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humans (341) 341
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basic helix-loop-helix leucine zipper transcription factors - metabolism (204) 204
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basic helix-loop-helix leucine zipper transcription factors - antagonists & inhibitors (38) 38
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autophagy (32) 32
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liver (28) 28
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Cancer Cell, ISSN 1535-6108, 11/2016, Volume 30, Issue 5, pp. 764 - 778
Journal Article
Diabetes, ISSN 0012-1797, 12/2015, Volume 64, Issue 12, pp. 4158 - 4170
Carbohydrate-responsive element-binding protein (ChREBP) is a glucose-sensing transcription factor required for glucose-stimulated proliferation of pancreatic... 
ACTIVATION | REPLICATION | GENE | METABOLISM | LIPOGENESIS | TRANSCRIPTION | ENDOCRINOLOGY & METABOLISM | ELEMENT-BINDING PROTEIN | INFUSION | EXPRESSION | ADIPOSE-TISSUE | Adipocytes, White - cytology | Up-Regulation | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - antagonists & inhibitors | Cell Proliferation | Alternative Splicing | Rats, Wistar | Humans | Insulin-Secreting Cells - metabolism | Protein Isoforms - metabolism | RNA Interference | Hyperglycemia - pathology | Adult | Electrophoretic Mobility Shift Assay | Insulin-Secreting Cells - cytology | Nuclear Proteins - genetics | Recombinant Proteins - metabolism | Cells, Cultured | Rats | Recombinant Proteins - chemistry | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | 3T3-L1 Cells | Hyperglycemia - metabolism | Transcription Factors - metabolism | Adipocytes, White - pathology | Animals | Hyperglycemia - blood | Nuclear Proteins - antagonists & inhibitors | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Cell Line, Tumor | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | HeLa Cells | Insulin-Secreting Cells - pathology | Adipocytes, White - metabolism | Cadaver | Protein Isoforms - antagonists & inhibitors | Protein Isoforms - genetics | Islet Studies
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2014, Volume 111, Issue 34, pp. 12556 - 12561
In a fluorescence polarization screen for the MYC-MAX interaction, we have identified a novel small-molecule inhibitor of MYC, KJ-Pyr-9, from a Kröhnke... 
Molecules | Cell culture techniques | Cell growth | Genes | Cell lines | Fibroblasts | Fluorescence | Signatures | Tumors | Cancer | Gene signature | Xenograft | Transcriptional control | Combinatorial library | Protein-protein interactions | TRANSFORMATION | MYC/MAX DIMERIZATION | DNA-BINDING | gene signature | MULTIDISCIPLINARY SCIENCES | C-MYC | TUMOR-CELLS | CANCER | protein-protein interactions | CHICKEN-EMBRYO FIBROBLASTS | transcriptional control | xenograft | SMALL-MOLECULE INHIBITORS | IN-VIVO | combinatorial library | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - antagonists & inhibitors | Pyridines - chemistry | Humans | Genes, myc | Pyrimidines - chemistry | Multiprotein Complexes - antagonists & inhibitors | Cell Transformation, Neoplastic - genetics | Female | Antineoplastic Agents - pharmacology | Drug Evaluation, Preclinical | Interferometry | Protein Interaction Domains and Motifs - drug effects | Cells, Cultured | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - chemistry | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Chick Embryo | Xenograft Model Antitumor Assays | Multiprotein Complexes - chemistry | Animals | Mice, Nude | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Pyridines - pharmacology | Cell Transformation, Neoplastic - drug effects | Fluorescence Polarization | Proto-Oncogene Proteins c-myc - chemistry | Transcription factors | Pyridine | Physiological aspects | Genetic research | Genetic aspects | Genetic transcription | Research | Oncogenes | protein–protein interactions | Biological Sciences
Journal Article
Experimental Cell Research, ISSN 0014-4827, 08/2014, Volume 326, Issue 1, pp. 22 - 35
Glioma contains abundant hypoxic regions which provide niches to promote the maintenance and expansion of glioma stem cells (GSCs), which are resistant to... 
