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Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, pp. 599 - 13
Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of... 
GENETIC-VARIATION | ALPHA-ENOLASE | JAPANESE POPULATION | MULTIDISCIPLINARY SCIENCES | HERPES-ZOSTER | DISEASE | INNER-EAR MORPHOGENESIS | MIDDLE-EAR | STEM-CELL ANTIGEN | EXPRESSION | SECRETOR STATUS | Tonsillitis - genetics | Otitis Media - surgery | Hepatitis B - genetics | Humans | Candidiasis, Vulvovaginal - genetics | Male | HLA Antigens - genetics | Rheumatic Fever - genetics | Tuberculin Test | Tuberculosis - diagnosis | Case-Control Studies | Pharyngitis - genetics | Streptococcal Infections - genetics | Hepatitis A - genetics | Sinusitis - genetics | Infections - genetics | Female | Otitis Media - genetics | Warts - genetics | Pneumonia - genetics | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Urinary Tract Infections - genetics | Mumps - genetics | Common Cold - genetics | Middle Ear Ventilation | Rubella - genetics | Scarlet Fever - genetics | Infectious Mononucleosis - genetics | Chickenpox - genetics | Tuberculosis - genetics | Meningitis, Bacterial - genetics | Tonsillectomy | Herpes Labialis - genetics | Herpes Zoster - genetics | Tonsillitis - surgery | Measles - genetics | Chronic Disease | Rubella | Yeast | Hepatitis A virus | Scarlet fever | Pathogenesis | Chronic infection | Amino acids | Mapping | Genomes | Infections | Urinary tract | Immunity | Hepatitis | Embryogenesis | Sinus | Mononucleosis | Measles | Varicella | Bacteria | Meningitis | Genetics | Mumps | Hepatitis B virus | Children | Rheumatic fever | Antigens | Health risks | Pharynx | Loci | Fever | Embryonic growth stage | Warts | Herpes labialis | Tuberculosis | Infectious diseases | Ear | Histocompatibility antigen HLA | Gene mapping | Hepatitis A | Hepatitis B
Journal Article
PLoS pathogens, ISSN 1553-7374, 2010, Volume 6, Issue 9, p. e1001125
Although polymicrobial infections, caused by combinations of viruses, bacteria, fungi and parasites, are being recognised with increasing frequency, little is known about the occurrence of within... 
RNA | MULTICELLULAR BEHAVIOR | MICROBIOLOGY | BACTERIAL | VIRULENCE | GENETIC DIVERSITY | STATIONARY-PHASE | VIROLOGY | PSEUDOMONAS-AERUGINOSA | CYSTIC-FIBROSIS | GROWTH-PHASE | EXPRESSION | PARASITOLOGY | Molecular evolution | Bacterial infections | Gastrointestinal diseases | Escherichia coli | Colorectal diseases | Genetic aspects | Research | Bacterial genetics | Health aspects | Escherichia coli/classification | Hydrogen Peroxide/pharmacology | Humans | Escherichia coli/pathogenicity | Escherichia coli Infections/genetics | Immunoblotting | Electrophoresis, Gel, Two-Dimensional | Anti-Bacterial Agents/pharmacology | Virulence Factors/genetics | Virulence/genetics | Genetic Variation | Microbial Sensitivity Tests | Life Sciences | Polymerase Chain Reaction | Sigma Factor/metabolism | Adult | Escherichia coli Proteins/genetics | Female | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Models, Theoretical | Genome, Bacterial | Oxidants/pharmacology | Mutation/genetics | Genotype | Escherichia coli/genetics | Escherichia coli Infections/epidemiology | Bacteriology | Biological Evolution | Microbiology and Parasitology | Bacterial Proteins/metabolism | Animals | Bacterial Proteins/genetics | Drug Resistance, Bacterial/genetics | Sigma Factor/genetics | Mice | Escherichia coli Infections/microbiology | DNA, Bacterial/genetics | Cell Movement | Microbiology | Cloning | Infections | Experiments | Patients | Molecular weight | Antibiotics | E coli | Bacteria | Evolution | Mathematical models | Mutation
Journal Article
American journal of respiratory and critical care medicine, ISSN 1535-4970, 2016, Volume 193, Issue 5, pp. 504 - 515
Rationale: Cystic fibrosis (CF) is characterized by early structural lung disease caused by pulmonary infections... 
