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Antimicrobial agents and chemotherapy, ISSN 0066-4804, 04/2016, Volume 60, Issue 4, pp. 1974 - 1983
In this study, we tested five compounds belonging to a novel series of piperazine arylideneimidazolones for the ability to inhibit the AcrAB-TolC efflux pump.... 
MICROBIOLOGY | PHARMACOLOGY & PHARMACY | 5-ARYLIDENE AROMATIC DERIVATIVES | MULTIDRUG-RESISTANCE | IDENTIFICATION | PSEUDOMONAS-AERUGINOSA | Fluorescent Dyes - chemical synthesis | Protein Kinases - metabolism | Protein Kinases - genetics | Escherichia coli - drug effects | Cephalosporins - chemistry | Levofloxacin - pharmacology | Repressor Proteins - antagonists & inhibitors | Microbial Sensitivity Tests | Membrane Transport Proteins - genetics | Escherichia coli - metabolism | Linezolid - pharmacology | Biological Assay | Fluorescent Dyes - pharmacology | Membrane Transport Proteins - metabolism | Biological Transport - drug effects | Cell Membrane - metabolism | Membrane Proteins - metabolism | Escherichia coli - growth & development | Escherichia coli Proteins - antagonists & inhibitors | Imidazoles - chemical synthesis | Indicators and Reagents - chemistry | Bacterial Outer Membrane Proteins - antagonists & inhibitors | Bacterial Outer Membrane Proteins - genetics | Cell Membrane - drug effects | Repressor Proteins - metabolism | Gene Expression | Membrane Proteins - genetics | Oxacillin - pharmacology | Repressor Proteins - genetics | Escherichia coli Proteins - metabolism | Imidazoles - pharmacology | Piperazines - pharmacology | Anti-Bacterial Agents - chemical synthesis | Drug Synergism | Bacterial Outer Membrane Proteins - metabolism | Membrane Proteins - antagonists & inhibitors | Escherichia coli - genetics | Escherichia coli Proteins - genetics | Piperazines - chemical synthesis | Anti-Bacterial Agents - pharmacology | Kinetics | Rifampin - pharmacology | Clarithromycin - pharmacology
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 488, Issue 7413, pp. 670 - 674
...)-1 beta, IL-18 and high-mobility group box 1 (HMGB1)(1-5). By studying HMGB1 release mechanisms, here we identify a role for double-stranded RNA-dependent protein kinase... 
PATHWAYS | APOPTOSIS | ACID | PROTEIN-KINASE PKR | MULTIDISCIPLINARY SCIENCES | INFECTION | NLRP3 INFLAMMASOME | ELF2-ALPHA | STRESS | BINDING | SUBSTRATE RECOGNITION | Crystallins - metabolism | Interleukin-6 - analysis | Phosphorylation | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | eIF-2 Kinase - metabolism | Humans | Salmonella Infections - immunology | Male | Salmonella Infections - metabolism | HMGB1 Protein - secretion | Interleukin-1beta - blood | eIF-2 Kinase - deficiency | Adenosine Triphosphate - pharmacology | CARD Signaling Adaptor Proteins - metabolism | Transfection | Interleukin-6 - blood | Rotenone - pharmacology | Female | Membrane Proteins - metabolism | Escherichia coli - physiology | Macrophages, Peritoneal - drug effects | eIF-2 Kinase - genetics | Calcium-Binding Proteins - metabolism | Cell Line | Salmonella typhimurium - physiology | Interleukin-18 - blood | Salmonella typhimurium - immunology | Inflammasomes - agonists | Mice, Inbred C57BL | Peritonitis - metabolism | Cells, Cultured | Escherichia coli - immunology | Antigens, Bacterial - pharmacology | Escherichia coli Infections - metabolism | eIF-2 Kinase - antagonists & inhibitors | Apoptosis Regulatory Proteins - metabolism | Animals | Carrier Proteins - metabolism | Bacterial Toxins - pharmacology | Uric Acid - pharmacology | RNA, Double-Stranded - immunology | RNA, Double-Stranded - pharmacology | Escherichia coli Infections - immunology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | HMGB1 Protein - blood | Physiological aspects | Chromosomal proteins | Research | Cytokines | Aluminum | Health aspects | Proteins | E coli | Pathogenesis | Plasmids | Bone marrow | Bacteria | Kinases
Journal Article
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2014, Volume 58, Issue 12, pp. 7250 - 7257
Journal Article
PLoS pathogens, ISSN 1553-7366, 05/2011, Volume 7, Issue 5, p. e1002042
.... In humans, the most widely studied antimicrobial peptide is LL-37, a 37-residue peptide containing an amphipathic helix that is released via proteolytic cleavage of the precursor protein CAP18... 
