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ampk, amp-activated protein kinase (5) 5
brsk, brain-specific kinase (5) 5
humans (5) 5
index medicus (5) 5
phosphorylation (5) 5
research article (5) 5
amino acid sequence (4) 4
amp-activated protein kinase (4) 4
biochemistry & molecular biology (4) 4
acc, acetyl-coa carboxylase (3) 3
animals (3) 3
cell line (3) 3
hek, human embryonic kidney (3) 3
mark, microtubule-affinity-regulating kinase (3) 3
aicar, 5-amino-4-imidazolecarboxamide riboside (2) 2
amp-activated protein kinases - metabolism (2) 2
cells (2) 2
dmem, dulbecco’s modified eagle’s medium (2) 2
enzyme activation (2) 2
gfp, green fluorescent protein (2) 2
gsk3, glycogen synthase kinase 3 (2) 2
gst, glutathione transferase (2) 2
ha, haemagglutinin (2) 2
hek293 cells (2) 2
kinase profiling (2) 2
life sciences (2) 2
lkb1, liver kinase b1 (2) 2
mef, mouse embryonic fibroblast (2) 2
mo25, mouse protein 25 (2) 2
models, molecular (2) 2
molecular sequence data (2) 2
protein binding (2) 2
protein kinase inhibitors - pharmacology (2) 2
protein structure, tertiary (2) 2
protein-kinase (2) 2
protein-serine-threonine kinases - genetics (2) 2
protein-serine-threonine kinases - metabolism (2) 2
pten, phosphatase and tensin homologue deleted on chromosome 10 (2) 2
s6k1, s6 kinase 1 (2) 2
sequence homology, amino acid (2) 2
sik, salt-induced kinase (2) 2
strad, ste20-related adaptor (2) 2
577 - bioquímica. biologia molecular. biofísica (1) 1
adenosine diphosphate - metabolism (1) 1
adenosine triphosphate - metabolism (1) 1
aicar, aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (1) 1
akt (1) 1
amp-activated protein kinase-related kinase (1) 1
amp-activated protein kinases (1) 1
amp-activated protein kinases - genetics (1) 1
ampactivated protein kinase-related kinase (1) 1
ampk (1) 1
ampk-related kinase 5 (1) 1
ampkrelated protein kinase (1) 1
anilides - pharmacology (1) 1
anti-cancer drugs (1) 1
ark, ampk-related kinase (1) 1
ark5 (1) 1
association (1) 1
atf2, activating transcription factor 2 (1) 1
atm, ataxia telangiectasia mutated (1) 1
benzodiazepinones - pharmacology (1) 1
brsk (1) 1
ca2 (1) 1
ca2+/calmodulin-dependent protein kinase (1) 1
ca2+/calmodulin-dependent protein kinase kinase (1) 1
ca2+/calmodulindependent protein kinase (1) 1
cak, cyclin-dependent kinase-activating kinase (1) 1
calcimycin - pharmacology (1) 1
calcium - metabolism (1) 1
calcium - physiology (1) 1
calcium-calmodulin-dependent protein kinase kinase - metabolism (1) 1
calmodulin-dependent protein kinase (1) 1
calmodulin-dependent protein kinase kinase (1) 1
calmodulindependent protein kinase (1) 1
camk, ca2 (1) 1
camk, ca2+/calmodulin-dependent protein kinase (1) 1
camk, calmodulin-dependent kinase (1) 1
camkk, ca2 (1) 1
camkk, ca2+/calmodulin-dependent protein kinase kinase (1) 1
camkk, calmodulin-dependent kinase kinase β (1) 1
camkk, camk kinase (1) 1
cancer (1) 1
cascade (1) 1
cdk, cyclin-dependent protein kinase (1) 1
cell movement - drug effects (1) 1
cell proliferation - drug effects (1) 1
cell-proliferation (1) 1
cells, cultured (1) 1
chk, checkpoint kinase (1) 1
ciències de la salut (1) 1
ck, casein kinase (1) 1
cross-talk (1) 1
crystal-structure (1) 1
csk, c-terminal src kinase (1) 1
cyclic amp - pharmacology (1) 1
cyclin-dependent kinases (1) 1
down-regulation - physiology (1) 1
drug design (1) 1
drug discovery (1) 1
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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2014, Volume 459, Issue 2, pp. 275 - 287
The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser487 in the 'ST loop'... 
