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Autophagy, ISSN 1554-8627, 08/2018, Volume 14, Issue 8, pp. 1435 - 1455
Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then... 
fusion | lysosomal degradation | bafilomycin A | degradative compartments | Golgi | lysosomal inhibitors | Autophagy | CANCER-CELLS | INTRALYSOSOMAL PH | PERITONEAL-MACROPHAGES | ISOLATED RAT HEPATOCYTES | CELL BIOLOGY | GROWTH-FACTOR RECEPTOR | MANNOSE 6-PHOSPHATE RECEPTOR | NONSELECTIVE AUTOPHAGY | LC3 LIPIDATION | INTEGRAL MEMBRANE-PROTEIN | SELF-DIGESTION
Journal Article
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 1965 - 1977
Journal Article
Autophagy, ISSN 1554-8627, 03/2015, Volume 11, Issue 3, pp. 547 - 559
Cigarette smoke (CS)-induced mitochondrial damage with increased reactive oxygen species (ROS) production has been implicated in COPD pathogenesis by... 
Baf A1, bafilomycin A | PCD, programmed cell death | CS, cigarette smoke | COPD, chronic obstructive pulmonary disease | PINK1, PTEN-induced putative kinase 1 | CSE, cigarette smoke extract | FEV1, forced expiratory volume in one second | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | SA-β-Gal, senescence-associated β-galactosidase | NAC, N-acetylcysteine | PARK2 | senescence | FVC, forced vital capacity | 1 | EM, electron microscopy | mitophagy | WB, western blotting | ROS | HBEC, human bronchial epithelial cell | ROS, reactive oxygen species | COPD | TLR, toll-like receptor | Senescence | Mitophagy | PROTEIN | bafilomycin A | forced vital capacity | Baf A1 | cigarette smoke | N-acetylcysteine | CELL BIOLOGY | microtubule-associated protein 1 light chain 3 | PTEN-induced putative kinase 1 | CSE | reactive oxygen species | electron microscopy | MITOCHONDRIAL DYSFUNCTION | SA--Gal | TLR | programmed cell death | INSUFFICIENT AUTOPHAGY | LC3 | LIFE | cigarette smoke extract | western blotting | senescence-associated -galactosidase | human bronchial epithelial cell | CELLULAR SENESCENCE | MAP1LC3 | forced expiratory volume in one second | PCD | NAC | PARKIN | FVC | PINK1 | INFLAMMATION | HBEC | FEV1 | toll-like receptor | PROMOTES | chronic obstructive pulmonary disease | Immunohistochemistry | Smoking - adverse effects | Reactive Oxygen Species - metabolism | Humans | Middle Aged | Epithelial Cells - pathology | Male | Lung - physiopathology | Pulmonary Disease, Chronic Obstructive - physiopathology | Mitochondria - pathology | Microscopy, Electron | Ubiquitin-Protein Ligases - physiology | Autophagy | Mitochondrial Degradation | Tobacco Products | Cellular Senescence | Protein Kinases - physiology | Adult | Female | Aged | Pulmonary Disease, Chronic Obstructive - immunology | Bronchi - cytology
Journal Article
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2018, Volume 1780, pp. 17 - 29
The accumulation of mutant aggregate-prone proteins is a hallmark of the majority of neurodegenerative disorders, including Alzheimer's, Parkinson's, and... 
LC3-II | Bafilomycin A1 | Autophagy | Bafilomycin A | Huntingtin aggregates | Autophagic flux
Journal Article
Journal of Experimental Biology, ISSN 0022-0949, 05/2000, Volume 203, Issue 9, pp. 1459 - 1468
The effects of bafilomycin A sub(1), a blocker of V-type H super(+)-ATPases, were investigated in Malpighian tubules of Aedes aegypti. Bafilomycin A sub(1)... 
bafilomycin
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 04/2019, Volume 27, Issue 8, pp. 1677 - 1682
Molecular behavior under bilayer membrane environments is one of the important research topics concerning how organic molecules exert their biological... 
Solid-state NMR | Bafilomycin | PAMPA | Membrane affinity | Lipophilic ligand
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 04/2019, Volume 27, Issue 8, pp. 1677 - 1682
Molecular behavior under bilayer membrane environments is one of the important research topics concerning how organic molecules exert their biological... 