PROTEIN SECONDARY STRUCTURE | ENTERIC NEMATODE | MICROBIOLOGY | DEFENSE PEPTIDES | SIZE-DISTRIBUTION ANALYSIS | LPS | CIRCULAR-DICHROISM SPECTRA | ALTERNATIVELY ACTIVATED MACROPHAGES | VIROLOGY | CATHELICIDIN FAMILY | LIPOPOLYSACCHARIDE-BINDING | INHIBIT | PARASITOLOGY | Helminth Proteins - pharmacology | Membrane Glycoproteins - metabolism | Anti-Infective Agents - metabolism | Humans | Helminth Proteins - chemistry | Lipopolysaccharides - metabolism | Molecular Sequence Data | Antimicrobial Cationic Peptides - metabolism | Anti-Infective Agents - immunology | Inflammation - metabolism | Molecular Mimicry | Fasciola hepatica - chemistry | Fascioliasis - parasitology | Sepsis - metabolism | Carrier Proteins - pharmacology | Endotoxemia - immunology | Toll-Like Receptors - metabolism | Helminth Proteins - metabolism | Fasciola hepatica - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Sepsis - immunology | Acute-Phase Proteins - metabolism | Antimicrobial Cationic Peptides - chemistry | Membrane Glycoproteins - pharmacology | Toll-Like Receptors - immunology | Antimicrobial Cationic Peptides - pharmacology | Helminth Proteins - genetics | Inflammation - immunology | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Immunity, Innate | Fasciola hepatica - immunology | Animals | Carrier Proteins - metabolism | Fascioliasis - immunology | Lipopolysaccharides - pharmacology | Mice | Mice, Inbred BALB C | Endotoxemia - metabolism | Acute-Phase Proteins - pharmacology | Proteolysis | Antimicrobial peptides | Worms, Intestinal and parasitic | Physiological aspects | Research | Health aspects | Helminths | Medical research | Peptides | Cytokines | Rodents | Immune system
Journal Article
Gut, ISSN 0017-5749, 06/2017, Volume 66, Issue 6, pp. 1060 - 1073
...-binding oligomerization domain-containing protein 2 (NOD2) variants or mutations in X-linked inhibitor of apoptosis (XIAP... 
IBD-GENETICS | IBD CLINICAL | IMMUNODEFICIENCY | IBD BASIC RESEARCH | Crohn'S DISEASE | MIGLUSTAT THERAPY | PATHOGENESIS | APOPTOSIS | DENDRITIC CELLS | MACROPHAGES | SUSCEPTIBILITY | ILEAL MUCOSA | PHAGOSOME PROTEOME | GASTROENTEROLOGY & HEPATOLOGY | BOWEL-DISEASE | INNATE IMMUNITY | Tumor Necrosis Factor-alpha - metabolism | Crohn Disease - genetics | X-Linked Inhibitor of Apoptosis Protein - deficiency | Humans | Child, Preschool | Lysosomes | Male | Nod2 Signaling Adaptor Protein - genetics | Leukocytes, Mononuclear | Pyridazines - pharmacology | Niemann-Pick Disease, Type C - physiopathology | Autophagy - drug effects | Crohn Disease - complications | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Young Adult | Gentamicins - pharmacology | Adult | Bacteria | Female | Genetic Diseases, X-Linked - genetics | Autophagy - genetics | Child | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Macrophages - physiology | Granuloma - genetics | Cells, Cultured | Chlorpromazine - pharmacology | Imidazoles - pharmacology | Acetylmuramyl-Alanyl-Isoglutamine - metabolism | X-Linked Inhibitor of Apoptosis Protein - genetics | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Granuloma - pathology | Nod2 Signaling Adaptor Protein - metabolism | Crohn Disease - pathology | Dopamine Antagonists - pharmacology | Adolescent | X-Linked Inhibitor of Apoptosis Protein - metabolism | Macrophages - drug effects | Anti-Bacterial Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | Mutation | Niemann-Pick Disease, Type C - complications | Niemann-Pick Disease, Type C - genetics | Autophagy (Cytology) | Inflammatory bowel diseases | Gastrointestinal diseases | Causes of | Colorectal diseases | Crohn's disease | Research | Niemann-Pick disease | Salmonella | Granuloma | Muramyl dipeptide | Liver | XIAP protein | Kinases | Macrophages | Autophagy | Defects | Genotype & phenotype | Cell activation | Intestine | Neurodegeneration | Npc1 protein | Age | NOD2 protein | Oligomerization | Dendritic cells | Cytokines | Blood & organ donations | Inflammation | Patients | Crohns disease | Studies | Inflammatory bowel disease | Monocytes | Proteomics | Colitis | Adapter proteins | Phagocytosis | Apoptosis | IBD - GENETICS | CROHN'S DISEASE | Inflammatory Bowel Disease | 1506
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 02/2014, Volume 58, Issue 2, pp. 722 - 733
Journal Article
Journal Article
ChemMedChem, ISSN 1860-7179, 04/2018, Volume 13, Issue 7, pp. 754 - 761
Cytotoxic necrotizing factor 1 (CNF1) is a toxin produced by pathogenic strains of Escherichia coli responsible for extra‐intestinal infections. CNF1... 
inhibitors | CNF1 | screening | Rac1 | drug discovery | URINARY-TRACT-INFECTIONS | ACTIVATION | CHEMISTRY, MEDICINAL | MEMBRANE TRANSLOCATION | MECHANISM | CYTOTOXIC NECROTIZING FACTOR | VIRULENCE GENES | DIPHTHERIA-TOXIN | P21 RHO | E