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bronchodilatory activity (19) 19
animals (15) 15
pharmacology & pharmacy (14) 14
chemistry, medicinal (13) 13
index medicus (13) 13
asthma (12) 12
bronchodilatory (12) 12
guinea pigs (11) 11
male (11) 11
rats (9) 9
bronchodilator agents - pharmacology (7) 7
trachea - drug effects (7) 7
anti-inflammatory (6) 6
chemistry, organic (6) 6
dose-response relationship, drug (6) 6
obstructive pulmonary-disease (6) 6
analysis (5) 5
bronchodilator agents - therapeutic use (5) 5
extract (5) 5
histamine (5) 5
humans (5) 5
mice (5) 5
muscle, smooth - drug effects (5) 5
plant extracts - pharmacology (5) 5
acetylcholine (4) 4
antitussive agents - pharmacology (4) 4
asthma - drug therapy (4) 4
biochemistry & molecular biology (4) 4
bronchodilator agents - administration & dosage (4) 4
bronchodilatory effect (4) 4
copd (4) 4
cough - drug therapy (4) 4
design (4) 4
female (4) 4
in-vitro (4) 4
inhibition (4) 4
integrative & complementary medicine (4) 4
molecular structure (4) 4
plant extracts - therapeutic use (4) 4
plant sciences (4) 4
smooth-muscle (4) 4
structure-activity relationship (4) 4
airways (3) 3
albuterol (3) 3
anti-inflammatory agents - chemistry (3) 3
anti-inflammatory agents - pharmacology (3) 3
antioxidant (3) 3
antitussive agents - chemistry (3) 3
asthma - physiopathology (3) 3
bronchodilator agents - chemistry (3) 3
cardiotonic agents (3) 3
chemistry, multidisciplinary (3) 3
chronic obstructive pulmonary disease (3) 3
contraction (3) 3
cough - chemically induced (3) 3
drug design (3) 3
long-acting bronchodilatory activity (3) 3
mepenzolate (3) 3
phytotherapy (3) 3
plant extracts - chemistry (3) 3
pyridazines - chemistry (3) 3
pyridine (3) 3
pyridines - chemistry (3) 3
research (3) 3
respiratory system - drug effects (3) 3
responses (3) 3
roflumilast (3) 3
sugars (3) 3
administration, inhalation (2) 2
aerosols (2) 2
aframomum melegueta (2) 2
aged (2) 2
agents (2) 2
agonists (2) 2
anti-asthmatic agents - pharmacology (2) 2
anti-inflammatory agents - chemical synthesis (2) 2
anti-inflammatory drugs (2) 2
antiasthmatic agent (2) 2
antidiarreicos (2) 2
antidiarrheal (2) 2
antidiarrheal; bronchodilatory; olea europea, olive (2) 2
antitussive activity (2) 2
antitussive agents - isolation & purification (2) 2
antitussive agents - therapeutic use (2) 2
asthma - immunology (2) 2
bronchoconstriction - drug effects (2) 2
calcium (2) 2
cell-cultures (2) 2
channels (2) 2
chemistry (2) 2
chemistry, applied (2) 2
citrus aurantifolia (2) 2
cyclic nucleotide phosphodiesterases, type 3 - metabolism (2) 2
cyclic nucleotide phosphodiesterases, type 4 - metabolism (2) 2
disease models, animal (2) 2
dual pde3/4 inhibitor (2) 2
echinacea purpurea (2) 2
extractos vegetales (2) 2
farmacia (2) 2
glycoconjugate (2) 2
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Journal Article
PLoS ONE, ISSN 1932-6203, 12/2017, Volume 12, Issue 12, p. e0189213
PDE3s belong to the phosphodiesterases family, where the PDE3A isoform is the major subtype in platelets involved in the cAMP regulation pathway of platelet... 
BRONCHODILATORY ACTIVITY | DESIGN | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | ACCURATE DOCKING | PLATELETS | MULTIDISCIPLINARY SCIENCES | TEMPLATE COMFA | PROTEINS | PROGRAM | MOLECULES | PREDICTION | Proteins | Research | Phosphodiesterases | Structure | Pyridazine
Journal Article
Frontiers in pharmacology, ISSN 1663-9812, 2018, Volume 9, p. 344
The standard treatment for chronic obstructive pulmonary disease is a combination of anti-inflammatory drugs and bronchodilators. We recently found that... 
Journal Article
FRONTIERS IN PHARMACOLOGY, ISSN 1663-9812, 04/2018, Volume 9
The standard treatment for chronic obstructive pulmonary disease is a combination of anti-inflammatory drugs and bronchodilators. We recently found that... 
long-acting bronchodilatory activity | GLOBAL STRATEGY | LUNG | MANAGEMENT | PREVENTION | TOCAINIDE | mepenzolate | OBSTRUCTIVE PULMONARY-DISEASE | ANTISPASMODIC ACTIVITY | METHOBROMIDE | EMPHYSEMA | anti-inflammatory | PHARMACOLOGY & PHARMACY | FLUTICASONE | chronic obstructive pulmonary disease | Pharmacology, Experimental | Mepenzolate | Bronchodilator agents | Testing
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2012, Volume 22, Issue 18, pp. 5833 - 5838
Journal Article
Oriental Pharmacy and Experimental Medicine, ISSN 1598-2386, 12/2015, Volume 15, Issue 4, pp. 341 - 346
Curcuma longa, Zingiber officinale and Alpinia galanga are traditionally and scientifically reported for the treatment of respiratory disorders such as asthma,... 