Tumour suppressor | Akt | AMP-activated protein kinase (AMPK) | Cross-talk | Cancer | Protein Structure, Tertiary | Amino Acid Sequence | PTEN Phosphohydrolase - genetics | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Humans | Models, Molecular | PTEN Phosphohydrolase - metabolism | Proto-Oncogene Proteins c-akt - genetics | Down-Regulation - physiology | Animals | HEK293 Cells | Protein Binding | Protein Conformation | Proto-Oncogene Proteins c-akt - metabolism | Gene Expression Regulation, Neoplastic - physiology | AMP-Activated Protein Kinases - genetics | Index Medicus | mTORC1, mammalian (or mechanistic) target of rapamycin complex 1 | ACC, acetyl-CoA carboxylase | WT, wild-type | PI3K, phosphoinositide 3-kinase | cross-talk | HEK, human embryonic kidney | AMPK, AMP-activated protein kinase | STRADα, Ste20-related adapter protein-α | BRSK, brain-specific kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | MO25α, mouse protein-25α | S6K1, S6 kinase 1 | ST loop, serine | LKB1, liver kinase B1 | tumour suppressor | PKA, protein kinase A (cAMP-dependent protein kinase) | GSK3, glycogen synthase kinase 3 | IGF-1, insulin-like growth factor 1 | threonine-rich loop | DMEM, Dulbecco’s modified Eagle’s medium | MEF, mouse embryonic fibroblast | AICAR, 5-amino-4-imidazolecarboxamide riboside | cancer | CaMKK, calmodulin-dependent kinase kinase β | NEAA, non-essential amino acid
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2010, Volume 426, Issue 1, pp. 109 - 118
Activation of AMPK (AMP-activated protein kinase) by phosphorylation at Thr(172) is catalysed by at least two distinct upstream kinases, i.e. the tumour... 
calmodulin-dependent protein kinase (CaMK) | AMP-activated protein kinase-related kinase (ARK) | calmodulin-dependent protein kinase kinase (CaMKK) | AMP-activated protein kinase (AMPK) | TUMOR-SUPPRESSOR LKB1 | RESPIRATORY-CHAIN | CELLS | LOCALIZATION | ENERGY | Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CASCADE | UPSTREAM KINASE | Ca2+/calmodulin-dependent protein kinase (CaMK) | SUBSTRATE-SPECIFICITY | METABOLISM | Amino Acid Sequence | Cell Line | AMP-Activated Protein Kinases - metabolism | Immunoprecipitation | Calcium - metabolism | Humans | Molecular Sequence Data | Calcimycin - pharmacology | Phenformin - pharmacology | Cyclic AMP - pharmacology | Sequence Homology, Amino Acid | Calcium - physiology | Adenosine Triphosphate - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism | Protein Binding | Adenosine Diphosphate - metabolism | HeLa Cells | Phosphorylation - drug effects | Ionophores - pharmacology | Index Medicus | ACC, acetyl-CoA carboxylase | calmodulin-dependent protein kinase kinase | HEK, human embryonic kidney | MARK, microtubule affinity-regulating kinase | AMPK, AMP-activated protein kinase | TBS, Tris-buffered saline | BRSK, brain-specific kinase | UBA, ubiquitin-associated | MO25, mouse protein 25 | CaMK, Ca2 | ARK, AMPK-related kinase | NUAK, SNF1 (sucrose-non-fermenting kinase-1)-like kinase | AMPactivated protein kinase-related kinase (ARK) | GST, glutathione transferase | STRAD, Ste20-related adaptor | GFP, green fluorescent protein | calmodulin-dependent protein kinase | SIK, salt-inducible kinase | calmodulindependent protein kinase (CaMK) | Ca2 | AICAR, 5-amino-4-imidazolecarboxamide riboside | FBS, foetal bovine serum | CaMKK, Ca2
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2014, Volume 457, Issue 1, pp. 215 - 225
The related NUAK1 and NUAK2 are members of the AMPK (AMP-activated protein kinase) family of protein kinases that are activated by the LKB1 (liver kinase B1)... 
