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humans (280) 280
science & technology (278) 278
baculoviral iap repeat-containing 3 protein (265) 265
life sciences & biomedicine (260) 260
ubiquitin-protein ligases (185) 185
inhibitor of apoptosis proteins - metabolism (171) 171
inhibitor of apoptosis proteins - genetics (159) 159
apoptosis (155) 155
animals (127) 127
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cell line, tumor (101) 101
apoptosis - drug effects (87) 87
female (86) 86
mice (83) 83
cell biology (77) 77
male (75) 75
nf-kappa b - metabolism (70) 70
proteins (64) 64
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signal transduction (49) 49
ubiquitin-protein ligases - metabolism (49) 49
gene expression (44) 44
middle aged (43) 43
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cancer (39) 39
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aged (38) 38
medical sciences (38) 38
x-linked inhibitor of apoptosis protein - metabolism (38) 38
genetic aspects (37) 37
ubiquitin-protein ligases - genetics (36) 36
apoptosis - physiology (35) 35
tumors (35) 35
hematology (34) 34
baculoviral iap repeat-containing 3 protein - metabolism (33) 33
inhibitor of apoptosis proteins - antagonists & inhibitors (33) 33
research (33) 33
apoptosis - genetics (31) 31
cell line (31) 31
gene expression regulation, neoplastic (31) 31
prognosis (31) 31
signal transduction - drug effects (31) 31
antineoplastic agents - pharmacology (30) 30
blotting, western (29) 29
health aspects (29) 29
x-linked inhibitor of apoptosis protein - genetics (29) 29
caspases - metabolism (28) 28
cell proliferation - drug effects (27) 27
inhibitor of apoptosis proteins (26) 26
inhibitor of apoptosis proteins - biosynthesis (26) 26
reverse transcriptase polymerase chain reaction (26) 26
tumor necrosis factor-alpha - pharmacology (26) 26
analysis (25) 25
baculoviral iap repeat-containing 3 protein - genetics (25) 25
mutation (24) 24
cell proliferation (22) 22
cell survival - drug effects (22) 22
rna, messenger - metabolism (22) 22
care and treatment (21) 21
caspase 3 - metabolism (21) 21
cell survival (21) 21
ciap2 (21) 21
immunology (21) 21
kinases (21) 21
caspase 8 - metabolism (20) 20
cell death (20) 20
leukemia, lymphocytic, chronic, b-cell - genetics (20) 20
proto-oncogene proteins c-bcl-2 - metabolism (20) 20
rna interference (20) 20
tumor necrosis factor-alpha - metabolism (20) 20
gene expression profiling (19) 19
inflammation (19) 19
rats (19) 19
tnf receptor-associated factor 2 - metabolism (19) 19
ubiquitination (19) 19
up-regulation (19) 19
immunohistochemistry (18) 18
intracellular signaling peptides and proteins - metabolism (18) 18
mice, inbred c57bl (18) 18
multidisciplinary sciences (18) 18
nf-kappa b - genetics (18) 18
science & technology - other topics (18) 18
abridged index medicus (17) 17
gene expression regulation, neoplastic - drug effects (17) 17
mice, knockout (17) 17
receptor-interacting protein serine-threonine kinases - metabolism (17) 17
rna, messenger - genetics (17) 17
ubiquitin (17) 17
cancer research (16) 16
down-regulation (16) 16
drug resistance, neoplasm - genetics (16) 16
genes (16) 16
hek293 cells (16) 16
molecular sequence data (16) 16
tumor suppressor protein p53 - genetics (16) 16
aged, 80 and over (15) 15
fundamental and applied biological sciences. psychology (15) 15
iap protein (15) 15
neoplasm proteins - genetics (15) 15
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1. Full Text SHh-Gli1 signaling pathway promotes cell survival by mediating baculoviral IAP repeat-containing 3 (BIRC3) gene in pancreatic cancer cells
by Gan, Huizhong and Liu, Hua and Zhang, Hui and Li, Yueyue and Xu, Xiaorong and Xu, Xuanfu and Xu, Jianming
