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2010, Advances in experimental medicine and biology, ISBN 1441967052, Volume 687., xvii, 145
This book highlights the relevance of the BCL‑2 family of proteins in apoptosis, physiology and disease. It examines the potential therapeutic benefits of... 
pathology | physiology | metabolism | Proto-Oncogene Proteins c-bcl-2 | Tumor proteins | Neoplasms | Apoptosis
Book
Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 10, Issue 5, pp. 375 - 388
BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that exhibits single-agent activity... 
CELLCYCLE | PROGRAMMED CELL-DEATH | CANCER-CELLS | STEM-CELLS | PROAPOPTOTIC ACTIVITY | ONCOLOGY | X-L | ACUTE MYELOGENOUS LEUKEMIA | IN-VIVO | MITOCHONDRIAL-MEMBRANE | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | RNA, Small Interfering - genetics | bcl-2-Associated X Protein - chemistry | Humans | Leukemia, Myeloid, Acute - metabolism | Nitrophenols - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Piperazines - metabolism | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - metabolism | Biphenyl Compounds - therapeutic use | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Nitrophenols - therapeutic use | Hematopoietic Stem Cells - physiology | Leukemia, Myeloid, Acute - drug therapy | Proto-Oncogene Proteins c-bcl-2 - chemistry | Dimerization | bcl-2-Associated X Protein - genetics | Protein Structure, Tertiary | Cell Line | bcl-2-Associated X Protein - metabolism | Piperazines - therapeutic use | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - metabolism | Recombinant Fusion Proteins - genetics | Protein Conformation | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Apoptosis - physiology | Drug Resistance, Neoplasm - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Proteins | Oncology, Experimental | Lung cancer | Bone marrow | Transplantation | Lymphomas | Research | Hematopoietic stem cells | Cancer | Apoptosis | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2007, Volume 104, Issue 49, pp. 19512 - 19517
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2013, Volume 452, Issue 1, pp. 111 - 119
Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 10, Issue 5, pp. 389 - 399
Since apoptosis is impaired in malignant cells overexpressing prosurvival Bcl-2 proteins, drugs mimicking their natural antagonists, BH3-only proteins, might... 
CELLCYCLE | SURVIVAL | SELICICLIB CYC202 | R-ROSCOVITINE | ONCOLOGY | SMALL-MOLECULE INHIBITORS | DOWN-REGULATION | DEATH | KINASE INHIBITOR | FAMILY PROTEINS | MULTIPLE-MYELOMA CELLS | BH3-ONLY PROTEINS | bcl-2-Associated X Protein - chemistry | Humans | Leukemia, Myeloid, Acute - metabolism | Nitrophenols - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Male | Piperazines - metabolism | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - metabolism | Biphenyl Compounds - therapeutic use | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | Nitrophenols - therapeutic use | Leukemia, Myeloid, Acute - drug therapy | Proto-Oncogene Proteins c-bcl-2 - chemistry | bcl-2-Associated X Protein - genetics | Disease Models, Animal | Fibroblasts - metabolism | Protein Structure, Tertiary | Cytokines - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Mice, Transgenic | Piperazines - therapeutic use | Sulfonamides - pharmacology | Piperazines - pharmacology | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - metabolism | Recombinant Fusion Proteins - genetics | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Fibroblasts - cytology | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Proteins | Lymphomas | Analysis | Index Medicus
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 08/2011, Volume 1813, Issue 8, pp. 1465 - 1474
(SB) and SB-derived polyphenols possess anti-proliferative activities in several cancers, including pancreatic cancer (PaCa). However, the precise molecular... 
