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bub1 (197) 197
humans (116) 116
index medicus (108) 108
cell biology (105) 105
mitosis (98) 98
spindle assembly checkpoint (74) 74
mitotic checkpoint (63) 63
animals (61) 61
cell cycle proteins - metabolism (59) 59
phosphorylation (59) 59
chromosome segregation (57) 57
proteins (55) 55
protein-serine-threonine kinases - metabolism (54) 54
spindle checkpoint (53) 53
cancer (52) 52
biochemistry & molecular biology (51) 51
kinetochores - metabolism (50) 50
protein-serine-threonine kinases (46) 46
chromosomes (45) 45
cell cycle proteins - genetics (44) 44
kinetochores (43) 43
oncology (43) 43
kinetochore (42) 42
kinetochore localization (42) 42
aneuploidy (40) 40
cenp-e (38) 38
research (36) 36
cell cycle (35) 35
protein kinases - genetics (35) 35
hela cells (34) 34
localization (34) 34
budding yeast (33) 33
protein-serine-threonine kinases - genetics (33) 33
biology (32) 32
female (32) 32
mad2 (31) 31
spindle apparatus - metabolism (31) 31
chromosomal instability (29) 29
binding (28) 28
cells (28) 28
protein kinases - metabolism (28) 28
mice (26) 26
spindle-assembly checkpoint (26) 26
anaphase (25) 25
article (25) 25
complex (24) 24
kinases (24) 24
chromosomal proteins, non-histone - metabolism (23) 23
kinase (23) 23
nuclear proteins - metabolism (23) 23
protein (23) 23
cell division (22) 22
genetic aspects (22) 22
mutation (22) 22
protein binding (22) 22
anaphase-promoting complex (21) 21
bub3 (21) 21
recruitment (21) 21
signal transduction (21) 21
assembly checkpoint (20) 20
bubr1 (20) 20
gene expression (20) 20
mad2 proteins (20) 20
meiosis (20) 20
amino acid sequence (19) 19
cycle (19) 19
molecular sequence data (19) 19
calcium (18) 18
overexpression (18) 18
apoptosis (17) 17
expression (17) 17
genetics & heredity (17) 17
physiological aspects (17) 17
bioscience (16) 16
cell (16) 16
landes (16) 16
mitosis - physiology (16) 16
mps1 (16) 16
multidisciplinary sciences (16) 16
organogenesis (16) 16
protein-kinase (16) 16
spindle (16) 16
activation (15) 15
cell cycle proteins (15) 15
cell cycle proteins - physiology (15) 15
centromere (15) 15
middle aged (15) 15
shugoshin (15) 15
spindle apparatus - physiology (15) 15
unattached kinetochores (15) 15
cell-cycle (14) 14
checkpoint (14) 14
genes (14) 14
mad1 (14) 14
male (14) 14
nuclear proteins - genetics (14) 14
poly-adp-ribose binding proteins (14) 14
sister-chromatid cohesion (14) 14
tumorigenesis (14) 14
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1. Full Text Cancer cells display intra- and interline variation profound following prolonged exposure to antimitotic drugs
by Gascoigne, KE and Taylor, SS
CANCER CELL, ISSN 1535-6108, 08/2008, Volume 14, Issue 2, pp. 111 - 122
Drugs targeting the mitotic spindle are used extensively during chemotherapy, but surprisingly, little is known about how they kill tumor cells. This is... 
APOPTOSIS | ANAPHASE | INSTABILITY | ONCOLOGY | PHOSPHORYLATION | MICROTUBULES | INDUCTION | MITOTIC CHECKPOINT | INHIBITOR | BUB1 | SPINDLE-ASSEMBLY CHECKPOINT | CELL BIOLOGY
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2. Full Text Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex
by Laura Hewitt and Anthony Tighe and Stefano Santaguida and Anne M. White and Clifford D. Jones and Andrea Musacchio and Stephen Green and Stephen S. Taylor
The Journal of Cell Biology, ISSN 0021-9525, 7/2010, Volume 190, Issue 1, pp. 25 - 34
Mps1 is an essential component of the spindle assembly checkpoint. In this study, we describe a novel Mps1 inhibitor, AZ3146, and use it to probe the role of... 
