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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 350 - 359
Based on genetic studies that establish the role of spleen tyrosine kinase (Syk) in immune function, inhibitors of this kinase are being investigated as... 
ANTIBODIES | SURVIVAL | B-CELL LYMPHOMA | COLLAGEN | SYK | PLATELETS | DISEASE | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHARMACOLOGY & PHARMACY | MICE | INDUCTION | Edema - complications | Synovitis - prevention & control | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - drug effects | Precursor Cells, B-Lymphoid - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Precursor Cells, B-Lymphoid - drug effects | Receptors, Antigen, B-Cell - metabolism | Blood - metabolism | Cyclohexylamines - administration & dosage | Lymphocyte Activation - immunology | Synovitis - etiology | Phosphorylation - drug effects | Syk Kinase | B-Lymphocytes - metabolism | Disease Models, Animal | Edema - prevention & control | Protein Kinase Inhibitors - pharmacokinetics | Rats | Pyrimidines - pharmacology | Cyclohexylamines - therapeutic use | Synovitis - pathology | Protein Kinase Inhibitors - administration & dosage | B-Lymphocytes - immunology | Signal Transduction - drug effects | Cell Line, Tumor | Pyrimidines - pharmacokinetics | Leukocytes - drug effects | Mice | Mice, Inbred BALB C | Edema - pathology | Leukocytes - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Blood - immunology | Rats, Inbred Lew | Precursor Cells, B-Lymphoid - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Cyclohexylamines - pharmacokinetics | Arthritis, Experimental - pathology | Leukocytes - immunology | Signal Transduction - immunology | Biocatalysis - drug effects | Cyclohexylamines - pharmacology | Arthritis, Experimental - prevention & control | Basophils - immunology | Protein-Tyrosine Kinases - drug effects | Inhibitory Concentration 50 | Female | Receptors, Antigen, B-Cell - agonists | Molecular Structure | Foot - pathology | Basophils - drug effects | Cell Line | Pyrimidines - administration & dosage | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Blood - drug effects | Arthritis, Experimental - complications | B-Lymphocytes - drug effects | Animals | Lymphocyte Activation - drug effects | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Cell Degranulation - drug effects
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 132, Issue 5, pp. 1086 - 1096.e5
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2012, Volume 18, Issue 4, pp. 538 - 546
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Science Translational Medicine, ISSN 1946-6234, 08/2010, Volume 2, Issue 43, pp. 43ra55 - 43ra55
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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2006, Volume 319, Issue 3, pp. 998 - 1008
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The Journal of Immunology, ISSN 0022-1767, 07/2007, Volume 179, Issue 1, pp. 665 - 672
Journal Article
NATURE, ISSN 0028-0836, 07/2011, Volume 475, Issue 7354, pp. 110 - U133
High-dose intravenous immunoglobulin is a widely used therapeutic preparation of highly purified immunoglobulin G (IgG) antibodies. It is administered at high... 
IMMUNITY IN-VIVO | ALLERGIC INFLAMMATION | RESPONSES | ANTIINFLAMMATORY ACTIVITY | DC-SIGN | DENDRITIC CELL | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | TYPE-2 IMMUNITY | AUTOIMMUNE-DISEASE | Cell Adhesion Molecules - genetics | Dendritic Cells - immunology | Humans | Lectins, C-Type - immunology | Th2 Cells - immunology | Cell Adhesion Molecules - immunology | Lectins, C-Type - genetics | Th2 Cells - drug effects | Interleukins - metabolism | Receptors, IgG - metabolism | Immunoglobulins, Intravenous - metabolism | Lectins, C-Type - metabolism | Immunoglobulin G - immunology | Inflammation - drug therapy | Interleukins - immunology | Basophils - immunology | Arthritis - immunology | Immunoglobulin G - pharmacology | Interleukins - pharmacology | Bone Marrow | Autoimmune Diseases - drug therapy | Macrophages - immunology | Basophils - drug effects | Arthritis - pathology | Interleukin-33 | Immunoglobulin G - chemistry | Interleukin-4 - metabolism | Autoimmune Diseases - immunology | Crystallization | Receptors, Cell Surface - metabolism | Inflammation - immunology | Macrophages - cytology | Receptors, IgG - immunology | Cell Adhesion Molecules - metabolism | Immunoglobulins, Intravenous - pharmacology | Receptors, Cell Surface - immunology | Interleukin-4 - immunology | Animals | Arthritis - drug therapy | Ligands | Dendritic Cells - cytology | Immunoglobulins, Intravenous - chemistry | Mice | Basophils - metabolism | Immunoglobulins, Intravenous - immunology | Immunoglobulin G - metabolism | Receptors, Cell Surface - genetics
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2013, Volume 19, Issue 8, pp. 1005 - 1013
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