Bioorganic Chemistry, ISSN 0045-2068, 10/2015, Volume 62, pp. 41 - 63
GyrB and ParE are type IIA topoisomerases and found in most bacteria. Its function is vital for DNA replication, repair and decatenation. The highly conserved...
GyrB | Pyrrolopyrimidines | ParE | ATPase inhibitors | BROAD-SPECTRUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | VIVO ANTIBACTERIAL ACTIVITIES | CHEMISTRY, ORGANIC | PYRROLOPYRIMIDINE INHIBITORS | STREPTOCOCCUS-PNEUMONIAE | BIOLOGICAL EVALUATION | NEISSERIA-GONORRHOEAE | STAPHYLOCOCCUS-AUREUS | ANTISTAPHYLOCOCCAL ACTIVITIES | IN-VITRO ACTIVITY | DNA Topoisomerase IV - drug effects | Amino Acid Sequence | DNA Gyrase - drug effects | Topoisomerase II Inhibitors - pharmacology | Quinolines - pharmacology | Pyrrolidines - pharmacology | Indazoles - pharmacology | Organophosphates - pharmacology | Topoisomerase Inhibitors - pharmacology | Pyrroles - pharmacology | Barbiturates - pharmacology | Aminopyridines - pharmacology | Fluoroquinolones - pharmacology | Pyrrolidinones - pharmacology | Urea - analogs & derivatives | Benzimidazoles - pharmacology | Anti-Bacterial Agents - pharmacology | Prodrugs - pharmacology | Quinazolinones - pharmacology | Spiro Compounds - pharmacology | Urea - pharmacology | Pyrazoles - pharmacology | DNA
GyrB | Pyrrolopyrimidines | ParE | ATPase inhibitors | BROAD-SPECTRUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | VIVO ANTIBACTERIAL ACTIVITIES | CHEMISTRY, ORGANIC | PYRROLOPYRIMIDINE INHIBITORS | STREPTOCOCCUS-PNEUMONIAE | BIOLOGICAL EVALUATION | NEISSERIA-GONORRHOEAE | STAPHYLOCOCCUS-AUREUS | ANTISTAPHYLOCOCCAL ACTIVITIES | IN-VITRO ACTIVITY | DNA Topoisomerase IV - drug effects | Amino Acid Sequence | DNA Gyrase - drug effects | Topoisomerase II Inhibitors - pharmacology | Quinolines - pharmacology | Pyrrolidines - pharmacology | Indazoles - pharmacology | Organophosphates - pharmacology | Topoisomerase Inhibitors - pharmacology | Pyrroles - pharmacology | Barbiturates - pharmacology | Aminopyridines - pharmacology | Fluoroquinolones - pharmacology | Pyrrolidinones - pharmacology | Urea - analogs & derivatives | Benzimidazoles - pharmacology | Anti-Bacterial Agents - pharmacology | Prodrugs - pharmacology | Quinazolinones - pharmacology | Spiro Compounds - pharmacology | Urea - pharmacology | Pyrazoles - pharmacology | DNA
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 05/2012, Volume 166, Issue 2, pp. 476 - 485
GABAA receptors are ligand-gated chloride channels composed of five subunits that can belong to different subunit classes. The existence of 19 different...
barbiturates | benzodiazepines | allosteric binding sites | receptors | CGS 9895 | anesthetics | pharmacology | GABA | steroids | receptor subtypes | structure | SINGLE AMINO-ACID | GATED ION-CHANNEL | GENERAL ANESTHETIC ETOMIDATE | SELECTIVE PARTIAL AGONIST | EPSILON-SUBUNIT | A RECEPTOR | ALPHA-5 SUBUNIT | PHARMACOLOGY & PHARMACY | GAMMA-AMINOBUTYRIC-ACID | RAT-BRAIN | BENZODIAZEPINE BINDING-SITE | GABAA receptors | Pharmaceutical Preparations - metabolism | Animals | Humans | Protein Subunits - chemistry | Receptors, GABA-A - metabolism | Receptors, GABA-A - chemistry | Benzodiazepines - metabolism | Protein Subunits - metabolism
barbiturates | benzodiazepines | allosteric binding sites | receptors | CGS 9895 | anesthetics | pharmacology | GABA | steroids | receptor subtypes | structure | SINGLE AMINO-ACID | GATED ION-CHANNEL | GENERAL ANESTHETIC ETOMIDATE | SELECTIVE PARTIAL AGONIST | EPSILON-SUBUNIT | A RECEPTOR | ALPHA-5 SUBUNIT | PHARMACOLOGY & PHARMACY | GAMMA-AMINOBUTYRIC-ACID | RAT-BRAIN | BENZODIAZEPINE BINDING-SITE | GABAA receptors | Pharmaceutical Preparations - metabolism | Animals | Humans | Protein Subunits - chemistry | Receptors, GABA-A - metabolism | Receptors, GABA-A - chemistry | Benzodiazepines - metabolism | Protein Subunits - metabolism
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 07/2017, Volume 174, Issue 13, pp. 1881 - 1894
The homomeric GABA- ligand-gated ion channels (also known as GABA(C) or GABA(A)- receptors) are similar to heteromeric GABA(A) receptors in structure, function...
