X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (52945) 52945
Book Review (4158) 4158
Publication (4115) 4115
Book Chapter (304) 304
Conference Proceeding (158) 158
Dissertation (140) 140
Government Document (25) 25
Newspaper Article (7) 7
Web Resource (7) 7
Book / eBook (4) 4
Magazine Article (2) 2
Reference (2) 2
Journal / eJournal (1) 1
Paper (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (44720) 44720
apoptosis (33604) 33604
humans (32064) 32064
animals (20936) 20936
proto-oncogene proteins c-bcl-2 - metabolism (17249) 17249
bcl-2 (17242) 17242
apoptosis - drug effects (14428) 14428
oncology (11595) 11595
male (11257) 11257
female (10870) 10870
mice (10769) 10769
expression (9707) 9707
biochemistry & molecular biology (9085) 9085
proto-oncogene proteins c-bcl-2 - genetics (8837) 8837
cell biology (8752) 8752
proteins (7914) 7914
cell line, tumor (7879) 7879
cancer (7758) 7758
death (6616) 6616
rats (6552) 6552
bcl-2 protein (6171) 6171
activation (6008) 6008
apoptosis - physiology (5828) 5828
bax (5309) 5309
immunohistochemistry (5278) 5278
mitochondria (5254) 5254
middle aged (5190) 5190
bcl-2-associated x protein - metabolism (4955) 4955
gene expression (4788) 4788
bcl-2-associated x protein (4612) 4612
adult (4567) 4567
p53 (4540) 4540
signal transduction (4488) 4488
caspases - metabolism (4284) 4284
cell-death (4195) 4195
aged (4072) 4072
protein (3964) 3964
oxidative stress (3949) 3949
cells, cultured (3874) 3874
proto-oncogene proteins c-bcl-2 - biosynthesis (3872) 3872
antineoplastic agents - pharmacology (3818) 3818
flow cytometry (3817) 3817
mitochondria - metabolism (3784) 3784
tumor cells, cultured (3773) 3773
phosphorylation (3750) 3750
blotting, western (3734) 3734
cell death (3680) 3680
pharmacology & pharmacy (3644) 3644
inhibition (3580) 3580
survival (3576) 3576
proto-oncogene proteins c-bcl-2 (3570) 3570
proto-oncogene proteins - metabolism (3521) 3521
apoptosis - genetics (3519) 3519
cell survival - drug effects (3516) 3516
caspase (3454) 3454
research (3453) 3453
cell line (3400) 3400
caspase 3 - metabolism (3326) 3326
analysis (3292) 3292
cells (3254) 3254
in-vivo (3219) 3219
caspase-3 (3150) 3150
bcl-x protein (3127) 3127
cell proliferation - drug effects (3125) 3125
cell cycle (3064) 3064
bax protein (3062) 3062
tumor suppressor protein p53 - metabolism (3049) 3049
medicine, research & experimental (2985) 2985
neurosciences (2977) 2977
in-vitro (2950) 2950
bcl-2 family (2948) 2948
cytochrome-c (2906) 2906
cell proliferation (2850) 2850
chemotherapy (2833) 2833
proto-oncogene proteins - genetics (2808) 2808
proliferation (2798) 2798
hematology (2765) 2765
dose-response relationship, drug (2740) 2740
transfection (2706) 2706
programmed cell-death (2685) 2685
down-regulation (2669) 2669
gene (2655) 2655
immunology (2634) 2634
prognosis (2634) 2634
abridged index medicus (2630) 2630
pathology (2603) 2603
signal transduction - drug effects (2600) 2600
cell survival (2502) 2502
tumors (2484) 2484
proto-oncogene proteins c-bcl-2 - analysis (2437) 2437
time factors (2398) 2398
induction (2391) 2391
rats, sprague-dawley (2387) 2387
article (2368) 2368
growth (2354) 2354
health aspects (2352) 2352
kinases (2342) 2342
up-regulation (2268) 2268
mitochondria - drug effects (2251) 2251
induced apoptosis (2209) 2209
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (50896) 50896
Chinese (1675) 1675
Japanese (184) 184
Russian (134) 134
French (104) 104
Spanish (65) 65
Korean (64) 64
German (63) 63
Polish (51) 51
Portuguese (38) 38
Turkish (17) 17
Czech (13) 13
Italian (12) 12
Croatian (8) 8
Ukrainian (8) 8
Romanian (7) 7
Serbian (6) 6
Hungarian (5) 5
Swedish (4) 4
Persian (3) 3
Slovak (3) 3
Bulgarian (2) 2
Catalan (1) 1
Danish (1) 1
Slovenian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


2010, Advances in experimental medicine and biology, ISBN 1441967052, Volume 687., xvii, 145
This book highlights the relevance of the BCL‑2 family of proteins in apoptosis, physiology and disease. It examines the potential therapeutic benefits of... 