Healthy controls | Cystic fibrosis | Microbiota | Nasopharynx | Longitudinal | microbiota | SMALL-COLONY VARIANTS | CARRIAGE | HAEMOPHILUS-INFLUENZAE | COMMUNITIES | CHILDREN | STREPTOCOCCUS-PNEUMONIAE | INHIBITION | RESPIRATORY SYSTEM | cystic fibrosis | INFLAMMATION | LUNG-DISEASE | STAPHYLOCOCCUS-AUREUS | longitudinal | nasopharynx | healthy controls | CRITICAL CARE MEDICINE | Carrier State - epidemiology | Streptococcus mitis - genetics | Prospective Studies | Humans | Corynebacterium Infections - epidemiology | Carrier State - microbiology | Haemophilus Infections - epidemiology | Infant | Male | Corynebacterium Infections - microbiology | Case-Control Studies | Anti-Bacterial Agents - therapeutic use | Enterobacteriaceae Infections - epidemiology | Female | Staphylococcal Infections - microbiology | Nasopharynx - microbiology | Real-Time Polymerase Chain Reaction | Burkholderia Infections - microbiology | Haemophilus Infections - drug therapy | Infant, Newborn | Staphylococcus aureus - genetics | Moraxellaceae Infections - epidemiology | Streptococcal Infections - microbiology | Burkholderia - genetics | Staphylococcal Infections - drug therapy | Burkholderia Infections - epidemiology | Cystic Fibrosis - microbiology | Enterobacteriaceae Infections - microbiology | Enterobacteriaceae - genetics | Moraxellaceae Infections - microbiology | Streptococcal Infections - epidemiology | Haemophilus influenzae - genetics | Corynebacterium - genetics | Cystic Fibrosis - epidemiology | Moraxellaceae Infections - drug therapy | DNA, Bacterial - genetics | Staphylococcal Infections - epidemiology | Corynebacterium Infections - drug therapy | Microbiota - genetics | Burkholderia Infections - drug therapy | Haemophilus Infections - microbiology | RNA, Ribosomal, 16S - genetics | Streptococcal Infections - drug therapy | Moraxella - genetics | Cohort Studies | Enterobacteriaceae Infections - drug therapy
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 51, pp. E7128 - E7137
.... The monogenic component of the genetic theory provides a plausible explanation for the occurrence of severe infectious diseases during primary infection... 
Pediatrics | Immunology | Infectious diseases | Human genetics | Primary immunodeficiency | human genetics | LINKED LYMPHOPROLIFERATIVE SYNDROME | CALMETTE-GUERIN INFECTION | RECEPTOR BETA-1 DEFICIENCY | MULTIDISCIPLINARY SCIENCES | infectious diseases | ANHIDROTIC ECTODERMAL DYSPLASIA | T-CELL IMMUNODEFICIENCY | CHRONIC MUCOCUTANEOUS CANDIDIASIS | PRIMARY IMMUNODEFICIENCY DISEASES | PYOGENIC BACTERIAL-INFECTIONS | pediatrics | primary immunodeficiency | immunology | HERPES-SIMPLEX ENCEPHALITIS | INHERITED CARD9 DEFICIENCY | Encephalitis, Herpes Simplex - immunology | Humans | Genetic Diseases, Inborn - genetics | Lymphoproliferative Disorders - immunology | Mycobacterium Infections - immunology | Young Adult | Pneumococcal Infections - immunology | Mycobacterium Infections - genetics | Pneumococcal Infections - genetics | Complement System Proteins - genetics | Encephalitis, Herpes Simplex - genetics | Epidermodysplasia Verruciformis - immunology | Interferon-gamma - genetics | Immunologic Deficiency Syndromes - immunology | Child | Genetic Predisposition to Disease | Neisseria - immunology | Tinea - immunology | Infection - immunology | Candidiasis, Chronic Mucocutaneous - genetics | Malaria - immunology | Candidiasis, Chronic Mucocutaneous - immunology | Genetic Diseases, Inborn - immunology | Tinea - genetics | Epidermodysplasia Verruciformis - genetics | Lymphoproliferative Disorders - genetics | Infection - genetics | Models, Immunological | Neisseria - pathogenicity | Influenza, Human - genetics | Interferon-gamma - immunology | Adolescent | Immunologic Deficiency Syndromes - genetics | Models, Genetic | Malaria - genetics | Influenza, Human - immunology | Development and progression | Genetic aspects | Disease susceptibility | Immune response | Communicable diseases | Biological Sciences | PNAS Plus
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2008, Volume 321, Issue 5889, pp. 691 - 696
...). MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens in experimental settings of infection... 