C RECEPTOR | CONFERS BARBITURATE SENSITIVITY | RETINAL BIPOLAR CELLS | BINDING-SITE | TRANSMEMBRANE DOMAIN | PHARMACOLOGY & PHARMACY | GATED ION CHANNELS | XENOPUS OOCYTES | GAMMA-AMINOBUTYRIC-ACID | AGONIST BINDING | BETA-SUBUNIT | Receptors | γ-Aminobutyric acid A receptors | Ion channels (ligand-gated) | Ligands | Pharmacology | Ion channels | Selectivity | Receptor mechanisms | γ-Aminobutyric acid C receptors | Structure-activity relationships | Binding sites | Structure-function relationships
C RECEPTOR | CONFERS BARBITURATE SENSITIVITY | RETINAL BIPOLAR CELLS | BINDING-SITE | TRANSMEMBRANE DOMAIN | PHARMACOLOGY & PHARMACY | GATED ION CHANNELS | XENOPUS OOCYTES | GAMMA-AMINOBUTYRIC-ACID | AGONIST BINDING | BETA-SUBUNIT | Receptors | γ-Aminobutyric acid A receptors | Ion channels (ligand-gated) | Ligands | Pharmacology | Ion channels | Selectivity | Receptor mechanisms | γ-Aminobutyric acid C receptors | Structure-activity relationships | Binding sites | Structure-function relationships
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2009, Volume 616, Issue 1, pp. 73 - 80
Harmaline-induced tremor in rodents is a model of essential tremor. We utilized a novel assay to quantify tremor activity in mice and found that tremor...
Harmaline | Dopamine | Gabapentin | Primidone | Lithium | Glutamate | Carbamazepine | Valproate | Validity | D 1 receptor | GABA | Propranolol | Essential tremor | ICR mouse | D 2 receptor | γ-Hydroxy-butyrate | receptor | GAMMA-HYDROXYBUTYRIC ACID | NUCLEUS-ACCUMBENS DOPAMINE | D-2 receptor | SUBUNIT MESSENGER-RNAS | AMINO-ACIDS | SODIUM-VALPROATE | PHARMACOLOGY & PHARMACY | gamma-Hydroxy-butyrate | AMINOBUTYRIC-ACID | RECEPTOR SUBUNITS | NEUROTRANSMITTER RELEASE | INFERIOR OLIVE | D-1 receptor | DRUG-INDUCED TREMOR | Receptors, Glutamate - metabolism | Muscimol - pharmacology | gamma-Aminobutyric Acid - metabolism | Glutamates - metabolism | Male | Anticonvulsants - pharmacology | Dose-Response Relationship, Drug | Propranolol - pharmacology | Lithium Chloride - pharmacology | Neurotransmitter Agents - pharmacology | Tremor - chemically induced | Behavior, Animal - drug effects | Raclopride - pharmacology | Chlordiazepoxide - pharmacology | Dopamine - metabolism | Baclofen - pharmacology | Harmaline - pharmacology | Affect - drug effects | Benzazepines - pharmacology | Piperazines - pharmacology | Mice, Inbred ICR | Sodium Oxybate - pharmacology | Animals | Mice | Carbolines - pharmacology | Propranolol hydrochloride | Methyl aspartate | Pyridine | Analysis | Gamma-hydroxybutyrate | Chemical properties | Barbiturates | Index Medicus
Harmaline | Dopamine | Gabapentin | Primidone | Lithium | Glutamate | Carbamazepine | Valproate | Validity | D 1 receptor | GABA | Propranolol | Essential tremor | ICR mouse | D 2 receptor | γ-Hydroxy-butyrate | receptor | GAMMA-HYDROXYBUTYRIC ACID | NUCLEUS-ACCUMBENS DOPAMINE | D-2 receptor | SUBUNIT MESSENGER-RNAS | AMINO-ACIDS | SODIUM-VALPROATE | PHARMACOLOGY & PHARMACY | gamma-Hydroxy-butyrate | AMINOBUTYRIC-ACID | RECEPTOR SUBUNITS | NEUROTRANSMITTER RELEASE | INFERIOR OLIVE | D-1 receptor | DRUG-INDUCED TREMOR | Receptors, Glutamate - metabolism | Muscimol - pharmacology | gamma-Aminobutyric Acid - metabolism | Glutamates - metabolism | Male | Anticonvulsants - pharmacology | Dose-Response Relationship, Drug | Propranolol - pharmacology | Lithium Chloride - pharmacology | Neurotransmitter Agents - pharmacology | Tremor - chemically induced | Behavior, Animal - drug effects | Raclopride - pharmacology | Chlordiazepoxide - pharmacology | Dopamine - metabolism | Baclofen - pharmacology | Harmaline - pharmacology | Affect - drug effects | Benzazepines - pharmacology | Piperazines - pharmacology | Mice, Inbred ICR | Sodium Oxybate - pharmacology | Animals | Mice | Carbolines - pharmacology | Propranolol hydrochloride | Methyl aspartate | Pyridine | Analysis | Gamma-hydroxybutyrate | Chemical properties | Barbiturates | Index Medicus
Journal Article
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 2015, Volume 59, Issue 9, pp. 5220 - 5225
Resistance in Neisseria gonorrhoeae against all antimicrobials available for the treatment of gonorrhea has emerged. The first gonococcal strains with...
MULTIDRUG-RESISTANT | CEFTRIAXONE TREATMENT | ANTIBACTERIAL ACTIVITY | PHARYNGEAL GONORRHEA | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | FUTURE | UNTREATABLE GONORRHEA | ANTIMICROBIAL RESISTANCE | 500 MG | DNA GYRASE INHIBITOR | TREATMENT FAILURE | Neisseria gonorrhoeae - drug effects | Europe | Humans | Ciprofloxacin - pharmacology | Drug Resistance, Bacterial | Ceftriaxone - pharmacology | Azithromycin - pharmacology | Microbial Sensitivity Tests | Barbiturates - pharmacology | Fluoroquinolones - pharmacology | Anti-Bacterial Agents - pharmacology | Cefixime - pharmacology | Spiro Compounds - pharmacology | Susceptibility | Basic Medicine | Medical and Health Sciences | Microbiology in the medical area | Microbiology | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Mikrobiologi | Farmakologi och toxikologi | Mikrobiologi inom det medicinska området | Pharmacology and Toxicology
MULTIDRUG-RESISTANT | CEFTRIAXONE TREATMENT | ANTIBACTERIAL ACTIVITY | PHARYNGEAL GONORRHEA | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | FUTURE | UNTREATABLE GONORRHEA | ANTIMICROBIAL RESISTANCE | 500 MG | DNA GYRASE INHIBITOR | TREATMENT FAILURE | Neisseria gonorrhoeae - drug effects | Europe | Humans | Ciprofloxacin - pharmacology | Drug Resistance, Bacterial | Ceftriaxone - pharmacology | Azithromycin - pharmacology | Microbial Sensitivity Tests | Barbiturates - pharmacology | Fluoroquinolones - pharmacology | Anti-Bacterial Agents - pharmacology | Cefixime - pharmacology | Spiro Compounds - pharmacology | Susceptibility | Basic Medicine | Medical and Health Sciences | Microbiology in the medical area | Microbiology | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Mikrobiologi | Farmakologi och toxikologi | Mikrobiologi inom det medicinska området | Pharmacology and Toxicology
Journal Article
1983, ISBN 0444804307, xix, 475
Book
1986, ISBN 0306421305, xv, 518
Book
Current Opinion in Anaesthesiology, ISSN 0952-7907, 10/2006, Volume 19, Issue 5, pp. 481 - 486
Purpose of review Patients at risk for perioperative stroke, or those who have suffered recent cerebral injury, may benefit from neuroprotective properties of...
