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Infection and immunity, ISSN 0019-9567, 2015, Volume 83, Issue 12, pp. 4673 - 4681
The human skin exerts many functions in order to maintain its barrier integrity and protect the host from invading microorganisms. One such pathogen is... 
Infectious Diseases | Immunology | Life Sciences & Biomedicine | Science & Technology | Interleukin-1 Receptor-Like 1 Protein | Interleukin-8 - genetics | Intramolecular Oxidoreductases - immunology | Interleukin-1alpha - immunology | Toll-Like Receptor 2 - genetics | Transcription Factor AP-1 - genetics | Humans | Macrophage Migration-Inhibitory Factors - immunology | Antigens, Bacterial - immunology | NF-kappa B - immunology | Transcription Factor AP-1 - immunology | Interleukin 1 Receptor Antagonist Protein - genetics | Intracellular Signaling Peptides and Proteins - immunology | Chemokine CXCL1 - genetics | Antigens, Bacterial - genetics | Signal Transduction - immunology | Macrophage Migration-Inhibitory Factors - genetics | Basigin - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Basigin - immunology | Interleukin-1alpha - genetics | Intracellular Signaling Peptides and Proteins - genetics | Keratinocytes - microbiology | Bacterial Outer Membrane Proteins - genetics | Carrier Proteins - immunology | Mitogen-Activated Protein Kinase 3 - immunology | Mitogen-Activated Protein Kinase 1 - immunology | Bacterial Outer Membrane Proteins - immunology | Interleukin 1 Receptor Antagonist Protein - immunology | Mitogen-Activated Protein Kinase 3 - genetics | Streptococcus pyogenes - immunology | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | p38 Mitogen-Activated Protein Kinases - immunology | Receptors, Cell Surface - immunology | Keratinocytes - immunology | Host-Pathogen Interactions | Carrier Proteins - genetics | Chemokine CXCL1 - immunology | Intramolecular Oxidoreductases - genetics | NF-kappa B - genetics | Toll-Like Receptor 2 - immunology | Interleukin-8 - immunology | Cell Line, Transformed | Receptors, Cell Surface - genetics | Index Medicus | Host Response and Inflammation
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 5, pp. e20164 - e20164
Background: Diosgenin, a steroidal saponin obtained from fenugreek (Trigonella foenum graecum), was found to exert anti-carcinogenic properties, such as... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Prostatic Neoplasms - metabolism | Humans | Immunoblotting | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Tissue Inhibitor of Metalloproteinase-2 - genetics | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 7 - metabolism | Basigin - genetics | Matrix Metalloproteinase 9 - genetics | Polymerase Chain Reaction | JNK Mitogen-Activated Protein Kinases - genetics | Phosphatidylinositol 3-Kinase - metabolism | Diosgenin - pharmacology | Matrix Metalloproteinase 2 - metabolism | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Matrix Metalloproteinase 7 - genetics | NF-kappa B - genetics | Phosphatidylinositol 3-Kinase - genetics | Basigin - metabolism | Cell Line, Tumor | Progesterone | Metastasis | Vascular endothelial growth factor | Health aspects | Prostate cancer | Apoptosis | Transcription factors | Boyden chamber | Matrix metalloproteinases | Leukocyte migration | AKT protein | Assaying | Metastases | Proteins | Angiogenesis | Cell growth | Gelatin | Inhibition | Enzymes | NF-κB protein | Medical technology | Wound healing | Gene expression | 1-Phosphatidylinositol 3-kinase | Pharmacy | Cell migration | Cell proliferation | Biotechnology | Tissue inhibitor of metalloproteinases | Phosphorylation | Colorectal cancer | Science | mRNA | Matrix metalloproteinase | Kinases | Cell adhesion & migration | Carcinogens | Cell cycle | Fenugreek | Metalloproteinase | Tumor cells | Extracellular signal-regulated kinase | c-Jun protein | Breast cancer | Endothelial cells | Gelatinase B | Gelatinase A | Signaling | Collagen | Prostate | Tumors | Cancer | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, pp. e0166715 - e0166715
