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Nature (London), ISSN 1476-4687, 03/2019, Volume 567, Issue 7747, pp. 262 - 266
Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self DNA in the cytoplasm(1). Upon binding DNA, cGAS... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Nucleotides, Cyclic - metabolism | Interferons - biosynthesis | Beclin-1 - deficiency | Vesicular Transport Proteins - metabolism | Humans | Endoplasmic Reticulum - metabolism | Autophagy-Related Protein 5 - genetics | Autophagy-Related Protein-1 Homolog - metabolism | DNA Viruses - metabolism | Interferons - immunology | Autophagy | DNA Viruses - genetics | Sea Anemones | Membrane Proteins - deficiency | HEK293 Cells | Membrane Proteins - metabolism | Nucleotidyltransferases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Phosphate-Binding Proteins | Signal Transduction | Membrane Proteins - genetics | DNA, Viral - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Autophagosomes - metabolism | Cytosol - virology | Protein Transport | Carrier Proteins - genetics | Animals | Autophagy-Related Protein-1 Homolog - deficiency | Carrier Proteins - metabolism | Monomeric GTP-Binding Proteins - metabolism | Autophagy-Related Protein 5 - deficiency | Autophagy-Related Protein 5 - metabolism | Beclin-1 - genetics | Golgi Apparatus - metabolism | Mice | Beclin-1 - metabolism | Autophagy-Related Protein-1 Homolog - genetics | Nucleotides, Cyclic - immunology | Evolution, Molecular | Biological research | Autophagy (Cytology) | Enzymes | Physiological aspects | Interferon | Research | Cytoplasm | Biology, Experimental | Index Medicus
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0173676 - e0173676
Autophagy is a catabolic mechanism to degrade cellular components to maintain cellular energy levels during starvation, a condition where PPAR alpha may be... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | TOR Serine-Threonine Kinases - metabolism | Autophagy-Related Protein 7 - metabolism | Fibroblast Growth Factors - genetics | Autophagy-Related Protein 5 - genetics | fas Receptor - metabolism | Autophagy - drug effects | Fibroblast Growth Factors - metabolism | TOR Serine-Threonine Kinases - genetics | Liver - drug effects | fas Receptor - genetics | Autophagy - genetics | Proto-Oncogene Proteins c-akt - metabolism | Forkhead Box Protein O1 - metabolism | Signal Transduction | Liver - metabolism | PPAR alpha - genetics | Ubiquitin-Conjugating Enzymes - genetics | Stearoyl-CoA Desaturase - genetics | Mice, Knockout | Triglycerides - metabolism | Sequestosome-1 Protein - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Cysteine Endopeptidases - genetics | Autophagy-Related Protein 5 - metabolism | Beclin-1 - genetics | Stearoyl-CoA Desaturase - metabolism | Mice | PPAR alpha - metabolism | Autophagy-Related Proteins - antagonists & inhibitors | Blood Glucose - metabolism | Autophagy-Related Proteins - metabolism | Forkhead Box Protein O1 - genetics | Autophagy-Related Protein 5 - antagonists & inhibitors | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Fenofibrate - pharmacology | Cysteine Endopeptidases - metabolism | Autophagy-Related Proteins - genetics | Sequestosome-1 Protein - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Autophagy-Related Protein 7 - antagonists & inhibitors | Mice, Inbred C57BL | Autophagy-Related Protein 7 - genetics | Gene Expression Regulation - drug effects | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | PPAR alpha - agonists | Ubiquitin-Conjugating Enzymes - antagonists & inhibitors | Beclin-1 - metabolism | Transcription factors | Adipose tissue | Liver | Body weight | AKT protein | Biochemistry | Glucose | Assaying | Proteins | Signal transduction | Temperature effects | Fibroblasts | Physiology | Acetylation | Inhibition | Growth factors | Hepatotoxicity | Activation analysis | Methanol | Starvation | Ethanol | AMP | Metabolism | Insulin | Fatty acids | Studies | Acetaminophen | Food intake | Weight reduction | Animal welfare | Circulation | Drugs | Biotechnology | Drug abuse | Laboratories | Centrifugation | Glass | Homeostasis | Activation | Biology | Kinases | AMP-activated protein kinase | Autophagy | Nutrient status | Rodents | Nutrients | Oxidation | Heart diseases | Age | Epinephrine | AKT1 protein | Fasting | Chloroform | Diabetes mellitus | Cardiomyocytes | Acclimatization | Triglycerides | Pharmacology | Nitrogen | Calories | Medicine | Nuclear fuels | Protein kinase | Insulin resistance | Diabetes | Index Medicus
Journal Article
The Journal of physiology, ISSN 0022-3751, 10/2014, Volume 592, Issue 20, pp. 4575 - 4589
.... We indicate that alterations of oxidative metabolism, occurring in slow soleus muscle, are not just a consequence of disuse, but a major cause of activation of catabolic pathways and loss of mass... 
