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apoptosis (1180) 1180
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animals (1002) 1002
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bim (519) 519
cell biology (517) 517
biochemistry & molecular biology (430) 430
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proto-oncogene proteins c-bcl-2 - metabolism (353) 353
phosphorylation (337) 337
female (329) 329
expression (327) 327
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cancer (290) 290
male (255) 255
signal transduction (253) 253
apoptosis - physiology (249) 249
article (227) 227
apoptosis - genetics (222) 222
mice, knockout (221) 221
hemic and lymphatic diseases (217) 217
cells, cultured (216) 216
death (208) 208
mice, inbred c57bl (202) 202
apoptosis regulatory proteins (196) 196
proto-oncogene proteins c-bcl-2 - genetics (196) 196
survival (195) 195
bcl-2 family (194) 194
biological phenomena, cell phenomena, and immunity (194) 194
mitochondria - metabolism (191) 191
immunology (188) 188
bcl-2 (186) 186
bh3-only proteins (182) 182
cell line (181) 181
cell-death (181) 181
antineoplastic agents - pharmacology (177) 177
bcl-2-associated x protein - metabolism (172) 172
down-regulation (171) 171
gene expression (170) 170
research (170) 170
bim protein (167) 167
cell death (167) 167
bcl-2-like protein 11 - metabolism (166) 166
in-vivo (161) 161
abridged index medicus (158) 158
bax (151) 151
rna interference (148) 148
up-regulation (146) 146
mitochondria (145) 145
cell survival (144) 144
proto-oncogene proteins - physiology (143) 143
rats (142) 142
signal transduction - drug effects (142) 142
hematology (140) 140
blotting, western (137) 137
membrane proteins - physiology (137) 137
mutation (136) 136
bcl-2-like protein 11 - genetics (131) 131
cells (129) 129
apoptosis regulatory proteins - physiology (124) 124
analysis (123) 123
bcl-x protein - metabolism (123) 123
multidisciplinary sciences (123) 123
carrier proteins - metabolism (121) 121
family-member bim (119) 119
proto-oncogene proteins - biosynthesis (117) 117
cell survival - drug effects (114) 114
membrane proteins - biosynthesis (113) 113
mice, transgenic (113) 113
myeloid cell leukemia sequence 1 protein (111) 111
neoplasms (111) 111
research article (111) 111
kinases (110) 110
genetic aspects (108) 108
apoptosis regulatory proteins - biosynthesis (107) 107
caspases - metabolism (107) 107
forkhead transcription factors - metabolism (106) 106
protein binding (106) 106
reverse transcriptase polymerase chain reaction (105) 105
transfection (105) 105
induced apoptosis (104) 104
mcl-1 (104) 104
proto-oncogene proteins c-akt - metabolism (104) 104
caspase 3 - metabolism (103) 103
cell proliferation - drug effects (103) 103
flow cytometry (102) 102
membrane proteins (102) 102
gene expression regulation, neoplastic (101) 101
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Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2011, Volume 17, Issue 8, pp. 2140 - 2148
Purpose: EML4-ALK (echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase) was recently identified as a transforming fusion gene in... 
ANAPLASTIC LYMPHOMA KINASE | NPM-ALK | GEFITINIB | ONCOLOGY | SURVIVIN | EML4-ALK FUSION GENE | STAT3 | CELL-CYCLE ARREST | MUTATIONS | IDENTIFICATION | EGFR | NIH 3T3 Cells | Oncogene Proteins, Fusion - metabolism | Cell Proliferation | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Immunoblotting | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-akt - genetics | Neoplasms, Experimental - pathology | Protein-Tyrosine Kinases - genetics | Transfection | Bcl-2-Like Protein 11 | RNA Interference | Cell Transformation, Neoplastic - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Neoplasms, Experimental - genetics | Apoptosis Regulatory Proteins - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Inhibitor of Apoptosis Proteins - metabolism | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Apoptosis Regulatory Proteins - metabolism | Animals | Signal Transduction - drug effects | Mice, Nude | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Mice | Neoplasms, Experimental - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 02/2013, Volume 210, Issue 2, pp. 269 - 285
Acquisition of self-tolerance in the thymus requires T cells to discriminate strong versus weak T cell receptor binding by self-peptide-MHC complexes. We find... 
