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1. Full Text A negative-feedback function of pkcb in the formation and accumulation of signalingactive b cell receptor microclusters within b cell immunological synapse
by Liu, Ce and Zhao, Xing Wang and Xu, Li Ling and Yi, Jun Yang and Shaheen, Samina and Han, Weidong and Wang, Fei and Zheng, Wenjie and Xu, Chenqi and Liu, Wanli
Journal of leukocyte biology, ISSN 0741-5400, 05/2015, Volume 97, Issue 5, pp. 887 - 900
Btk | Activation
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2. Full Text First-in-human phase 1 study of the BTK inhibitor GDC-0853 in relapsed or refractory B-cell NHL and CLL
by Byrd, John C and Smith, Stephen and Wagner-Johnston, Nina and Sharman, Jeff and Chen, Andy I and Advani, Ranjana and Augustson, Bradley and Marlton, Paula and Commerford, S. Renee and Okrah, Kwame and Liu, Lichuan and Murray, Elaine and Penuel, Elicia and Ward, Ashley F and Flinn, Ian W
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 16, pp. 13023 - 13035
BTK | CLL | GCD0853
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3. Full Text The Bruton's tyrosine kinase inhibitor ibrutinib exerts immunomodulatory effects through regulation of tumorinfiltrating macrophages
by Ping, Lingyan and Ding, Ning and Shi, Yunfei and Feng, Lixia and Li, Jiao and Liu, Yalu and Lin, Yufu and Shi, Cunzhen and Wang, Xing and Pan, Zhengying and Song, Yuqin and Zhu, Jun
Oncotarget, 2017, Volume 8, Issue 24, pp. 39218 - 39229
Btk | Immunomodulatory effect | Macrophages | Ibrutinib
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4. Full Text Development of BTK inhibitors for the treatment of B-cell malignancies
by Kim, Hyung-Ook
Archives of pharmacal research, ISSN 0253-6269, 2/2019, Volume 42, Issue 2, pp. 171 - 181
Pharmacy | BTK inhibitors | Noncovalent BTK inhibitors | BTK | Pharmacology/Toxicology | Ibrutinib | B-cell malignancies | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Care and treatment | Cancer
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5. Full Text A Manufacturing Process to an Intermediate in the Synthesis of Acalabrutinib
by Chen, Bo and Golden, Michael and Li, Zhonglian and Xu, Liwen and Xu, Zhaofu and Yao, Xiaolong
Organic process research & development, ISSN 1083-6160, 10/2018, Volume 22, Issue 10, pp. 1458 - 1460
Tyrosine | BTK | Bruton | Acalabrutinib | Kinase
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6. Full Text Discovery of quinoline-based irreversible BTK inhibitors
by de Bruin, Gerjan and Demont, Dennis and de Zwart, Edwin and Verkaik, Saskia and Hoogenboom, Niels and van de Kar, Bas and van Lith, Bart and Emmelot- van Hoek, Maaike and Gulrajani, Michael and Covey, Todd and Kaptein, Allard and Barf, Tjeerd
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 07/2020, Volume 30, Issue 14, pp. 127261 - 127261
BTK | Quinoline | Covalent | Irreversible | Kinases | Index Medicus
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7. Full Text Evaluating the Therapeutic Potential of Zanubrutinib in the Treatment of Relapsed/Refractory Mantle Cell Lymphoma: Evidence to Date
by Sawalha, Yazeed and Bond, David A and Alinari, Lapo
OncoTargets and therapy, ISSN 1178-6930, 07/2020, Volume 13, pp. 6573 - 6581
ibrutinib | btk | zanubrutinib | acalabrutinib
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8. Full Text The role of ibrutinib in COVID-19 hyperinflammation: a case report
by Maynard, Suzanne and Ros-Soto, Jose and Chaidos, Aris and Innes, Andrew and Paleja, Krushika and Mirvis, Eitan and Buti, Noora and Sharp, Harriet and Palanicawandar, Renuka and Milojkovic, Dragana
International journal of infectious diseases, ISSN 1201-9712, 02/2021
COVID-19 | Ibrutinib | Waldenstrom Macroglobulinaemia | BTK-inhibitor
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9. Full Text BTK inhibition modulates multiple immune cell populations involved in the pathogenesis of immune mediated nephritis
by Chalmers, Samantha A and Garcia, Sayra J and Webb, Deborah and Herlitz, Leal and Fine, Jay and Klein, Elliott and Ramanujam, Meera and Putterman, Chaim
Clinical immunology (Orlando, Fla.), ISSN 1521-6616, 02/2021, Volume 223, pp. 108640 - 108640
BTK | Immune cell infiltration | Lupus nephritis | BTK inhibitors | Lupus | Medical research | Nephritis | Analysis | Medicine, Experimental | B cells | T cells | Macrophages | Index Medicus
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10. Full Text A fit for purpose synthesis of Bruton’s tyrosine kinase inhibitor GDC-0852
by Lim, Ngiap-Kie and Zhang, Haiming and Sowell, C. Gregory and Gosselin, Francis
Tetrahedron letters, ISSN 0040-4039, 10/2020, Volume 61, Issue 44, p. 152447
C[sbnd]N coupling | Regioselective | Palladium-catalyzed | BTK inhibitor | Tetrahydroindolizine
