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Infection and Immunity, ISSN 0019-9567, 2015, Volume 83, Issue 12, pp. 4673 - 4681
The human skin exerts many functions in order to maintain its barrier integrity and protect the host from invading microorganisms. One such pathogen is... 
TOLL-LIKE-RECEPTORS | INFECTIOUS DISEASES | GROUP-A STREPTOCOCCUS | C-FOS | PHOSPHORYLATION | PYOGENES TRIGGERS | SURFACE-PROTEINS | GENE-EXPRESSION | IMMUNOLOGY | NF-KAPPA-B | CYSTEINE PROTEINASE | INNATE IMMUNITY | Interleukin-1 Receptor-Like 1 Protein | Interleukin-8 - genetics | Intramolecular Oxidoreductases - immunology | Interleukin-1alpha - immunology | Toll-Like Receptor 2 - genetics | Transcription Factor AP-1 - genetics | Humans | Macrophage Migration-Inhibitory Factors - immunology | Antigens, Bacterial - immunology | NF-kappa B - immunology | Transcription Factor AP-1 - immunology | Interleukin 1 Receptor Antagonist Protein - genetics | Intracellular Signaling Peptides and Proteins - immunology | Chemokine CXCL1 - genetics | Antigens, Bacterial - genetics | Signal Transduction - immunology | Macrophage Migration-Inhibitory Factors - genetics | Basigin - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Basigin - immunology | Interleukin-1alpha - genetics | Intracellular Signaling Peptides and Proteins - genetics | Keratinocytes - microbiology | Bacterial Outer Membrane Proteins - genetics | Carrier Proteins - immunology | Mitogen-Activated Protein Kinase 3 - immunology | Mitogen-Activated Protein Kinase 1 - immunology | Bacterial Outer Membrane Proteins - immunology | Interleukin 1 Receptor Antagonist Protein - immunology | Mitogen-Activated Protein Kinase 3 - genetics | Streptococcus pyogenes - immunology | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | p38 Mitogen-Activated Protein Kinases - immunology | Receptors, Cell Surface - immunology | Keratinocytes - immunology | Host-Pathogen Interactions | Carrier Proteins - genetics | Chemokine CXCL1 - immunology | Intramolecular Oxidoreductases - genetics | NF-kappa B - genetics | Toll-Like Receptor 2 - immunology | Interleukin-8 - immunology | Cell Line, Transformed | Receptors, Cell Surface - genetics | Index Medicus | Host Response and Inflammation
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 04/2017, Volume 268, pp. 129 - 135
Solasodine, a naturally occurring aglycone of glycoalkaloid in eggplant ( ), was found to inhibit proliferation in various tumor cells. However, the effect of... 
Matrix metalloproteinase | MicroRNA-21 | Cell invasion | Solasodine | Lung cancer | CARCINOMA-CELLS | MIGRATION | SIGNALING PATHWAYS | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | MATRIX METALLOPROTEINASES | COLORECTAL-CANCER | PHARMACOLOGY & PHARMACY | TOXICOLOGY | RECK | PROGRESSION | Lung Neoplasms - drug therapy | Matrix Metalloproteinases - genetics | Phosphorylation | Humans | MicroRNAs - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Tissue Inhibitor of Metalloproteinase-2 - genetics | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Matrix Metalloproteinase 9 - metabolism | Neoplasm Metastasis | Basigin - genetics | Matrix Metalloproteinase 9 - genetics | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | A549 Cells | Matrix Metalloproteinase 2 - metabolism | Neoplasm Invasiveness | Down-Regulation | Solanaceous Alkaloids - pharmacology | GPI-Linked Proteins - metabolism | Phosphatidylinositol 3-Kinases - genetics | Matrix Metalloproteinase 2 - genetics | Tissue Inhibitor of Metalloproteinase-1 - genetics | Basigin - metabolism | MicroRNAs - genetics | Matrix Metalloproteinases - metabolism | GPI-Linked Proteins - genetics | Cysteine | Metastasis | RNA | Health aspects | MicroRNA | Index Medicus
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 09/2013, Volume 1833, Issue 9, pp. 2045 - 2056
4F2hc is a type-II glycoprotein whose covalent-bound association with one of several described light chains yields a heterodimer mainly involved in large... 
