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Neuro-Oncology, ISSN 1522-8517, 08/2009, Volume 11, Issue 4, pp. 368 - 380
Lactate dehydrogenase type A (LDH-A) is a key metabolic enzyme catalyzing pyruvate into lactate and is excessively expressed by tumor cells. Transforming... 
LDH-A | TGF-β2 | Glioma | Lactate | MMP-2 | glioma | lactate | Basic and Translational Investigations
Journal Article
Neuro-oncology, ISSN 1522-8517, 05/2019, Volume 21, Issue 10, pp. 1263 - 1272
Precision medicine trials targeting the epidermal growth factor receptor (EGFR) in glioblastoma patients require selection for EGFR-amplified tumors. However,... 
amplification | screening | glioblastoma | Basic and Translational Investigations | EGFRvIII | FISH | biomarker | EGFR
Journal Article
Neuro-Oncology, ISSN 1522-8517, 10/2019, Volume 21, Issue 10, pp. 1273 - 1283
Abstract Background Medical treatment in Cushing’s disease (CD) is limited due to poor understanding of its pathogenesis. Pathogenic variants of ubiquitin... 
driver mutations | genome sequencing | USP48 | Cushing’s disease | TP53 | Basic and Translational Investigations
Journal Article
Neuro-Oncology, ISSN 1522-8517, 08/2019, Volume 21, Issue 8, pp. 1005 - 1015
Abstract Background Spinal chordomas, a subtype of primary spinal column malignancies (PSCM), are rare tumors with poor prognosis, and we have limited... 
hTERT promoter mutation | chordoma | Basic and Translational Investigations | primary spinal column malignancy | survival
Journal Article
Journal Article
Neuro-Oncology, ISSN 1522-8517, 08/2017, Volume 19, Issue 8, pp. 1047 - 1057
Background. Despite a multiplicity of clinical trials testing immune checkpoint inhibitors, the frequency of expression of potential predictive biomarkers is... 
mutational load | glioma | mismatch repair | glioblastoma | immune checkpoint | CANCERS | SAFETY | LOAD | PD-1 BLOCKADE | OPEN-LABEL | CLINICAL NEUROLOGY | GLIOBLASTOMAS | PIK3CA GENE | ONCOLOGY | HIGH-FREQUENCY | MSH6 MUTATIONS | NIVOLUMAB | Basic and Translational Investigations
Journal Article
Neuro-Oncology, ISSN 1522-8517, 05/2018, Volume 20, Issue 6, pp. 764 - 775
Clinical trials of therapies directed against nodes of the signaling axis of phosphatidylinositol-3 kinase/Akt/mammalian target of rapamycin (mTOR) in... 
microtubule | GSK3B | MEK | glioblastoma | MAP1B | mTOR | tubulin | glioma | cancer | ERK | Basic and Translational Investigations
Journal Article
Neuro-Oncology, ISSN 1522-8517, 05/2018, Volume 20, Issue 6, pp. 799 - 809
Standard therapy for chordoma consists of surgical resection followed by high-dose irradiation. Protein phosphatase 2A (PP2A) is a ubiquitously expressed... 
PP2A | chordoma | LB100 | radiation therapy | Basic and Translational Investigations
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2017, Volume 19, Issue 11, pp. 1494 - 1502
Background. RNAs within extracellular vesicles (EVs) have potential as diagnostic biomarkers for patients with cancer and are identified in a variety of... 
Vesicle | EGFRvIII | Biomarker | Glioma | CSF | EFFICACY | RNA | SAFETY | BIOPSY | vesicle | MICROVESICLES | biomarker | CEREBROSPINAL-FLUID | MULTIFORME | CLINICAL NEUROLOGY | GROWTH-FACTOR RECEPTOR | ONCOLOGY | EXOSOMES | glioma | CONCURRENT | Basic and Translational Investigations
Journal Article
Neuro-Oncology, ISSN 1522-8517, 05/2018, Volume 20, Issue 6, pp. 788 - 798
Children with brain tumors treated with cranial radiation therapy (RT) often exhibit cognitive late effects, commonly associated with reduced white matter (WM)... 
brain development | neurogenesis | white matter | MRI | radiation | Basic and Translational Investigations
Journal Article
Journal Article
Journal Article
Neuro-Oncology, ISSN 1522-8517, 04/2013, Volume 15, Issue 4, pp. 433 - 441
BackgroundThe metabolic phenotype that derives disproportionate energy via glycolysis in solid tumors, including glioma, leads to elevated lactate labeling in... 
Dichloroacetate | Pyruvate | Bicarbonate | Hyperpolarized | Glioma | hyperpolarized 13C | glioma | dichloroacetate | bicarbonate | pyruvate | Basic and Translational Investigations
Journal Article
Neuro-oncology, ISSN 1522-8517, 08/2017, Volume 19, Issue 8, pp. 1088 - 1096
Skull base meningiomas are considered to be difficult for surgical treatment. We wondered whether genetic alterations recently identified in benign... 
meningioma | AKT1 | skull base | KLF4 | Basic and Translational Investigations
Journal Article