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11. Full Text Geniposide protects depression through BTK/JAK2/STAT1 signaling pathway in lipopolysaccharide-induced depressive mice
by Zheng, Menglin and Li, Ke and Chen, Tong and Liu, Shengnan and He, Ling
Brain research bulletin, ISSN 0361-9230, 05/2021, Volume 170, pp. 65 - 73
BTK | Geniposide | Depression | Inflammation | JAK2/STAT1 | LPS | Index Medicus
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12. Full Text Primary Central Nervous System Lymphoma: Evolving Biologic Insights and Recent Therapeutic Advances
by Chihara, Dai and Dunleavy, Kieron
Clinical lymphoma, myeloma and leukemia, ISSN 2152-2650, 02/2021, Volume 21, Issue 2, pp. 73 - 79
BTK | CAR T-cell therapy | Primary central nervous system lymphoma | BTK inhibitors | Activated B-cell (ABC) subtype | Index Medicus
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13. Full Text Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4
by Degorce, Sébastien L and Anjum, Rana and Dillman, Keith S and Drew, Lisa and Groombridge, Sam D and Halsall, Christopher T and Lenz, Eva M and Lindsay, Nicola A and Mayo, Michele F and Pink, Jennifer H and Robb, Graeme R and Scott, James S and Stokes, Stephen and Xue, Yafeng
Bioorganic & medicinal chemistry, ISSN 0968-0896, 02/2018, Volume 26, Issue 4, pp. 913 - 924
BTK | DLBCL | Pyrrolotriazine | IRAK4 | Mutant MyD88 | Index Medicus
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14. Full Text Discovery of Novel Bruton’s Tyrosine Kinase (BTK) Inhibitors Bearing a N,9-Diphenyl‑9H‑purin-2-amine Scaffold
by Ge, Yang and Jin, Yue and Wang, Changyuan and Zhang, Jianbin and Tang, Zeyao and Peng, Jinyong and Liu, Kexin and Li, Yanxia and Zhou, Youwen and Ma, Xiaodong
ACS medicinal chemistry letters, ISSN 1948-5875, 12/2016, Volume 7, Issue 12, pp. 1050 - 1055
synthesis | purin | activity | BTK inhibitor | Leukemia
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15. Full Text Inhibition of Bruton’s tyrosine kinase and IL-2 inducible T-cell kinase suppresses both neutrophilic and eosinophilic airway inflammation in a cockroach allergen extract-induced mixed granulocytic mouse model of asthma using preventative and therapeutic strategy
by Nadeem, Ahmed and Ahmad, Sheikh F and Al-Harbi, Naif O and Ibrahim, Khalid E and Siddiqui, Nahid and Al-Harbi, Mohammed M and Attia, Sabry M and Bakheet, Saleh A
Pharmacological research, ISSN 1043-6618, 10/2019, Volume 148, pp. 104441 - 104441
Th2/Th17 | BTK | ITK | Mixed granulocytic asthma | Ibrutinib | Index Medicus
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16. Full Text Analyse primaire d’une étude de Phase 2 randomisée, contrôlée par placebo évaluant l’évobrutinib (M2951), un inhibiteur de la tyrosine kinase de Bruton, chez des patients atteints d’une forme récurrente de sclérose en plaques
by Montalban, Xavier and Arnold, Douglas and Weber, Martin S and Martin, Emily and Syed, Sana and Dangond, Fernando and Wolinsky, Jerry S
Revue neurologique, ISSN 0035-3787, 04/2019, Volume 175, pp. S100 - S100
BTK inhibiteur | Evobrutinib | Sclérose En Plaques
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17. Full Text ABBV-105, a selective and irreversible inhibitor of Bruton's tyrosine kinase, is efficacious in multiple preclinical models of inflammation
by Goess, Christian and Harris, Christopher M and Murdock, Sara and McCarthy, Richard W and Sampson, Erik and Twomey, Rachel and Mathieu, Suzanne and Mario, Regina and Perham, Matthew and Goedken, Eric R and Long, Andrew J
Modern rheumatology, ISSN 1439-7595, 05/2019, Volume 29, Issue 3, pp. 510 - 522
Bruton's tyrosine kinase (BTK) | rheumatoid arthritis | lupus | covalent inhibitor | Bruton’s tyrosine kinase (BTK) | Life Sciences & Biomedicine | Rheumatology | Science & Technology | Index Medicus
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18. Full Text Partial responses to ibrutinib in Waldenström macroglobulinaemia ‐ good enough?
by Vitolo, Umberto and Novo, Mattia and Santambrogio, Elisa
British journal of haematology, ISSN 0007-1048, 02/2021, Volume 192, Issue 3, pp. 423 - 424
ibrutinib | Waldenstrom macroglobulinemia | BTK inhibitors | response | progression‐free survival | Index Medicus
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19. Full Text Successful Long-Term Ibrutinib Treatment in a Hemodialysis Patient With Leukemic Nonnodal Mantle Cell Lymphoma
by Yasuda, Hajime and Tsukune, Yutaka and Inano, Tadaaki and Mori, Yosuke and Ota, Yasunori and Komatsu, Norio
Clinical lymphoma, myeloma and leukemia, ISSN 2152-2650, 02/2021, Volume 21, Issue 2, pp. e176 - e178
Dialysis | Renal replacement therapy | Safety | BTK inhibitor | Renal failure
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