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Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 330, Issue 6009, pp. 1390 - 1393
Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled... 
T lymphocytes | Mitochondria | Cytokines | Thymocytes | Neurons | Cell death | REPORTS | Cytochromes | Mice | Potassium | Apoptosis | NEURONAL APOPTOSIS | CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | MECHANISM | MULTIDISCIPLINARY SCIENCES | BH3 DOMAINS | RELEASE | JNK PATHWAY | PROTEINS | BCL-2 FAMILY-MEMBERS | MEMBRANE PERMEABILIZATION | BH3 Interacting Domain Death Agonist Protein - deficiency | T-Lymphocytes - physiology | bcl-2-Associated X Protein - chemistry | Protein Multimerization | Stress, Physiological | bcl-2 Homologous Antagonist-Killer Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Membrane Proteins - deficiency | Caspases - metabolism | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - deficiency | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Neurons - physiology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Permeability | Proto-Oncogene Proteins - deficiency | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Cerebellum - cytology | Intracellular Membranes - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Protein research | Genetic aspects | Mitochondrial DNA | Biochemical genetics | Research | Properties | Methods
Journal Article
Molecular cell, ISSN 1097-2765, 2005, Volume 17, Issue 3, pp. 393 - 403
Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic BH3-only proteins via interaction of its BH3 domain with a groove on the Bcl-2-like proteins... 
CYTOCHROME-C | COMPLEX | SURVIVAL FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | BIM | RELEASE | PEPTIDE | CELL-DEATH | FAMILY | MEMBER | CELL BIOLOGY | Humans | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | Genetic Complementation Test | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Carrier Proteins - chemistry | Proto-Oncogene Proteins c-bcl-2 - chemistry | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | Peptide Fragments - genetics | Cell Survival - physiology | Binding, Competitive | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | bcl-X Protein | Peptide Fragments - metabolism | Membrane Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Proto-Oncogene Proteins - genetics | Recombinant Proteins - genetics | Proteins - genetics | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Peptide Fragments - chemistry | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Proteins - metabolism | Membrane Proteins - chemistry | Models, Biological | Myeloid Cell Leukemia Sequence 1 Protein | Biosensing Techniques | Ligands | Mice | Apoptosis - physiology | Proteins - chemistry | In Vitro Techniques | Proto-Oncogene Proteins c-bcl-2 - genetics
Journal Article
Molecular cell, ISSN 1097-2765, 2009, Volume 36, Issue 3, pp. 487 - 499
.... BAK, an integral mitochondrial membrane protein, has bypassed the first activation step, explaining why its killing kinetics are faster than those of... 
CELLCYCLE | CYTOCHROME-C | PROAPOPTOTIC BAX | OLIGOMERIZES BAK | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM | SUBCELLULAR LOCATION | PROTEINS | BCL-2 FAMILY-MEMBERS | BH3 DOMAIN | CELL-DEATH | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | bcl-2-Associated X Protein - chemistry | Immunoprecipitation | Apoptosis - drug effects | Protein Multimerization | bcl-2 Homologous Antagonist-Killer Protein - genetics | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | Green Fluorescent Proteins - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Bcl-2-Like Protein 11 | Protein Binding - drug effects | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Green Fluorescent Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Etoposide - pharmacology | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Tunicamycin - pharmacology | Fibroblasts - drug effects | Thapsigargin - pharmacology | Fibroblasts - cytology | Mice | Mutation | Microscopy, Fluorescence | Staurosporine - pharmacology | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Monomers | Apoptosis | Oligomers
Journal Article
Cell death & disease, ISSN 2041-4889, 06/2016, Volume 7, Issue 6, pp. e2266 - e2266
How BH3-only proteins activate Bax/Bak, the two gateway proteins of the mitochondria-dependent apoptotic pathway, remains incompletely understood... 
