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Nature communications, ISSN 2041-1723, 07/2017, Volume 8, Issue 1, pp. 16078 - 16078
BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anticancer targets... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Drug Resistance, Neoplasm | Molecular Targeted Therapy | Apoptosis Regulatory Proteins - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - drug effects | Small Cell Lung Carcinoma - drug therapy | Small Cell Lung Carcinoma - metabolism | bcl-X Protein - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | bcl-X Protein - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Aniline Compounds - pharmacology | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Sulfonamides - pharmacology | Apoptosis Regulatory Proteins - metabolism | Drug Synergism | Pyridinium Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | High-Throughput Screening Assays | Apoptosis Regulatory Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - drug effects | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | bcl-X Protein - metabolism | Doxorubicin - pharmacology | Regulators | Bax protein | Bcl-2 protein | Small cell lung carcinoma | Lung cancer | High-throughput screening | Doxorubicin | BAK protein | Mcl-1 protein | Proteins | Mitochondria | Inhibitors | Bcl-x protein | Anthracycline | Addiction | Cell death | Sequestering | Cancer | Apoptosis | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, pp. e0145780 - e0145780
.... Additionally, we are providing information that deguelin binds directly to anti-apoptotic Bcl-2, Bcl-xl and Mcl-1 in the hydrophobic grooves, thereby releasing BAD and BAX from dimerization with these proteins... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Ribosomal Protein S6 Kinases - metabolism | Apoptosis - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Rotenone - analogs & derivatives | bcl-X Protein - chemistry | Proto-Oncogene Proteins c-bcl-2 - metabolism | RNA Interference | Mitogen-Activated Protein Kinase 1 - genetics | Rotenone - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | bcl-Associated Death Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - chemistry | Phosphorylation - drug effects | Binding Sites | Protein Structure, Tertiary | Mitogen-Activated Protein Kinase 3 - genetics | bcl-Associated Death Protein - chemistry | Cytochromes c - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Rotenone - chemistry | Mitochondrial Membranes - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Protein Binding | Molecular Docking Simulation | HeLa Cells | bcl-X Protein - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Phosphorylation | Apoptotic proteins | RNA | HeLa cells | Genetic aspects | Research | Health aspects | Rotenone | Cytochrome | Biotechnology | Bax protein | Bcl-2 protein | Serine | Multiple myeloma | Oncology | Hydrophobicity | Kinases | Autophagy | Stomach cancer | Proteins | Angiogenesis | Mitochondria | Bcl-x protein | Cell cycle | Life sciences | Inhibition | Dimerization | Medical research | Extracellular signal-regulated kinase | Pharmacology | Grooves | siRNA | Chemical compounds | Mcl-1 protein | Cytochrome c | Medicine | Molecular biology | Apoptosis | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 3, pp. e18330 - e18330
TRAIL is a promising therapeutic agent for human malignancies. TRAIL often requires mitochondrial dysfunction, referred to as the Type II death receptor... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Zinc Finger Protein Gli2 | bcl-2 Homologous Antagonist-Killer Protein - genetics | Hedgehog Proteins - metabolism | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Promoter Regions, Genetic - genetics | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Bcl-2-Like Protein 11 | Chromatin Immunoprecipitation | Hedgehog Proteins - genetics | RNA Interference | Kruppel-Like Transcription Factors - metabolism | Veratrum Alkaloids - pharmacology | Apoptosis Regulatory Proteins - genetics | Electrophoretic Mobility Shift Assay | Inhibitor of Apoptosis Proteins - metabolism | Membrane Proteins - metabolism | Nuclear Proteins - genetics | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Cell Line | Membrane Proteins - genetics | bcl-2-Associated X Protein - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | X-Linked Inhibitor of Apoptosis Protein - genetics | Apoptosis Regulatory Proteins - metabolism | Transcription Factors - metabolism | Signal Transduction - drug effects | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Zinc Finger Protein GLI1 | Kruppel-Like Transcription Factors - genetics | Biochemistry | Cell death | Health aspects | Analysis | Cancer cells | Cancer | Bax protein | Toxicity | Cytotoxicity | XIAP protein | Metastasis | Neoplasms | Proteins | Signal transduction | Hepatitis | Mitochondria | Hepatology | Gastroenterology | Tumor necrosis factor-TNF | Inhibition | Cholangiocarcinoma | Immunoglobulins | Mortality | Pharmacology | siRNA | Chemical compounds | Signaling | Glioma | Hedgehog protein | Pancreatic cancer | Ligands | BIM protein | Apoptosis | Tumors | Index Medicus
Journal Article
Scientific reports, ISSN 2045-2322, 07/2017, Volume 7, Issue 1, pp. 4795 - 13
