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bcl-2-like protein 11 (1291) 1291
apoptosis (1063) 1063
humans (1049) 1049
proto-oncogene proteins - metabolism (894) 894
membrane proteins - metabolism (877) 877
animals (873) 873
apoptosis regulatory proteins - metabolism (840) 840
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membrane proteins - genetics (613) 613
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apoptosis - drug effects (503) 503
cell biology (487) 487
cell line, tumor (480) 480
bim (475) 475
biochemistry & molecular biology (380) 380
oncology (342) 342
proto-oncogene proteins c-bcl-2 - metabolism (326) 326
proteins (305) 305
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expression (288) 288
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activation (253) 253
signal transduction (227) 227
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apoptosis - physiology (209) 209
mice, knockout (200) 200
apoptosis - genetics (194) 194
biological phenomena, cell phenomena, and immunity (191) 191
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cells, cultured (187) 187
mice, inbred c57bl (180) 180
proto-oncogene proteins c-bcl-2 - genetics (178) 178
bcl-2 (171) 171
bcl-2 family (170) 170
survival (170) 170
immunology (167) 167
research (166) 166
mitochondria - metabolism (165) 165
bim protein (163) 163
gene expression (163) 163
antineoplastic agents - pharmacology (161) 161
bh3-only proteins (160) 160
cell death (160) 160
cell-death (158) 158
bcl-2-like protein 11 - metabolism (152) 152
apoptosis regulatory proteins (150) 150
cell line (149) 149
bcl-2-associated x protein - metabolism (148) 148
in-vivo (146) 146
down-regulation (145) 145
mitochondria (139) 139
bax (135) 135
rna interference (135) 135
up-regulation (131) 131
hematology (128) 128
signal transduction - drug effects (126) 126
abridged index medicus (125) 125
cell survival (123) 123
cells (123) 123
mutation (123) 123
multidisciplinary sciences (122) 122
analysis (121) 121
bcl-2-like protein 11 - genetics (118) 118
proto-oncogene proteins - physiology (118) 118
bcl-x protein - metabolism (114) 114
membrane proteins - physiology (114) 114
rats (114) 114
blotting, western (112) 112
myeloid cell leukemia sequence 1 protein (111) 111
research article (111) 111
apoptosis regulatory proteins - physiology (109) 109
neoplasms (109) 109
kinases (107) 107
genetic aspects (105) 105
family-member bim (103) 103
mice, transgenic (103) 103
mcl-1 (101) 101
cell survival - drug effects (100) 100
protein binding (100) 100
carrier proteins - metabolism (97) 97
caspase 3 - metabolism (96) 96
health aspects (96) 96
forkhead transcription factors - metabolism (93) 93
inhibition (93) 93
proto-oncogene proteins - biosynthesis (93) 93
cell proliferation - drug effects (92) 92
gene expression regulation, neoplastic (91) 91
induced apoptosis (91) 91
membrane proteins - biosynthesis (91) 91
caspases - metabolism (90) 90
apoptosis regulatory proteins - biosynthesis (88) 88
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reverse transcriptase polymerase chain reaction (87) 87
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Diabetes, ISSN 0012-1797, 12/2011, Volume 60, Issue 12, pp. 3279 - 3288
OBJECTIVE-Genome-wide association studies allowed the identification of several associations between specific loci and type 1 diabetes (T1D). However, the... 
DOUBLE-STRANDED-RNA | INTERFERON-ALPHA | ACTIVATION | PHOSPHORYLATION | ENDOCRINOLOGY & METABOLISM | INSULIN-PRODUCING CELLS | FACTOR-KAPPA-B | ENDOPLASMIC-RETICULUM STRESS | EXPRESSION | TYROSINE-PHOSPHATASE | CELIAC-DISEASE | Interferon-alpha - pharmacology | Apoptosis - drug effects | Humans | Cell Survival - genetics | Diabetes Mellitus, Type 1 - metabolism | Apoptosis - genetics | Insulin-Secreting Cells - metabolism | STAT1 Transcription Factor - metabolism | Bcl-2-Like Protein 11 | RNA Interference | Apoptosis Regulatory Proteins - genetics | Insulin-Secreting Cells - cytology | Membrane Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Membrane Proteins - genetics | Cells, Cultured | Diabetes Mellitus, Type 1 - genetics | Rats | Proto-Oncogene Proteins - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | STAT1 Transcription Factor - genetics | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Animals | Interferon-beta - pharmacology | Fluorescent Antibody Technique | Aged | Translocation | Phosphorylation | Bax protein | Cytokines | Diabetes mellitus | siRNA | Caspase-3 | Western blotting | Beta cells | Cytochrome c | Mitochondria | Lymphocytes B | c-Jun amino-terminal kinase | Interferon | Pancreas | Stat1 protein | BIM protein | Apoptosis | PTPN2 protein | Index Medicus | Abridged Index Medicus | Genetics
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2015, Volume 21, Issue 4, pp. 327 - 334
Journal Article
BMC Cancer, ISSN 1471-2407, 01/2014, Volume 14, Issue 1, pp. 32 - 32
Background: Although MYC is an attractive therapeutic target for breast cancer treatment, it has proven challenging to inhibit MYC directly, and clinically... 