Neuroprotection | Anesthesia | Neurotoxicity | Perioperative cerebral ischemia | Posttreatment | Preconditioning | neurotoxicity | perioperative cerebral ischemia | neuroprotection | ANESTHESIOLOGY | posttreatment | anesthesia | preconditioning | Anesthetics, Inhalation - pharmacology | Lidocaine - pharmacology | Xenon - pharmacology | Anesthetics, Dissociative - pharmacology | Isoflurane - pharmacology | Humans | Propofol - pharmacology | Anesthetics - pharmacology | Neuroprotective Agents - toxicity | Anesthetics, Local - pharmacology | Brain - drug effects | Anesthetics, Intravenous - pharmacology | Anesthetics - toxicity | Animals | Neuroprotective Agents - pharmacology | Cerebrovascular Disorders - prevention & control | Time Factors | Barbiturates - pharmacology | Brain - pathology | Neuroprotective Agents - adverse effects | Ketamine - pharmacology | Anesthetics - adverse effects
Neuroprotection | Anesthesia | Neurotoxicity | Perioperative cerebral ischemia | Posttreatment | Preconditioning | neurotoxicity | perioperative cerebral ischemia | neuroprotection | ANESTHESIOLOGY | posttreatment | anesthesia | preconditioning | Anesthetics, Inhalation - pharmacology | Lidocaine - pharmacology | Xenon - pharmacology | Anesthetics, Dissociative - pharmacology | Isoflurane - pharmacology | Humans | Propofol - pharmacology | Anesthetics - pharmacology | Neuroprotective Agents - toxicity | Anesthetics, Local - pharmacology | Brain - drug effects | Anesthetics, Intravenous - pharmacology | Anesthetics - toxicity | Animals | Neuroprotective Agents - pharmacology | Cerebrovascular Disorders - prevention & control | Time Factors | Barbiturates - pharmacology | Brain - pathology | Neuroprotective Agents - adverse effects | Ketamine - pharmacology | Anesthetics - adverse effects
Journal Article
Psychopharmacology, ISSN 0033-3158, 1/2014, Volume 231, Issue 1, pp. 181 - 190
Neuroactive steroids and benzodiazepines can positively modulate GABA by acting at distinct binding sites on synaptic GABAA receptors. Although these receptors...
Drug discrimination | Neurosciences | Biomedicine | Pharmacology/Toxicology | Psychiatry | Pregnanolone | Benzodiazepines | Rhesus monkeys | DIAZEPAM | PSYCHIATRY | NEUROSTEROIDS | RATS | ANTAGONISM | NEUROSCIENCES | GABA(A) RECEPTOR SUBTYPES | NEUROACTIVE STEROID PREGNANOLONE | AMINOBUTYRIC ACID(A) MODULATORS | ANTICONVULSANT TOLERANCE | PHARMACOLOGY & PHARMACY | MIDAZOLAM | Data Interpretation, Statistical | Gonadal Steroid Hormones - pharmacology | Male | Excitatory Amino Acid Antagonists - pharmacology | Macaca mulatta | Dose-Response Relationship, Drug | Isoxazoles - pharmacology | Flumazenil - pharmacology | Reinforcement Schedule | Animals | Pregnanolone - pharmacology | Conditioning, Operant - drug effects | GABA Modulators - pharmacology | Receptors, GABA-A - drug effects | Discrimination (Psychology) - drug effects | Hypnotics and Sedatives - pharmacology | Dizocilpine Maleate - pharmacology | Midazolam - pharmacology | Flunitrazepam - pharmacology | Complications and side effects | Rhesus monkey | Receptors | Physiological aspects | GABA | Dosage and administration | Genetic aspects | Research | Psychotropic drugs | Stimulants | Animal behavior | Monkeys & apes | Psychopharmacology | Barbiturates | benzodiazepines | rhesus monkeys | drug discrimination | pregnanolone
Drug discrimination | Neurosciences | Biomedicine | Pharmacology/Toxicology | Psychiatry | Pregnanolone | Benzodiazepines | Rhesus monkeys | DIAZEPAM | PSYCHIATRY | NEUROSTEROIDS | RATS | ANTAGONISM | NEUROSCIENCES | GABA(A) RECEPTOR SUBTYPES | NEUROACTIVE STEROID PREGNANOLONE | AMINOBUTYRIC ACID(A) MODULATORS | ANTICONVULSANT TOLERANCE | PHARMACOLOGY & PHARMACY | MIDAZOLAM | Data Interpretation, Statistical | Gonadal Steroid Hormones - pharmacology | Male | Excitatory Amino Acid Antagonists - pharmacology | Macaca mulatta | Dose-Response Relationship, Drug | Isoxazoles - pharmacology | Flumazenil - pharmacology | Reinforcement Schedule | Animals | Pregnanolone - pharmacology | Conditioning, Operant - drug effects | GABA Modulators - pharmacology | Receptors, GABA-A - drug effects | Discrimination (Psychology) - drug effects | Hypnotics and Sedatives - pharmacology | Dizocilpine Maleate - pharmacology | Midazolam - pharmacology | Flunitrazepam - pharmacology | Complications and side effects | Rhesus monkey | Receptors | Physiological aspects | GABA | Dosage and administration | Genetic aspects | Research | Psychotropic drugs | Stimulants | Animal behavior | Monkeys & apes | Psychopharmacology | Barbiturates | benzodiazepines | rhesus monkeys | drug discrimination | pregnanolone