Solid-state NMR | Bafilomycin | PAMPA | Membrane affinity | Lipophilic ligand
Journal Article
Autophagy, ISSN 1554-8627, 03/2015, Volume 11, Issue 3, pp. 452 - 459
Disruption of the complex of BECN1 with BCL2 or BCL2L1/BCL-X L is an essential switch that turns on cellular autophagy in response to environmental stress or... 
STS, staurosporine | apoptosis | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | HRP, horseradish peroxidase | PBS, phosphate-buffered saline | BAK1 | HBSS, Hanks' balanced salt solution | BCL2, B-cell CLL/lymphoma 2 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | Baf A1, bafilomycin A | MTOR, mechanistic target of rapamycin | autophagy | ACTB, actin, β | FBS, fetal bovine serum | WT, wild type | ABT-737 | BECN1 (Beclin 1) | BECN1, Beclin 1, autophagy-related | DKO, double-knockout | 1 | SQSTM1, sequestosome 1 | BAX, BCL2-associated X protein | BCL2 | BAX | MEFs, mouse embryonic fibroblasts | MCL1, myeloid cell leukemia 1 | BAK1, BCL2-antagonist/killer 1 | Autophagy | Apoptosis | bafilomycin A | sequestosome 1 | HRP | BCL2-associated X protein | mechanistic target of rapamycin | phosphate-buffered saline | ACTB | PEPTIDE | CELL BIOLOGY | 1 PHOSPHORYLATION | STS | FBS | X-L | autophagy-related | horseradish peroxidase | Hanks' balanced salt solution | mouse embryonic fibroblasts | LC3 | MOLECULAR-BASIS | PBS | MEFs | BECLIN 1-DEPENDENT AUTOPHAGY | killer 1 | lymphoma 2 | BH3-ONLY PROTEIN | DKO | double-knockout | MAP1LC3 | fetal bovine serum | actin | BCL2-antagonist | wild type | GAPDH | SQSTM1 | BECN1 | staurosporine | myeloid cell leukemia 1 | Baf A1 | BH3 DOMAIN | microtubule-associated protein 1 light chain 3 | glyceraldehyde-3-phosphate dehydrogenase | B-cell CLL | BCL-2 FAMILY-MEMBERS | MCL1 | SUPPRESSION | MTOR | Beclin 1 | HBSS | Beclin-1 | Peptide Fragments | Sulfonamides - chemistry | HCT116 Cells | Humans | bcl-2-Associated X Protein - metabolism | Piperazines - chemistry | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Nitrophenols - chemistry | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Flow Cytometry | Cell Line, Tumor | Protein Binding | Membrane Proteins - metabolism | Mice | Proto-Oncogene Proteins | Biphenyl Compounds - chemistry | Microscopy, Fluorescence | Fibroblasts - metabolism
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 06/2016, Volume 57, Issue 22, pp. 2426 - 2429
Based on previously reported structure–activity relationships, an analogue of bafilomycin A with a site-specific fluorine label at the C2 position was designed... 
Fluorine-label | Bafilomycin | V-ATPase | Chemical synthesis | Conformational analysis | KETONES | SUBUNIT-C | V-ATPASES | CHEMISTRY, ORGANIC | BAFILOMYCIN/CONCANAMYCIN-BINDING-SITE | MODEL | Adenosine triphosphatase | Fluorides
Journal Article
Chemistry - A European Journal, ISSN 0947-6539, 03/2012, Volume 18, Issue 12, pp. 3598 - 3610
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 10/2016, Volume 57, Issue 43, pp. 4863 - 4865
A new 16-membered diene macrolide, bafilomycin M ( ), was produced from a sp. GIC10-1, which was originally isolated from a marine sponge sp. The structure of... 
Streptomyces | Cytotoxicity | Bafilomycin | Theonella | CGH2XX | PSEUDOALTEROMONE | MACROLIDE | CHEMISTRY, ORGANIC
Journal Article
Journal Article
Journal of Clinical Lipidology, ISSN 1933-2874, 07/2019
Journal Article
Molecular & Cellular Oncology, ISSN 2372-3556, 01/2014, Volume 1, Issue 1, p. e29911
Macroautophagy (herein referred to as autophagy) is a highly conserved mechanism for the lysosomal degradation of cytoplasmic components. Autophagy is critical... 
mTOR | proteasome | beclin 1 | lysosomes | bafilomycin A1 | autophagosomes
Journal Article
Journal Article