Receptors | Phenotypes | Transfection | Cytokines | HEK293 cells | Genes | Cell lines | Fibroblasts | Agonists | Reports | Children | MYD88-DEFICIENT MICE | HERPES-SIMPLEX-VIRUS | PROTECTIVE IMMUNITY | MYELOID DIFFERENTIATION FACTOR-88 | PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | HUMORAL IMMUNITY | STAPHYLOCOCCUS-AUREUS | AERUGINOSA LUNG INFECTION | HOST RESPONSE | CUTTING EDGE | Humans | Child, Preschool | Male | Mutation, Missense | Bacterial Infections - genetics | Pneumococcal Infections - immunology | Bacterial Infections - immunology | Gene Deletion | Pneumococcal Infections - genetics | Female | Toll-Like Receptors - metabolism | Child | Staphylococcal Infections - genetics | Disease Susceptibility | Cytokines - metabolism | Signal Transduction | Staphylococcal Infections - immunology | Receptors, Interleukin-1 - immunology | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Immunity, Innate | Pseudomonas Infections - genetics | Pseudomonas Infections - immunology | Receptors, Interleukin-1 - metabolism | Animals | Myeloid Differentiation Factor 88 - deficiency | Adolescent | Mice | Myeloid Differentiation Factor 88 - metabolism | Cell Line, Transformed | Genetic aspects | Bacterial infections | Pediatrics | Bacteria | Biomedical research | Genetic disorders | Immunology | Pneumococcal Infections | Life Sciences | Toll-Like Receptors | Bacterial Infections | Myeloid Differentiation Factor 88 | Bacteriology | Staphylococcal Infections | Microbiology and Parasitology | Pseudomonas Infections | Receptors, Interleukin-1
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2012, Volume 129, Issue 3, pp. 787 - 793.e6
.... Objective We sought to describe the clinical and immunologic phenotypes of patients with genetic CD27 deficiency... 
Allergy and Immunology | phenotype | B cell | T cell | EBV | CD27 | immunodeficiency | hypogammaglobulinemia | natural killer cell | viremia | CD70 | T-CELL | IMMUNOLOGY | HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS | B-CELLS | MEMORY | ALLERGY | XIAP DEFICIENCY | GENERATION | DIFFERENTIATION | EXPRESSION | EPSTEIN-BARR-VIRUS | Gram-Positive Bacterial Infections - immunology | Anemia, Aplastic - virology | Humans | Male | Gram-Positive Bacterial Infections - virology | Severe Combined Immunodeficiency - physiopathology | Young Adult | Severe Combined Immunodeficiency - virology | T-Lymphocytes - metabolism | Fatal Outcome | Epstein-Barr Virus Infections - genetics | Gram-Positive Bacterial Infections - genetics | Herpesvirus 4, Human - pathogenicity | B-Lymphocytes - pathology | T-Lymphocytes - pathology | Gram-Positive Bacterial Infections - complications | Anemia, Aplastic - complications | Anemia, Aplastic - genetics | B-Lymphocytes - metabolism | Siblings | Epstein-Barr Virus Infections - physiopathology | Gram-Positive Bacterial Infections - physiopathology | Epstein-Barr Virus Infections - virology | Epstein-Barr Virus Infections - immunology | Immunity, Humoral - genetics | Cells, Cultured | Herpesvirus 4, Human - immunology | Viremia - genetics | Severe Combined Immunodeficiency - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 7 - genetics | Mutation - genetics | Agammaglobulinemia - etiology | Anemia, Aplastic - physiopathology | Severe Combined Immunodeficiency - complications | Severe Combined Immunodeficiency - genetics | B-Lymphocytes - immunology | Viremia - virology | Pedigree | Epstein-Barr Virus Infections - complications | T-Lymphocytes - immunology | Viremia - immunology | Consanguinity | Anemia, Aplastic - immunology | Antigens | Genes | Staphylococcus aureus infections | T cells | Diseases | Virus diseases | Lymphocytes | Virus diseases in children | Medical genetics | Cross infection | Children | Tetanus | Nosocomial infections | Mitogens | Ligands | Infections | T cell receptors | Family medical history | Patients | Age | Viral infections | Fever | Immune system | CD27 antigen | Immunoglobulins | Cell survival | Viremia | Aplastic anemia | Immunodeficiency | Hypogammaglobulinemia | Lymphocytes T | Costimulator | Infection | Lymphocytes B | Plasma cells | Sepsis | Mutation | Natural killer cells | Differentiation | NK cell
Journal Article
Seminars in immunopathology, ISSN 1863-2300, 2011, Volume 34, Issue 1, pp. 43 - 62
The interaction of coagulation factors with the perivascular environment affects the development of disease in ways that extend beyond their traditional roles... 