Baicalein | Mcl-1 | Bcl-2 family protein | Pancreatic cancer | Apoptosis | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | MEDIATED APOPTOSIS | CELL BIOLOGY | IMMUNOHISTOCHEMICAL ANALYSIS | IN-VIVO | GROWTH | INHIBITOR | PROTEINS | BCL-2 FAMILY | EXPRESSION | CARCINOMA | Flavanones - isolation & purification | Phenols - isolation & purification | Pancreatic Neoplasms - metabolism | Proto-Oncogene Proteins c-bcl-2 - physiology | Apoptosis - drug effects | Humans | Apoptosis - genetics | Viral Proteins - metabolism | Gene Knockdown Techniques | Pancreatic Neoplasms - drug therapy | Caspases - metabolism | Polyphenols | Flavonoids - pharmacology | Phytotherapy | Scutellaria baicalensis - chemistry | Phenols - pharmacology | Flavanones - pharmacology | Pancreatic Neoplasms - pathology | Oncogene Proteins - metabolism | Pancreatic Neoplasms - genetics | Down-Regulation - drug effects | Myeloid Cell Leukemia Sequence 1 Protein | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Cell Proliferation - drug effects | Flavonoids - isolation & purification | Genes, bcl-2 - drug effects | Apoptosis - physiology | Antineoplastic Agents, Phytogenic - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Antineoplastic Agents, Phytogenic - isolation & purification | Cytochrome c | Mitochondrial DNA | Cancer cells
Journal Article
Oncogene, ISSN 0950-9232, 06/2012, Volume 31, Issue 26, pp. 3177 - 3189
The intrinsic mitochondrial apoptotic pathway acts through two core pro-apoptotic proteins Bax (Bcl2-associated X protein) and Bak (Bcl2-antagonist/killer 1).... 
Bax | apoptosis | DKO | HCT116 | Bak | BH3-only | TRAIL | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | MEDIATED APOPTOSIS | BH3 MIMETIC ABT-737 | CELL BIOLOGY | NBK/BIK | GENE | ONCOLOGY | MITOCHONDRIAL PATHWAY | BCL-2 HOMOLOG BAX | GENETICS & HEREDITY | RESISTANCE | BH3-ONLY PROTEINS | Proto-Oncogene Proteins - metabolism | Apoptosis - drug effects | HCT116 Cells | Humans | bcl-2 Homologous Antagonist-Killer Protein - antagonists & inhibitors | bcl-2 Homologous Antagonist-Killer Protein - deficiency | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-2-Associated X Protein - metabolism | Gene Knockout Techniques | Sulfonamides - pharmacology | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Piperazines - pharmacology | Apoptosis Regulatory Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Phenotype | Animals | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein | Fluorouracil - pharmacology | Mice | Gene Expression Regulation, Neoplastic - drug effects | bcl-2-Associated X Protein - deficiency | bcl-2-Associated X Protein - genetics | Cellular proteins | Colon cancer | Cancer cells | Development and progression | Research | Properties | Health aspects | Apoptosis | Proteins | Oncology | Cellular biology | Gene expression | Colorectal cancer | Index Medicus | Drugs | Camptothecin | Mitochondria | Bax protein | Bcl-2 protein | Data processing | Colon | X protein | BAK protein | Mcl-1 protein
Journal Article
PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 9, pp. e107045 - e107045
Grape seed proanthocyanidins (GSPs), a biologically active component of grape seeds, have been reported to possess a wide array of pharmacological and... 
