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Nature, ISSN 0028-0836, 2016, Volume 539, Issue 7627, pp. 112 - 117
Clear cell renal cell carcinoma (ccRCC) is characterized by inactivation of the von Hippel-Lindau tumour suppressor gene (VHL)(1,2). Because no other gene is... 
HIF-2-ALPHA | INHIBITION | RNA | PAS-B DOMAIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TUMOR-SUPPRESSOR GENE | HIF2-ALPHA | HYPOXIA-INDUCIBLE FACTOR-2 | TRANSCRIPTION FACTOR | EXPRESSION | Sulfones - therapeutic use | Kidney Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Carcinoma, Renal Cell - genetics | Male | Kidney Neoplasms - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Molecular Targeted Therapy | Sulfones - pharmacology | Indans - therapeutic use | Erythropoietin - blood | Sunitinib | Basic Helix-Loop-Helix Transcription Factors - metabolism | Female | Indoles - pharmacology | Indans - administration & dosage | Carcinoma, Renal Cell - drug therapy | Pyrroles - therapeutic use | Binding Sites | Reproducibility of Results | Basic Helix-Loop-Helix Transcription Factors - genetics | Carcinoma, Renal Cell - pathology | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Mice, SCID | Xenograft Model Antitumor Assays | Carcinoma, Renal Cell - metabolism | Pyrroles - pharmacology | Animals | Cell Transformation, Neoplastic | Cell Line, Tumor | Erythropoietin - antagonists & inhibitors | Indoles - therapeutic use | Kidney Neoplasms - pathology | Mice, Inbred NOD | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Mice | Mutation | Kidney Neoplasms - drug therapy | Drug Resistance, Neoplasm - drug effects | Indans - pharmacology | Sulfones - administration & dosage | Physiological aspects | Molecular targeted therapy | Transcription factors | Carcinoma, Renal cell | Methods | kidney cancer | HIF-1β (F446L) | RCC | patient-derived xenograft | EPAS1 | HIF-2α (G323E) | renal cancer | ARNT
Journal Article
Nature, ISSN 0028-0836, 2016, Volume 539, Issue 7627, pp. 107 - 111
Journal Article
Nature, ISSN 0028-0836, 03/2014, Volume 507, Issue 7493, pp. 513 - 8
Journal Article
The Plant Cell, ISSN 1040-4651, 4/2012, Volume 24, Issue 4, pp. 1398 - 1419
Plants respond to shade-modulated light signals via phytochrome (phy)-induced adaptive changes, termed shade avoidance. To examine the roles of... 
Datasets | Hypocotyls | Phenotypes | Genes | Auxins | Gene expression regulation | Plants | Repression | Seedlings | Plant cells | AVOIDANCE-RESPONSE | SEED-GERMINATION | REGULATED GENE-EXPRESSION | RED-LIGHT | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHLOROPHYLL BIOSYNTHESIS | MEDIATED DEGRADATION | NEGATIVE REGULATOR | PLANT SCIENCES | CELL BIOLOGY | SIGNAL-TRANSDUCTION | CHLOROPLAST DEVELOPMENT | INTERACTING FACTOR-3 | Transcription, Genetic - drug effects | Arabidopsis - growth & development | Nucleotide Motifs - genetics | Transcription, Genetic - radiation effects | Gene Regulatory Networks - drug effects | Light Signal Transduction - radiation effects | Promoter Regions, Genetic - genetics | Seedlings - growth & development | Arabidopsis Proteins - metabolism | Arabidopsis - radiation effects | Basic Helix-Loop-Helix Transcription Factors - metabolism | Light Signal Transduction - drug effects | Light | Phytochrome - metabolism | Arabidopsis Proteins - genetics | Gene Expression Regulation, Plant - radiation effects | Arabidopsis - drug effects | Basic Helix-Loop-Helix Transcription Factors - genetics | Gene Regulatory Networks - genetics | Morphogenesis - radiation effects | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Seedlings - drug effects | Mutation - genetics | Arabidopsis - genetics | Gene Expression Regulation, Plant - drug effects | Phenotype | Genes, Plant - genetics | Indoleacetic Acids - pharmacology | Gene Regulatory Networks - radiation effects | Morphogenesis - drug effects | Seedlings - radiation effects | Seedlings - metabolism | Arabidopsis | Plant genetics | Phytochrome | Physiological aspects | Genetic aspects | Genetic transcription | Research
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 08/2016, Volume 164, pp. 152 - 169
Journal Article
Pharmacological Reviews, ISSN 0031-6997, 2015, Volume 67, Issue 2, pp. 259 - 279
Journal Article
Nature, ISSN 0028-0836, 10/2012, Volume 490, Issue 7418, pp. 116 - 120
Journal Article
CA Cancer Journal for Clinicians, ISSN 0007-9235, 07/2010, Volume 60, Issue 4, pp. 222 - 243
Angiogenesis has become an attractive target for drug therapy because of its key role in tumor growth. An extensive array of compounds is currently in... 
CELL LUNG-CANCER | TYROSINE KINASE INHIBITORS | PHASE-III TRIAL | FARNESYL-PROTEIN TRANSFERASE | HYPOXIA-INDUCIBLE FACTOR | SUPPRESSES TUMOR-GROWTH | ONCOLOGY | ENDOTHELIAL-GROWTH-FACTOR | FACTOR EXPRESSION | VASCULAR-PERMEABILITY FACTOR | METASTATIC COLORECTAL-CANCER | Neoplasms - metabolism | Nucleic Acid Synthesis Inhibitors - pharmacology | Humans | Receptor Protein-Tyrosine Kinases - physiology | Antibodies, Monoclonal - therapeutic use | Receptors, Notch - antagonists & inhibitors | Protein Binding - drug effects | Angiogenesis Inhibitors - therapeutic use | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Neovascularization, Pathologic - prevention & control | Farnesyltranstransferase - antagonists & inhibitors | Thioredoxins - antagonists & inhibitors | Nucleic Acid Synthesis Inhibitors - therapeutic use | Basic Helix-Loop-Helix Transcription Factors - physiology | Antibodies, Monoclonal - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Angiogenesis Inhibitors - pharmacology | Receptors, Notch - physiology | Neoplasms - blood supply | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Neoplasms - drug therapy | Signal Transduction - drug effects | Cell Transformation, Neoplastic | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - physiology | Complications and side effects | Care and treatment | Ligands (Biochemistry) | Physiological aspects | Development and progression | Dosage and administration | Angiogenesis inhibitors | Neovascularization | Identification and classification | Growth factors | Cancer | Angiogenesis | Pharmacology | FDA approval | Drug therapy | Kinases | Tumors | hypoxia inducible factor (HIF) | kinase inhibitors | growth factors | angiogenesis inhibitors | VEGF | anti-angiogenesis
Journal Article
Nature, ISSN 0028-0836, 01/2008, Volume 451, Issue 7177, pp. 475 - 479
Journal Article