HEK293 cells | Mitosis | Auroras | Kinetochores | Cell lines | Centromeres | HeLa cells | Antibodies | Reports | Chromosomes | Cells | MITOTIC CHECKPOINT PROTEINS | MAD2 | ACTIVATION | KINASE | DYNAMICS | CENP-E | CHROMOSOME ALIGNMENT | BUB1 | KINETOCHORE LOCALIZATION | SPINDLE-ASSEMBLY CHECKPOINT | CELL BIOLOGY | Phosphorylation - physiology | Humans | Multiprotein Complexes - genetics | Cell Cycle Proteins - antagonists & inhibitors | Aurora Kinase B | Multiprotein Complexes - metabolism | Protein Multimerization - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Mad2 Proteins | Phosphorylation - drug effects | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Calcium-Binding Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Aurora Kinases | Chromosomal Proteins, Non-Histone - genetics | Mitosis - drug effects | Mitosis - physiology | Signal Transduction - drug effects | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Protein-Tyrosine Kinases | Protein Multimerization - drug effects | Calcium-Binding Proteins - genetics | Genetic aspects | Chemical properties
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3. Full Text The BUB3-BUB1 Complex Promotes Telomere DNA Replication
by Li, Feng and Kim, Hyeung and Ji, Zhejian and Zhang, Youwei and Zhang, Tianpeng and Chen, Bohong and Ge, Yuanlong and Hu, Yang and Feng, Xuyang and Han, Xin and Xu, Huimin and Yu, Hongtao and Liu, Dan and Ma, Wenbin and Songyang, Zhou
Molecular Cell, ISSN 1097-2765, 05/2018, Volume 70, Issue 3, pp. 395 - 407.e4
Telomeres and telomere-binding proteins form complex secondary nucleoprotein structures that are critical for genome integrity but can present serious... 
DNA replication | BLM | telomere | BUB 3 | BUB1 | TRF2 | telomere length | TRF1 | SPINDLE CHECKPOINT | KINASE BUB1 | MAMMALIAN TELOMERES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DYSKERATOSIS-CONGENITA | FILL-IN | MITOTIC SPINDLE | CHROMOSOME SEGREGATION | HUMAN CANCER | T-LOOPS | CELL BIOLOGY | Telomeres | Medical colleges | Genomics | DNA | Genetically modified organisms | Genetic engineering | Binding proteins | Protein binding
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4. Full Text Killing a zombie: a full deletion of the BUB1 gene in HAP1 cells
by Raaijmakers, Jonne A and Medema, René H
The EMBO Journal, ISSN 0261-4189, 11/2019, Volume 38, Issue 22, p. n/a
Deletion | Clonal deletion | Gene deletion | BUB1 gene | Cell Cycle | Correspondence
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5. Full Text MiR-490-5p Suppresses Cell Proliferation and Invasion by Targeting BUB1 in Hepatocellular Carcinoma Cells
by Xu, Bin and Xu, Tangpeng and Liu, Huali and Min, Qian and Wang, Shidong and Song, Qibin
Pharmacology, ISSN 0031-7012, 11/2017, Volume 100, Issue 5-6, pp. 269 - 282
Objective: To verify that miR-490-5p could influence hepatocellular carcinoma (HCC) cells' proliferation, invasion, cycle, and apoptosis by targeting BUB1.... 
Original Paper | Hepatocellular carcinoma | Transforming growth factor-beta/Smad signaling pathways | MiR-490-5p | BUB1 | SPINDLE CHECKPOINT | BLADDER-CANCER | KINASE BUB1 | TGF-BETA | METASTASIS | TUMOR PROGRESSION | C-FOS | miR-490-5p | ANEUPLOIDY | PHARMACOLOGY & PHARMACY | MITOTIC CHECKPOINT | PROTEINS
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6. Full Text Hsa-miR-155-5p drives aneuploidy at early stages of cellular transformation
by Pagotto, Sara and Veronese, Angelo and Soranno, Alessandra and Lanuti, Paola and di Marco, Mirco and Russo, Marco Vincenzo and Ramassone, Alice and Marchisio, Marco and Simeone, Pasquale and Franchi, Paolo E. Guanciali and Palka, Giandomenico and Costantini, Renato Mariani and Croce, Carlo M and Visone, Rosa
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 16, pp. 13036 - 13047
is overexpressed in most solid and hematological malignancies. It promotes loss of genomic integrity in cancer cells by targeting genes involved in... 
CENP-F | Aneuploidy | BUB1 | miR-155 | ZW10
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7. Full Text Insights into mitotic checkpoint by integrating CRISPR and RNAi
by Zhang, Gang
Molecular & Cellular Oncology, ISSN 2372-3556, 07/2019, Volume 6, Issue 4, p. 1603436
Our recent study of the mitotic checkpoint protein BUB1 (budding uninhibited by benzimidazoles 1) revealed several apparent BUB1 knock-out cell lines... 
CRISPR | Spindle assembly checkpoint | BUB1 | ROD
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8. Full Text The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis
by Kawashima, Shigehiro A and Watanabe, Yoshinori and Kitajima, Tomoya S
Nature, ISSN 0028-0836, 02/2004, Volume 427, Issue 6974, pp. 510 - 517
Meiosis comprises a pair of specialized nuclear divisions that produce haploid germ cells. To accomplish this, sister chromatids must segregate together during... 
