X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (122) 122
index medicus (102) 102
biochemistry & molecular biology (71) 71
humans (69) 69
parasitology (66) 66
trypanosoma-brucei (58) 58
trypanosoma brucei (53) 53
microbiology (46) 46
trypanosoma brucei brucei - enzymology (46) 46
molecular sequence data (41) 41
amino acid sequence (38) 38
parasitic diseases (34) 34
brucei (33) 33
parasites (33) 33
proteins (33) 33
article (32) 32
protozoan proteins - metabolism (31) 31
trypanosoma brucei brucei - drug effects (31) 31
phosphodiesterase (29) 29
camp (28) 28
differentiation (28) 28
trypanosoma brucei brucei - genetics (28) 28
african trypanosomes (27) 27
enzymes (27) 27
research article (25) 25
sleeping sickness (24) 24
chemistry, medicinal (23) 23
signal transduction (23) 23
rna interference (22) 22
trypanosoma brucei brucei - metabolism (22) 22
biology (21) 21
expression (21) 21
blood-stream forms (20) 20
cell biology (20) 20
phosphodiesterase inhibitors - pharmacology (20) 20
protozoa (20) 20
protozoan proteins - genetics (20) 20
research (20) 20
trypanosoma brucei brucei - growth & development (20) 20
cyclic amp - metabolism (19) 19
drug discovery (19) 19
trypanocidal agents - pharmacology (19) 19
african trypanosomiasis (18) 18
gene expression (18) 18
phosphoric diester hydrolases - metabolism (18) 18
analysis (17) 17
in-vitro (17) 17
trypanosoma brucei brucei - physiology (17) 17
trypanosome (17) 17
3',5'-cyclic-amp phosphodiesterases - metabolism (16) 16
human african trypanosomiasis (16) 16
mice (16) 16
multidisciplinary sciences (16) 16
physiological aspects (16) 16
protein (16) 16
sequence alignment (16) 16
trypanosoma (16) 16
base sequence (15) 15
biochemistry (15) 15
genetic aspects (15) 15
identification (15) 15
kinases (15) 15
protozoan proteins - chemistry (15) 15
trypanosoma cruzi (15) 15
trypanosomiasis, african - drug therapy (15) 15
trypanosomiasis, african - parasitology (15) 15
catalytic domain (14) 14
cloning (14) 14
cloning, molecular (14) 14
gene (14) 14
inhibitors (14) 14
saccharomyces-cerevisiae (14) 14
substrate specificity (14) 14
dna (13) 13
kinetics (13) 13
models, molecular (13) 13
pharmacological validation (13) 13
pharmacology & pharmacy (13) 13
structure-activity relationship (13) 13
adenylyl cyclases - metabolism (12) 12
flagella (12) 12
genomes (12) 12
infections (12) 12
molecular biology (12) 12
motility (12) 12
phosphodiesterases (12) 12
protein binding (12) 12
tbrpdeb1 (12) 12
trypanocidal agents - chemistry (12) 12
biology and life sciences (11) 11
cell cycle (11) 11
cells (11) 11
chemistry (11) 11
chemistry, organic (11) 11
drugs (11) 11
gene-expression (11) 11
leishmania-donovani (11) 11
medicine (11) 11
parasite (11) 11
phosphoric diester hydrolases - genetics (11) 11
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


The Journal of Infectious Diseases, ISSN 0022-1899, 7/2012, Volume 206, Issue 2, pp. 229 - 237
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 07/2017, Volume 11, Issue 7, p. e0005680
Background Reliance on just one drug to treat the prevalent tropical disease, schistosomiasis, spurs the search for new drugs and drug targets. Inhibitors of... 