PROSURVIVAL BCL-2 PROTEINS | APOPTOTIC PORE | X-L | MCL-1 | MITOCHONDRIA | BAX | BH3 DOMAINS | BCL-X(L) | CELL-DEATH | REVEALS | CELL BIOLOGY | BH3 Interacting Domain Death Agonist Protein - deficiency | RNA, Small Interfering - antagonists & inhibitors | RNA, Small Interfering - genetics | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-X Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | Green Fluorescent Proteins - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Recombinant Fusion Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Apoptosis Regulatory Proteins - deficiency | bcl-X Protein - antagonists & inhibitors | Apoptosis Regulatory Proteins - genetics | Genes, Reporter | bcl-2-Associated X Protein - genetics | Green Fluorescent Proteins - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Signal Transduction | HCT116 Cells | Gene Expression Regulation | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Bcl-2-Like Protein 11 - genetics | Mitochondria - metabolism | Proto-Oncogene Proteins - deficiency | Gene Knockout Techniques | Sulfonamides - pharmacology | Tumor Suppressor Protein p53 - deficiency | Piperazines - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Recombinant Fusion Proteins - genetics | Bcl-2-Like Protein 11 - deficiency | bcl-X Protein - metabolism | Apoptosis | RNA, Small Interfering - metabolism | Original
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 01/2007, Volume 14, Issue 1, pp. 128 - 136
All BH3-only proteins, key initiators of programmed cell death, interact tightly with multiple binding partners and have sequences of low complexity, properties that are the hallmark of intrinsically... 
Bcl-2 | intrinsically unstructured | APOPTOSIS | EGL-1 | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | UNFOLDED PROTEINS | DISORDERED PROTEINS | BH3-only | FAMILY | MEMBER | CELL BIOLOGY | STRUCTURAL BASIS | ROLES | molecular recognition | PEPTIDE COMPLEX | Adaptor Proteins, Signal Transducing - chemistry | Recombinant Fusion Proteins - isolation & purification | Adaptor Proteins, Signal Transducing - isolation & purification | Apoptosis Regulatory Proteins - isolation & purification | Proto-Oncogene Proteins - chemistry | Recombinant Fusion Proteins - metabolism | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - genetics | Nuclear Magnetic Resonance, Biomolecular | bcl-Associated Death Protein - metabolism | Membrane Proteins - metabolism | Circular Dichroism | Proto-Oncogene Proteins - isolation & purification | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | bcl-Associated Death Protein - genetics | Membrane Proteins - isolation & purification | Protein Structure, Secondary | bcl-Associated Death Protein - chemistry | Membrane Proteins - genetics | bcl-Associated Death Protein - isolation & purification | Apoptosis Regulatory Proteins - chemistry | Proto-Oncogene Proteins - genetics | Recombinant Fusion Proteins - chemistry | Protein Folding | Apoptosis Regulatory Proteins - metabolism | Animals | Membrane Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Recombinant Fusion Proteins - genetics | Mice | Adaptor Proteins, Signal Transducing - metabolism
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 6, p. e39586
... death, independent of p53. CHOP (C/EBP homologous protein also known as GADD153; gene name Ddit3), a critical initiator of ER stress-induced apoptosis, was found... 