SISTER-CHROMATID COHESION | MEI-S332 | RECOMBINATION | MICROTUBULES | MULTIDISCIPLINARY SCIENCES | HETEROCHROMATIN | SPINDLE | FISSION YEAST BUB1 | AXIAL ELEMENTS | REC8 | REDUCTIONAL CHROMOSOME SEGREGATION | Protein Kinases - metabolism | Schizosaccharomyces pombe Proteins - chemistry | Protein Kinases - genetics | Mitosis | Saccharomyces cerevisiae - genetics | Protein-Serine-Threonine Kinases | Molecular Sequence Data | Centromere - metabolism | Phosphoproteins - metabolism | Schizosaccharomyces - genetics | Sequence Homology | Schizosaccharomyces pombe Proteins - metabolism | Conserved Sequence | Amino Acid Sequence | Chromosome Segregation | Schizosaccharomyces pombe Proteins - genetics | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Meiosis | Saccharomyces cerevisiae Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Protein Transport | Schizosaccharomyces - metabolism | Chromosomal Proteins, Non-Histone - chemistry | Schizosaccharomyces - cytology | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Cell division | Chromatin | Biochemistry | Genes | Rec8 protein | Sgo1 protein | shigoshin protein | Bub1 protein | Sgo2 protein | Kinetochores
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9. Full Text ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint
by Yuan, Fengjie and Jin, Ximin and Li, Dan and Song, Yuanshuai and Zhang, Nan and Yang, Xin and Wang, Lina and Zhu, Wei-Guo and Tian, Chan and Zhao, Ying
Nucleic Acids Research, ISSN 0305-1048, 09/2019, Volume 47, Issue 15, pp. 8096 - 8110
Abstract The spindle assembly checkpoint (SAC) ensures the fidelity of chromosome segregation during mitosis. Here, we show that ULK1, a serine/threonine... 
RECRUITMENT | LOCALIZATION | COMPLEX | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENSITIVITY | AUTOPHAGY | MITOTIC CHECKPOINT | IDENTIFICATION | BUB1 | BINDING | Molecular Biology
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10. Full Text Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment
by Yang, HD and Zhang, FX and Huang, CJ and Liao, J and Han, Y and Hao, PL and Chu, YJ and Lu, XA and Li, WS and Yu, HT and Kang, JS
MOLECULAR BIOLOGY OF THE CELL, ISSN 1059-1524, 04/2019, Volume 30, Issue 9, pp. 1060 - 1068
Accurate partitioning of chromosomes during mitosis is essential for genetic stability and requires the assembly of the dynamic mitotic spindle and proper... 
MITOSIS | LOCALIZATION | KINETOCHORES | KIF2A | MICROTUBULE-BINDING | CHECKPOINT | BUB1 | MSP58 | 58-KDA MICROSPHERULE PROTEIN | AURORA-B | CELL BIOLOGY
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11. Full Text Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C
by Ji, Zhejian and Gao, Haishan and Yu, Hongtao
Science, ISSN 0036-8075, 06/2015, Volume 348, Issue 6240, pp. 1260 - 1264
The spindle checkpoint of the cell division cycle senses kinetochores that are not attached to microtubules and prevents precocious onset of anaphase, which... 
LOCALIZATION | RECRUITMENT | PROTEIN | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | SPINDLE ASSEMBLY CHECKPOINT | HEC1 | KINASE MPS1 | BUB1 | AURORA-B | REVEALS | Proteins | Cell division | Microbiology | Molecular biology | Kinases | Binding | Attachment | Spindles | Chromosomes | Recruitment
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12. Full Text PP2A is required for centromeric localization of sgol and proper chromosome segregation
by Tang, ZY and Shu, HJ and Qi, W and Mahmood, NA and Mumby, MC and Yu, HT
DEVELOPMENTAL CELL, ISSN 1534-5807, 05/2006, Volume 10, Issue 5, pp. 575 - 585
Loss of sister-chromatid cohesion triggers chromosome segregation in mitosis and occurs through two mechanisms in vertebrate cells: (1) phosphorylation and... 
SISTER-CHROMATID COHESION | RNA INTERFERENCE | MITOSIS | SPINDLE-CHECKPOINT | MAINTENANCE | DEVELOPMENTAL BIOLOGY | PROTEIN PHOSPHATASE 2A | MEIOSIS-I | SHUGOSHIN | BUB1 | DROSOPHILA MEI-S332 | CELL BIOLOGY
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13. Full Text Effect of KNL1 on the proliferation and apoptosis of colorectal cancer cells
by Bai, Tianliang and Zhao, Yalei and Liu, Yabin and Cai, Bindan and Dong, Ning and Li, Binghui
Technology in Cancer Research & Treatment, ISSN 1533-0346, 7/2019, Volume 18, p. 1533033819858668
Objective: To identify the expression of kinetochore scaffold 1 (KNL1) in colorectal tumor tissues and to clarify the role of this gene in the proliferation... 
