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1. Full Text Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3β-dependent inhibition of apoptosis and ER stress
by Dong, Maolong and Hu, Nan and Hua, Yinan and Xu, Xihui and Kandadi, Machender R and Guo, Rui and Jiang, Shasha and Nair, Sreejayan and Hu, Dahai and Ren, Jun
Biochimica et biophysica acta. Molecular basis of disease, ISSN 0925-4439, 06/2013, Volume 1832, Issue 6, pp. 848 - 863
Heart | ER stress | Sepsis | Akt | Contractile function | Apoptosis | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Caspase 9 - genetics | Apoptosis - drug effects | Calcium - metabolism | Heat-Shock Proteins - biosynthesis | Myocardial Contraction - drug effects | bcl-2-Associated X Protein - biosynthesis | Apoptosis - genetics | Glycogen Synthase Kinase 3 beta | Transcription Factor TFIIH | Heat-Shock Proteins - genetics | Phosphorylation - genetics | Caspase 3 - genetics | Phosphorylation - drug effects | Transcription Factor CHOP - biosynthesis | Proto-Oncogene Proteins c-akt - metabolism | Apoptosis Regulatory Proteins - biosynthesis | Lipopolysaccharides - toxicity | Endoplasmic Reticulum Stress - drug effects | Mice, Transgenic | Glycogen Synthase Kinase 3 - genetics | Eukaryotic Initiation Factor-2 - genetics | Mice | Enzyme Activation - genetics | Transcription Factor CHOP - genetics | Eukaryotic Initiation Factor-2 - biosynthesis | Microtubule-Associated Proteins - genetics | bcl-X Protein - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Endoplasmic Reticulum Stress - genetics | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Myocardial Contraction - genetics | MAP Kinase Signaling System - genetics | Apoptosis Regulatory Proteins - genetics | Caspase 3 - biosynthesis | bcl-X Protein - biosynthesis | bcl-2-Associated X Protein - genetics | Beclin-1 | Gene Expression Regulation - genetics | Myocardium - pathology | Transcription Factors - biosynthesis | Transcription Factors - genetics | Enzyme Activation - drug effects | Glycogen Synthase Kinase 3 - metabolism | Microtubule-Associated Proteins - biosynthesis | Gene Expression Regulation - drug effects | Autophagy-Related Protein 7 | Myocardium - enzymology | Animals | MAP Kinase Signaling System - drug effects | Caspase 9 - biosynthesis
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2. Full Text Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease
by Nascimento-Ferreira, Isabel and Nóbrega, Clévio and Vasconcelos-Ferreira, Ana and Onofre, Isabel and Albuquerque, David and Aveleira, Célia and Hirai, Hirokazu and Déglon, Nicole and Pereira De Almeida, Luís
Brain (London, England : 1878), ISSN 0006-8950, 2013, Volume 136, Issue 7, pp. 2173 - 2188
ataxin-3 | autophagy | beclin-1, Machado-Joseph disease, spinocerebellar ataxia type 3 | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Biological and medical sciences | Medical sciences | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Age Factors | Ataxin-3 | Machado-Joseph Disease - metabolism | Humans | Peptides - genetics | Motor Activity - drug effects | Sensation Disorders - etiology | Male | Green Fluorescent Proteins - genetics | Membrane Proteins - therapeutic use | Psychomotor Performance - physiology | Machado-Joseph Disease - complications | Transfection | Nerve Degeneration - prevention & control | Apoptosis Regulatory Proteins - genetics | Female | Membrane Proteins - metabolism | Autophagy - genetics | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Disease Models, Animal | Animals, Newborn | Beclin-1 | Gene Expression Regulation - genetics | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | Repressor Proteins - genetics | Sensation Disorders - metabolism | Mice, Transgenic | Nuclear Proteins - metabolism | Postural Balance - genetics | Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism | Nerve Tissue Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Machado-Joseph Disease - drug therapy | Nerve Tissue Proteins - metabolism | Motor Activity - genetics | Animals | Analysis of Variance | Cerebellum - cytology | Mice | Sensation Disorders - genetics | Apoptosis Regulatory Proteins - therapeutic use | Nerve Degeneration - etiology | Machado-Joseph Disease - genetics | Index Medicus | Abridged Index Medicus | Animal models