Tumor biology, ISSN 1010-4283, 7/2016, Volume 37, Issue 7, pp. 9943 - 9950
SHh-Gli1 signaling pathway | Biomedicine | Pancreatic cancer | Cancer Research | Proliferation | BIRC3 | Apoptosis | Life Sciences & Biomedicine | Oncology | Science & Technology | Cell Proliferation | Pancreatic Neoplasms - metabolism | Signal Transduction | Zinc Finger Protein GLI1 - metabolism | Inhibitor of Apoptosis Proteins - genetics | Zinc Finger Protein GLI1 - genetics | Humans | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | Ubiquitin-Protein Ligases - metabolism | Hedgehog Proteins - metabolism | Pancreatic Neoplasms - genetics | Baculoviral IAP Repeat-Containing 3 Protein | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Chromatin Immunoprecipitation | Hedgehog Proteins - genetics | Biomarkers, Tumor - metabolism | Biomarkers, Tumor - genetics | Inhibitor of Apoptosis Proteins - metabolism | Tumor Cells, Cultured | Ubiquitin-Protein Ligases - genetics | Real-Time Polymerase Chain Reaction | Messenger RNA | Analysis | Genes | Luciferase | Cancer cells | Genetic research | Genetic aspects | Internet service providers | Genetic transcription | Cancer | Signal transduction | Cell growth | Gene expression | Index Medicus
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2. Full Text Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)
by Flygare, John A and Beresini, Maureen and Budha, Nageshwar and Chan, Helen and Chan, Iris T and Cheeti, Sravanthi and Cohen, Frederick and Deshayes, Kurt and Doerner, Karl and Eckhardt, S. Gail and Elliott, Linda O and Feng, Bainian and Franklin, Matthew C and Reisner, Stacy Frankovitz and Gazzard, Lewis and Halladay, Jason and Hymowitz, Sarah G and La, Hank and LoRusso, Patricia and Maurer, Brigitte and Murray, Lesley and Plise, Emile and Quan, Clifford and Stephan, Jean-Philippe and Young, Shin G and Tom, Jeffrey and Tsui, Vickie and Um, Joanne and Varfolomeev, Eugene and Vucic, Domagoj and Wagner, Andrew J and Wallweber, Heidi J. A and Wang, Lan and Ware, Joseph and Wen, Zhaoyang and Wong, Harvey and Wong, Jonathan M and Wong, Melisa and Wong, Susan and Yu, Ron and Zobel, Kerry and Fairbrother, Wayne J
Journal of medicinal chemistry, ISSN 0022-2623, 05/2012, Volume 55, Issue 9, pp. 4101 - 4113
Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Male | Baculoviral IAP Repeat-Containing 3 Protein | Breast Neoplasms - metabolism | Caspases - metabolism | Thiadiazoles - chemistry | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Thiadiazoles - pharmacology | Binding, Competitive | Cell Survival - drug effects | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Ubiquitin-Protein Ligases | Animals | Thiadiazoles - chemical synthesis | Breast Neoplasms - pathology | Cell Line, Tumor | Thiadiazoles - pharmacokinetics | Clinical Trials, Phase I as Topic | Index Medicus
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3. Regulation of innate and adaptive antitumor immunity by IAP antagonists
by Dougan, Stephanie K and Dougan, Michael
Immunotherapy, ISSN 1750-743X, 07/2018, Volume 10, Issue 9, pp. 787 - 796