The Rac1 GTPase plays key roles in cytoskeletal organization, cell motility and a variety of physiological and disease-linked responses. Wild type Rac1... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | rho Guanine Nucleotide Dissociation Inhibitor alpha - genetics | RNA, Small Interfering - genetics | Cell Fractionation | Membrane Glycoproteins - metabolism | Humans | Actins - metabolism | rho Guanine Nucleotide Dissociation Inhibitor alpha - metabolism | Cercopithecus aethiops | Green Fluorescent Proteins - genetics | Actins - genetics | Basigin - genetics | HEK293 Cells | Cell Membrane - metabolism | Microfilament Proteins - metabolism | Microfilament Proteins - genetics | Genes, Reporter | Green Fluorescent Proteins - metabolism | Signal Transduction | Gene Expression Regulation | Caveolin 1 - genetics | Membrane Glycoproteins - genetics | Protein Transport | Caveolin 1 - metabolism | Proteins - genetics | Animals | Proteins - metabolism | Basigin - metabolism | HeLa Cells | COS Cells | rac1 GTP-Binding Protein - metabolism | RNA, Small Interfering - metabolism | rac1 GTP-Binding Protein - genetics | Muscle proteins | Protein binding | Biotechnology | Membranes | Regulators | Phosphorylation | Laboratories | Lipids | Activation | Biochemistry | Feedback loops | CD147 antigen | Kinases | Cell adhesion & migration | Proteins | Signal transduction | Actin | Cascades | Dissociation | Polyclonal antibodies | Binding | Translocation | Caveolin | Cloning | Rac1 protein | Guanosine triphosphatases | Signaling | Molecular modelling | Internalization | Cytoskeleton | Molecular biology | Index Medicus | Guanosinetriphosphatase
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 09/2011, Volume 108, Issue 40, pp. 16663 - 16668
Malignant tumors exhibit increased dependence on glycolysis, resulting in abundant export of lactic acid, a hypothesized key step in tumorigenesis. Lactic acid... 
Embigin | EMMPRIN | Lactate transport | Cancer metabolism | Warburg effect | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Immunohistochemistry | Humans | DNA Primers - genetics | Glycolysis - drug effects | Oxygen Consumption - physiology | Protein Subunits - metabolism | Uracil - pharmacology | Monocarboxylic Acid Transporters - antagonists & inhibitors | Monocarboxylic Acid Transporters - metabolism | Flow Cytometry | Basigin - genetics | Cell Transformation, Neoplastic - genetics | Symporters - antagonists & inhibitors | Muscle Proteins - metabolism | Protein Subunits - genetics | Lactic Acid - metabolism | Gene Silencing | Thiophenes - pharmacology | Gene Knockout Techniques | Symporters - metabolism | Muscle Proteins - genetics | Symporters - genetics | Fluorescent Antibody Technique | Basigin - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Cell Transformation, Neoplastic - drug effects | Monocarboxylic Acid Transporters - genetics | Uracil - analogs & derivatives | Index Medicus | Protein Subunits | Cell Proliferation | Lactic Acid | Oxygen Consumption | DNA Primers | Life Sciences | Muscle Proteins | Monocarboxylic Acid Transporters | Thiophenes | Cell Transformation, Neoplastic | Symporters | Glycolysis | Development Biology | Antigens, CD147 | Uracil | cancer metabolism | Biological Sciences | lactate transport
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 5, pp. 5613 - 5629
The acquisition of inappropriate migratory feature is crucial for tumor metastasis. It has been suggested that CD147 and Annexin A2 are involved in regulating... 
WAVE2 | Cell movement | DOCK3 | Annexin A2 | CD147 | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Surface Plasmon Resonance | RNA, Small Interfering - genetics | Phosphorylation | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Male | Carcinoma, Hepatocellular - secondary | Basigin - genetics | Guanine Nucleotide Exchange Factors - metabolism | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - pathology | Annexin A2 - antagonists & inhibitors | Tumor Cells, Cultured | Wiskott-Aldrich Syndrome Protein Family - genetics | Real-Time Polymerase Chain Reaction | Nerve Tissue Proteins - antagonists & inhibitors | Guanine Nucleotide Exchange Factors - genetics | Liver Neoplasms - genetics | Signal Transduction | Wiskott-Aldrich Syndrome Protein Family - metabolism | RNA, Messenger - genetics | Wiskott-Aldrich Syndrome Protein Family - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Nerve Tissue Proteins - genetics | beta Catenin - metabolism | Blotting, Western | beta Catenin - genetics | Nerve Tissue Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Annexin A2 - genetics | Guanine Nucleotide Exchange Factors - antagonists & inhibitors | Basigin - chemistry | Mice, Nude | beta Catenin - antagonists & inhibitors | Fluorescent Antibody Technique | Liver Neoplasms - metabolism | Basigin - metabolism | Mice | Mice, Inbred BALB C | Annexin A2 - metabolism | Apoptosis | Carcinoma, Hepatocellular - metabolism | Cell Movement | Index Medicus
Journal Article