Neurosciences | Physiology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Up-Regulation | Dynamins - metabolism | Superoxide Dismutase - genetics | Oxidative Stress | SKP Cullin F-Box Protein Ligases - genetics | Mitochondria, Muscle - metabolism | Male | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | RNA, Messenger - metabolism | Autophagy | Tripartite Motif Proteins | Chromans - pharmacology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | NF-E2-Related Factor 2 - genetics | Muscular Atrophy - prevention & control | Muscle Fibers, Skeletal - physiology | Superoxide Dismutase - metabolism | Beclin-1 | Muscular Atrophy - metabolism | Catalase - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Ubiquitin-Protein Ligases - metabolism | Dynamins - genetics | SKP Cullin F-Box Protein Ligases - metabolism | Antioxidants - pharmacology | Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Catalase - metabolism | Muscle Proteins - genetics | Transcription Factors - metabolism | Antioxidants - therapeutic use | Animals | Chromans - therapeutic use | Hindlimb Suspension - adverse effects | NF-E2-Related Factor 2 - metabolism | Mice | Mitochondria, Muscle - drug effects | Superoxide Dismutase-1 | Ubiquitin-Protein Ligases - genetics | Index Medicus | Muscle
Journal Article
The American journal of sports medicine, ISSN 1552-3365, 09/2014, Volume 42, Issue 12, pp. 2860 - 2868
Background: The repair and restoration of function after chronic rotator cuff tears are often complicated by muscle atrophy, fibrosis, and fatty degeneration... 
fatty degeneration | rotator cuff | myosteatosis | licofelone | Sport Sciences | Life Sciences & Biomedicine | Orthopedics | Science & Technology | Muscle Fibers, Fast-Twitch - drug effects | Vesicular Transport Proteins - metabolism | Male | Muscle, Skeletal - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | PPAR gamma - metabolism | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Rotator Cuff - surgery | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | Interleukin-10 - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Wound Healing - drug effects | Fibrocartilage - pathology | PPAR gamma - genetics | Beclin-1 | Rotator Cuff - pathology | Hydroxyproline - metabolism | Vesicular Transport Proteins - genetics | Enzyme Inhibitors - pharmacology | Phosphoproteins - genetics | Rats, Sprague-Dawley | Apoptosis Regulatory Proteins - metabolism | Acetyl-CoA C-Acetyltransferase - genetics | Muscle Proteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Biomechanical Phenomena | Pyrroles - pharmacology | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Autophagy-Related Protein 5 | Diacylglycerol O-Acyltransferase - genetics | Muscle Contraction - drug effects | Interleukin-10 - genetics | Fibrosis | Lipid Metabolism - drug effects | Wound Healing - physiology | Muscle, Skeletal - pathology | Acetyl-CoA C-Acetyltransferase - metabolism | Diacylglycerol O-Acyltransferase - metabolism | Perilipin-1 | Index Medicus
Journal Article
Journal Article
Cell host & microbe, ISSN 1931-3128, 11/2018, Volume 24, Issue 5, pp. 689 - 702.e7
Long-lived resting memory CD4+ T cells (TCM) are a major reservoir of latent HIV infection. We hypothesized that latent HIV-TCM cells are maintained by... 
caspase 8 | autophagy | HIV | CD4+ T cell | SMAC mimetics | apoptosis | XIAP | Fas | RIPK1 | BIRC2 | CD4+ T cell | Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | HIV-1 - pathogenicity | Apoptosis - drug effects | Autophagy-Related Protein 7 - metabolism | Cyclohexanes - pharmacology | Humans | Caspase 8 - metabolism | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy - drug effects | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | HIV-1 - physiology | Mitochondrial Proteins - metabolism | Baculoviral IAP Repeat-Containing 3 Protein - metabolism | Cell Death | Indoles - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Sequestosome-1 Protein - metabolism | Cell Line | HIV-1 - drug effects | Dipeptides - pharmacology | Fas-Associated Death Domain Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Benzoquinones - pharmacology | Pyrroles - pharmacology | Apoptosis Regulatory Proteins | X-Linked Inhibitor of Apoptosis Protein - metabolism | Autophagy-Related Protein 5 - metabolism | Apoptosis - physiology | Beclin-1 - metabolism | Proteins | Medical colleges | Trout | Communicable diseases | T cells | HIV (Viruses) | Health aspects | HIV infection | Apoptosis | Index Medicus
Journal Article
Nature medicine, ISSN 1546-170X, 10/2013, Volume 19, Issue 11, pp. 1478 - 1488
Here we show that Mst1, a proapoptotic kinase, impairs protein quality control mechanisms in the heart through inhibition of autophagy. Stress-induced... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Cardiomyopathy, Dilated - pathology | Phosphorylation | Humans | Middle Aged | Protein Multimerization | Molecular Sequence Data | Male | Autophagy - physiology | Young Adult | Proto-Oncogene Proteins c-bcl-2 - metabolism | Myocardial Infarction - pathology | Apoptosis Regulatory Proteins - genetics | Hepatocyte Growth Factor - genetics | Adult | Female | Membrane Proteins - metabolism | Beclin-1 | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Myocytes, Cardiac - cytology | Membrane Proteins - genetics | Apoptosis Regulatory Proteins - chemistry | Mice, Inbred C57BL | bcl-2-Associated X Protein - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Models, Molecular | Rats | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Myocardial Infarction - metabolism | Proto-Oncogene Proteins - deficiency | Cardiomyopathy, Dilated - metabolism | Apoptosis Regulatory Proteins - metabolism | Hepatocyte Growth Factor - metabolism | Mice, Knockout | Hepatocyte Growth Factor - deficiency | Animals | Membrane Proteins - chemistry | Myocytes, Cardiac - metabolism | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Mice | Apoptosis - physiology | Autophagy (Cytology) | Heart cells | Physiological aspects | Research | Properties | Phosphotransferases | Apoptosis | Cardiomyocytes | Kinases | Cardiomyopathy | Autophagy | Index Medicus
Journal Article