HeLa cells | β-catenin | Matrix metalloproteinases | Galectin-3 | CD98hc | Integrin signaling | β-Catenin | Hela cells | beta-catenin | COLON ADENOCARCINOMA CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MATRIX METALLOPROTEINASE INDUCER | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | GENE-EXPRESSION | THERAPEUTIC TARGETS | EXTRACELLULAR-MATRIX | PROGNOSTIC MARKERS | ACTIVATED PROTEIN-KINASES | MONOCLONAL-ANTIBODIES | Neoplasm Transplantation | Humans | Galectin 3 - metabolism | Gene Expression Regulation, Neoplastic | Transplantation, Heterologous | Extracellular Signal-Regulated MAP Kinases - metabolism | Epithelial-Mesenchymal Transition - genetics | Extracellular Signal-Regulated MAP Kinases - genetics | Cell Movement - genetics | Proto-Oncogene Proteins c-akt - genetics | MAP Kinase Signaling System | Neoplasms, Experimental - pathology | Basigin - genetics | Proteolysis | Fusion Regulatory Protein 1, Heavy Chain - biosynthesis | Fusion Regulatory Protein 1, Heavy Chain - genetics | Neoplasms, Experimental - genetics | Proto-Oncogene Proteins c-akt - metabolism | Matrix Metalloproteinase 2 - biosynthesis | Neoplasm Invasiveness | Gene Silencing | Galectin 3 - genetics | beta Catenin - metabolism | beta Catenin - genetics | Gene Expression Regulation, Enzymologic | Integrin beta1 - metabolism | Proteasome Endopeptidase Complex - genetics | Matrix Metalloproteinase 2 - genetics | Animals | Mice, Nude | Basigin - metabolism | Mice | Mice, Inbred BALB C | HeLa Cells | Neoplasms, Experimental - metabolism | Proteasome Endopeptidase Complex - metabolism | Integrin beta1 - genetics
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2013, Volume 288, Issue 36, pp. 26089 - 26104
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, pp. e20164 - e20164
Background: Diosgenin, a steroidal saponin obtained from fenugreek (Trigonella foenum graecum), was found to exert anti-carcinogenic properties, such as... 
APOPTOSIS | SIGNALING PATHWAYS | ACTIVATION | METASTASIS | ANGIOGENESIS | COLORECTAL-CANCER | KINASE | BIOLOGY | CYCLE ARREST | OSTEOSARCOMA CELLS | PROGRESSION | Prostatic Neoplasms - metabolism | Humans | Immunoblotting | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Tissue Inhibitor of Metalloproteinase-2 - genetics | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 7 - metabolism | Basigin - genetics | Matrix Metalloproteinase 9 - genetics | Polymerase Chain Reaction | JNK Mitogen-Activated Protein Kinases - genetics | Phosphatidylinositol 3-Kinase - metabolism | Diosgenin - pharmacology | Matrix Metalloproteinase 2 - metabolism | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Matrix Metalloproteinase 7 - genetics | NF-kappa B - genetics | Phosphatidylinositol 3-Kinase - genetics | Basigin - metabolism | Cell Line, Tumor | Progesterone | Metastasis | Vascular endothelial growth factor | Health aspects | Prostate cancer | Apoptosis | Transcription factors | Boyden chamber | Matrix metalloproteinases | Leukocyte migration | AKT protein | Assaying | Metastases | Proteins | Angiogenesis | Cell growth | Gelatin | Inhibition | Enzymes | NF-κB protein | Medical technology | Wound healing | Gene expression | 1-Phosphatidylinositol 3-kinase | Pharmacy | Cell migration | Cell proliferation | Biotechnology | Tissue inhibitor of metalloproteinases | Phosphorylation | Colorectal cancer | Science | mRNA | Matrix metalloproteinase | Kinases | Cell adhesion & migration | Carcinogens | Cell cycle | Fenugreek | Metalloproteinase | Tumor cells | Extracellular signal-regulated kinase | c-Jun protein | Breast cancer | Endothelial cells | Gelatinase B | Gelatinase A | Signaling | Collagen | Prostate | Tumors | Cancer | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 10/2011, Volume 108, Issue 40, pp. 16663 - 16668
Malignant tumors exhibit increased dependence on glycolysis, resulting in abundant export of lactic acid, a hypothesized key step in tumorigenesis. Lactic acid... 