pathology | physiology | metabolism | Proto-Oncogene Proteins c-bcl-2 | Tumor proteins | Neoplasms | Apoptosis
Book
Nature Biotechnology, ISSN 1087-0156, 06/2002, Volume 20, Issue 6, pp. 619 - 622
Journal Article
Science, ISSN 0036-8075, 12/2010, Volume 330, Issue 6009, pp. 1390 - 1393
Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled. We provide in... 
T lymphocytes | Mitochondria | Cytokines | Thymocytes | Neurons | Cell death | REPORTS | Cytochromes | Mice | Potassium | Apoptosis | NEURONAL APOPTOSIS | CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | MECHANISM | MULTIDISCIPLINARY SCIENCES | BH3 DOMAINS | RELEASE | JNK PATHWAY | PROTEINS | BCL-2 FAMILY-MEMBERS | MEMBRANE PERMEABILIZATION | BH3 Interacting Domain Death Agonist Protein - deficiency | T-Lymphocytes - physiology | bcl-2-Associated X Protein - chemistry | Protein Multimerization | Stress, Physiological | bcl-2 Homologous Antagonist-Killer Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Membrane Proteins - deficiency | Caspases - metabolism | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - deficiency | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Neurons - physiology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Permeability | Proto-Oncogene Proteins - deficiency | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Cerebellum - cytology | Intracellular Membranes - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Protein research | Genetic aspects | Mitochondrial DNA | Biochemical genetics | Research | Properties | Methods | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2009, Volume 36, Issue 3, pp. 487 - 499
While activation of BAX/BAK by BH3-only molecules (BH3s) is essential for mitochondrial apoptosis, the underlying mechanisms remain unsettled. Here we... 
CELLCYCLE | CYTOCHROME-C | PROAPOPTOTIC BAX | OLIGOMERIZES BAK | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM | SUBCELLULAR LOCATION | PROTEINS | BCL-2 FAMILY-MEMBERS | BH3 DOMAIN | CELL-DEATH | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | bcl-2-Associated X Protein - chemistry | Immunoprecipitation | Apoptosis - drug effects | Protein Multimerization | bcl-2 Homologous Antagonist-Killer Protein - genetics | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | Green Fluorescent Proteins - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Bcl-2-Like Protein 11 | Protein Binding - drug effects | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Green Fluorescent Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Etoposide - pharmacology | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Tunicamycin - pharmacology | Fibroblasts - drug effects | Thapsigargin - pharmacology | Fibroblasts - cytology | Mice | Mutation | Microscopy, Fluorescence | Staurosporine - pharmacology | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Monomers | Apoptosis | Oligomers | Index Medicus
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 12/2015, Volume 22, Issue 12, pp. 2098 - 2106
Breast cancer is the second-most frequently diagnosed malignancy in US women. The triple-negative breast cancer (TNBC) subtype, which lacks expression of the... 
MCL-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ABT-737 | CHEMORESISTANCE | MELANOMA-CELLS | BCL-2 PROTEINS | INHIBITOR | ADDICTION | ABT-199 | INDEX PREDICTS | FAMILY | CELL BIOLOGY | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-X Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | RNA Interference | bcl-X Protein - antagonists & inhibitors | Triple Negative Breast Neoplasms - pathology | Apoptosis Regulatory Proteins - genetics | Female | Membrane Proteins - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Membrane Proteins - genetics | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Sulfonamides - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Apoptosis Regulatory Proteins - metabolism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Index Medicus | Original Paper
Journal Article
Oncogene, ISSN 0950-9232, 06/2012, Volume 31, Issue 26, pp. 3177 - 3189
The intrinsic mitochondrial apoptotic pathway acts through two core pro-apoptotic proteins Bax (Bcl2-associated X protein) and Bak (Bcl2-antagonist/killer 1).... 