MIR-210 | Glioma stem cells | Hypoxia | MNT | Radiosensitivity | C-MYC | PROLIFERATION | MICRORNA-210 | CELL BIOLOGY | LUNG-CANCER | IN-VITRO | GLIOBLASTOMA | ONCOLOGY | GENE-EXPRESSION | MALIGNANT GLIOMAS | PROMOTES | RNA, Small Interfering - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - antagonists & inhibitors | Cell Proliferation | Immunoprecipitation | MicroRNAs - antagonists & inhibitors | Reactive Oxygen Species - radiation effects | Humans | Brain Neoplasms - pathology | Glioma - radiotherapy | Immunoenzyme Techniques | Repressor Proteins - antagonists & inhibitors | Glioma - genetics | Flow Cytometry | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glioma - pathology | Neoplastic Stem Cells - pathology | Tumor Cells, Cultured | Brain Neoplasms - radiotherapy | Real-Time Polymerase Chain Reaction | Repressor Proteins - metabolism | Neoplastic Stem Cells - radiation effects | Basic Helix-Loop-Helix Transcription Factors - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | RNA, Messenger - genetics | Brain Neoplasms - genetics | Radiation Tolerance - genetics | Repressor Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Cell Cycle | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Fluorescent Antibody Technique | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | MicroRNAs - genetics | Apoptosis | Cell Movement | Lactates | RNA | Gene expression | Gliomas | Analysis | Stem cells | Oxygen
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2017, Volume 486, Issue 3, pp. 796 - 803
Jasmonic acid (JA) plays central roles in various events in plants, especially defence against pathogens and insects. The basic helix-loop-helix (bHLH)... 
RNA-sequencing | OsMYC2 | Jasmonic acid signaling | Specialized metabolite | Defense response | Rice | BIOCHEMISTRY & MOLECULAR BIOLOGY | SAKURANETIN | IDENTIFICATION | REPRESSORS | SYNTHASE | BIOPHYSICS | BIOSYNTHESIS | BACTERIAL-BLIGHT | KEY ENZYME | RESISTANCE | EXPRESSION | MYC2 | RNA, Small Interfering - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - antagonists & inhibitors | Oryza - metabolism | Oryza - genetics | Plant Proteins - antagonists & inhibitors | Gene Expression Regulation, Plant | Trans-Activators - genetics | Transcription, Genetic | Plant Proteins - metabolism | Disease Resistance - genetics | Gene Ontology | Signal Transduction | Molecular Sequence Annotation | Gene Silencing | Cyclopentanes - pharmacology | Oryza - drug effects | Oxylipins - metabolism | Plant Proteins - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Oxylipins - pharmacology | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Cyclopentanes - metabolism | Trans-Activators - metabolism | High-Throughput Nucleotide Sequencing | Metabolic Networks and Pathways - drug effects | Trans-Activators - antagonists & inhibitors | Plant Growth Regulators - pharmacology | RNA, Small Interfering - metabolism | Biotechnology | Metabolites | Genomics | Genetic research | Genetic aspects | Genetic transcription | Plants | DNA binding proteins | RNA sequencing | Phenylalanine | RNA | Analysis
Journal Article
Diabetes, ISSN 0012-1797, 03/2018, Volume 67, Issue 3, pp. 461 - 472
Journal Article
JOURNAL OF NUTRITION, ISSN 0022-3166, 10/2015, Volume 145, Issue 10, pp. 2273 - 2279
Background: Fructose induces nonalcoholic, fatty liver disease (NAFLD). Citrulline (Crt) may exert a beneficial effect on steatosis. Objective: We compared the... 