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 01/2015, Volume 59, Issue 1, pp. 467 - 474
AZD0914 is a new spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor with potent in vitro antibacterial activity against key Gram-positive...
GYRB MUTATIONS | RESISTANT | GRLA | CEFTRIAXONE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | Microbial Sensitivity Tests | Gram-Negative Bacteria - drug effects | Nucleic Acid Synthesis Inhibitors - pharmacology | Barbiturates - pharmacology | Gram-Positive Bacteria - drug effects | Atypical Bacterial Forms - drug effects | DNA Gyrase - drug effects | Fluoroquinolones - pharmacology | Drug Resistance, Bacterial | Anti-Bacterial Agents - pharmacology | Topoisomerase II Inhibitors - pharmacology | Spiro Compounds - pharmacology | Susceptibility
GYRB MUTATIONS | RESISTANT | GRLA | CEFTRIAXONE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | Microbial Sensitivity Tests | Gram-Negative Bacteria - drug effects | Nucleic Acid Synthesis Inhibitors - pharmacology | Barbiturates - pharmacology | Gram-Positive Bacteria - drug effects | Atypical Bacterial Forms - drug effects | DNA Gyrase - drug effects | Fluoroquinolones - pharmacology | Drug Resistance, Bacterial | Anti-Bacterial Agents - pharmacology | Topoisomerase II Inhibitors - pharmacology | Spiro Compounds - pharmacology | Susceptibility
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 01/2016, Volume 60, Issue 1, pp. 621 - 623
We tested the activity of ETX0914 against 187 Neisseria gonorrhoeae isolates from men with urethritis in Nanjing, China, in 2013. The MIC50, MIC90, and MIC...
GUANGZHOU | SWEDEN | CEFTRIAXONE TREATMENT | CEFIXIME | SUSCEPTIBILITY | PHARYNGEAL GONORRHEA | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | IN-VITRO ACTIVITY | TREATMENT FAILURE | Gene Expression | Gonorrhea - microbiology | Neisseria gonorrhoeae - drug effects | Humans | Tetracycline - pharmacology | Urethritis - microbiology | Ciprofloxacin - pharmacology | Ceftriaxone - pharmacology | Male | Topoisomerase II Inhibitors - pharmacology | Neisseria gonorrhoeae - enzymology | Azithromycin - pharmacology | Microbial Sensitivity Tests | DNA Gyrase - metabolism | Neisseria gonorrhoeae - isolation & purification | DNA Gyrase - genetics | Barbiturates - pharmacology | Anti-Bacterial Agents - pharmacology | Drug Resistance, Multiple, Bacterial - genetics | Neisseria gonorrhoeae - genetics | Drug Resistance, Multiple, Bacterial - drug effects | Spiro Compounds - pharmacology
GUANGZHOU | SWEDEN | CEFTRIAXONE TREATMENT | CEFIXIME | SUSCEPTIBILITY | PHARYNGEAL GONORRHEA | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | IN-VITRO ACTIVITY | TREATMENT FAILURE | Gene Expression | Gonorrhea - microbiology | Neisseria gonorrhoeae - drug effects | Humans | Tetracycline - pharmacology | Urethritis - microbiology | Ciprofloxacin - pharmacology | Ceftriaxone - pharmacology | Male | Topoisomerase II Inhibitors - pharmacology | Neisseria gonorrhoeae - enzymology | Azithromycin - pharmacology | Microbial Sensitivity Tests | DNA Gyrase - metabolism | Neisseria gonorrhoeae - isolation & purification | DNA Gyrase - genetics | Barbiturates - pharmacology | Anti-Bacterial Agents - pharmacology | Drug Resistance, Multiple, Bacterial - genetics | Neisseria gonorrhoeae - genetics | Drug Resistance, Multiple, Bacterial - drug effects | Spiro Compounds - pharmacology
Journal Article
Neuropharmacology, ISSN 0028-3908, 2010, Volume 58, Issue 2, pp. 357 - 364
Previous reports suggest that γ-aminobutyric acid type A (GABA ) receptors containing α1 subunits may play a pivotal role in mediating the discriminative...
