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bub1 (197) 197
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cell biology (105) 105
mitosis (98) 98
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cell cycle proteins - metabolism (59) 59
phosphorylation (59) 59
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anaphase-promoting complex (21) 21
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recruitment (21) 21
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CANCER CELL, ISSN 1535-6108, 08/2008, Volume 14, Issue 2, pp. 111 - 122
Drugs targeting the mitotic spindle are used extensively during chemotherapy, but surprisingly, little is known about how they kill tumor cells. This is... 
APOPTOSIS | ANAPHASE | INSTABILITY | ONCOLOGY | PHOSPHORYLATION | MICROTUBULES | INDUCTION | MITOTIC CHECKPOINT | INHIBITOR | BUB1 | SPINDLE-ASSEMBLY CHECKPOINT | CELL BIOLOGY
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 7/2010, Volume 190, Issue 1, pp. 25 - 34
Mps1 is an essential component of the spindle assembly checkpoint. In this study, we describe a novel Mps1 inhibitor, AZ3146, and use it to probe the role of... 
HEK293 cells | Mitosis | Auroras | Kinetochores | Cell lines | Centromeres | HeLa cells | Antibodies | Reports | Chromosomes | Cells | MITOTIC CHECKPOINT PROTEINS | MAD2 | ACTIVATION | KINASE | DYNAMICS | CENP-E | CHROMOSOME ALIGNMENT | BUB1 | KINETOCHORE LOCALIZATION | SPINDLE-ASSEMBLY CHECKPOINT | CELL BIOLOGY | Phosphorylation - physiology | Humans | Multiprotein Complexes - genetics | Cell Cycle Proteins - antagonists & inhibitors | Aurora Kinase B | Multiprotein Complexes - metabolism | Protein Multimerization - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Mad2 Proteins | Phosphorylation - drug effects | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Calcium-Binding Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Aurora Kinases | Chromosomal Proteins, Non-Histone - genetics | Mitosis - drug effects | Mitosis - physiology | Signal Transduction - drug effects | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Protein-Tyrosine Kinases | Protein Multimerization - drug effects | Calcium-Binding Proteins - genetics | Genetic aspects | Chemical properties
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2018, Volume 70, Issue 3, pp. 395 - 407.e4
Telomeres and telomere-binding proteins form complex secondary nucleoprotein structures that are critical for genome integrity but can present serious... 
DNA replication | BLM | telomere | BUB 3 | BUB1 | TRF2 | telomere length | TRF1 | SPINDLE CHECKPOINT | KINASE BUB1 | MAMMALIAN TELOMERES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DYSKERATOSIS-CONGENITA | FILL-IN | MITOTIC SPINDLE | CHROMOSOME SEGREGATION | HUMAN CANCER | T-LOOPS | CELL BIOLOGY | Telomeres | Medical colleges | Genomics | DNA | Genetically modified organisms | Genetic engineering | Binding proteins | Protein binding
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2019, Volume 38, Issue 22, p. n/a
Journal Article
Pharmacology, ISSN 0031-7012, 11/2017, Volume 100, Issue 5-6, pp. 269 - 282
Objective: To verify that miR-490-5p could influence hepatocellular carcinoma (HCC) cells' proliferation, invasion, cycle, and apoptosis by targeting BUB1.... 
Original Paper | Hepatocellular carcinoma | Transforming growth factor-beta/Smad signaling pathways | MiR-490-5p | BUB1 | SPINDLE CHECKPOINT | BLADDER-CANCER | KINASE BUB1 | TGF-BETA | METASTASIS | TUMOR PROGRESSION | C-FOS | miR-490-5p | ANEUPLOIDY | PHARMACOLOGY & PHARMACY | MITOTIC CHECKPOINT | PROTEINS
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 16, pp. 13036 - 13047
is overexpressed in most solid and hematological malignancies. It promotes loss of genomic integrity in cancer cells by targeting genes involved in... 
CENP-F | Aneuploidy | BUB1 | miR-155 | ZW10
Journal Article
Molecular & Cellular Oncology, ISSN 2372-3556, 07/2019, Volume 6, Issue 4, p. 1603436
Our recent study of the mitotic checkpoint protein BUB1 (budding uninhibited by benzimidazoles 1) revealed several apparent BUB1 knock-out cell lines... 
CRISPR | Spindle assembly checkpoint | BUB1 | ROD
Journal Article
Nature, ISSN 0028-0836, 02/2004, Volume 427, Issue 6974, pp. 510 - 517
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 09/2019, Volume 47, Issue 15, pp. 8096 - 8110
Abstract The spindle assembly checkpoint (SAC) ensures the fidelity of chromosome segregation during mitosis. Here, we show that ULK1, a serine/threonine... 
RECRUITMENT | LOCALIZATION | COMPLEX | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENSITIVITY | AUTOPHAGY | MITOTIC CHECKPOINT | IDENTIFICATION | BUB1 | BINDING | Molecular Biology
Journal Article
by Yang, HD and Zhang, FX and Huang, CJ and Liao, J and Han, Y and Hao, PL and Chu, YJ and Lu, XA and Li, WS and Yu, HT and Kang, JS
MOLECULAR BIOLOGY OF THE CELL, ISSN 1059-1524, 04/2019, Volume 30, Issue 9, pp. 1060 - 1068
Accurate partitioning of chromosomes during mitosis is essential for genetic stability and requires the assembly of the dynamic mitotic spindle and proper... 