Biomedicine | Airway inflammation | Herbal formulation | Pharmacy | Mast cell | Anticataleptic activity | Biomedicine general | Asthma | Bronchodilatory activity
Journal Article
Journal of Physiology and Pharmacology, ISSN 0867-5910, 08/2013, Volume 64, Issue 4, pp. 479 - 484
The present study was undertaken to validate some of the folkloric claims about the effectiveness of the use of a Myrtus communis L. crude methanol extract... 
Vasorelaxant effect | Myrtus communis | Bronchodilatory effect | Spasmolytic effect | CONSTIPATION | PHYSIOLOGY | DIARRHEA | ESSENTIAL OIL | PAKISTAN | LEAVES | spasmolytic effect | IN-VITRO | bronchodilatory effect | ANTIOXIDANT | CHEMICAL-COMPOSITION | CALCIUM | vasorelaxant effect | ANTAGONISTS
Journal Article
Journal Article
Pharmaceutical Biology, ISSN 1388-0209, 10/2009, Volume 47, Issue 10, pp. 962 - 967
This study describes the antidiarrheal, antisecretory, and bronchodilatory activities of Hypericum perforatum Linn. (Hypericaceae), commonly known as St.... 
Hypericum perforatum | bronchodilatory | antisecretory | in vivo | St. John's wort | antidiarrheal | Antisecretory | In vivo | Bronchodilatory | Antidiarrheal | DEPRESSION | INTESTINAL SECRETION | TEA ASPALATHUS-LINEARIS | RATS | CASTOR-OIL | PLANT SCIENCES | INHIBITION | PHARMACOLOGY & PHARMACY | ST-JOHNS-WORT | MICE | MEDICAL LABORATORY TECHNOLOGY | EXTRACT | MOTILITY
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2013, Volume 23, Issue 1, pp. 375 - 381
(−)-6-(7-Methoxy-2-(trifluoromethyl)pyrazolo[1,5- ]pyridin-4-yl)-5-methyl-4,5-dihydropyridazin-3(2 )-one (KCA-1490) exhibits moderate dual PDE3/4-inhibitory... 
Phosphodiesterase (PDE) | Inhaled administration | Dual PDE3/4 inhibitor | Asthma | COPD | MORTALITY | CHRONIC HEART-FAILURE | BRONCHODILATORY ACTIVITY | DESIGN | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | 4,5-DIHYDRO-6-<4-(1H-IMIDAZOL-1-YL)PHENYL>-3(2H)-PYRIDAZINONES | OBSTRUCTIVE PULMONARY-DISEASE | POSITIVE INOTROPIC AGENTS | CORTICOSTEROIDS | CARDIOTONIC AGENTS | ROFLUMILAST | Cyclic Nucleotide Phosphodiesterases, Type 3 - chemistry | Phosphodiesterase 3 Inhibitors - chemistry | Phosphodiesterase 3 Inhibitors - pharmacology | Pyridines - chemistry | Structure-Activity Relationship | Phosphodiesterase 4 Inhibitors - chemical synthesis | Bronchodilator Agents - chemistry | Drug Design | Bronchoalveolar Lavage Fluid - cytology | Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Phosphodiesterase 4 Inhibitors - chemistry | Anti-Inflammatory Agents - pharmacology | Administration, Inhalation | Rats | Bronchodilator Agents - pharmacology | Bronchodilator Agents - chemical synthesis | Phosphodiesterase 4 Inhibitors - pharmacology | Pyridazines - chemistry | Phosphodiesterase 3 Inhibitors - chemical synthesis | Animals | Anti-Inflammatory Agents - chemistry | Protein Binding | Leukocytes - drug effects | Anti-Inflammatory Agents - chemical synthesis | Anti-inflammatory drugs | Respiratory agents
Journal Article
Tetrahedron, ISSN 0040-4020, 02/2013, Volume 69, Issue 5, pp. 1658 - 1662
We found a mild and efficient reaction condition for construction of a chiral 5-methyl-4,5-dihydropyridazin-3(2 )-one from a chiral β-methyl γ-ketocarboxylic... 
Acid hydrazide | Intramolecular cyclization | Chiral dihydropyridazinone | One-pot reaction | BRONCHODILATORY ACTIVITY | DESIGN | CHEMISTRY, ORGANIC
Journal Article
Chinese Chemical Letters, ISSN 1001-8417, 12/2003, Volume 14, Issue 12, pp. 1223 - 1226
Twelve novel pyrazolo [4,3-d] pyrimidin-7-ones were synthesized and their structures were confirmed by IR, H-1 NMR and MS. Their in vitro bronchodilatory... 
Synthesis | Pyrazolo [4,3-d] pyrimidin-7-ones | Bronchodilatory activity | synthesis | bronchodilatory activity | pyrazolo [4,3-d] pyrimidin-7-ones | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
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