MITOCHONDRIAL APOPTOSIS | TRANSCRIPTION FACTOR CHOP | UNFOLDED PROTEIN RESPONSE | INDUCED APOPTOSIS | KINASE | BIOLOGY | GENE-EXPRESSION | SYMPATHETIC NEURONS | DEATH | ENDOPLASMIC-RETICULUM STRESS | BH3-ONLY PROTEINS | Transcription Factor CHOP - genetics | Apoptosis - drug effects | Neurons - cytology | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Telencephalon - drug effects | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Neurons - metabolism | Neurons - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - physiology | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Tumor Suppressor Proteins - metabolism | Telencephalon - metabolism | Telencephalon - cytology | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Animals | Signal Transduction - drug effects | Tunicamycin - pharmacology | Signal Transduction - physiology | Mice | Apoptosis - physiology | Forkhead Box Protein O3 | Transcription Factor CHOP - metabolism | Endoplasmic Reticulum Stress - physiology | Nervous system diseases | Parkinson's disease | Huntington's chorea | Neurons | Tumor proteins | Protein kinases | Apoptosis | Phosphorylation | Transcription factors | Transcription | p53 Protein | Tunicamycin | Homology | AKT protein | CCAAT/enhancer-binding protein | Kinases | Proteins | Signal transduction | Mitochondria | Cell activation | Cell growth | Cascades | Rodents | Forkhead protein | Alzheimer's disease | Movement disorders | Deoxyribonucleic acid--DNA | FOXO3 protein | Stresses | Neurodegenerative diseases | Mortality | Gene expression | Stress | Neurological diseases | Pathology | Signaling | Cell death | Endoplasmic reticulum | CHOP protein | BIM protein | Deoxyribonucleic acid | DNA
Journal Article
Nature cell biology, ISSN 1476-4679, 2015, Volume 17, Issue 10, pp. 1270 - 1281
...Central players of the mitochondrion-dependent apoptotic program are the BCL-2 family proteins (1-3), consisting of: multidomain anti-apoptotic BCL-2, BCL... 
CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | ACTIVATION | CONFORMATIONAL-CHANGE | MEMBERS | PROAPOPTOTIC BAX | BH3 DOMAINS | PUMA | BH3-ONLY PROTEINS | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | bcl-2 Homologous Antagonist-Killer Protein - genetics | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | Cytochromes c - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Embryo, Mammalian - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Mitochondria - genetics | RNA Interference | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Mice, Inbred C57BL | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Intestine, Small - cytology | Embryo, Mammalian - cytology | Models, Biological | Fibroblasts - cytology | Intestine, Small - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Genotype | Genetic aspects | Properties | Cell death | Cellular control mechanisms
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 11/2016, Volume 291, Issue 48, pp. 25207 - 25216
...) protein family in the mitochondrial outer membrane (MOM) induce structural changes that commit cells to apoptosis. Bcl-2 homology-3 (BH3... 
TRANSMEMBRANE HELIX ASSOCIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FORCE-FIELD | PARTICLE MESH EWALD | ENDOPLASMIC-RETICULUM | SEC61 TRANSLOCON | OUTER MITOCHONDRIAL-MEMBRANE | BCL-2 FAMILY | PAIR INTERACTIONS | PROLINE RESIDUES | CELL-DEATH | Adaptor Proteins, Signal Transducing - chemistry | Microsomes - metabolism | Humans | Cell Membrane - genetics | Proto-Oncogene Proteins - chemistry | Cell Membrane - chemistry | Proto-Oncogene Proteins c-bcl-2 - metabolism | Apoptosis Regulatory Proteins - genetics | Protein Domains | Proto-Oncogene Proteins c-bcl-2 - chemistry | Cell Membrane - metabolism | Membrane Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Membrane Proteins - genetics | Apoptosis Regulatory Proteins - chemistry | Proto-Oncogene Proteins - genetics | Bcl-2-Like Protein 11 - genetics | Apoptosis Regulatory Proteins - metabolism | Microsomes - chemistry | Bcl-2-Like Protein 11 - metabolism | Membrane Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Bcl-2-Like Protein 11 - chemistry | Hydrophobic and Hydrophilic Interactions | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | transmembrane domain | Membrane Biology | mitochondrial apoptosis | apoptosis | membrane protein | membrane insertion | B-cell lymphoma 2 (Bcl-2) family | BH3-only
Journal Article
Cell death and differentiation, ISSN 1476-5403, 2015, Volume 22, Issue 12, pp. 2098 - 2106
...% of patients and is refractory to current targeted therapies. Like many cancers, TNBC cells often deregulate programmed cell death by upregulating anti-apoptotic proteins of the B-cell CLL/lymphoma 2 (Bcl-2) family... 