SMAC mimetics | inhibitor of apoptosis proteins | IAP antagonists | tumor immunotherapy | c-IAP1/c-IAP2 | Life Sciences & Biomedicine | Immunology | Science & Technology | Adaptive Immunity | Tumor Necrosis Factor-alpha - metabolism | Immunotherapy - methods | Humans | Baculoviral IAP Repeat-Containing 3 Protein - antagonists & inhibitors | NF-kappa B - metabolism | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Intracellular Signaling Peptides and Proteins - metabolism | Immunity, Innate | Neoplasms - therapy | Animals | Biomimetics | Signal Transduction - drug effects | Mitochondrial Proteins - metabolism | Neoplasms - immunology | Baculoviral IAP Repeat-Containing 3 Protein - metabolism | Disease Models, Animal | Drugs | PD-1 protein | Multiple myeloma | Antagonists | Lymphocytes T | Kinases | Macrophages | Cancer therapies | Immunosuppressive agents | Proteins | Phagocytes | CTLA-4 protein | Cell activation | Lymphocytes | Immunotherapy | Tumor necrosis factor-TNF | Pharmaceutical industry | NF-κB protein | Antigens | IAP protein | Immunoglobulins | Cell survival | Cytokines | Dendritic cells | Immunoregulation | Inflammation | Adaptive immunity | Mammals | Immune checkpoint | Lymphocytes B | PD-L1 protein | Monoclonal antibodies | Antitumor activity | Ligands | Regulation | Apoptosis | Tumors
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4. Full Text WX20120108, a novel IAP antagonist, induces tumor cell autophagy via activating ROS-FOXO pathway
by Ding, Rui and Wang, Xin and Chen, Wei and Li, Zhi and Wei, Ai-li and Wang, Qing-bin and Nie, Ai-hua and Wang, Li-li
Acta pharmacologica Sinica, ISSN 1671-4083, 11/2019, Volume 40, Issue 11, pp. 1466 - 1479
Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Reactive Oxygen Species - metabolism | Dipeptides - pharmacology | Humans | Autophagy - drug effects | Baculoviral IAP Repeat-Containing 3 Protein - chemistry | Antineoplastic Agents - metabolism | Signal Transduction - drug effects | Forkhead Transcription Factors - metabolism | Baculoviral IAP Repeat-Containing 3 Protein - metabolism | Benzimidazoles - metabolism | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | X-Linked Inhibitor of Apoptosis Protein - chemistry | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Protein Binding | Protein Domains | Benzimidazoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Docking Simulation | Dipeptides - metabolism | Cell proliferation | Biotechnology | Reactive oxygen species | Fluorescence | XIAP protein | Antagonists | Autophagy | Molecular docking | Anticancer properties | Time dependence | Cell activation | Catalase | Forkhead protein | FOXO3 protein | Translocation | Fluorescence polarization | IAP protein | Tumor cells | Caspase | Tumor cell lines | Tumor necrosis factor-α | Gene expression | BNIP3 protein | Nuclear transport | Domains | Gene silencing | Anisotropy | Regulatory mechanisms (biology) | Phagocytosis | Apoptosis | Index Medicus | carcinoma cells | IAP antagonists | autophagy | GDC-0152 | ROS | apoptosis | Foxo3 | catalase | WX20120108
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5. Full Text A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy
by He, W and Wang, Q and Srinivasan, B and Xu, J and Padilla, M.T and Li, Z and Wang, X and Liu, Y and Gou, X and Shen, H.-M and Xing, C and Lin, Y
Oncogene, ISSN 0950-9232, 06/2014, Volume 33, Issue 23, pp. 3004 - 3013
apoptosis | autophagy | RIP3 | c-IAP | RIP1 | necroptosis | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | RNA, Small Interfering - genetics | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | Baculoviral IAP Repeat-Containing 3 Protein | Autophagy - drug effects | Gene Knockdown Techniques | MAP Kinase Kinase 4 - metabolism | MAP Kinase Signaling System - genetics | Chalcones - pharmacology | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Membrane Proteins - metabolism | Beclin-1 | Nuclear Pore Complex Proteins - metabolism | RNA, Small Interfering - pharmacology | Imidazoles - pharmacology | Ubiquitin-Activating Enzymes - metabolism | Apoptosis Regulatory Proteins - metabolism | Ubiquitin-Protein Ligases | Autophagy-Related Protein 7 | Drug Resistance, Neoplasm - genetics | MAP Kinase Signaling System - drug effects | Membrane Proteins - antagonists & inhibitors | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | RNA-Binding Proteins - metabolism | Autophagy (Cytology) | Chemotherapy | Physiological aspects | Health aspects | c-Jun N-terminal kinases | Apoptosis | Cancer | Biodegradation | Autophagy | Index Medicus