DEVELOPING THYMOCYTES | MEDICINE, RESEARCH & EXPERIMENTAL | TISSUE-RESTRICTED ANTIGENS | SELF-PEPTIDE | RECEPTOR TRANSGENIC MICE | IN-VIVO | BIM | NEGATIVE SELECTION | C-MYC | CLONAL DELETION | IMMUNOLOGY | EXPRESSION | Autoimmunity | Cell Proliferation | NF-kappa B - immunology | Proto-Oncogene Proteins c-rel - metabolism | Proto-Oncogene Proteins - biosynthesis | Proto-Oncogene Proteins c-rel - immunology | CARD Signaling Adaptor Proteins - genetics | CD4-Positive T-Lymphocytes - immunology | Membrane Proteins - deficiency | CARD Signaling Adaptor Proteins - metabolism | Bcl-2-Like Protein 11 | Receptors, CCR7 - metabolism | Apoptosis Regulatory Proteins - deficiency | Programmed Cell Death 1 Receptor - biosynthesis | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Transcription Factors - immunology | Apoptosis Regulatory Proteins - biosynthesis | CARD Signaling Adaptor Proteins - immunology | Apoptosis Regulatory Proteins - immunology | DNA-Binding Proteins - immunology | Lymphocyte Activation | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Self Tolerance | Membrane Proteins - immunology | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Transcription Factors - biosynthesis | Proto-Oncogene Proteins - deficiency | Clonal Deletion - immunology | Mice, Knockout | Membrane Proteins - biosynthesis | Animals | Apoptosis - immunology | Proto-Oncogene Proteins c-rel - genetics | NF-kappa B - biosynthesis | Mice | Mutation | Programmed Cell Death 1 Receptor - immunology | DNA-Binding Proteins - biosynthesis | Index Medicus | 309
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 41, pp. 16570 - 16575
MicroRNAs (miRNAs) have an important role in the development of chemosensitivity or chemoresistance in different types of cancer. Activation of the ERK1/2... 
Up regulation | MicroRNA | Transfection | Cell lines | Gene expression regulation | Down regulation | Apoptosis | Tumors | Application programming interfaces | Lung neoplasms | Noncoding small RNA | Drug resistance | PROTEIN-KINASE-C | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | PEA-15 | MICRORNA-494 | noncoding small RNA | ASTROCYTES | PED/PEA-15 | PATHWAY | RESISTANCE | CHRONIC LYMPHOCYTIC-LEUKEMIA | drug resistance | Cell Proliferation | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Apoptosis - genetics | Lung Neoplasms - pathology | Male | Gene Expression Profiling | MAP Kinase Signaling System - genetics | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Bcl-2-Like Protein 11 | RNA Interference | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Apoptosis Regulatory Proteins - genetics | Tumor Burden - genetics | Membrane Proteins - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Membrane Proteins - genetics | Down-Regulation | Carcinoma, Non-Small-Cell Lung - metabolism | Proto-Oncogene Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Mice, Nude | Cell Line, Tumor | Mice | MicroRNAs - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Lung cancer | Physiological aspects | Development and progression | Genetic aspects | Metastasis | Research | Health aspects | Phosphotransferases | Cancer | Proteins | Cell growth | TNF inhibitors | Ribonucleic acid--RNA | Gene expression | Index Medicus | Biological Sciences
Journal Article
The EMBO Journal, ISSN 0261-4189, 05/2012, Volume 31, Issue 10, pp. 2322 - 2335
Journal Article
Nature, ISSN 0028-0836, 08/2005, Volume 436, Issue 7052, pp. 807 - 811
The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during... 
APOPTOSIS | ONCOGENE | GENE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | N-TERMINAL DOMAIN | C-MYC | TRANSFORMING ACTIVITY | BURKITT-LYMPHOMA CELLS | TRANSACTIVATION DOMAIN | MUTATIONS | Cell Proliferation | Humans | Adoptive Transfer | Cyclin-Dependent Kinase Inhibitor p16 | Burkitt Lymphoma - pathology | Stem Cell Transplantation | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Burkitt Lymphoma - genetics | Membrane Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Burkitt Lymphoma - metabolism | Mutation - genetics | Proto-Oncogene Proteins c-myc - metabolism | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Genes, myc - genetics | Alleles | Mice | Proto-Oncogene Proteins c-myc - genetics | Tumor Suppressor Protein p14ARF - metabolism | Apoptosis | Proteins | Oncology | Mutation | Cellular biology | Tumors | Index Medicus | Proto-Oncogene Proteins c-myc/genetics/metabolism | Mutation/genetics | Tumor Suppressor Protein p14ARF/metabolism | Cell Cycle Proteins/metabolism | Proto-Oncogene Proteins/metabolism | Tumor Suppressor Protein p53/metabolism | Burkitt Lymphoma/genetics/metabolism/pathology | Genes; myc/genetics | Membrane Proteins/metabolism | Mice; Inbred C57BL | Proto-Oncogene Proteins c-bcl-2/metabolism | Carrier Proteins/metabolism
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2006, Volume 281, Issue 17, pp. 12093 - 12101
Elevated serum free fatty acids (FFAs) and hepatocyte lipoapoptosis are features of non-alcoholic fatty liver disease. However, the mechanism by which FFAs... 