Bax | apoptosis | DKO | HCT116 | Bak | BH3-only | TRAIL | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | MEDIATED APOPTOSIS | BH3 MIMETIC ABT-737 | CELL BIOLOGY | NBK/BIK | GENE | ONCOLOGY | MITOCHONDRIAL PATHWAY | BCL-2 HOMOLOG BAX | GENETICS & HEREDITY | RESISTANCE | BH3-ONLY PROTEINS | Proto-Oncogene Proteins - metabolism | Apoptosis - drug effects | HCT116 Cells | Humans | bcl-2 Homologous Antagonist-Killer Protein - antagonists & inhibitors | bcl-2 Homologous Antagonist-Killer Protein - deficiency | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-2-Associated X Protein - metabolism | Gene Knockout Techniques | Sulfonamides - pharmacology | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Piperazines - pharmacology | Apoptosis Regulatory Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Phenotype | Animals | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein | Fluorouracil - pharmacology | Mice | Gene Expression Regulation, Neoplastic - drug effects | bcl-2-Associated X Protein - deficiency | bcl-2-Associated X Protein - genetics | Cellular proteins | Colon cancer | Cancer cells | Development and progression | Research | Properties | Health aspects | Apoptosis | Proteins | Oncology | Cellular biology | Gene expression | Colorectal cancer | Index Medicus | Drugs | Camptothecin | Mitochondria | Bax protein | Bcl-2 protein | Data processing | Colon | X protein | BAK protein | Mcl-1 protein
Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 10, Issue 5, pp. 389 - 399
Since apoptosis is impaired in malignant cells overexpressing prosurvival Bcl-2 proteins, drugs mimicking their natural antagonists, BH3-only proteins, might... 
CELLCYCLE | SURVIVAL | SELICICLIB CYC202 | R-ROSCOVITINE | ONCOLOGY | SMALL-MOLECULE INHIBITORS | DOWN-REGULATION | DEATH | KINASE INHIBITOR | FAMILY PROTEINS | MULTIPLE-MYELOMA CELLS | BH3-ONLY PROTEINS | bcl-2-Associated X Protein - chemistry | Humans | Leukemia, Myeloid, Acute - metabolism | Nitrophenols - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Male | Piperazines - metabolism | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - metabolism | Biphenyl Compounds - therapeutic use | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | Nitrophenols - therapeutic use | Leukemia, Myeloid, Acute - drug therapy | Proto-Oncogene Proteins c-bcl-2 - chemistry | bcl-2-Associated X Protein - genetics | Disease Models, Animal | Fibroblasts - metabolism | Protein Structure, Tertiary | Cytokines - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Mice, Transgenic | Piperazines - therapeutic use | Sulfonamides - pharmacology | Piperazines - pharmacology | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - metabolism | Recombinant Fusion Proteins - genetics | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Fibroblasts - cytology | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Proteins | Lymphomas | Analysis | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 10, Issue 5, pp. 375 - 388
BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that exhibits single-agent activity... 
CELLCYCLE | PROGRAMMED CELL-DEATH | CANCER-CELLS | STEM-CELLS | PROAPOPTOTIC ACTIVITY | ONCOLOGY | X-L | ACUTE MYELOGENOUS LEUKEMIA | IN-VIVO | MITOCHONDRIAL-MEMBRANE | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | RNA, Small Interfering - genetics | bcl-2-Associated X Protein - chemistry | Humans | Leukemia, Myeloid, Acute - metabolism | Nitrophenols - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Piperazines - metabolism | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - metabolism | Biphenyl Compounds - therapeutic use | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Nitrophenols - therapeutic use | Hematopoietic Stem Cells - physiology | Leukemia, Myeloid, Acute - drug therapy | Proto-Oncogene Proteins c-bcl-2 - chemistry | Dimerization | bcl-2-Associated X Protein - genetics | Protein Structure, Tertiary | Cell Line | bcl-2-Associated X Protein - metabolism | Piperazines - therapeutic use | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - metabolism | Recombinant Fusion Proteins - genetics | Protein Conformation | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Apoptosis - physiology | Drug Resistance, Neoplasm - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Proteins | Oncology, Experimental | Lung cancer | Bone marrow | Transplantation | Lymphomas | Research | Hematopoietic stem cells | Cancer | Apoptosis | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 2005, Volume 17, Issue 3, pp. 393 - 403
Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic BH3-only proteins via interaction of its BH3 domain with a groove... 