Discriminative stimulus | Squirrel monkey | L-838,417 | GABAA receptor | Subjective effects | Benzodiazepine | SQUIRREL-MONKEYS | EFFICACY | RHESUS-MONKEYS | ANTAGONISM | TRIAZOLAM | NEUROSCIENCES | DRUG DISCRIMINATION | ZOLPIDEM | BENZODIAZEPINE SITE LIGANDS | ABUSE | PHARMACOLOGY & PHARMACY | SELECTIVITY | Triazoles - administration & dosage | Catheterization | GABA Modulators - administration & dosage | Saimiri | Fluorobenzenes - administration & dosage | Diazepam - pharmacology | GABA Antagonists - pharmacology | Central Nervous System Depressants - pharmacology | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Neuropsychological Tests | Triazoles - pharmacology | Flumazenil - pharmacology | Ethanol - pharmacology | Animals | Barbiturates - pharmacology | GABA Agonists - pharmacology | GABA Modulators - pharmacology | Discrimination (Psychology) - drug effects | Pyridines - pharmacology | Receptors, GABA-A - metabolism | Carbolines - pharmacology
Discriminative stimulus | Squirrel monkey | L-838,417 | GABAA receptor | Subjective effects | Benzodiazepine | SQUIRREL-MONKEYS | EFFICACY | RHESUS-MONKEYS | ANTAGONISM | TRIAZOLAM | NEUROSCIENCES | DRUG DISCRIMINATION | ZOLPIDEM | BENZODIAZEPINE SITE LIGANDS | ABUSE | PHARMACOLOGY & PHARMACY | SELECTIVITY | Triazoles - administration & dosage | Catheterization | GABA Modulators - administration & dosage | Saimiri | Fluorobenzenes - administration & dosage | Diazepam - pharmacology | GABA Antagonists - pharmacology | Central Nervous System Depressants - pharmacology | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Neuropsychological Tests | Triazoles - pharmacology | Flumazenil - pharmacology | Ethanol - pharmacology | Animals | Barbiturates - pharmacology | GABA Agonists - pharmacology | GABA Modulators - pharmacology | Discrimination (Psychology) - drug effects | Pyridines - pharmacology | Receptors, GABA-A - metabolism | Carbolines - pharmacology
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2014, Volume 58, Issue 12, pp. 7595 - 7596
The in vitro activities of AZD0914, levofloxacin, azithromycin, and doxycycline against 10 isolates each of Chlamydia trachomatis and Chlamydia pneumoniae were...