PROGRAMMED CELL-DEATH | OXIDATIVE STRESS | RAT HEPATOCYTES | INDUCED APOPTOSIS | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-TERMINAL KINASE | ENDOTHELIAL-CELLS | SYMPATHETIC NEURONS | NONALCOHOLIC STEATOHEPATITIS | DIRECT ACTIVATION | Cathepsin B - physiology | Cathepsin B - genetics | Fatty Acids, Nonesterified - pharmacology | Hepatocytes - metabolism | Hepatocytes - cytology | Flow Cytometry | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - genetics | Liver Neoplasms - pathology | Membrane Proteins - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Hepatocytes - drug effects | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Membrane Proteins - genetics | Cytochromes c - metabolism | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | bcl-2-Associated X Protein - metabolism | Rats | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Fatty Liver | Animals | Membrane Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Carcinoma, Hepatocellular - pathology | JNK Mitogen-Activated Protein Kinases - physiology | Liver Neoplasms - metabolism | Mice | Apoptosis - physiology | Carcinoma, Hepatocellular - metabolism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2007, Volume 104, Issue 15, pp. 6217 - 6222
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2010, Volume 52, Issue 4, pp. 586 - 593
Background & Aims Saturated free fatty acids induce hepatocyte lipoapoptosis. This lipotoxicity involves an endoplasmic reticulum stress response, activation... 
Gastroenterology and Hepatology | Nile Red | Bcl-2 proteins | Human hepatocytes | Apoptosis | Endoplasmic reticulum stress | Steatosis | ACID | FATTY LIVER-DISEASE | NONALCOHOLIC STEATOHEPATITIS | ENDOPLASMIC-RETICULUM STRESS | CELL-DEATH | UNFOLDED PROTEIN RESPONSE | INSULIN-RESISTANCE | MICE | GASTROENTEROLOGY & HEPATOLOGY | HEPATIC STEATOSIS | Phosphorylation - physiology | Transcription Factor CHOP - genetics | Fatty Acids, Monounsaturated - pharmacology | Apoptosis - drug effects | Fatty Liver - pathology | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | RNA, Messenger - metabolism | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Hepatocytes - cytology | Drug Interactions | Bcl-2-Like Protein 11 | Fatty Acids, Monounsaturated - metabolism | Palmitates - pharmacology | Tumor Suppressor Proteins - genetics | Up-Regulation - physiology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Phosphorylation - drug effects | Hepatocytes - drug effects | Hepatocytes - physiology | Proto-Oncogene Proteins - metabolism | Stress, Physiological - physiology | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Fatty Liver - physiopathology | Endoplasmic Reticulum - physiology | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Regulatory Factor X Transcription Factors | Apoptosis Regulatory Proteins - metabolism | Transcription Factors - metabolism | Up-Regulation - drug effects | Animals | Cell Line, Tumor | Mice | Palmitates - metabolism | Apoptosis - physiology | Transcription Factor CHOP - metabolism | Beeswax | Glucose | Tumor proteins | Protein kinases | Fatty acids | Dextrose | Protein binding | Index Medicus | Nile Red, Steatosis
Journal Article
Journal Article
BLOOD, ISSN 0006-4971, 06/2012, Volume 119, Issue 24, pp. 5807 - 5816
The BH3-mimetic ABT-737 and an orally bioavailable compound of the same class, navitoclax (ABT-263), have shown promising antitumor efficacy in preclinical and... 