Embigin | EMMPRIN | Lactate transport | Cancer metabolism | Warburg effect | IMMUNOGLOBULIN SUPERFAMILY | MONOCARBOXYLATE TRANSPORTER 4 | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR PH | lactate transport | PLASMA-MEMBRANE | CANCER | cancer metabolism | PYRUVATE-KINASE | CARBONIC-ANHYDRASE IX | NA+/H+ ANTIPORT | INHIBITORS | CELL-METABOLISM | Immunohistochemistry | Humans | DNA Primers - genetics | Glycolysis - drug effects | Oxygen Consumption - physiology | Protein Subunits - metabolism | Uracil - pharmacology | Monocarboxylic Acid Transporters - antagonists & inhibitors | Monocarboxylic Acid Transporters - metabolism | Flow Cytometry | Basigin - genetics | Cell Transformation, Neoplastic - genetics | Symporters - antagonists & inhibitors | Muscle Proteins - metabolism | Protein Subunits - genetics | Lactic Acid - metabolism | Gene Silencing | Thiophenes - pharmacology | Gene Knockout Techniques | Symporters - metabolism | Muscle Proteins - genetics | Symporters - genetics | Fluorescent Antibody Technique | Basigin - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Cell Transformation, Neoplastic - drug effects | Monocarboxylic Acid Transporters - genetics | Uracil - analogs & derivatives | Proteins | Hypoxia | Cell growth | Cells | Tumors | Index Medicus | Protein Subunits | Cell Proliferation | Lactic Acid | Oxygen Consumption | DNA Primers | Life Sciences | Muscle Proteins | Monocarboxylic Acid Transporters | Thiophenes | Cell Transformation, Neoplastic | Symporters | Glycolysis | Development Biology | Antigens, CD147 | Uracil | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, pp. e0166715 - e0166715
The Rac1 GTPase plays key roles in cytoskeletal organization, cell motility and a variety of physiological and disease-linked responses. Wild type Rac1... 
CORONIN 1A | SIGNAL-TRANSDUCTION | G-BETA-GAMMA | ACTIVATION | DISSOCIATION | CELL-MIGRATION | MULTIDISCIPLINARY SCIENCES | LIPID RAFTS | SMALL GTPASE RAC | INTEGRIN-ASSOCIATED PROTEIN | PLASMA-MEMBRANE | rho Guanine Nucleotide Dissociation Inhibitor alpha - genetics | RNA, Small Interfering - genetics | Cell Fractionation | Membrane Glycoproteins - metabolism | Humans | Actins - metabolism | rho Guanine Nucleotide Dissociation Inhibitor alpha - metabolism | Cercopithecus aethiops | Green Fluorescent Proteins - genetics | Actins - genetics | Basigin - genetics | HEK293 Cells | Cell Membrane - metabolism | Microfilament Proteins - metabolism | Microfilament Proteins - genetics | Genes, Reporter | Green Fluorescent Proteins - metabolism | Signal Transduction | Gene Expression Regulation | Caveolin 1 - genetics | Membrane Glycoproteins - genetics | Protein Transport | Caveolin 1 - metabolism | Proteins - genetics | Animals | Proteins - metabolism | Basigin - metabolism | HeLa Cells | COS Cells | rac1 GTP-Binding Protein - metabolism | RNA, Small Interfering - metabolism | rac1 GTP-Binding Protein - genetics | Muscle proteins | Protein binding | Biotechnology | Membranes | Regulators | Phosphorylation | Laboratories | Lipids | Activation | Biochemistry | Feedback loops | CD147 antigen | Kinases | Cell adhesion & migration | Proteins | Signal transduction | Actin | Cascades | Polyclonal antibodies | Binding | Translocation | Caveolin | Cloning | Rac1 protein | Signaling | Molecular modelling | Internalization | Cytoskeleton | Molecular biology | Guanosinetriphosphatase | Index Medicus
Journal Article
Reproductive biology and endocrinology : RB&E, ISSN 1477-7827, 11/2018, Volume 16, Issue 1, pp. 116 - 116
BackgroundMatrix metalloproteinases (Mmps) and their tissue inhibitors (Timps) are widely recognized as crucial factors for extracellular matrix remodeling in... 