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3. Full Text A pathogenic role for ER stress‐induced autophagy and ER chaperone GRP78/BiP in T lymphocyte systemic lupus erythematosus
by Lee, Won‐Seok and Sung, Myung‐Soon and Lee, Eun‐Gyeong and Yoo, Han‐Gyul and Cheon, Yun‐Hong and Chae, Han‐Jung and Yoo, Wan‐Hee
Journal of leukocyte biology, ISSN 0741-5400, 02/2015, Volume 97, Issue 2, pp. 425 - 433
T cells | apoptosis | SLE | Immunology | Life Sciences & Biomedicine | Hematology | Science & Technology | Cell Biology | RNA, Small Interfering - genetics | Transcription Factor CHOP - genetics | Endoribonucleases - genetics | Activating Transcription Factor 6 - immunology | Humans | bcl-X Protein - genetics | eIF-2 Kinase - immunology | Male | Endoplasmic Reticulum Stress - genetics | Activating Transcription Factor 6 - genetics | Endoplasmic Reticulum Stress - immunology | Autophagy - immunology | Heat-Shock Proteins - genetics | RNA, Small Interfering - immunology | Lupus Erythematosus, Systemic - immunology | Transcription Factor CHOP - immunology | bcl-X Protein - immunology | Apoptosis Regulatory Proteins - genetics | Female | Autophagy - genetics | T-Lymphocytes - pathology | bcl-2-Associated X Protein - genetics | eIF-2 Kinase - genetics | Beclin-1 | Apoptosis Regulatory Proteins - immunology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Membrane Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Membrane Proteins - immunology | Heat-Shock Proteins - immunology | bcl-2-Associated X Protein - immunology | Caspase 6 - genetics | Eukaryotic Initiation Factor-2 - genetics | Lupus Erythematosus, Systemic - genetics | Protein-Serine-Threonine Kinases - immunology | T-Lymphocytes - immunology | Caspase 6 - immunology | Eukaryotic Initiation Factor-2 - immunology | Lupus Erythematosus, Systemic - pathology | Endoribonucleases - immunology | Index Medicus
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4. Full Text A novel CXCR3-B Chemokine Receptor-induced Growth-inhibitory signal in cancer cells is Mediated through the Regulation of Bach-1 Protein and Nrf2 Protein Nuclear Translocation
by Balan, Murugabaskar and Pal, Soumitro
The Journal of biological chemistry, ISSN 0021-9258, 02/2014, Volume 289, Issue 6, pp. 3126 - 3137
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Basic-Leucine Zipper Transcription Factors - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | bcl-X Protein - genetics | Apoptosis - genetics | Breast Neoplasms - metabolism | MAP Kinase Signaling System | Heme Oxygenase-1 - genetics | Fanconi Anemia Complementation Group Proteins - metabolism | Cell Nucleus - metabolism | Protein Isoforms - metabolism | Cell Nucleus - pathology | Mitogen-Activated Protein Kinase 1 - genetics | Apoptosis Regulatory Proteins - genetics | Female | NF-E2-Related Factor 2 - genetics | Membrane Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Active Transport, Cell Nucleus - genetics | Beclin-1 | Receptors, CXCR3 - metabolism | Heme Oxygenase-1 - biosynthesis | Mitogen-Activated Protein Kinase 3 - genetics | Membrane Proteins - genetics | Alternative Splicing - genetics | Fanconi Anemia Complementation Group Proteins - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Basic-Leucine Zipper Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Breast Neoplasms - genetics | Cell Nucleus - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Breast Neoplasms - pathology | NF-E2-Related Factor 2 - metabolism | Receptors, CXCR3 - genetics | Cell Line, Tumor | bcl-X Protein - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Protein Isoforms - genetics | Index Medicus | Signaling | Signal Transduction | Nrf2 | Heme Oxygenase | Nuclear Transport | Chemokines | Apoptosis
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5. Full Text Exosomal transfer of miR-30a between cardiomyocytes regulates autophagy after hypoxia
by Yang, Yan and Li, Yingying and Chen, Xiao and Cheng, Xiang and Liao, Yuhua and Yu, Xian