MICROBIOLOGY | PHARMACOLOGY & PHARMACY | COMMUNITY-ACQUIRED PNEUMONIA | EFFICACY | Chlamydophila pneumoniae - drug effects | Topoisomerase II Inhibitors - pharmacology | Chlamydophila pneumoniae - growth & development | Levofloxacin - pharmacology | Chlamydophila pneumoniae - enzymology | Azithromycin - pharmacology | Chlamydia trachomatis - growth & development | Microbial Sensitivity Tests | DNA Gyrase - metabolism | Barbiturates - pharmacology | Doxycycline - pharmacology | Anti-Bacterial Agents - pharmacology | Chlamydia trachomatis - drug effects | Chlamydia trachomatis - enzymology | Spiro Compounds - pharmacology | Susceptibility
MICROBIOLOGY | PHARMACOLOGY & PHARMACY | COMMUNITY-ACQUIRED PNEUMONIA | EFFICACY | Chlamydophila pneumoniae - drug effects | Topoisomerase II Inhibitors - pharmacology | Chlamydophila pneumoniae - growth & development | Levofloxacin - pharmacology | Chlamydophila pneumoniae - enzymology | Azithromycin - pharmacology | Chlamydia trachomatis - growth & development | Microbial Sensitivity Tests | DNA Gyrase - metabolism | Barbiturates - pharmacology | Doxycycline - pharmacology | Anti-Bacterial Agents - pharmacology | Chlamydia trachomatis - drug effects | Chlamydia trachomatis - enzymology | Spiro Compounds - pharmacology | Susceptibility
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2010, Volume 285, Issue 12, pp. 8615 - 8620
Enhancement of gamma-aminobutyric acid type A receptor (GABA(A)R)-mediated inhibition is a property of most general anesthetics and a candidate for a molecular...
GLYCINE RECEPTORS | ALCOHOL | SUBTYPES | ISOFLURANE | PHARMACOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SITES | GATED ION CHANNELS | ACETYLCHOLINE-RECEPTOR | MODULATION | PROPOFOL | Isoflurane - pharmacology | Humans | Propofol - pharmacology | Octanols - pharmacology | Receptors, GABA-A - chemistry | Dose-Response Relationship, Drug | Anesthetics, General | Ethanol - pharmacology | Animals | Barbiturates - pharmacology | Cattle | Allosteric Site | Etomidate - pharmacology | Protein Binding | Binding Sites | Membrane Proteins | Protein Structure and Folding | Ethanol | Protein Drug Interactions | Protein Domains | GABA Receptors | Protein Conformation | Propofol | Barbiturates | Etomidate | Isoflurane
GLYCINE RECEPTORS | ALCOHOL | SUBTYPES | ISOFLURANE | PHARMACOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SITES | GATED ION CHANNELS | ACETYLCHOLINE-RECEPTOR | MODULATION | PROPOFOL | Isoflurane - pharmacology | Humans | Propofol - pharmacology | Octanols - pharmacology | Receptors, GABA-A - chemistry | Dose-Response Relationship, Drug | Anesthetics, General | Ethanol - pharmacology | Animals | Barbiturates - pharmacology | Cattle | Allosteric Site | Etomidate - pharmacology | Protein Binding | Binding Sites | Membrane Proteins | Protein Structure and Folding | Ethanol | Protein Drug Interactions | Protein Domains | GABA Receptors | Protein Conformation | Propofol | Barbiturates | Etomidate | Isoflurane
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 1996, Volume 69, Issue 3, pp. 173 - 198
γ-Aminobutyric acid (GABA) receptors for the inhibitory neurotransmitter GABA are likely to be found on most, if not all, neurons in the brain and spinal cord....
Neuroactive steroids | Barbiturates | GABA receptors | Benzodiazepines | Bicuculline | Receptors, GABA - classification | Receptors, GABA - physiology | Humans | GABA Agonists - pharmacology | GABA Antagonists - pharmacology
Neuroactive steroids | Barbiturates | GABA receptors | Benzodiazepines | Bicuculline | Receptors, GABA - classification | Receptors, GABA - physiology | Humans | GABA Agonists - pharmacology | GABA Antagonists - pharmacology
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 06/2015, Volume 59, Issue 6, pp. 3627 - 3629
In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against...
RESISTANCE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | DNA GYRASE INHIBITOR | Microbial Sensitivity Tests | Mycoplasma pneumoniae - drug effects | Barbiturates - pharmacology | Humans | Doxycycline - pharmacology | Anti-Bacterial Agents - pharmacology | Ureaplasma - drug effects | Levofloxacin - pharmacology | Mycoplasma genitalium - drug effects | Mycoplasma - drug effects | Spiro Compounds - pharmacology | Azithromycin - pharmacology | Susceptibility
RESISTANCE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | DNA GYRASE INHIBITOR | Microbial Sensitivity Tests | Mycoplasma pneumoniae - drug effects | Barbiturates - pharmacology | Humans | Doxycycline - pharmacology | Anti-Bacterial Agents - pharmacology | Ureaplasma - drug effects | Levofloxacin - pharmacology | Mycoplasma genitalium - drug effects | Mycoplasma - drug effects | Spiro Compounds - pharmacology | Azithromycin - pharmacology | Susceptibility
Journal Article
Current topics in medicinal chemistry, ISSN 1568-0266, 2002, Volume 2, Issue 8, pp. 903 - 913
GABA(C) receptors belong to the nicotinicoid superfamily of ionotropic receptors that include nicotinic acetylcholine receptors, bicuculline-sensitive GABA(A)...