CYTOCHROME-C | COMPLEX | SURVIVAL FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | BIM | RELEASE | PEPTIDE | CELL-DEATH | FAMILY | MEMBER | CELL BIOLOGY | Humans | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | Genetic Complementation Test | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Carrier Proteins - chemistry | Proto-Oncogene Proteins c-bcl-2 - chemistry | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | Peptide Fragments - genetics | Cell Survival - physiology | Binding, Competitive | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | bcl-X Protein | Peptide Fragments - metabolism | Membrane Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Proto-Oncogene Proteins - genetics | Recombinant Proteins - genetics | Proteins - genetics | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Peptide Fragments - chemistry | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Proteins - metabolism | Membrane Proteins - chemistry | Models, Biological | Myeloid Cell Leukemia Sequence 1 Protein | Biosensing Techniques | Ligands | Mice | Apoptosis - physiology | Proteins - chemistry | In Vitro Techniques | Proto-Oncogene Proteins c-bcl-2 - genetics | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2011, Volume 286, Issue 1, pp. 491 - 501
Bcl-2 family proteins regulate a critical step in apoptosis referred to as mitochondrial outer membrane permeabilization (MOMP). Members of a subgroup of the... 
MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | ANTAGONIST ABT-737 | MCL-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MIMETIC ABT-737 | APOPTOTIC PROTEIN BAK | SENSITIVITY | OLIGOMERIZATION | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | CELL-DEATH | bcl-2-Associated X Protein - chemistry | Humans | Protein Multimerization | Cell Membrane Permeability | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | BH3 Interacting Domain Death Agonist Protein - chemistry | HEK293 Cells | Protein Structure, Quaternary | Cell Membrane - metabolism | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Peptide Fragments - metabolism | Cytochromes c - secretion | Apoptosis Regulatory Proteins - chemistry | bcl-2-Associated X Protein - metabolism | Apoptosis Regulatory Proteins - metabolism | Animals | Membrane Proteins - chemistry | Liposomes - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | bcl-X Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Apoptosis | Index Medicus | Cytochrome c | BH3 Peptides | Mitochondria | Cell Death | Liposomes | Cell Biology | Bcl-2 Family Proteins
Journal Article
EMBO reports, ISSN 1469-221X, 06/2017, Volume 18, Issue 6, pp. 947 - 961
Mitophagy, the selective removal of damaged or excess mitochondria by autophagy, is an important process in cellular homeostasis. The outer mitochondrial... 
mitophagy | autophagy | FKBP | 38 | LC | 8 | 3A | FKBP8 | FKBP38 | LC3A | PROTEIN | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | DAMAGED MITOCHONDRIA | LIR MOTIF | SELECTIVE AUTOPHAGY | CELL BIOLOGY | BCL-2 | MITOCHONDRIAL DYNAMICS | LC3-INTERACTING REGION | BASAL AUTOPHAGY | DEGRADATION | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Microtubule-Associated Proteins - genetics | Membrane Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Ubiquitin-Protein Ligases - metabolism | Proto-Oncogene Proteins - genetics | Tacrolimus Binding Proteins - metabolism | Mitochondrial Degradation | Mitochondrial Membranes - metabolism | Tacrolimus Binding Proteins - genetics | Saccharomyces cerevisiae - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Two-Hybrid System Techniques | Mitochondrial Proteins - metabolism | Tumor Suppressor Proteins - genetics | Membrane Proteins - metabolism | HeLa Cells | Proto-Oncogene Proteins c-bcl-2 - genetics | Biodegradation | Yeast | Cell survival | Homeostasis | In vitro testing | Autophagy | BNIP3 protein | Recruitment | Proteins | Degradation | Mitochondria | Receptors | Tacrolimus-binding protein | Tacrolimus | Parkin protein | GABARAP protein | Damage | Phagocytosis | Apoptosis | Index Medicus | Membrane & Intracellular Transport | Autophagy & Cell Death
Journal Article