Journal of molecular medicine (Berlin, Germany), ISSN 0946-2716, 6/2016, Volume 94, Issue 6, pp. 711 - 724
Human Genetics | miR-30a | Biomedicine | Internal Medicine | Hypoxia | Cardiomyocytes | Molecular Medicine | Exosomes | Autophagy | Genetics & Heredity | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Exosomes - metabolism | Myocardial Infarction - genetics | MicroRNAs - antagonists & inhibitors | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Middle Aged | Male | MicroRNAs - metabolism | Hypoxia - metabolism | Cell Hypoxia | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Myocardial Infarction - pathology | Adult | Female | Autophagy - genetics | Oligoribonucleotides, Antisense - metabolism | Cell Line | Autophagy-Related Protein 12 - genetics | Paracrine Communication | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Gene Expression Regulation | Myocardial Infarction - metabolism | Autophagy-Related Protein 12 - metabolism | Myocytes, Cardiac - pathology | Hypoxia - genetics | Hypoxia - pathology | Oligoribonucleotides, Antisense - genetics | Beclin-1 - genetics | Myocytes, Cardiac - metabolism | Aged | MicroRNAs - genetics | Beclin-1 - metabolism | Autophagy (Cytology) | Heart cells | Physiological aspects | Development and progression | Genetic aspects | Research | Heart diseases | Index Medicus
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6. Full Text Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1‐mediated autophagy regulation
by Ren, Jun and Yang, Lifang and Zhu, Li and Xu, Xihui and Ceylan, Asli F and Guo, Wei and Yang, Jian and Zhang, Yingmei
Aging cell, ISSN 1474-9718, 10/2017, Volume 16, Issue 5, pp. 976 - 987
cardiac geometry | contractile function | autophagy | aging | Akt | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Cell Biology | Adaptation, Physiological | Protein Kinases - metabolism | Sirtuin 1 - metabolism | Phosphorylation | Protein Kinases - genetics | Microtubule-Associated Proteins - genetics | Calcium - metabolism | Microtubule-Associated Proteins - metabolism | Autophagy-Related Protein 7 - metabolism | Proto-Oncogene Proteins c-akt - deficiency | Atrial Remodeling - drug effects | Myocardial Contraction - drug effects | Cardiomegaly - pathology | Male | Mitochondrial Proteins - genetics | Sirtuin 1 - genetics | Autophagy - drug effects | Heterocyclic Compounds, 4 or More Rings - pharmacology | Proto-Oncogene Proteins c-akt - genetics | Mitochondrial Proteins - metabolism | Myocardium - metabolism | Membrane Proteins - metabolism | Autophagy - genetics | Forkhead Box Protein O1 - metabolism | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Signal Transduction | Membrane Proteins - genetics | Gene Expression Regulation | Myocardium - pathology | Mitochondria - metabolism | Longevity - genetics | Mitochondria - pathology | Autophagy-Related Protein 7 - genetics | Sirolimus - pharmacology | Mice, Knockout | Animals | Cardiomegaly - prevention & control | Beclin-1 - genetics | Mice | Beclin-1 - metabolism | Cardiomegaly - genetics | Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics | Forkhead Box Protein O1 - genetics | Cardiomegaly - metabolism | Heart | Laws, regulations and rules | Ablation (Surgery) | AKT protein | Autophagy | Ca2+-transporting ATPase | Mitochondria | FOXO1 protein | Aging | Oxidation | Fura-2 | Acetylation | Heart diseases | Calcium (intracellular) | Echocardiography | AKT2 protein | Cardiomyocytes | Rapamycin | Insulin | Muscle contraction | BNIP3 protein | Life span | PTEN-induced putative kinase | Parkin protein | Intracellular | PTEN protein | Phagocytosis | Hypertrophy | Index Medicus | Original
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7. Full Text STING directly activates autophagy to tune the innate immune response
by Liu, Dong and Wu, Hao and Wang, Chenguang and Li, Yanjun and Tian, Huabin and Siraj, Sami and Sehgal, Sheikh Arslan and Wang, Xiaohui and Wang, Jun and Shang, Yingli and Jiang, Zhengfan and Liu, Lei and Chen, Quan
Cell death and differentiation, ISSN 1350-9047, 2018, Volume 26, Issue 9, pp. 1735 - 1749
