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Journal of Experimental Medicine, ISSN 0022-1007, 05/2017, Volume 214, Issue 5, pp. 1529 - 1546
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 51, pp. 21060 - 21070
The human cytomegalovirus opening reading frame UL144 is an ortholog of the TNF receptor superfamily member, herpesvirus entry mediator (HVEM; TNFRSF14). HVEM... 
POLYMORPHISMS | HVEM | CD160 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CO-STIMULATION | BTLA | INNATE | UL144 GENE | EXPRESSION | CANCER | CELL-ACTIVATION | Membrane Glycoproteins - metabolism | Recombinant Fusion Proteins - pharmacology | Humans | Antigens, CD - genetics | Viral Proteins - metabolism | Antigens, CD - metabolism | Receptors, Immunologic - agonists | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Protein Engineering | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Binding Sites | B-Lymphocytes - metabolism | B-Lymphocytes - cytology | Viral Proteins - chemistry | Models, Molecular | Viral Proteins - genetics | Recombinant Fusion Proteins - chemistry | Killer Cells, Natural - cytology | B-Lymphocytes - immunology | GPI-Linked Proteins - chemistry | Cell Line, Tumor | Ligands | Protein Conformation | T-Lymphocytes - immunology | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | Kinetics | Mutation | Receptors, Immunologic - genetics | GPI-Linked Proteins - genetics | Receptors, Immunologic - chemistry | Membrane Glycoproteins - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Recombinant Fusion Proteins - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Drug Design | HEK293 Cells | Killer Cells, Natural - immunology | Antigens, CD - chemistry | Protein Interaction Domains and Motifs | Receptors, Tumor Necrosis Factor, Member 14 - genetics | Receptors, Tumor Necrosis Factor, Member 14 - chemistry | GPI-Linked Proteins - metabolism | Membrane Glycoproteins - genetics | B-Lymphocytes - drug effects | Receptors, Tumor Necrosis Factor, Member 14 - metabolism | T-Lymphocytes - cytology | Receptors, Immunologic - metabolism | Amino Acid Substitution | cytokine | Immunology | viral immunology | signal transduction | herpesvirus | structural biology | receptor structure-function | structural model | lymphocyte
Journal Article
Cell, ISSN 0092-8674, 10/2016, Volume 167, Issue 2, pp. 405 - 418.e13
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 07/2019, Volume 294, Issue 27, pp. 10519 - 10529
Human cytomegalovirus (HCMV) is a beta-herpesvirus that has co-evolved with the host immune system to establish lifelong persistence. HCMV encodes many... 
tumor necrosis factor (TNF) | ACTIVATION | ENTRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | VACCINE | recombinant protein expression | TNF SUPERFAMILY | viral protein | MEMBER | X-ray crystallography | GENE | BTLA | protein-protein interaction | HERPESVIRUSES | cell-surface receptor | LYMPHOTOXIN | PROGRAM | Index Medicus | protein–protein interaction
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2017, Volume 127, Issue 8, pp. 3052 - 3064
BACKGROUND. Ibrutinib has been shown to have immunomodulatory effects by inhibiting Bruton's tyrosine kinase (BTK) and IL-2-inducible T cell kinase (ITK). The... 
MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | ITK | BRUTONS TYROSINE KINASE | ACTIVATION | IN-VIVO | BTK | CHRONIC LYMPHOCYTIC-LEUKEMIA | PERIPHERAL-BLOOD | INHIBITOR | ANTIGEN RECEPTOR | CD8-Positive T-Lymphocytes - cytology | Leukocytes, Mononuclear - metabolism | Pyrazoles - therapeutic use | Protein-Tyrosine Kinases - metabolism | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Pyrazines - therapeutic use | Antigens, CD - metabolism | Benzamides - therapeutic use | T-Lymphocytes - metabolism | Immunotherapy | Interleukin-10 - metabolism | Female | Lymphocyte Activation | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CTLA-4 Antigen - metabolism | Programmed Cell Death 1 Receptor - metabolism | Mice, Transgenic | Animals | T-Lymphocytes - cytology | Pyrimidines - therapeutic use | Agammaglobulinaemia Tyrosine Kinase | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Aged | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Receptors, Immunologic - metabolism | Cohort Studies | Treatment outcome | Chronic lymphocytic leukemia | Research | Drug therapy | T cells | Analysis | PD-1 protein | CD8 antigen | Leukemia | Clinical trials | Leukocytes (mononuclear) | Lymphocytes T | Kinases | Genotype & phenotype | CTLA-4 protein | Cell activation | Interleukin 2 | CD200 antigen | BTLA protein | Lymphocytes | Peripheral blood mononuclear cells | Protein-tyrosine kinase | Tyrosine | Antigens | Chronic lymphatic leukemia | Immune response | Immunomodulation | T cell receptors | Lymphatic leukemia | Bruton's tyrosine kinase | Patients | CD4 antigen | Itk protein | Immunosuppression | Cell death | Cell number | Interleukin 10 | Lymphomas | Regulation | Cancer | Apoptosis
Journal Article
Journal Article
Cellular & molecular immunology, ISSN 1672-7681, 01/2019, Volume 16, Issue 3, pp. 314 - 314
In this article, one of the grating agencies requested us to incorporate the information, Spanish Government and co-funded by European Union ERDF/ESF,... 
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2018, Volume 128, Issue 10, pp. 4441 - 4453
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e30852
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 08/2016, Volume 14, Issue 2, pp. 1107 - 1116
The aim of the present study was to investigate the overall clinical expression characteristics of the cluster of differentiation (CD)28 family receptors... 
chronic hepatitis B | programmed death-ligand 1 | programmed cell death 1 | cluster of differentiation 28 family of receptors | Chronic hepatitis B | Programmed death-ligand 1 | Cluster of differentiation 28 family of receptors | Programmed cell death 1 | MEDICINE, RESEARCH & EXPERIMENTAL | LYMPHOCYTE | CHRONIC HEPATITIS-B | GATA-3 | BET | ONCOLOGY | DYSREGULATION | CD4(+) | BTLA | CTLA-4 | DIFFERENTIATION | ICOS | T-Lymphocyte Subsets - immunology | Leukocytes, Mononuclear - metabolism | HLA-A2 Antigen - genetics | Hepatitis B, Chronic - immunology | Humans | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Case-Control Studies | Viral Load | CD28 Antigens - metabolism | CD28 Antigens - genetics | Hepatitis B, Chronic - genetics | Leukocytes, Mononuclear - immunology | GATA3 Transcription Factor - metabolism | Hepatitis B virus - immunology | Hepatitis B, Chronic - metabolism | Gene Expression | Leukocytes, Mononuclear - drug effects | HLA-A2 Antigen - immunology | Antibodies, Monoclonal - pharmacology | Immunophenotyping | T-Box Domain Proteins - metabolism | Hepatitis B, Chronic - virology | B7-H1 Antigen - metabolism | T-Lymphocyte Subsets - metabolism | Biomarkers | Interferon-gamma - biosynthesis | PD-1 protein | CD8 antigen | Chronic infection | Cytotoxicity | Viruses | Leukocytes (mononuclear) | Infections | Lymphocytes T | CD28 antigen | Proteins | Hepatitis | CTLA-4 protein | Immunology | BTLA protein | Lymphocytes | Human immunodeficiency virus--HIV | Peripheral blood mononuclear cells | Deoxyribonucleic acid--DNA | Antigens | Immunoglobulins | Gene expression | CD4 antigen | Studies | Infectious diseases | Lymphocytes B | Cell death | ICOS protein | γ-Interferon | GATA-3 protein | Viral infections | Hepatitis B | Apoptosis
Journal Article