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Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 04/2016, Volume 71, Issue 4, pp. 964 - 974
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7484, pp. 559 - 563
Journal Article
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7698, pp. 623 - 628
Journal Article
RSC Advances, ISSN 2046-2069, 2017, Volume 7, Issue 69, pp. 43764 - 43771
New mechanical biomarkers were discovered and used to investigate drug effects on HeLa cells. HeLa cells were measured using advanced atomic force microscopy... 
NANOPARTICLES | CHALLENGE | BACTERIA | ATOMIC-FORCE MICROSCOPY | NANOMECHANICS | PRODUCTIVITY | CANCER | DOCETAXEL | CHEMISTRY, MULTIDISCIPLINARY | BIOFILM FORMATION | PACLITAXEL
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2015, Volume 112, Issue 32, pp. 10038 - 10043
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits... 
Mucolysis | (Tri)sulfides | Red meat | Mucus barrier | Colorectal cancer | colorectal cancer | MUCIN | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | red meat | mucus barrier | (tri)sulfides | mucolysis | COLORECTAL-CANCER | CALCIUM | FAT | MICE | INHIBITOR | CYTOTOXICITY | EXPRESSION | Immunohistochemistry | Cell Cycle - genetics | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Colon - drug effects | Microbiota - drug effects | Body Weight - drug effects | Ki-67 Antigen - metabolism | Male | Mucus - drug effects | Colony Count, Microbial | Intestinal Mucosa - drug effects | Feces - microbiology | Heme - pharmacology | Mucus - metabolism | Sulfides - metabolism | Cell Death - drug effects | Biomarkers - metabolism | Colon - pathology | Mice, Inbred C57BL | Epithelial Cells - pathology | Up-Regulation - genetics | Antioxidants - pharmacology | Intestinal Mucosa - microbiology | Down-Regulation - drug effects | Down-Regulation - genetics | Up-Regulation - drug effects | Animals | Diet | Models, Biological | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Colon - microbiology | Cell Cycle - drug effects | Intestinal Mucosa - pathology | Cell proliferation | Colon cancer | Epithelial cells | Heme | Physiological aspects | Observations | Health aspects | Bacteria | Microorganisms | Colon | Rodents | Genes | Index Medicus | Biological Sciences | susceptibility | expression | bacterial | inhibitor | mucin | fat | colorectal-cancer | mice | cytotoxicity
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 6, pp. e1004174 - e1004174
Bacterial signaling systems are prime drug targets for combating the global health threat of antibiotic resistant bacterial infections including those caused... 
NADPH OXIDASE | ANTIBIOTICS | LYTTR DOMAIN | MODE | MICROBIOLOGY | INDUCTION | VIRULENCE | IDENTIFICATION | DISCOVERY | VIROLOGY | GENE-EXPRESSION | SKIN | PARASITOLOGY | Staphylococcus epidermidis - physiology | Skin - microbiology | Molecular Conformation | Bacterial Proteins - chemistry | Male | Promoter Regions, Genetic - drug effects | Trans-Activators - chemistry | Staphylococcal Skin Infections - immunology | Anti-Bacterial Agents - adverse effects | Macrophages - microbiology | Triazoles - therapeutic use | Bacterial Proteins - antagonists & inhibitors | Quorum Sensing - drug effects | Mice, Knockout | Macrophages - metabolism | Staphylococcus epidermidis - growth & development | Staphylococcus aureus - immunology | Anti-Bacterial Agents - pharmacology | Molecular Docking Simulation | Quinazolinones - chemistry | Mutation | Staphylococcal Skin Infections - microbiology | Triazoles - adverse effects | Staphylococcus epidermidis - drug effects | Staphylococcus aureus - physiology | Staphylococcus epidermidis - immunology | Triazoles - chemistry | Anti-Bacterial Agents - therapeutic use | Staphylococcal Skin Infections - drug therapy | Anti-Bacterial Agents - chemistry | Trans-Activators - genetics | Macrophages - immunology | Quinazolinones - pharmacology | Molecular Targeted Therapy - adverse effects | Phagocytosis - drug effects | Immunity, Innate - drug effects | Bacterial Proteins - genetics | Mice, Hairless | Drug Discovery | Triazoles - pharmacology | Animals | High-Throughput Screening Assays | Bacterial Proteins - metabolism | Genes, Reporter - drug effects | Macrophages - drug effects | Trans-Activators - metabolism | Quinazolinones - therapeutic use | Trans-Activators - antagonists & inhibitors | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Cell Line, Transformed | Quinazolinones - adverse effects | Skin - drug effects | Staphylococcus aureus infections | Physiological aspects | Development and progression | Genetic aspects | Quorum sensing | Virulence (Microbiology) | Research | Staphylococcus aureus | Index Medicus | Medical research | Bacteria | Staphylococcus infections | Bacterial infections | Antibiotics | Bacteriology
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 153 - 158
Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to microbial infection and danger signals. When activated, they cleave mouse and... 