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Nucleotides, Cyclic - metabolism | Protein Binding - genetics | Microtubule-Associated Proteins - genetics | Membrane Proteins - genetics | Humans | Vesicular Transport Proteins - genetics | Immunity, Innate - genetics | Autophagy-Related Protein 5 - genetics | Autophagy - immunology | Immunity, Innate - immunology | Animals | Nucleotides, Cyclic - genetics | Beclin-1 - genetics | Fibroblasts - immunology | Mice | Autophagy - genetics | HeLa Cells | Autophagy-Related Protein-1 Homolog - genetics | Autophagy-Related Proteins - genetics | Immune response | AMP | Cyclic GMP | Innate immunity | Interferon | Autophagy | Dimerization | Phagocytosis | Index Medicus | Signal transduction | Macroautophagy | Antimicrobial responses
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8. Full Text USP1 (ubiquitin specific peptidase 1) targets ULK1 and regulates its cellular compartmentalization and autophagy
by Raimondi, Marzia and Cesselli, Daniela and Di Loreto, Carla and La Marra, Francesco and Schneider, Claudio and Demarchi, Francesca
Autophagy, ISSN 1554-8627, 04/2019, Volume 15, Issue 4, pp. 613 - 630
breast cancer | MAP1LC3B | Aggresomes | pimozide | noncanonical autophagy | deubiquitinating enzymes | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Phosphorylation | Ubiquitin-Specific Proteases - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Protein Processing, Post-Translational - genetics | Cell Survival - genetics | Autophagy-Related Protein-1 Homolog - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Breast Neoplasms - metabolism | Ubiquitination - drug effects | HEK293 Cells | Apoptosis Regulatory Proteins - genetics | Female | Autophagy - genetics | Ubiquitin-Specific Proteases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Sequestosome-1 Protein - metabolism | Fibroblasts - metabolism | Cell Survival - drug effects | Cell Compartmentation - genetics | Signal Transduction - genetics | Autophagy-Related Protein-1 Homolog - chemistry | Sequestosome-1 Protein - genetics | Animals | Breast Neoplasms - genetics | Intracellular Signaling Peptides and Proteins - chemistry | Fibroblasts - drug effects | Beclin-1 - genetics | Mice | Beclin-1 - metabolism | Autophagy-Related Protein-1 Homolog - genetics | Ubiquitination - genetics | Index Medicus
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9. Full Text Downregulation of E3 ubiquitin ligases and mitophagy-related genes in skeletal muscle of physically inactive, frail older women: A cross-sectional comparison
by Drummond, Micah J and Addison, Odessa and Brunker, Lucille and Hopkins, Paul N and McClain, Donald A and Lastayo, Paul C and Marcus, Robin L
The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, 2014, Volume 69, Issue 8, pp. 1040 - 1048
Atrophy | Aging | Mobility | Mitochondrial dysfunction | Autophagy | Gerontology | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Phosphorylation - physiology | Sarcopenia - genetics | Microtubule-Associated Proteins - genetics | SKP Cullin F-Box Protein Ligases - genetics | Humans | Endosomal Sorting Complexes Required for Transport - genetics | Mitochondrial Proteins - genetics | Ubiquitin-Protein Ligases - physiology | Tripartite Motif Proteins | Muscular Atrophy - physiopathology | Proteolysis | Gene Expression - physiology | Genes, Tumor Suppressor - physiology | Aged, 80 and over | Apoptosis Regulatory Proteins - genetics | Female | Nedd4 Ubiquitin Protein Ligases | Beclin-1 | Cross-Sectional Studies | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Frail Elderly | Muscle, Skeletal - physiology | Forkhead Transcription Factors - genetics | Mitochondrial Degradation - physiology | Down-Regulation - physiology | Muscle Proteins - genetics | Sarcopenia - physiopathology | GTP Phosphohydrolases - genetics | Aged | Muscle, Skeletal - pathology | Forkhead Box Protein O3 | Ubiquitin-Protein Ligases - genetics | AMP-Activated Protein Kinases - genetics | Ubiquitin | Physiological aspects | Muscles | Aged women | Ligases | Musculoskeletal system | Physical fitness | Genetic markers | Biochemistry | Gene expression | Kinases | Index Medicus | Abridged Index Medicus
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