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proto-oncogene proteins c-bcl-2 - genetics (196) 196
survival (195) 195
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biological phenomena, cell phenomena, and immunity (194) 194
mitochondria - metabolism (191) 191
immunology (188) 188
bcl-2 (186) 186
bh3-only proteins (182) 182
cell line (181) 181
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antineoplastic agents - pharmacology (177) 177
bcl-2-associated x protein - metabolism (172) 172
down-regulation (171) 171
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research (170) 170
bim protein (167) 167
cell death (167) 167
bcl-2-like protein 11 - metabolism (166) 166
in-vivo (161) 161
abridged index medicus (158) 158
bax (151) 151
rna interference (148) 148
up-regulation (146) 146
mitochondria (145) 145
cell survival (144) 144
proto-oncogene proteins - physiology (143) 143
rats (142) 142
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blotting, western (137) 137
membrane proteins - physiology (137) 137
mutation (136) 136
bcl-2-like protein 11 - genetics (131) 131
cells (129) 129
apoptosis regulatory proteins - physiology (124) 124
analysis (123) 123
bcl-x protein - metabolism (123) 123
multidisciplinary sciences (123) 123
carrier proteins - metabolism (121) 121
family-member bim (119) 119
proto-oncogene proteins - biosynthesis (117) 117
cell survival - drug effects (114) 114
membrane proteins - biosynthesis (113) 113
mice, transgenic (113) 113
myeloid cell leukemia sequence 1 protein (111) 111
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caspases - metabolism (107) 107
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reverse transcriptase polymerase chain reaction (105) 105
transfection (105) 105
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mcl-1 (104) 104
proto-oncogene proteins c-akt - metabolism (104) 104
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PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, pp. e99404 - e99404
Bcl-2 and Bcl-xL are critical regulators of apoptosis that are overexpressed in a variety of human cancers and pharmacological inhibition of Bcl-2 and Bcl-xL... 
BCL-X-L | APOPTOSIS | POTENT | SMALL-MOLECULE INHIBITORS | MCL-1 | MULTIDISCIPLINARY SCIENCES | CHRONIC LYMPHOCYTIC-LEUKEMIA | BH3 MIMETIC ABT-737 | PROTEINS | ABT-263 | FAMILY | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Transplantation, Heterologous | Antineoplastic Agents - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | RNA Interference | bcl-X Protein - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Tumor Suppressor Proteins - metabolism | Aniline Compounds - pharmacology | Sulfonamides - chemistry | Cytochromes c - metabolism | bcl-2-Associated X Protein - metabolism | Antineoplastic Agents - chemistry | Mice, SCID | Sulfonamides - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Apoptosis Regulatory Proteins - metabolism | Animals | Sulfonamides - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Aniline Compounds - chemistry | Aniline Compounds - therapeutic use | bcl-X Protein - metabolism | RNA, Small Interfering - metabolism | Prevention | Proteins | Cancer | Tumors | Apoptosis | Cytochrome | Cell culture | Regulators | Animal models | Bax protein | Bcl-2 protein | Leukemia | Lung cancer | Values | Cancer therapies | Cytosol | Mitochondria | Bcl-x protein | Xenografts | Membrane potential | Small cell lung carcinoma | Internal medicine | Melanoma | Caspase | Pharmacology | Embryo fibroblasts | Tumor cell lines | Mcl-1 protein | Membrane proteins | Cytochrome c | Medicine | Inhibitors | Cell death | Cell lines | Lymphomas | Laboratory animals | Index Medicus
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 2008, Volume 31, Issue 4, pp. 557 - 569
Journal Article
Cancer Research, ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5204 - 5213
Most cancer cells utilize aerobic glycolysis, and activation of the phosphoinositide 3-kinase/Akt/mTOR pathway can promote this metabolic program to render... 