Cyclin-dependent kinase | Breast cancer | Synthetic lethality | MYC | SYNTHETIC LETHAL | C-MYC | TUMOR-CELLS | PROLIFERATION | INHIBITION | GENE | ONCOLOGY | PATHWAY | ESTROGEN | THERAPEUTIC TARGETS | EXPRESSION | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Phosphorylation | Cyclin-Dependent Kinase 4 - genetics | Humans | Molecular Targeted Therapy | CDC2 Protein Kinase - metabolism | Dose-Response Relationship, Drug | Breast Neoplasms - enzymology | Transfection | Bcl-2-Like Protein 11 | RNA Interference | Female | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Cell Death - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Proto-Oncogene Proteins - metabolism | Cyclin-Dependent Kinase 2 - metabolism | CDC2 Protein Kinase - genetics | CDC2 Protein Kinase - antagonists & inhibitors | Cyclin-Dependent Kinase 6 - genetics | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase 2 - genetics | Cyclin-Dependent Kinase 6 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Apoptosis Regulatory Proteins - metabolism | Breast Neoplasms - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-myc - genetics | Care and treatment | Patient outcomes | Cancer cells | Physiological aspects | Genetic aspects | Research | Risk factors | Cyclins | Index Medicus
Journal Article
Gene, ISSN 0378-1119, 01/2017, Volume 599, pp. 36 - 52
In old animals, bone's ability to adapt its mass and architecture to functional load-bearing requirements is diminished, resulting in bone loss characteristic... 
Bone | Proliferation | Mechanical loading | Ageing | OSTEOBLAST | SCLEROSTIN ANTIBODY | RNA | CYTOSCAPE | RECEPTOR | CANCELLOUS BONE | PATHWAY | GENETICS & HEREDITY | GENE-EXPRESSION | MICE | ADAPTIVE RESPONSE | Adaptation, Physiological | Cell Cycle - genetics | Cell Proliferation - genetics | Osteocytes - metabolism | Humans | Mice, Inbred C57BL | Transcriptome | Carbohydrate Metabolism - genetics | Signal Transduction - genetics | Gene Regulatory Networks | Tibia - pathology | Aging - pathology | Weight-Bearing - physiology | Extracellular Matrix - genetics | Animals | Aging - genetics | Aging - physiology | Female | Osteocytes - pathology | Mice | E2F1 Transcription Factor - genetics | Energy Metabolism - genetics | Tibia - physiopathology | DNA microarrays | Analysis | Cell cycle | Physiological aspects | Carbohydrate metabolism | Genetic transcription | DNA binding proteins | Transforming growth factors | Index Medicus | NADH, Nicotinamide adenine dinucleotide | EGF, epidermal growth factor | Sp7, Sp7 transcription factor 7 | Ezh2, enhancer of zeste 2 polycomb repressive complex 2 subunit | Gtse, G2 and S-phase expressed 1 | Cdk6, cyclin dependent kinase 6 | Cdca3, cell division cycle associated 3 | RNA, Ribonucleic acid | BMD, bone mineral density | Research Paper | E2F1, E2F transcription factor 1 | CO2, Carbon dioxide | BMP, bone morphogenetic protein | Ttn, titin | DAVID, Database for Annotation, Visualization and Integrated Discovery | Bcl212, Bcl-2-like protein 2 | Itgb1, integrin subunit beta 1 | Bcl11a, B-cell CLL | Sox9, SRY-box 9 | Gnas, GNAS complex locus | Grb10, growth factor receptor bound protein 10 | ATP, Adenosine triphosphate | EGR2, early growth response 2 | Wnt16, Wnt family member 16 | Vcam1, vascular cell adhesion molecule 1 | Mark3, microtubule affinity regulating kinase 3 | Fzd7, frizzled class receptor 7 | b2MG, Beta-2-microglobulin | KEGG, Kyoto Encyclopaedia of Genes