Extracellular matrix | Sparc | Folliculogenesis | Reck | Mmps system | Ovary remodeling | GRANULOSA-CELLS | PHYSIOLOGICAL SIGNALS | TISSUE INHIBITORS | HORMONAL-REGULATION | INDUCED OVULATION | SECRETED PROTEIN | REPRODUCTIVE BIOLOGY | MESSENGER-RIBONUCLEIC-ACID | FOLLICULAR DEVELOPMENT | ENDOCRINOLOGY & METABOLISM | EXTRACELLULAR-MATRIX | CORPUS-LUTEUM | Matrix Metalloproteinases - genetics | Ovulation - genetics | Tumor Suppressor Proteins - metabolism | Sexual Maturation - genetics | Osteonectin - metabolism | Gene Expression Profiling | Blood Proteins - metabolism | Rats, Sprague-Dawley | GPI-Linked Proteins - metabolism | Tissue Inhibitor of Metalloproteinases - metabolism | Tissue Inhibitor of Metalloproteinases - genetics | Animals | Osteonectin - genetics | Estrous Cycle - genetics | Time Factors | Basigin - genetics | Blood Proteins - genetics | Tumor Suppressor Proteins - genetics | Basigin - metabolism | Female | Matrix Metalloproteinases - metabolism | GPI-Linked Proteins - genetics | Ovary - metabolism | Physiological aspects | Genetic aspects | Research | Ovaries | Menstrual cycle | Proteases | Immunohistochemistry | Estrus | Immunomodulation | Homeostasis | Tissue inhibitor of metalloproteinase 2 | CD147 antigen | Estrus cycle | Matrix metalloproteinase | Gene expression | Ovulation | Gelatinase B | Ovarian cancer | Gelatinase A | Proteins | Cattle | Rodents | Osteonectin | Corpus luteum | Protein expression | Metalloproteinase | Cancer | Index Medicus
Journal Article
Oncology Reports, ISSN 1021-335X, 4/2015, Volume 33, Issue 4, pp. 2045 - 2051
Gastric cancer cell are not particularly sensitive to Ara-C, a deoxycytidine analog that affects DNA synthesis. In the present study, AGS and MKN-45 gastric... 
CD-147 | MMP-2 | proliferation | invasion | gastric cancer cell | MMP-9 | Ara-C | Proliferation | Invasion | Gastric cancer cell | CHEMOTHERAPY | RESISTANT | MEK | ONCOLOGY | PROSTATE-CANCER | INHIBITORS | CD147 | RNA, Small Interfering - genetics | Cytarabine - pharmacology | Nitriles - pharmacology | Humans | Cell Movement - genetics | MAP Kinase Signaling System - genetics | Basigin - genetics | Matrix Metalloproteinase 9 - genetics | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Stomach Neoplasms - genetics | Butadienes - pharmacology | Cell Proliferation - genetics | Jurkat Cells | RNA, Messenger - genetics | Up-Regulation - genetics | Signal Transduction - genetics | Stomach Neoplasms - drug therapy | Up-Regulation - drug effects | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Neoplasm Invasiveness - genetics | Cell proliferation | Complications and side effects | Cytarabine | Oncology, Experimental | Research | Drug therapy | Stomach cancer | Cancer | Proteins | Cell growth | Chemotherapy | Medical prognosis | Metastasis | Cancer therapies | Deoxyribonucleic acid--DNA | Cell adhesion & migration | Index Medicus
Journal Article