CANCER-CELLS | APOPTOSIS | ONCOLOGY | PATHWAY | AEROBIC GLYCOLYSIS | GROWTH-FACTORS | KINASE | BH3 MIMETIC ABT-737 | FACTOR-INDEPENDENT SURVIVAL | MTOR | TRANSLATIONAL CONTROL | Proto-Oncogene Proteins c-bcl-2 - physiology | Humans | Multiprotein Complexes | Neoplasm Proteins - physiology | Cell Line, Tumor - drug effects | Glycolysis - drug effects | Mechanistic Target of Rapamycin Complex 1 | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | T-Lymphocytes - drug effects | Adenosine Triphosphate - metabolism | Membrane Proteins - metabolism | Phosphoproteins - physiology | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins - metabolism | Proteins - physiology | Proto-Oncogene Proteins - antagonists & inhibitors | Lymphoma, Large B-Cell, Diffuse - pathology | Cell Survival | Proto-Oncogene Proteins c-akt - physiology | Sulfonamides - pharmacology | Piperazines - pharmacology | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Apoptosis Regulatory Proteins - metabolism | Adaptor Proteins, Signal Transducing - physiology | Animals | Membrane Proteins - antagonists & inhibitors | Myeloid Cell Leukemia Sequence 1 Protein | Apoptosis Regulatory Proteins - antagonists & inhibitors | Glucose - metabolism | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Ribosomal Protein S6 Kinases - physiology | TOR Serine-Threonine Kinases | Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Jurkat Cells - drug effects | Index Medicus | mTOR | ABT-737 | Mcl-1 | apoptosis | glycolysis
Journal Article
The Journal of Immunology, ISSN 0022-1767, 12/2008, Volume 181, Issue 11, pp. 7617 - 7629
The magnitude of T cell responses is determined by proliferation and survival decisions made by the responding cells. We now demonstrate that the Erk MAPK... 
LOOP-HELIX PROTEINS | IMMUNE-RESPONSE | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | SIGNALING PATHWAYS | ACTIVATED PROTEIN-KINASE | IN-VIVO | NEGATIVE SELECTION | IMMUNOLOGY | FAMILY-MEMBER BIM | VIRAL-INFECTION | THYMOCYTE DIFFERENTIATION | Cell Proliferation | bcl-X Protein - genetics | Cell Survival - genetics | MAP Kinase Signaling System - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | MAP Kinase Signaling System - genetics | Bcl-2-Like Protein 11 | Mitogen-Activated Protein Kinase 1 - genetics | Proto-Oncogene Proteins - immunology | bcl-X Protein - immunology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - immunology | Apoptosis Regulatory Proteins - immunology | Mitogen-Activated Protein Kinase 1 - immunology | Mitogen-Activated Protein Kinase 3 - genetics | Membrane Proteins - genetics | Membrane Proteins - immunology | Proto-Oncogene Proteins - genetics | Cell Survival - immunology | Apoptosis Regulatory Proteins - metabolism | CD8-Positive T-Lymphocytes - enzymology | Mice, Knockout | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Transcription, Genetic - immunology | Mice | Transcription, Genetic - genetics | CD8-Positive T-Lymphocytes - immunology | bcl-X Protein - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 10/2003, Volume 22, Issue 43, pp. 6785 - 6793
Bim is a proapoptotic member of the Bcl-2 family that shares only the BH3 domain with this family. Three Bim proteins Bim-EL, Bim-L and Bim-S are synthesized... 
Erk1/2 | Bim | Apoptosis | Proteasome | proteasome | ACTIVATION | BAD | BIOCHEMISTRY & MOLECULAR BIOLOGY | BCL-2 FAMILY MEMBER | apoptosis | DEATH | INDUCTION | CELL-SURVIVAL | CELL BIOLOGY | ONCOLOGY | SIGNALING PATHWAY | GENETICS & HEREDITY | EXPRESSION | DEPENDENT DEGRADATION | Phosphorylation | Tetradecanoylphorbol Acetate | Humans | Molecular Sequence Data | Multienzyme Complexes - metabolism | Proteasome Endopeptidase Complex | Lymphoma - metabolism | Caspases - metabolism | Cysteine Endopeptidases - metabolism | Transfection | Bcl-2-Like Protein 11 | Time Factors | Carrier Proteins - chemistry | Proto-Oncogene Proteins | Tumor Cells, Cultured | Binding Sites | Amino Acid Sequence | Cell Line | Antineoplastic Agents, Hormonal - pharmacology | Cell Survival | Gene Expression Regulation | Glutathione Transferase - metabolism | Serine - chemistry | Proto-Oncogene Proteins c-raf - metabolism | Membrane Proteins | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Models, Biological | Protein Isoforms | K562 Cells | Tamoxifen - pharmacology | Mitogen-Activated Protein Kinase 3 | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Bim-L protein | Bim-EL protein | Bim-S protein | Bim protein | Index Medicus | Multienzyme Complexes | Serine | Life Sciences | Glutathione Transferase | Carrier Proteins | Mitogen-Activated Protein Kinases | Cysteine Endopeptidases | Antineoplastic Agents, Hormonal | Proto-Oncogene Proteins c-raf | Biochemistry, Molecular Biology | Tamoxifen | Lymphoma | Caspases | Mitogen-Activated Protein Kinase 1 | Molecular biology | Cancer
Journal Article
Journal Article
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2009, Volume 15, Issue 1, pp. 50 - 58
Gamma-secretase inhibitors (GSIs) block the activation of the oncogenic protein Notch homolog-1 (NOTCH1) in T cell acute lymphoblastic leukemia (T-ALL).... 