RECRUITMENT | PROTEIN | MICROTUBULE-BINDING | STATISTICS | cell growth | KNL1 | prognosis | Kinetochore scaffold 1 | ONCOLOGY | CANCER/TESTIS GENE D40/AF15Q14 | GASTRIC-CANCER | MITOTIC CHECKPOINT | protein expression | EXPRESSION | BUB1 | colorectal tumor | gene expression | OUTER KINETOCHORE
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14. Full Text Mps l phosphorylation of condensin II controls chromosome condensation at the onset of mitosis
by Kagami, Y and Nihira, K and Wada, S and Ono, M and Honda, M and Yoshida, K
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 06/2014, Volume 205, Issue 6, pp. 781 - 790
During mitosis, genomic DNA is condensed into chromosomes to promote its equal segregation into daughter cells. Chromosome condensation occurs during cell... 
RECRUITMENT | KINETOCHORES | MITOTIC CHROMOSOMES | KINASE | SPINDLE ASSEMBLY CHECKPOINT | ASSOCIATION | BUB1 | AURORA-B | CELL BIOLOGY
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15. Full Text Ectopic Activation of the Spindle Assembly Checkpoint Signaling Cascade Reveals Its Biochemical Design
by Chen, Chu and Whitney, Ian P and Banerjee, Anand and Sacristan, Carlos and Sekhri, Palak and Kern, David M and Fontan, Adrienne and Kops, Geert J.P.L and Tyson, John J and Cheeseman, Iain M and Joglekar, Ajit P
Current Biology, ISSN 0960-9822, 01/2019, Volume 29, Issue 1, pp. 104 - 119.e10
Switch-like activation of the spindle assembly checkpoint (SAC) is critical for accurate chromosome segregation and for cell division in a timely manner. To... 
kinetochore | mitosis | spindle assembly checkpoint | cell signaling | eSAC | MPS1 KINASE | CDC20 | MAD2 | RECRUITMENT | ANAPHASE | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | SWITCH | BINDING | BUB1 | AURORA-B | CELL BIOLOGY
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16. Full Text Distinct Roles of RZZ and Bub1-KNL1 in Mitotic Checkpoint Signaling and Kinetochore Expansion
by Rodriguez-Rodriguez, Jose-Antonio and Lewis, Clare and McKinley, Kara L and Sikirzhytski, Vitali and Corona, Jennifer and Maciejowski, John and Khodjakov, Alexey and Cheeseman, Iain M and Jallepalli, Prasad V
Current Biology, ISSN 0960-9822, 11/2018, Volume 28, Issue 21, pp. 3422 - 3429.e5
The Mad1-Mad2 heterodimer is the catalytic hub of the spindle assembly checkpoint (SAC), which controls M phase progression through a multi-subunit anaphase... 
aneuploidy | cell division | chromosome segregation | gene editing | spindle assembly checkpoint | OUTER PLATE | COMPLEX | PROTEIN | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICROTUBULE ATTACHMENT | SPINDLE ASSEMBLY CHECKPOINT | MESSENGER-RNA DECAY | CHROMOSOME SEGREGATION | BUB1 | UNATTACHED KINETOCHORES | CELL BIOLOGY | Genetic transcription | Genes | Genomics | Cells
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17. Full Text High expression of CDK1 and BUB1 predicts poor prognosis of pancreatic ductal adenocarcinoma
by Piao, Junjie and Zhu, Lianhua and Sun, Jie and Li, Nan and Dong, Bing and Yang, Yang and Chen, Liyan
Gene, ISSN 0378-1119, 06/2019, Volume 701, pp. 15 - 22
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer-related death. Increasing evidence suggests that cell cycle dysregulation is... 
Immunohistochemistry | CDK1 | PDAC | BUB1 | Survival | GENETICS & HEREDITY | CELL-CYCLE | CANCER | REVEALS | Adenocarcinoma | Prognosis | Pancreatic cancer | Oncology, Experimental | Research | Cancer
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18. Full Text Bub1—the zombie protein that CRISPR cannot kill
by Meraldi, Patrick
The EMBO Journal, ISSN 0261-4189, 04/2019, Volume 38, Issue 7, p. n/a
The conserved Bub1 kinase was proposed to be non‐essential for the mitotic spindle assembly checkpoint based on recent findings that knocking‐out Bub1 by... 
ACTIVATION | SPINDLE ASSEMBLY CHECKPOINT | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Proteins | CRISPR | Ribonucleic acids | RNA-mediated interference | Bub1 protein | Kinases | Assembly
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