Muscimol - pharmacology | Amino Acids, Cyclic - pharmacology | Receptors, GABA - genetics | Crotonates - pharmacology | Imidazoles - pharmacology | GABA Antagonists - pharmacology | Isoxazoles - pharmacology | Animals | Barbiturates - pharmacology | Phosphinic Acids - pharmacology | Receptors, GABA-A - genetics | GABA Agonists - pharmacology | Receptors, GABA-A - drug effects | Organophosphorus Compounds - pharmacology | Pyridines - pharmacology | Receptors, GABA - drug effects
Muscimol - pharmacology | Amino Acids, Cyclic - pharmacology | Receptors, GABA - genetics | Crotonates - pharmacology | Imidazoles - pharmacology | GABA Antagonists - pharmacology | Isoxazoles - pharmacology | Animals | Barbiturates - pharmacology | Phosphinic Acids - pharmacology | Receptors, GABA-A - genetics | GABA Agonists - pharmacology | Receptors, GABA-A - drug effects | Organophosphorus Compounds - pharmacology | Pyridines - pharmacology | Receptors, GABA - drug effects
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 04/2017, Volume 174, Issue 7, pp. 512 - 524
Background and Purpose Matrix metalloproteinase‐9 (MMP‐9) is up‐regulated in ulcerative colitis and implicated in the pathology of the disease. In this study,...
COLON-CANCER | CROHNS-DISEASE | CONCISE GUIDE | PHARMACOLOGY | ULCERATIVE-COLITIS | RECEPTOR | PHARMACOLOGY & PHARMACY | PHOSPHOLIPASE A | MICE | EXPRESSION | BOWEL-DISEASE | Dextran Sulfate - pharmacology | Inflammation - pathology | Rats, Wistar | Colitis - genetics | Enzyme Inhibitors - pharmacology | Nitrates - pharmacology | Rats | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Nitrates - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Matrix Metalloproteinase 9 - metabolism | Animals | Barbiturates - pharmacology | Inflammation - drug therapy | Matrix Metalloproteinase 9 - genetics | Colitis - chemically induced | Enzyme Inhibitors - chemistry | Inflammation - genetics | Colitis - drug therapy | Dextran Sulfate - administration & dosage | Barbiturates - administration & dosage | Disease Models, Animal | Animal experimentation | Dextran | Nitric oxide | Analysis | Genes | Genetic research | Inflammation | Gene expression | Ulcerative colitis | Drugs | Inflammatory bowel disease | Colon | Rodents | Research Papers | Research Paper
COLON-CANCER | CROHNS-DISEASE | CONCISE GUIDE | PHARMACOLOGY | ULCERATIVE-COLITIS | RECEPTOR | PHARMACOLOGY & PHARMACY | PHOSPHOLIPASE A | MICE | EXPRESSION | BOWEL-DISEASE | Dextran Sulfate - pharmacology | Inflammation - pathology | Rats, Wistar | Colitis - genetics | Enzyme Inhibitors - pharmacology | Nitrates - pharmacology | Rats | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Nitrates - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Matrix Metalloproteinase 9 - metabolism | Animals | Barbiturates - pharmacology | Inflammation - drug therapy | Matrix Metalloproteinase 9 - genetics | Colitis - chemically induced | Enzyme Inhibitors - chemistry | Inflammation - genetics | Colitis - drug therapy | Dextran Sulfate - administration & dosage | Barbiturates - administration & dosage | Disease Models, Animal | Animal experimentation | Dextran | Nitric oxide | Analysis | Genes | Genetic research | Inflammation | Gene expression | Ulcerative colitis | Drugs | Inflammatory bowel disease | Colon | Rodents | Research Papers | Research Paper
Journal Article