult | Female | Aged | Respiratory Function Tests | Nitric oxide | Airway management | Index Medicus
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