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6. Full Text c‐IAP ubiquitin protein ligase activity is required for 4‐1BB signaling and CD8+ memory T‐cell survival
by Giardino Torchia, Maria Letizia and Munitic, Ivana and Castro, Ehydel and Herz, Jasmin and McGavern, Dorian B and Ashwell, Jonathan D
European journal of immunology, ISSN 0014-2980, 09/2015, Volume 45, Issue 9, pp. 2672 - 2682
CD8+ memory T cell | Signal transduction | Ubiquitination | lymphocytic choriomeningitis virus | T‐cell memory | 4‐1BB | CD8 + memory T cell | 4-1BB | Lymphocytic choriomeningitis virus | T-cell memory | Life Sciences & Biomedicine | Immunology | Science & Technology | Lymphocytic choriomeningitis virus - immunology | CD8-Positive T-Lymphocytes - pathology | CD8-Positive T-Lymphocytes - transplantation | Inhibitor of Apoptosis Proteins - genetics | NF-kappa B - immunology | Cell Survival - genetics | Apoptosis - genetics | Baculoviral IAP Repeat-Containing 3 Protein | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | Adoptive Transfer | Lymphocytic Choriomeningitis - immunology | Ubiquitin-Protein Ligases - immunology | Female | Inhibitor of Apoptosis Proteins - metabolism | Immunologic Memory - genetics | Lymphocytic Choriomeningitis - genetics | Lymphocytic Choriomeningitis - virology | Signal Transduction | Lymphocytic Choriomeningitis - pathology | Antibodies, Monoclonal - pharmacology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Cells, Cultured | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Mice, Transgenic | Cell Survival - immunology | Animals | Apoptosis - immunology | NF-kappa B - genetics | CD8-Positive T-Lymphocytes - virology | Lymphocyte Activation - drug effects | Tumor Necrosis Factor Receptor Superfamily, Member 9 - antagonists & inhibitors | Lymphocyte Count | Inhibitor of Apoptosis Proteins - immunology | Mice | Mutation | CD8-Positive T-Lymphocytes - immunology | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Cellular signal transduction | Memory (Computers) | T cells | Ligases | Lymphocytes | Rodents | T cell receptors | Index Medicus | LCMV | signal transduction | ubiquitination
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7. Full Text Gain of Additional BIRC3 Protein Functions through 3ʹ-UTR-Mediated Protein Complex Formation
by Lee, Shih-Han and Mayr, Christine
Molecular cell, ISSN 1097-2765, 05/2019, Volume 74, Issue 4, pp. 701 - 712.e9
3′-UTR-independent protein functions | CLL | protein multi-functionality | CXCR4 receptor trafficking | 3′-UTR-facilitated protein complex assembly | RNA-binding proteins | E3 ubiquitin ligase BIRC3 | B cell migration | alternative 3′ UTRs | 3′-UTR-dependent protein functions | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA-Binding Proteins - genetics | Leukemia - pathology | Cytoskeletal Proteins - genetics | Humans | RNA, Messenger - genetics | RNA-Binding Proteins - chemistry | ELAV-Like Protein 1 - genetics | Gene Expression Regulation, Neoplastic | 3' Untranslated Regions - genetics | Multiprotein Complexes - genetics | Baculoviral IAP Repeat-Containing 3 Protein - genetics | Cell Movement - genetics | Baculoviral IAP Repeat-Containing 3 Protein - chemistry | Protein Transport | Multiprotein Complexes - chemistry | Receptors, CXCR4 - genetics | B-Lymphocytes - pathology | B-Lymphocytes - metabolism | Leukemia - genetics | Index Medicus