nonessential amino acids | LIPID-METABOLISM | PROTEIN | VISCERAL ADIPOSE-TISSUE | MUSCLE | fructose | PERITONEAL-MACROPHAGES | SUPPLEMENTATION | nonalcoholic fatty liver disease | IN-VITRO | NUTRITION & DIETETICS | INSULIN-RESISTANCE | ARGININE | DYSLIPIDEMIA | citrulline | steatosis | Fatty Acid Synthase, Type I - genetics | Amino Acids - blood | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - antagonists & inhibitors | Liver - enzymology | Ornithine - blood | Fructose - antagonists & inhibitors | Humans | Non-alcoholic Fatty Liver Disease - etiology | Male | Liver - physiopathology | Sterol Regulatory Element Binding Protein 1 - agonists | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - agonists | Sterol Regulatory Element Binding Protein 1 - metabolism | PPAR alpha - antagonists & inhibitors | Fructose - adverse effects | Liver - metabolism | Gene Expression Regulation | Insulin Resistance | PPAR alpha - genetics | Non-alcoholic Fatty Liver Disease - metabolism | Biomarkers - blood | Citrulline - therapeutic use | Non-alcoholic Fatty Liver Disease - physiopathology | Random Allocation | Fatty Acid Synthase, Type I - metabolism | Rats, Sprague-Dawley | Amino Acids - therapeutic use | Gene Expression Regulation, Enzymologic | Fatty Acid Synthase, Type I - chemistry | Algorithms | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Arginine - blood | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Non-alcoholic Fatty Liver Disease - prevention & control | Sterol Regulatory Element Binding Protein 1 - antagonists & inhibitors | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | PPAR alpha - agonists | PPAR alpha - metabolism | Dietary Supplements | Prevention | Fatty liver | Physiological aspects | Nutritional aspects | Amino acids | Citrulline | Research | Health aspects | Fructose
Journal Article
Acta Pharmacologica Sinica, ISSN 1671-4083, 09/2017, Volume 38, Issue 9, pp. 1305 - 1316
Transcription factor EB (TFEB) is a master regulator of autophagy activity and lysosomal biogenesis, but its role in autophagy-mediated cell survival and... 
Chemotherapy resistance | Transcription factor EB (TFEB) | HeLa cells | Autophagy | Doxorubicin | LoVo cells | 3-methyladenine | Apoptosis | ATG PROTEINS | autophagy | apoptosis | MECHANISMS | DRUG-RESISTANCE | CHEMISTRY, MULTIDISCIPLINARY | LYSOSOMAL BIOGENESIS | chemotherapy resistance | INHIBITION | BECLIN-1 | GENE | METABOLISM | transcription factor EB (TFEB) | PHARMACOLOGY & PHARMACY | doxorubicin | TUMORIGENESIS | Cell Survival - drug effects | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - antagonists & inhibitors | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Humans | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - analysis | Doxorubicin - chemistry | Structure-Activity Relationship | Autophagy - drug effects | Dose-Response Relationship, Drug | Antibiotics, Antineoplastic - chemistry | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | HeLa Cells | Tumor Cells, Cultured | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Drug Screening Assays, Antitumor | TOR protein | Translocation | Transcription factors | Cell survival | Deactivation | Toxicity | Chemoresistance | Cytotoxicity | Activation | In vitro testing | siRNA | Inactivation | Nuclear transport | Chemotherapy | Colon cancer | Ribonucleic acids | Cell death | Colon | Inhibition | Phagocytosis | Cancer | Hela cells | Original
Journal Article
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 03/2015, Volume 35, Issue 4, pp. 1289 - 1302
Background: Scavenger receptors including CD36 control the phagocytosis of oxidized low-density lipoprotein and play an important role in macrophage... 
Original Paper | β-catenin | TCF4 | CD36 | Wnt1 | PPAR-γ | beta-catenin | ACTIVATION | PHYSIOLOGY | LOW-DENSITY-LIPOPROTEIN | OXIDIZED LDL | PPAR-gamma | CELL BIOLOGY | IN-VITRO | SCAVENGER RECEPTOR | GENE | FOAM CELL-FORMATION | SIGNALING PATHWAY | DIFFERENTIATION | THROMBOSPONDIN | Paired Box Transcription Factors - chemistry | Wnt1 Protein - antagonists & inhibitors | Wnt1 Protein - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - antagonists & inhibitors | CD36 Antigens - genetics | Monocytes - cytology | Humans | Wnt1 Protein - metabolism | PPAR gamma - metabolism | CD36 Antigens - metabolism | Chromatin Immunoprecipitation | RNA Interference | Binding Sites | PPAR gamma - genetics | Promoter Regions, Genetic | PAX3 Transcription Factor | Transcription Factor 4 | Cells, Cultured | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Lipoproteins, LDL - pharmacology | Transcription Factors - antagonists & inhibitors | Macrophages - cytology | Transcription Factors - genetics | beta Catenin - metabolism | Transcription Factors - metabolism | Up-Regulation - drug effects | Macrophages - metabolism | PPAR gamma - antagonists & inhibitors | Cell Differentiation - drug effects | beta Catenin - antagonists & inhibitors | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Protein Binding | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Paired Box Transcription Factors - metabolism
Journal Article
Journal Article
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