MEDICINE, RESEARCH & EXPERIMENTAL | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR EXPRESSION | CYCLE ARREST | SRG3 | CELL BIOLOGY | NOTCH1 CONFERS | GOBLET CELLS | GENE | LINE | DIFFERENTIATION | PROMOTER | Glucocorticoids - administration & dosage | Glucocorticoids - therapeutic use | Cyclins - genetics | Receptors, Glucocorticoid - metabolism | Cyclin D2 | Enzyme Inhibitors - administration & dosage | Bcl-2-Like Protein 11 | Membrane Proteins - physiology | Apoptosis Regulatory Proteins - genetics | Female | Homeostasis - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Dexamethasone - administration & dosage | Membrane Proteins - genetics | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Leukemic - drug effects | Proto-Oncogene Proteins - genetics | Mice, SCID | Mice, Knockout | Dexamethasone - therapeutic use | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Models, Biological | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Homeostasis - physiology | Proto-Oncogene Proteins - physiology | Receptors, Glucocorticoid - genetics | Apoptosis Regulatory Proteins - physiology | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Receptors, Glucocorticoid - physiology | Receptor, Notch1 - physiology | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
Developmental Cell, ISSN 1534-5807, 2006, Volume 10, Issue 3, pp. 317 - 327
Little is known about how growth factors control tissue stem cell survival and proliferation. We analyzed mice with a null mutation of , a key component of... 
STEMCELL | DEVBIO | SIGNALING | Signaling | Dev Bio | Stem cell | MOLECULAR-MECHANISM | EARLY EMBRYONIC LETHALITY | TARGETED DISRUPTION | ACTIVATION | SHP-2 | EARLY MOUSE DEVELOPMENT | EPIDERMAL-GROWTH-FACTOR | SELF-RENEWAL | DEVELOPMENTAL BIOLOGY | SRC FAMILY | PROTEIN-TYROSINE-PHOSPHATASE | CELL BIOLOGY | ras Proteins - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | ras Proteins - metabolism | Male | Protein Tyrosine Phosphatases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Stem Cells - cytology | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Protein Tyrosine Phosphatases - genetics | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - genetics | Female | Membrane Proteins - metabolism | Trophoblasts - cytology | Intracellular Signaling Peptides and Proteins - genetics | Fibroblast Growth Factor 4 - metabolism | Proto-Oncogene Proteins - metabolism | Trophoblasts - metabolism | Cell Survival | Membrane Proteins - genetics | Cells, Cultured | Proto-Oncogene Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | src Homology Domains | Animals | SH2 Domain-Containing Protein Tyrosine Phosphatases | Signal Transduction - physiology | Stem Cells - physiology | Mice | Apoptosis - physiology | Enzyme Activation | Tyrosine | Fibroblast growth factors | T cells | Analysis | Stem cells | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2012, Volume 45, Issue 6, pp. 754 - 763
Overexpression of antiapoptotic proteins including Bcl-XL and/or Bcl-2 contributes to tumor initiation, progression, and resistance to therapy by direct... 
MULTIPLE-MYELOMA | APOPTOSIS | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | ABT-737 | BAX | DEATH | INHIBITOR | BH3-ONLY PROTEINS | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | Humans | bcl-X Protein - genetics | Molecular Sequence Data | BH3 Interacting Domain Death Agonist Protein - genetics | Breast Neoplasms - metabolism | Protein Interaction Maps | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Apoptosis Regulatory Proteins - genetics | Fluorescence Resonance Energy Transfer | bcl-Associated Death Protein - metabolism | Female | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Proto-Oncogene Proteins - metabolism | bcl-Associated Death Protein - genetics | Amino Acid Sequence | Membrane Proteins - genetics | Bacterial Proteins - genetics | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Sulfonamides - pharmacology | Breast Neoplasms - drug therapy | Piperazines - pharmacology | Apoptosis Regulatory Proteins - metabolism | Breast Neoplasms - pathology | Cell Line, Tumor | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Apoptosis - physiology | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Luminescent Proteins - metabolism | Proteins | Chemotherapy | Fluorescence | Development and progression | Mitochondrial DNA | Chemical properties | Cells | Protein binding | Apoptosis | Cancer | Index Medicus
Journal Article