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8. Full Text IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα
by Shekhar, Tanmay M and Miles, Mark A and Gupte, Ankita and Taylor, Scott and Tascone, Brianna and Walkley, Carl R and Hawkins, Christine J
Oncotarget, ISSN 1949-2553, 06/2016, Volume 7, Issue 23, pp. 33866 - 33886
IAP | Bone cancer | Smac | Osteosarcoma | RIP1 | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Osteosarcoma - drug therapy | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Cyclohexanes - pharmacology | Humans | Baculoviral IAP Repeat-Containing 3 Protein - antagonists & inhibitors | Ubiquitin-Protein Ligases - antagonists & inhibitors | Bone Neoplasms - pathology | Tumor Suppressor Protein p53 - genetics | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Bone Neoplasms - metabolism | Dose-Response Relationship, Drug | Bridged Bicyclo Compounds, Heterocyclic - toxicity | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Transfection | Triazoles - toxicity | Baculoviral IAP Repeat-Containing 3 Protein - metabolism | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | HEK293 Cells | Bone Neoplasms - genetics | Inhibitor of Apoptosis Proteins - metabolism | Bone Neoplasms - drug therapy | Cyclohexanes - toxicity | Osteosarcoma - metabolism | Cell Survival - drug effects | Genetic Predisposition to Disease | Ubiquitin-Protein Ligases - metabolism | Retinoblastoma Protein - deficiency | Tumor Suppressor Protein p53 - deficiency | Mice, Knockout | Triazoles - pharmacology | Thiazoles - toxicity | Tumor Necrosis Factor-alpha - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Phenotype | Pyrroles - pharmacology | Animals | Signal Transduction - drug effects | Pyrroles - toxicity | Retinoblastoma Protein - genetics | Cell Line, Tumor | Thiazoles - pharmacology | Osteosarcoma - genetics | Osteosarcoma - secondary | Index Medicus
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9. Full Text Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation
by Vince, James E and Wong, W. Wei-Lynn and Gentle, Ian and Lawlor, Kate E and Allam, Ramanjaneyulu and O'Reilly, Lorraine and Mason, Kylie and Gross, Olaf and Ma, Stephen and Guarda, Greta and Anderton, Holly and Castillo, Rosa and Häcker, Georg and Silke, John and Tschopp, Jürg
Immunity (Cambridge, Mass.), ISSN 1074-7613, 02/2012, Volume 36, Issue 2, pp. 215 - 227
Life Sciences & Biomedicine | Immunology | Science & Technology | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | X-Linked Inhibitor of Apoptosis Protein - deficiency | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Inhibitor of Apoptosis Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Baculoviral IAP Repeat-Containing 3 Protein | Mitochondrial Proteins - agonists | Carrier Proteins - agonists | Inhibitor of Apoptosis Proteins - deficiency | Molecular Mimicry | Interleukin-1beta - metabolism | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Inhibitor of Apoptosis Proteins - metabolism | Macrophages - immunology | Macrophages - cytology | X-Linked Inhibitor of Apoptosis Protein - genetics | Mice, Knockout | Ubiquitin-Protein Ligases | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | X-Linked Inhibitor of Apoptosis Protein - metabolism | Macrophages - drug effects | Mice | Apoptosis | Proteins | Interleukins | Genes | Membranes | Mammals | Immune system | Caspase-8 | DIABLO protein | Cell activation | IAP protein | Reactive oxygen species | Interleukin 1 | Toll-like receptors | XIAP protein | Inflammation | Macrophages | Caspase-1 | Index Medicus
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