LISTERIA-MONOCYTOGENES | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | MIXED LINEAGE KINASE | PERFORIN | NLRP3 INFLAMMASOME | INTRACELLULAR BACTERIA | GRANZYMES | CASPASE-1 ACTIVATION | GRANULYSIN | CELL-DEATH | Conserved Sequence - genetics | Inflammasomes - metabolism | Phosphatidylinositol Phosphates - metabolism | Pyroptosis - drug effects | Escherichia coli - drug effects | Humans | Molecular Sequence Data | Neoplasm Proteins - pharmacology | Escherichia coli - cytology | Neoplasm Proteins - metabolism | Escherichia coli - metabolism | Protein Multimerization - genetics | Listeria monocytogenes - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Listeria monocytogenes - cytology | Porosity - drug effects | Neoplasm Proteins - genetics | Cell Membrane - drug effects | Staphylococcus aureus - metabolism | Amino Acid Sequence | Cell Line | Microbial Viability - drug effects | Membrane Proteins - genetics | Mice, Inbred C57BL | Phosphatidylserines - metabolism | Neoplasm Proteins - chemistry | Cardiolipins - metabolism | Cell Membrane - ultrastructure | Protein Structure, Tertiary - genetics | Microscopy, Electron | Pyroptosis - genetics | Protein Transport | Liposomes - chemistry | Animals | Membrane Proteins - chemistry | Cell Membrane Permeability - drug effects | Staphylococcus aureus - cytology | Liposomes - metabolism | Mice | Mutation | Staphylococcus aureus - drug effects | Listeria monocytogenes - drug effects | Observations | Apoptosis | Proteins | Membranes | Bacterial infections | Immunology | Plasmids | Bacteria | Infections | Cells | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2015, Volume 112, Issue 27, pp. 8173 - 8180
Journal Article
PLoS Genetics, ISSN 1553-7390, 01/2013, Volume 9, Issue 1, pp. e1003144 - e1003144
High levels of antibiotic tolerance are a hallmark of bacterial biofilms. In contrast to well-characterized inherited antibiotic resistance, molecular... 
CELLS | BACTERIAL PERSISTENCE | PSEUDOMONAS-AERUGINOSA | ESCHERICHIA-COLI | GENETICS & HEREDITY | GENE-EXPRESSION | RESISTANCE | BETA-LACTAM ANTIBIOTICS | CYSTIC-FIBROSIS | INDUCTION | STRESS | Biofilms - drug effects | Plankton - drug effects | Starvation | Drug Tolerance - genetics | Biofilms - growth & development | Amino Acids - genetics | Ofloxacin - pharmacology | Mutagenesis | Escherichia coli - genetics | Fluoroquinolones - pharmacology | SOS Response (Genetics) | DNA Transposable Elements - genetics | Plankton - genetics | Anti-Bacterial Agents - pharmacology | Drug Resistance, Bacterial - drug effects | Escherichia coli - growth & development | Drug Resistance, Bacterial - genetics | Transposons | Antibiotics | Gene mutations | Physiological aspects | Genetic aspects | Dosage and administration | Research | Drug resistance | Health aspects | Biofilms | Microbiology | E coli | Bacteria | Mutation | Carbon | Index Medicus | Ofloxacin/pharmacology | DNA Transposable Elements/genetics | Bacterial/drug effects/genetics | Anti-Bacterial Agents/pharmacology | Plankton/drug effects/genetics | Escherichia coli/genetics/growth & development | Bacteriology | Fluoroquinolones/pharmacology | Life Sciences | Microbiology and Parasitology | Biofilms/drug effects/growth & development | Drug Tolerance/genetics | Amino Acids/genetics | Drug Resistance
Journal Article