Doxorubicin (DOX) is the mainstay chemotherapeutic agent against a variety of human neoplasmas. However, its clinical utility is limited by its marked... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Apoptosis - drug effects | Caspase 3 - metabolism | Cardiomyopathies - prevention & control | Male | NF-kappa B - metabolism | Cytochromes c - genetics | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Cardiomyopathies - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspase 3 - genetics | Apoptosis Regulatory Proteins - genetics | Flavonoids - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | bcl-2-Associated X Protein - genetics | Cardiotoxicity - prevention & control | Drug Administration Schedule | Signal Transduction | Cytochromes c - metabolism | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Cardiomyopathies - pathology | Antioxidants - pharmacology | Cardiotonic Agents - pharmacology | Rats, Sprague-Dawley | Doxorubicin - toxicity | Apoptosis Regulatory Proteins - metabolism | Gene Expression Regulation - drug effects | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | NF-kappa B - genetics | Myocytes, Cardiac - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Cardiomyopathies - chemically induced | Oxidative stress | NF-κB protein | Conduction | Bax protein | Bcl-2 protein | Cardiomyopathy | p53 Protein | Lipid peroxidation | Caspase | MAP kinase | JNK protein | AKT protein | Inflammation | Caspase-3 | Doxorubicin | Cytochrome c | Antioxidants | Molecular modelling | Rodents | Vascular endothelial growth factor | PTEN protein | Apoptosis | Cancer | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0123341 - e0123341
The pro-apoptotic Bcl-2-family protein Bim belongs to the BH3-only proteins known as initiators of apoptosis... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | bcl-2 Homologous Antagonist-Killer Protein - genetics | Apoptosis - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Mitochondrial Membrane Transport Proteins - genetics | Bcl-2-Like Protein 11 | RNA Interference | Membrane Transport Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Transport Proteins - metabolism | Membrane Proteins - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Mitochondrial Membrane Transport Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Receptors, Cell Surface - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Blotting, Western | Protein Transport - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Mitochondrial Membranes - metabolism | Animals | Protein Binding | HeLa Cells | Receptors, Cell Surface - genetics | Proteins | Physiological aspects | Mitochondrial DNA | Apoptosis | Cytochrome | Regulators | Science education | Phosphorylation | Yeast | Bax protein | Bcl-2 protein | Laboratories | Initiators | Insertion | Translocase | Biology | Imports | Mitochondria | Receptors | Penicillin | Localization | RNA-mediated interference | siRNA | Membrane proteins | Cytochrome c | Antibiotics | Proteomics | Hygiene | BIM protein | Index Medicus
Journal Article
FEBS letters, ISSN 0014-5793, 07/2010, Volume 584, Issue 14, pp. 2981 - 2989
.... Myeloid cell leukemia 1 (Mcl-1), an anti-apoptotic member of the B-cell lymphoma 2 (Bcl-2) family of apoptosis-regulating proteins, exemplifies a number of the mechanisms by which a protein’s... 
Post-translational modification | Phosphorylation | Myeloid cell leukemia 1 | Apoptosis | granzyme B | Bcl-2 homologous antagonist killer | MULE | JNK | HIF-1α | BFL-1/A1 | NF-κB | p53 upregulated modulator of apoptosis | CHX | GM-CSF | GrB | checkpoint 1 protein | cAMP response element binding protein | cyclin dependent kinase 1 | BCL-XL | Mir-29b | β-TrCP | Bcl-2 homology | proliferating cell nuclear antigen | extracellular regulated protein kinase | PEST | STAT response element | Bcl-2-associated protein X | CRE | micro inhibiting RNA 29b | BH3 interacting domain death agonist | proline/glutamic acid/serine/threonine | ERK | beta transducin-containing protein | Pin-1 | PCNA | MCL-1 | SRE | nuclear factor kappa B | C-Jun N-terminal kinase | peptidyl-prolyl cis-trans isomerase NIMA interacting protein 1 | BCL-2 | signal transducers and activators of transcription | CREB | BID | interleukin | B-cell lymphoma 2 | MCL-1 ubiquitin ligase | cAMP response element | hypoxia-inducible factor 1α | Bcl-2 like protein X | VEGF | BAK | Bcl-2 related protein A1 | cycloheximide | STAT | vascular endothelial growth factor | CHK-1 | granulocyte–macrophage colony-stimulating factor | BAX | PUMA | CDK-1 | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Myeloid Progenitor Cells - metabolism | Humans | Leukemia, Myeloid - genetics | Apoptosis - genetics | Leukemia - metabolism | Protein Structure, Tertiary - genetics | Lymphoma, B-Cell - genetics | Proteins - genetics | Proteins - metabolism | Myeloid Cells - metabolism | Protein Processing, Post-Translational | Dimerization | B-Lymphocytes - metabolism | Leukemia - genetics | Ubiquitin | Ligases | Cyclohexane | Proline | Lymphomas | Macrophage colony stimulating factor | Tumor proteins | Glutamate | Vascular endothelial growth factor | Protein binding | Index Medicus
Journal Article
Journal Article