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Molecular cell, ISSN 1097-2765, 02/2005, Volume 17, Issue 3, pp. 393 - 403
Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic BH3-only proteins via interaction of its BH3 domain with a groove on the Bcl-2-like proteins... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Humans | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | Genetic Complementation Test | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Carrier Proteins - chemistry | Proto-Oncogene Proteins c-bcl-2 - chemistry | Membrane Proteins - metabolism | Neoplasm Proteins - genetics | Peptide Fragments - genetics | Cell Survival - physiology | Binding, Competitive | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | bcl-X Protein | Peptide Fragments - metabolism | Membrane Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Proto-Oncogene Proteins - genetics | Recombinant Proteins - genetics | Proteins - genetics | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Peptide Fragments - chemistry | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Proteins - metabolism | Membrane Proteins - chemistry | Models, Biological | Myeloid Cell Leukemia Sequence 1 Protein | Biosensing Techniques | Ligands | Mice | Apoptosis - physiology | Proteins - chemistry | In Vitro Techniques | Proto-Oncogene Proteins c-bcl-2 - genetics
Journal Article
Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, p. 16078
BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anticancer targets... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Drug Resistance, Neoplasm | Molecular Targeted Therapy | Apoptosis Regulatory Proteins - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - drug effects | Small Cell Lung Carcinoma - drug therapy | Small Cell Lung Carcinoma - metabolism | bcl-X Protein - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | bcl-X Protein - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Aniline Compounds - pharmacology | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Sulfonamides - pharmacology | Apoptosis Regulatory Proteins - metabolism | Drug Synergism | Pyridinium Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | High-Throughput Screening Assays | Apoptosis Regulatory Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - drug effects | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | bcl-X Protein - metabolism | Doxorubicin - pharmacology | Regulators | Bax protein | Bcl-2 protein | Small cell lung carcinoma | Lung cancer | High-throughput screening | Doxorubicin | BAK protein | Mcl-1 protein | Proteins | Mitochondria | Inhibitors | Bcl-x protein | Anthracycline | Addiction | Cell death | Sequestering | Cancer | Apoptosis
Journal Article
Nature cell biology, ISSN 1465-7392, 2017, Volume 19, Issue 10, pp. 1226 - 1236
...). Here we report that three anti-apoptotic BCL-2 proteins (MCL-1, BCL-2 and BCL-XL) found untethered from the OMM function as transcriptional regulators of a prosurvival and growth program... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | NIH 3T3 Cells | Transcription, Genetic - drug effects | Cell Proliferation | Zinc Finger Protein GLI1 - metabolism | Humans | Gene Expression Regulation, Neoplastic | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-X Protein - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Molecular Mimicry | Transfection | Neoplasms - genetics | RNA Interference | Time Factors | Tumor Suppressor Proteins - genetics | HEK293 Cells | Female | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - deficiency | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Peptide Fragments - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cell Survival | Zinc Finger Protein GLI1 - genetics | Repressor Proteins - genetics | Genotype | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Mice, Knockout | Neoplasms - drug therapy | Phenotype | Animals | Mice, Nude | CRISPR-Cas Systems | Mice | Neoplasms - pathology | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Genes | Genetic aspects | Genetic transcription | Drug resistance | Binding proteins | Tumors | Protein binding | Regulators | Cell survival | Bcl-2 protein | Transcription | Decision making | Homology | Gene expression | Mcl-1 protein | Proteins | Signaling | Mitochondria | DNA-binding protein | Bcl-x protein | Cell death | Feedforward | Deoxyribonucleic acid--DNA | Cancer
Journal Article
PloS one, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, p. e0145780
.... Additionally, we are providing information that deguelin binds directly to anti-apoptotic Bcl-2, Bcl-xl and Mcl-1 in the hydrophobic grooves, thereby releasing BAD and BAX from dimerization with these proteins... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Ribosomal Protein S6 Kinases - metabolism | Apoptosis - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Rotenone - analogs & derivatives | bcl-X Protein - chemistry | Proto-Oncogene Proteins c-bcl-2 - metabolism | RNA Interference | Mitogen-Activated Protein Kinase 1 - genetics | Rotenone - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | bcl-Associated Death Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - chemistry | Phosphorylation - drug effects | Binding Sites | Protein Structure, Tertiary | Mitogen-Activated Protein Kinase 3 - genetics | bcl-Associated Death Protein - chemistry | Cytochromes c - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Rotenone - chemistry | Mitochondrial Membranes - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Protein Binding | Molecular Docking Simulation | HeLa Cells | bcl-X Protein - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Phosphorylation | Apoptotic proteins | RNA | HeLa cells | Genetic aspects | Research | Health aspects | Rotenone | Cytochrome | Biotechnology | Bax protein | Bcl-2 protein | Serine | Multiple myeloma | Oncology | Hydrophobicity | Kinases | Autophagy | Stomach cancer | Proteins | Angiogenesis | Mitochondria | Bcl-x protein | Cell cycle | Life sciences | Inhibition | Dimerization | Medical research | Extracellular signal-regulated kinase | Pharmacology | Grooves | siRNA | Chemical compounds | Mcl-1 protein | Cytochrome c | Medicine | Molecular biology | Apoptosis
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 03/2013, Volume 288, Issue 10, pp. 7387 - 7398
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 12/2008, Volume 181, Issue 11, pp. 7617 - 7629
Journal Article
PloS one, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e79739
Aim: Cardiac microvascular endothelial cells (CMECs) dysfunction contributes to cardiovascular complications in diabetes, whereas, the underlying mechanism is... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Phosphorylation - physiology | RNA, Small Interfering - genetics | Reactive Oxygen Species - metabolism | Heart - physiology | Oxidative Stress - physiology | Microvessels - metabolism | bcl-X Protein - genetics | Apoptosis - genetics | Male | Proto-Oncogene Proteins c-akt - genetics | Endothelium, Vascular - physiology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Phosphorylation - genetics | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Endothelial Cells - physiology | Proto-Oncogene Proteins - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | Oxidative Stress - genetics | Rats | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Rats, Sprague-Dawley | Down-Regulation - genetics | Apoptosis Regulatory Proteins - metabolism | Microvessels - physiology | Animals | Endothelium, Vascular - metabolism | Glucose - metabolism | Apoptosis - physiology | Forkhead Box Protein O3 | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | DNA binding proteins | Glucose | Dextrose | Apoptosis | Endothelium | Heart | Oxidative stress | Reactive oxygen species | Transcription factors | Phosphorylation | Bcl-2 protein | AKT protein | Cardiovascular disease | Kinases | Accumulation | Western blotting | Proteins | Hyperglycemia | Rodents | Forkhead protein | Heart diseases | FOXO3 protein | Oxygen | Incubation | Internal medicine | Complications | Diabetes mellitus | Cardiomyocytes | siRNA | Endothelial cells | Medicine | MicroRNAs | Microvasculature | Diabetes | Laboratory animals | BIM protein
Journal Article