MITOSIS | LOCALIZATION | KINETOCHORES | KIF2A | MICROTUBULE-BINDING | CHECKPOINT | BUB1 | MSP58 | 58-KDA MICROSPHERULE PROTEIN | AURORA-B | CELL BIOLOGY
Journal Article
Science, ISSN 0036-8075, 06/2015, Volume 348, Issue 6240, pp. 1260 - 1264
The spindle checkpoint of the cell division cycle senses kinetochores that are not attached to microtubules and prevents precocious onset of anaphase, which... 
LOCALIZATION | RECRUITMENT | PROTEIN | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | SPINDLE ASSEMBLY CHECKPOINT | HEC1 | KINASE MPS1 | BUB1 | AURORA-B | REVEALS | Proteins | Cell division | Microbiology | Molecular biology | Kinases | Binding | Attachment | Spindles | Chromosomes | Recruitment
Journal Article
DEVELOPMENTAL CELL, ISSN 1534-5807, 05/2006, Volume 10, Issue 5, pp. 575 - 585
Loss of sister-chromatid cohesion triggers chromosome segregation in mitosis and occurs through two mechanisms in vertebrate cells: (1) phosphorylation and... 
SISTER-CHROMATID COHESION | RNA INTERFERENCE | MITOSIS | SPINDLE-CHECKPOINT | MAINTENANCE | DEVELOPMENTAL BIOLOGY | PROTEIN PHOSPHATASE 2A | MEIOSIS-I | SHUGOSHIN | BUB1 | DROSOPHILA MEI-S332 | CELL BIOLOGY
Journal Article
Technology in Cancer Research & Treatment, ISSN 1533-0346, 7/2019, Volume 18, p. 1533033819858668
Objective: To identify the expression of kinetochore scaffold 1 (KNL1) in colorectal tumor tissues and to clarify the role of this gene in the proliferation... 
RECRUITMENT | PROTEIN | MICROTUBULE-BINDING | STATISTICS | cell growth | KNL1 | prognosis | Kinetochore scaffold 1 | ONCOLOGY | CANCER/TESTIS GENE D40/AF15Q14 | GASTRIC-CANCER | MITOTIC CHECKPOINT | protein expression | EXPRESSION | BUB1 | colorectal tumor | gene expression | OUTER KINETOCHORE
Journal Article
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 06/2014, Volume 205, Issue 6, pp. 781 - 790
During mitosis, genomic DNA is condensed into chromosomes to promote its equal segregation into daughter cells. Chromosome condensation occurs during cell... 
RECRUITMENT | KINETOCHORES | MITOTIC CHROMOSOMES | KINASE | SPINDLE ASSEMBLY CHECKPOINT | ASSOCIATION | BUB1 | AURORA-B | CELL BIOLOGY
Journal Article
Current Biology, ISSN 0960-9822, 01/2019, Volume 29, Issue 1, pp. 104 - 119.e10
Switch-like activation of the spindle assembly checkpoint (SAC) is critical for accurate chromosome segregation and for cell division in a timely manner. To... 
kinetochore | mitosis | spindle assembly checkpoint | cell signaling | eSAC | MPS1 KINASE | CDC20 | MAD2 | RECRUITMENT | ANAPHASE | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | SWITCH | BINDING | BUB1 | AURORA-B | CELL BIOLOGY
Journal Article
Current Biology, ISSN 0960-9822, 11/2018, Volume 28, Issue 21, pp. 3422 - 3429.e5
The Mad1-Mad2 heterodimer is the catalytic hub of the spindle assembly checkpoint (SAC), which controls M phase progression through a multi-subunit anaphase... 
aneuploidy | cell division | chromosome segregation | gene editing | spindle assembly checkpoint | OUTER PLATE | COMPLEX | PROTEIN | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICROTUBULE ATTACHMENT | SPINDLE ASSEMBLY CHECKPOINT | MESSENGER-RNA DECAY | CHROMOSOME SEGREGATION | BUB1 | UNATTACHED KINETOCHORES | CELL BIOLOGY | Genetic transcription | Genes | Genomics | Cells
Journal Article
Gene, ISSN 0378-1119, 06/2019, Volume 701, pp. 15 - 22
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer-related death. Increasing evidence suggests that cell cycle dysregulation is... 
Immunohistochemistry | CDK1 | PDAC | BUB1 | Survival | GENETICS & HEREDITY | CELL-CYCLE | CANCER | REVEALS | Adenocarcinoma | Prognosis | Pancreatic cancer | Oncology, Experimental | Research | Cancer
Journal Article
The EMBO Journal, ISSN 0261-4189, 04/2019, Volume 38, Issue 7, p. n/a
The conserved Bub1 kinase was proposed to be non‐essential for the mitotic spindle assembly checkpoint based on recent findings that knocking‐out Bub1 by... 
ACTIVATION | SPINDLE ASSEMBLY CHECKPOINT | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Proteins | CRISPR | Ribonucleic acids | RNA-mediated interference | Bub1 protein | Kinases | Assembly
Journal Article