MCL-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ABT-737 | CHEMORESISTANCE | MELANOMA-CELLS | BCL-2 PROTEINS | INHIBITOR | ADDICTION | ABT-199 | INDEX PREDICTS | FAMILY | CELL BIOLOGY | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-X Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | RNA Interference | bcl-X Protein - antagonists & inhibitors | Triple Negative Breast Neoplasms - pathology | Apoptosis Regulatory Proteins - genetics | Female | Membrane Proteins - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Membrane Proteins - genetics | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Sulfonamides - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Apoptosis Regulatory Proteins - metabolism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Original Paper
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2011, Volume 286, Issue 1, pp. 491 - 501
Bcl-2 family proteins regulate a critical step in apoptosis referred to as mitochondrial outer membrane permeabilization (MOMP... 
MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | ANTAGONIST ABT-737 | MCL-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MIMETIC ABT-737 | APOPTOTIC PROTEIN BAK | SENSITIVITY | OLIGOMERIZATION | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | CELL-DEATH | bcl-2-Associated X Protein - chemistry | Humans | Protein Multimerization | Cell Membrane Permeability | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | BH3 Interacting Domain Death Agonist Protein - chemistry | HEK293 Cells | Protein Structure, Quaternary | Cell Membrane - metabolism | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Peptide Fragments - metabolism | Cytochromes c - secretion | Apoptosis Regulatory Proteins - chemistry | bcl-2-Associated X Protein - metabolism | Apoptosis Regulatory Proteins - metabolism | Animals | Membrane Proteins - chemistry | Liposomes - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | bcl-X Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Apoptosis | Cytochrome c | BH3 Peptides | Mitochondria | Cell Death | Liposomes | Cell Biology | Bcl-2 Family Proteins
Journal Article
Oncogene, ISSN 1476-5594, 2003, Volume 22, Issue 43, pp. 6785 - 6793
.... Three Bim proteins Bim-EL, Bim-L and Bim-S are synthesized from the same transcript. We report here that Bim-EL when phosphorylated by Erk1/2 is rapidly degraded via the proteasome pathway... 
Erk1/2 | Bim | Apoptosis | Proteasome | proteasome | ACTIVATION | BAD | BIOCHEMISTRY & MOLECULAR BIOLOGY | BCL-2 FAMILY MEMBER | apoptosis | DEATH | INDUCTION | CELL-SURVIVAL | CELL BIOLOGY | ONCOLOGY | SIGNALING PATHWAY | GENETICS & HEREDITY | EXPRESSION | DEPENDENT DEGRADATION | Phosphorylation | Tetradecanoylphorbol Acetate | Humans | Molecular Sequence Data | Multienzyme Complexes - metabolism | Proteasome Endopeptidase Complex | Lymphoma - metabolism | Caspases - metabolism | Cysteine Endopeptidases - metabolism | Transfection | Bcl-2-Like Protein 11 | Time Factors | Carrier Proteins - chemistry | Proto-Oncogene Proteins | Tumor Cells, Cultured | Binding Sites | Amino Acid Sequence | Cell Line | Antineoplastic Agents, Hormonal - pharmacology | Cell Survival | Gene Expression Regulation | Glutathione Transferase - metabolism | Serine - chemistry | Proto-Oncogene Proteins c-raf - metabolism | Membrane Proteins | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Models, Biological | Protein Isoforms | K562 Cells | Tamoxifen - pharmacology | Mitogen-Activated Protein Kinase 3 | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Bim-L protein | Bim-EL protein | Bim-S protein | Bim protein | Multienzyme Complexes | Serine | Life Sciences | Glutathione Transferase | Carrier Proteins | Mitogen-Activated Protein Kinases | Cysteine Endopeptidases | Antineoplastic Agents, Hormonal | Proto-Oncogene Proteins c-raf | Biochemistry, Molecular Biology | Tamoxifen | Lymphoma | Caspases | Mitogen-Activated Protein Kinase 1 | Molecular biology | Cancer
Journal Article