AMPK-related kinase 5 (ARK5) | AMP-activated protein kinase (AMPK) | Sucrose-non-fermenting protein kinase/AMPKrelated protein kinase (SNARK) | Liver kinase B1 (LKB1) | Kinase profiling | Kinase inhibitor | Myosin phosphate-targeting subunit 1(MYPT1) | CELLS | liver kinase B1 (LKB1) | PHOSPHORYLATION | ARK5 | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | sucrose-non-fermenting protein kinase/AMPK-related protein kinase (SNARK) | kinase inhibitor | INVASION | PATHWAY | ROLES | kinase profiling | AMPK | myosin phosphate-targeting subunit 1(MYPT1) | ASSOCIATION | EXPRESSION | Protein Kinases - genetics | Humans | Substrate Specificity | Heterocyclic Compounds, 4 or More Rings - pharmacology | Repressor Proteins - antagonists & inhibitors | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Drug Evaluation, Preclinical | Protein-Serine-Threonine Kinases - metabolism | Protein-Serine-Threonine Kinases - physiology | Benzodiazepinones - pharmacology | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Repressor Proteins - agonists | Pyrimidines - pharmacology | Enzyme Activation - drug effects | Cell Movement - drug effects | Tumor Suppressor Proteins - physiology | Animals | Anilides - pharmacology | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Index Medicus | ACC, acetyl-CoA carboxylase | AMPKrelated protein kinase (SNARK) | SIK, salt-induced kinase | NF-κB, nuclear factor κB | HEK, human embryonic kidney | AMPK, AMP-activated protein kinase | HA, haemagglutinin | BRSK, brain-specific kinase | sucrose-non-fermenting protein kinase | DMEM, Dulbecco’s modified Eagle’s medium | PP1, protein phosphatase 1 | MEF, mouse embryonic fibroblast | PEI, polyethylenimine | MARK, microtubule-affinity-regulating kinase | MYPT1, myosin phosphate-targeting subunit 1 | LKB1, liver kinase B1
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2006, Volume 394, Issue 3, pp. 545 - 555
Recent work indicates that the LKB1 tumour suppressor protein kinase. which is mutated in Peutz-Jeghers cancer syndrome, phosphorylates and activates a group... 
LKB1 tumour suppressor protein kinase | Ubiquitination | Peutz-Jeghers syndrome (PJS) | Small-angle X-ray scattering analysis (SAXS analysis) | AMP-activated protein kinase (AMPK) | LYS48-LINKED POLYUBIQUITIN CHAIN | SMALL-ANGLE SCATTERING | RECOGNITION | SERINE-THREONINE KINASE | PROTEIN-KINASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LKB1 | STRAD | UBA DOMAIN | small-angle X-ray scattering analysis (SAXS analysis) | ubiquitination | TUMOR-SUPPRESSOR | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Phosphorylation | Escherichia coli | Humans | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Ubiquitin - metabolism | Models, Molecular | Molecular Sequence Data | Multienzyme Complexes - metabolism | Multienzyme Complexes - genetics | AMP-Activated Protein Kinases | Multienzyme Complexes - chemistry | Protein Transport | Sequence Homology, Amino Acid | Sequence Alignment | Protein-Serine-Threonine Kinases - chemistry | Enzyme Activation | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | AMPK, AMP-activated protein kinase | BRSK, brain-specific kinase | MO25, mouse protein 25 | NSD, normalized spatial discrepancy | Rhp23, a functional homologue of the human excision repair enzyme Hhr23A | SNRK, sucrose-non-fermenting-related kinase | SNF1, sucrose-non-fermenting kinase-1 | TAP, tandem affinity purification | PJS, Peutz–Jegher's syndrome | SAKS1, stress-activated-kinase substrate-1 | GFP, green fluorescent protein | GST, glutathione S-transferase | SIK, salt-induced kinase | SUMO1, small ubiquitin-related modifier-1 | SAXS, small-angle X-ray scattering | STRAD, STE20-related adaptor | UBA, ubiquitin-associated domain | HA, haemagglutinin | QIK, Qin-induced kinase | NUAK1 kinase, ARK5 (AMPK-related kinase 1) | Peutz–Jeghers syndrome (PJS) | MARK, microtubule-affinity-regulating kinase | NEDD8, neural precursor cell-expressed developmentally down-regulated 8
Journal Article
Las proteínas quinasas BRSK1 y BRSK2 (Brain-specific kinase 1 y 2) pertenecen a la familia de las AMPK-related kinases, y son activadas mediante fosforilación... 
Sinapsi | BRSK | 577 - Bioquímica. Biologia molecular. Biofísica | Ciències de la Salut | Neurona
Dissertation
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