MULTIPLE-MYELOMA | LUNG-CANCER | ANTAGONIST ABT-737 | FAMILY-MEMBERS | ACUTE LYMPHOBLASTIC-LEUKEMIA | APOPTOTIC RESPONSES | CHRONIC LYMPHOCYTIC-LEUKEMIA | BH3 MIMETIC ABT-737 | HEMATOLOGY | EXPRESSION | INHIBITOR ABT-737 | Leukemia - pathology | Humans | Molecular Targeted Therapy | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - metabolism | Lymphoma - drug therapy | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | bcl-X Protein - antagonists & inhibitors | Nitrophenols - therapeutic use | Protein Binding - drug effects | Cytoprotection - drug effects | Lymphoma - pathology | Membrane Proteins - metabolism | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Leukemia - genetics | Proto-Oncogene Proteins - metabolism | Aniline Compounds - pharmacology | bcl-2-Associated X Protein - metabolism | Etoposide - pharmacology | Leukemia - drug therapy | Lymphoma - genetics | Mutant Proteins - metabolism | Piperazines - therapeutic use | Sulfonamides - pharmacology | Piperazines - pharmacology | Apoptosis Regulatory Proteins - metabolism | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Apoptosis Regulatory Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Aniline Compounds - therapeutic use | bcl-X Protein - metabolism | Drug Resistance, Neoplasm - drug effects | Index Medicus | Abridged Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 03/2018, Volume 67, Issue 3, pp. 423 - 436
Progressive failure of insulin-producing beta-cells is the central event leading to diabetes, but the signaling networks controlling beta-cell fate remain... 
APOPTOSIS | FACTOR SRSF6 | GLUCOSE | ENDOCRINOLOGY & METABOLISM | GLIS3 | DEATH | LOCI | DIFFERENTIATION | STRESS | TYPE-1 | IDENTIFICATION | Mitochondria - enzymology | Phosphorylation | Alternative Splicing | Humans | Gene Expression Profiling | Phosphoproteins - antagonists & inhibitors | Serine-Arginine Splicing Factors - metabolism | Phosphoproteins - metabolism | Serine-Arginine Splicing Factors - genetics | Phosphoproteins - chemistry | MAP Kinase Signaling System | Insulin-Secreting Cells - metabolism | RNA Interference | Serine-Arginine Splicing Factors - chemistry | Insulin-Secreting Cells - cytology | Protein Interaction Domains and Motifs | Insulin Secretion | bcl-2-Associated X Protein - genetics | Cell Line | Cell Survival | Cells, Cultured | Gene Expression Regulation | bcl-2-Associated X Protein - metabolism | Bcl-2-Like Protein 11 - genetics | Mitochondria - metabolism | Phosphoproteins - genetics | Serine-Arginine Splicing Factors - antagonists & inhibitors | Insulin - metabolism | Bcl-2-Like Protein 11 - metabolism | Endoplasmic Reticulum Stress | Protein Processing, Post-Translational | Apoptosis | RNA sequencing | Control | Usage | Blood sugar | Diabetes | B cells | Research | Risk factors | Alternative splicing | Transcription factors | Cell survival | Bax protein | Secretion | Diabetes mellitus | c-Jun protein | Kinases | Ribonucleic acid--RNA | Insulin | Proteins | Beta cells | Survival analysis | Mitochondria | Cell fate | Cell death | Pancreas | Endoplasmic reticulum | Splicing factors | BIM protein | Index Medicus | Abridged Index Medicus | 0709 | Islet Studies
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 495 - 505
After exposure to stressful stimuli, apoptotic signals can be relayed to mitochondria by pro-apoptotic activator proteins, tBid (truncated Bid/p15) and Bim... 
Bax | Fluorescence | Cardiolipin | B-cell lymphoma 2 (Bcl-2) proteins | Cholesterol | Apoptosis | RAT-LIVER | PROTEIN | PROAPOPTOTIC BAX | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | MITOCHONDRIAL-MEMBRANE | cardiolipin | CONFORMATIONAL-CHANGE | fluorescence | cholesterol | CYTOCHROME-C RELEASE | BCL-2 FAMILY | CARDIOLIPIN PROVIDES | BINDING | Mitochondria, Liver - metabolism | Humans | bcl-2 Homologous Antagonist-Killer Protein - deficiency | bcl-2 Homologous Antagonist-Killer Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | Bcl-2-Like Protein 11 | BH3 Interacting Domain Death Agonist Protein - chemistry | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Mutagenesis, Site-Directed | Membrane Proteins - genetics | bcl-2-Associated X Protein - metabolism | Recombinant Proteins - chemistry | Proto-Oncogene Proteins - genetics | Cardiolipins - metabolism | Recombinant Proteins - genetics | Permeability | Cholesterol - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Mitochondrial Membranes - metabolism | Animals | Models, Biological | Membrane Lipids - metabolism | Liposomes - metabolism | Protein Conformation | Mice | Apoptosis - physiology | Index Medicus
Journal Article
Journal Article