and Genomes | Phex, phosphate regulating endopeptidase homolog, X-linked | RarB, retinoic acid receptor beta | SPEED, Signalling Pathway Enrichment using Experimental Datasets | BiNGO, A Biological Network Gene Ontology tool | PASTAA, Predicted Association of Transcription factors from Annotated Affinities | lymphoma 11A | TGFb, transforming growth factor beta 1 | Tcf15, transcription factor 15 | Igf1, insulin like growth factor 1 | Dkk1, dickkopf WNT signalling pathway inhibitor 1 | Des, desmin | MAPK, mitogen-activated protein kinase | Dab2IP, disabled 2 interacting protein | Mmp25, matrix metallopeptidase 25 | Actn2, actinin alpha 2 | qRT-PCR, quantitative real time polymerase chain reaction | Mef2c, myocyte enhancer factor 2C | Mki67, marker of proliferation Ki-67 | Pitx2, paired-like homeodomain transcription factor 2 | MCM, Minichromosome maintenance protein complex | Cdc20, cell division cycle 20 | MEPE, matrix extracellular phosphoglycoprotein | QTC, Quality Threshold Clustering | TNFa, tumor necrosis factor a | Fgf7, fibroblast growth factor 7 | Igf2, insulin like growth factor 2 | Ccna2, cyclin A2 | Fgfr1, fibroblast growth factor receptor 1 | Pkia, protein kinase (cAMP-dependent, catalytic) inhibitor alpha | Ccnd3, cyclin D3 | Myf6, myogenic factor 6 | Sost, sclerostin | Sox6, SRY-box 6 | Atf3, activating transcription factor 3 | MMP13, matrix metallopeptidase 13 | AMPK, adenosine monophosphate-activated protein kinase | Mapt, microtubule associated protein tau | Scyl1, SCY1 like pseudokinase 1 | Insig2, insulin induced gene 2 | PBS, Phosphate buffered saline | Kcnma1, potassium calcium-activated channel subfamily M alpha 1 | FDR, false discovery rate | VegfA, vascular endothelial growth factor A | Nusap1, nucleolar and spindle associated protein 1 | ECM, Extracellular matrix | PdgfA, platelet derived growth factor, alpha
Journal Article
The FEBS Journal, ISSN 1742-464X, 07/2018, Volume 285, Issue 14, pp. 2626 - 2640
Journal Article
Journal Article
Cancer Biology and Therapy, ISSN 1538-4047, 02/2015, Volume 16, Issue 2, pp. 276 - 286
The pediatric solid tumor neuroblastoma (NB) often depends on the anti-apoptotic protein, Mcl(-)1, for survival through Mcl(-)1 sequestration of pro-apoptotic... 
Bim regulation | 1 | 2 homology proteins | 2 antagonist | Mcl | ABT-737 | Bcl | EGFR | Apoptosis | MCL-1 | BH3-ONLY PROTEIN | apoptosis | CELL-LINES | Bcl(-)2 homology proteins | GROWTH-FACTOR RECEPTOR | BCL-2 | THERAPY | ONCOLOGY | Bcl(-)2 antagonist | Mcl(-)1 | MYELOMA CELLS | bim regulation | HIGH-RISK NEUROBLASTOMA | PHASE-I | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | Phosphorylation | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Receptor, Epidermal Growth Factor - metabolism | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Gene Expression | Neuroblastoma - genetics | Neoplasm Recurrence, Local | Neuroblastoma - diagnosis | Sulfonamides - pharmacology | Piperazines - pharmacology | Apoptosis Regulatory Proteins - metabolism | Drug Resistance, Neoplasm - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Protein Binding | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Neuroblastoma - metabolism | Protein Processing, Post-Translational | Index Medicus
Journal Article
PLoS Genetics, ISSN 1553-7390, 05/2013, Volume 9, Issue 5, pp. e1003532 - e1003532
Journal Article
Hepatology, ISSN 0270-9139, 07/2011, Volume 54, Issue 1, pp. 185 - 195
Journal Article