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NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 09/2013, Volume 369, Issue 13, pp. 1278 - 1279
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 05/2015, Volume 97, Issue 5, pp. 887 - 900
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2017, Volume 35, Issue 13, pp. 1437 - 1443
Purpose Therapeutic targeting of Bruton tyrosine kinase (BTK) with ibrutinib in chronic lymphocytic leukemia has led to a paradigm shift in therapy, and... 
BTK | OFATUMUMAB | THERAPY | ONCOLOGY | MUTATION | ORIGINAL REPORTS | Chemotherapy
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2018, Volume 61, Issue 6, pp. 2227 - 2245
Bruton's tyrosine kinase (Btk) is a nonreceptor cytoplasmic tyrosine kinase involved in B-cell and myeloid cell activation, downstream of B-cell and Fc gamma... 
IRREVERSIBLE INHIBITORS | CHEMISTRY, MEDICINAL | BTK INHIBITOR | INFLAMMATORY DISEASES | B-CELL MALIGNANCIES | MURINE LUPUS | DRUG DESIGN | IBRUTINIB | CHRONIC LYMPHOCYTIC-LEUKEMIA | MEDIATED GLOMERULONEPHRITIS | TARGETING BTK
Journal Article
Blood, ISSN 0006-4971, 2019, Volume 133, Issue 11, pp. 1201 - 1204
Single-agent ibrutinib is active in patients with previously treated mantle cell lymphoma (MCL); however, nearly half of all patients experience treatment... 
BTK | MULTICENTER | INHIBITION | SINGLE-ARM | HEMATOLOGY
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 16, pp. 13023 - 13035
GDC-0853 is a selective, reversible, and non-covalent inhibitor of Bruton's tyrosine kinase (BTK) that does not require interaction with the Cys481 residue for... 
BTK | CLL | GCD0853
Journal Article
BLOOD, ISSN 0006-4971, 02/2019, Volume 133, Issue 9, pp. 888 - 889
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2017, Volume 25, Issue 2, pp. 765 - 772
A family of phosphoryl-substituted diphenylpyrimidine derivatives (Pho-DPPYs) were synthesized and biologically evaluated as potent BTK inhibitors in this... 
BTK | Inhibitor | DPPY | Leukemia | Phosphoryl
Journal Article
by Yao, X and Sun, XY and Jin, SY and Yang, L and Xu, HJ and Rao, Y
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2019, Volume 62, Issue 14, pp. 6561 - 6574
A structure-hopping strategy was applied to discover a series of novel 4-aminoquinoline-3-carboxamide derivatives as potent, reversible BTK inhibitors.... 
BTK INHIBITORS | SELECTIVE-INHIBITION | IRREVERSIBLE INHIBITORS | RN486 | DESIGN | ACTIVATION | CHEMISTRY, MEDICINAL | B-CELL | IBRUTINIB | TARGETING BTK | DOSAGE
Journal Article
Archives of Pharmacal Research, ISSN 0253-6269, 2/2019, Volume 42, Issue 2, pp. 171 - 181
BTK is a key component of B-cell receptor signaling and functions as an important regulator of cell proliferation and survival in B-cell malignancies. The... 
Pharmacy | BTK inhibitors | Noncovalent BTK inhibitors | BTK | Pharmacology/Toxicology | Ibrutinib | B-cell malignancies | CHEMISTRY, MEDICINAL | PCI-32765 | ACALABRUTINIB ACP-196 | THERAPY | IBRUTINIB RESISTANCE | TYROSINE KINASE INHIBITOR | CHRONIC LYMPHOCYTIC-LEUKEMIA | LYMPHOMA | PHARMACOLOGY & PHARMACY | ONO/GS-4059 | MUTATIONS | NEXT-GENERATION | Care and treatment | Cancer
Journal Article
Oncology reports, 08/2019
Diffuse large B‑cell lymphoma (DLBCL), the most common type of non‑Hodgkin's lymphoma, is classified into germinal center and activated B cell (ABC) subtypes.... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2018, Volume 115, Issue 31, pp. E7285 - E7292
Journal Article
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