ANTICANCER PROPERTIES | CARCINOMA-CELLS | BCL-2 | DIETARY POLYPHENOLS | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | IN-VIVO | BAX | MODULATION | EXTRACT | P53 | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Gene Expression Regulation, Neoplastic | bcl-2 Homologous Antagonist-Killer Protein - genetics | Apoptosis - genetics | Uterine Cervical Neoplasms - pathology | Membrane Potential, Mitochondrial - drug effects | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Proanthocyanidins - pharmacology | Uterine Cervical Neoplasms - metabolism | Caspase 3 - genetics | Female | Transplantation, Heterotopic | Uterine Cervical Neoplasms - drug therapy | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Uterine Cervical Neoplasms - genetics | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Grape Seed Extract - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | bcl-2 Homologous Antagonist-Killer Protein - agonists | Prevention | Chemotherapy | Seeds | Growth | Analysis | Apoptosis | Cancer | Reproductive health | Drinking water | Animal models | Bcl-2 protein | Lung cancer | Colorectal cancer | Biochemistry | Kinases | Caspase-3 | Cancer therapies | Developing countries--LDCs | Proteins | Mitochondria | Cell growth | Cell cycle | Membrane potential | Inhibition | Proanthocyanidins | Medical research | Immunoglobulins | Cold | Caspase | Pharmacology | Breast cancer | Cervix | BAK protein | Biological activity | Phytochemicals | Hospitals | Pancreatic cancer | Molecular biology | Viability | Cervical cancer | Tumors | Index Medicus | Developing countries | LDCs
Journal Article
Scientific Reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, pp. 8587 - 8587
In this study, we assessed the role of different reactive oxygen species (ROS) generated by soft jet plasma and chemical-induced ROS systems with regard to... 
INACTIVATION | COPPER IONS | INDUCED APOPTOSIS | ATMOSPHERIC PLASMA | MULTIDISCIPLINARY SCIENCES | INVOLVEMENT | DEATH | DIELECTRIC BARRIER DISCHARGE | BCL-2 FAMILY | CANCER-THERAPY | MOLECULAR-MECHANISMS | Caspase 7 - metabolism | Up-Regulation | Oxidative Stress | Humans | Reactive Oxygen Species - pharmacology | Caspase 3 - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Plasma Gases - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Culture Media | Adenosine Triphosphate - metabolism | HEK293 Cells | Membrane Potential, Mitochondrial | bcl-2-Associated X Protein - genetics | Cell Survival - drug effects | Gene Expression | Oxidation-Reduction | bcl-2-Associated X Protein - metabolism | Histones - genetics | Reactive Nitrogen Species - pharmacology | Cell Line, Tumor | Histones - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Plasma | Cell culture | Hydrogen peroxide | Bax protein | Bcl-2 protein | Pyruvic acid | Mitochondria | Catalase | Mannitol | Hydroxyl radicals | Membrane potential | Oxygen | Tumor cells | Extracellular signal-regulated kinase | Caspase | MAP kinase | Superoxide | Gene expression | Sodium | Cell death | Cell lines | Bcl protein | Sodium pyruvate | Cancer | Index Medicus
Journal Article
Leukemia, ISSN 0887-6924, 2012, Volume 26, Issue 4, pp. 778 - 787
Recently, strategies for acute myeloid leukemia (AML) therapy have been developed that target anti-apoptotic BCL2 family members using BH3-mimetic drugs such... 
AML | ABT-737 | apoptosis | MCL-1 | BH3 mimetic | ERK | CANCER-CELLS | PROGNOSTIC IMPACT | BAK ACTIVATION | ACUTE MYELOGENOUS LEUKEMIA | BIM | BCL-2 FAMILY PROTEINS | ACUTE MYELOID-LEUKEMIA | BH3 MIMETIC ABT-737 | ARSENIC TRIOXIDE ATO | ONCOLOGY | BAX/BCL-2 RATIO | HEMATOLOGY | Diphenylamine - pharmacology | Apoptosis - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | bcl-2-Associated X Protein - physiology | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Diphenylamine - analogs & derivatives | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Proto-Oncogene Proteins c-bcl-2 - analysis | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Membrane Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - physiology | Proto-Oncogene Proteins - metabolism | Leukemia, Myeloid, Acute - pathology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Sulfonamides - pharmacology | Piperazines - pharmacology | Apoptosis Regulatory Proteins - metabolism | Animals | Mice, Nude | Myeloid Cell Leukemia Sequence 1 Protein | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Care and treatment | Leukemia | Cancer cells | Genetic aspects | Diagnosis | Research | Gene expression | Apoptosis | Index Medicus
Journal Article