Autoimmunity | Complement receptor 3 | Multiple sclerosis | Stroke | Alzheimer’s disease | Internal Medicine | Macrophages | Blood brain barrier | Inflammatory disease | Microglia | Biomedicine | Immunology | Rheumatoid arthritis | CD11b/CD18 | Atherosclerosis | Plasminogen | Anticoagulant therapy | Alzheimer's disease | ALZHEIMERS-DISEASE | IMMUNOLOGY | PATHOLOGY | GAMMA-C-DOMAIN | BINDING-SITE | CENTRAL-NERVOUS-SYSTEM | MULTIPLE-SCLEROSIS LESIONS | CRYSTAL-STRUCTURE | BLOOD-BRAIN-BARRIER | INTEGRIN ALPHA(M)BETA | PROTEASE-ACTIVATED RECEPTORS | PERIPHERAL ARTERIAL-DISEASE | Colitis - genetics | Humans | Brain Injuries - metabolism | Arthritis, Rheumatoid - metabolism | Bacterial Infections - genetics | Inflammation - metabolism | Blood Coagulation - immunology | Muscular Dystrophy, Duchenne - immunology | Alzheimer Disease - immunology | Fibrinogen - immunology | Thromboplastin - immunology | Pulmonary Fibrosis - immunology | Vascular Diseases - genetics | Brain Injuries - genetics | Thrombin - genetics | Kidney Diseases - immunology | Arthritis, Rheumatoid - genetics | Neoplasms - immunology | Colitis - metabolism | Muscular Dystrophy, Duchenne - genetics | Bacterial Infections - metabolism | Neoplasms - metabolism | Pulmonary Fibrosis - genetics | Spinal Cord Injuries - genetics | Kidney Diseases - genetics | Stroke - genetics | Brain Injuries - immunology | Neoplasms - genetics | Bacterial Infections - immunology | Pulmonary Fibrosis - metabolism | Colitis - immunology | Thrombin - immunology | Stroke - immunology | Kidney Diseases - metabolism | Multiple Sclerosis - metabolism | Vascular Diseases - immunology | Spinal Cord Injuries - metabolism | Multiple Sclerosis - genetics | Inflammation - immunology | Fibrinogen - genetics | Stroke - metabolism | Animals | Thromboplastin - genetics | Alzheimer Disease - metabolism | Fibrinogen - metabolism | Inflammation - genetics | Multiple Sclerosis - immunology | Blood Coagulation - genetics | Spinal Cord Injuries - immunology | Muscular Dystrophy, Duchenne - metabolism | Thrombin - metabolism | Thromboplastin - metabolism | Alzheimer Disease - genetics | Arthritis, Rheumatoid - immunology | Vascular Diseases - metabolism | Nervous system diseases | Bacterial infections | Oncology, Experimental | Thrombin | Inflammation | Anticoagulants (Medicine) | Research | Rheumatoid factor | Fibrin | Fibrinogen | Genetic research | Colitis | Cancer | Traumatic brain injury | Coagulation | Tissue factor | hemostasis | Spinal cord injury | Inflammatory diseases | Kidney | Signal transduction | Duchenne's muscular dystrophy | Neurodegenerative diseases | Therapeutic applications | Thrombosis | Coagulation factors | Infection | Molecular modelling | Fibrosis | Brain injury
Journal Article