CAENORHABDITIS-ELEGANS | PHARMACOLOGICAL VALIDATION | SCHISTOSOMA-MANSONI | PROTEIN-KINASE | ALZHEIMERS-DISEASE | 5 INHIBITOR ANALOGS | MIRACIDIAL TRANSFORMATION | TRYPANOSOMA-BRUCEI PHOSPHODIESTERASES | CONSERVED REGIONS UCRS | PARASITOLOGY | TROPICAL MEDICINE | CAMP-SPECIFIC PHOSPHODIESTERASES | Schistosoma mansoni - drug effects | Schistosoma mansoni - physiology | Catalytic Domain | Caenorhabditis elegans - genetics | Schistosoma mansoni - anatomy & histology | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Phosphodiesterase 4 Inhibitors - pharmacology | Animals | Caenorhabditis elegans - drug effects | Animals, Genetically Modified - genetics | Anthelmintics - pharmacology | Cloning, Molecular | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Locomotion - drug effects | Caenorhabditis elegans | Schistosomiasis | Care and treatment | Lung diseases, Obstructive | Genetic aspects | Research | Phosphodiesterases | Alzheimer's disease | Asthma | Drugs | Transgenic | Phosphodiesterase IV | Genomes | Parasites | Nucleotides | Drug development | Kinases | Gene sequencing | Parasitic diseases | Tropical environment | Degeneration | Chronic obstructive pulmonary disease | cDNA | Aquatic invertebrates | Catalysis | Phosphodiesterase | 3',5'-Cyclic-nucleotide phosphodiesterase | Lung diseases | Catechol | Gene expression | Diseases | Inhibitors | DNA | Obstructive lung disease | Nematodes | Hypothermia | Lines
Journal Article
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 05/2015, Volume 56, Issue 21, pp. 2832 - 2835
Human African trypanosomiasis (HAT) is a parasitic disease, caused by the protozoan pathogen , which affects thousands every year and which is in need of new... 
TbrPDEB1 | Neglected tropical disease | Trypanosoma brucei | Phosphodiesterases | DESIGN | DISEASES | HUMAN AFRICAN TRYPANOSOMIASIS | PHARMACOLOGICAL VALIDATION | BRUCEI PHOSPHODIESTERASES | CHEMISTRY, ORGANIC | TARGETS | phosphodiesterases | neglected tropical disease
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 04/2016, Volume 24, Issue 7, pp. 1573 - 1581
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2014, Volume 24, Issue 17, pp. 4084 - 4089
Journal Article
Chemical Biology & Drug Design, ISSN 1747-0277, 05/2015, Volume 85, Issue 5, pp. 549 - 564
Cyclic nucleotide phosphodiesterases (PDEs) have been identified as important enzyme targets for drug development in both humans and Trypanosoma brucei, the... 
TbrPDEB2 | TbrPDEB1 | Trypanosoma brucei | GSK‐256066 | phosphodiesterase inhibitors | GSK-256066 | ASPARAGINE | CHEMISTRY, MEDICINAL | PHARMACOLOGICAL VALIDATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | QUINOLINES | PHOSPHODIESTERASE B1 | POTENT | STRUCTURAL CLASS | LEAD COMPOUND | OPTIMIZATION | Sulfones - therapeutic use | Trypanosomiasis, African - drug therapy | Protozoan Proteins - antagonists & inhibitors | Humans | Neglected Diseases - drug therapy | Structure-Activity Relationship | Sulfones - pharmacology | Trypanosoma brucei brucei - enzymology | Quinolines - pharmacology | Protozoan Proteins - metabolism | Sulfones - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Aminoquinolines - pharmacology | Binding Sites | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Protein Structure, Tertiary | 3',5'-Cyclic-AMP Phosphodiesterases - metabolism | Phosphodiesterase 4 Inhibitors - chemistry | Quinolines - chemistry | Phosphodiesterase 4 Inhibitors - therapeutic use | Drug Repositioning | Phosphodiesterase 4 Inhibitors - pharmacology | Trypanosoma brucei brucei - drug effects | Quinolines - metabolism | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | Aminoquinolines - chemistry | Molecular Docking Simulation | Aminoquinolines - therapeutic use | Phosphodiesterase inhibitors
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2018, Volume 61, Issue 9, pp. 3870 - 3888
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2012, Volume 55, Issue 20, pp. 8745 - 8756
Journal Article