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Nature Medicine, ISSN 1078-8956, 04/2013, Volume 19, Issue 4, pp. 446 - 451
Journal Article
Kidney International, ISSN 0085-2538, 06/2006, Volume 69, Issue 12, pp. 2124 - 2130
The first non-peptide vasopressin receptor antagonist (VRA) was recently approved by the United States Food and Drug Administration, and several others are now... 
congestive heart failure | arginine vasopressin | polycystic kidney disease | hyponatremia | vasopressin receptor antagonists | nephrogenic diabetes insipidus | Hyponatremia | Congestive heart failure | Arginine vasopressin | Nephrogenic diabetes insipidus | Polycystic kidney disease | Vasopressin receptor antagonists | CONTROLLED-TRIAL | DIABETES-INSIPIDUS | HEART-FAILURE | ANTIDIURETIC-HORMONE | WATER-RETENTION | OUTPUT CARDIAC-FAILURE | INAPPROPRIATE SECRETION | DOUBLE-BLIND | UROLOGY & NEPHROLOGY | CIRRHOTIC-PATIENTS | NEPHROTIC SYNDROME | Fibrosis - drug therapy | Diabetes Insipidus, Nephrogenic - physiopathology | United States | Humans | Heart Failure - physiopathology | Pyrroles | Polycystic Kidney Diseases - drug therapy | Hyponatremia - blood | Receptors, Vasopressin - chemistry | Diabetes Insipidus, Nephrogenic - drug therapy | Benzamides - therapeutic use | Osmolar Concentration | Polycystic Kidney Diseases - physiopathology | Hyponatremia - physiopathology | Hyponatremia - drug therapy | United States Food and Drug Administration | Fibrosis - physiopathology | Clinical Trials as Topic | Sodium - blood | Azepines - therapeutic use | Heart Failure - drug therapy | Benzazepines - therapeutic use | Receptors, Vasopressin - physiology | Vasopressins - physiology | Antidiuretic Hormone Receptor Antagonists
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 8/2006, Volume 63, Issue 15, pp. 1766 - 1779
Journal Article
Cancer Discovery, ISSN 2159-8274, 04/2017, Volume 7, Issue 4, pp. 400 - 409
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was evaluated in two phase I studies in patients with advanced or... 
REARRANGEMENT | ONCOGENE | ONCOLOGY | ANALOG SECRETORY CARCINOMA | LANDSCAPE | KINASE FUSIONS | SARCOMAS | ETV6-NTRK3 GENE FUSION | CRIZOTINIB | GENOMIC ALTERATIONS | CLINICAL-RESPONSE | Benzamides - pharmacokinetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Receptor, trkA - antagonists & inhibitors | Male | Receptor, trkB - genetics | Indazoles - administration & dosage | Protein Kinase Inhibitors - adverse effects | Mammary Analogue Secretory Carcinoma - genetics | Dose-Response Relationship, Drug | Benzamides - administration & dosage | Membrane Glycoproteins - antagonists & inhibitors | Receptor, trkC - genetics | Anaplastic Lymphoma Kinase | Melanoma - genetics | Colorectal Neoplasms - drug therapy | Receptor, trkB - antagonists & inhibitors | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Benzamides - adverse effects | Carcinoma, Non-Small-Cell Lung - pathology | Crizotinib | Protein Kinase Inhibitors - pharmacokinetics | Proto-Oncogene Proteins - antagonists & inhibitors | Pyridines - administration & dosage | Carcinoma, Non-Small-Cell Lung - genetics | Receptor, trkC - antagonists & inhibitors | Melanoma - pathology | Mammary Analogue Secretory Carcinoma - drug therapy | Membrane Glycoproteins - genetics | Protein Kinase Inhibitors - administration & dosage | Sequestosome-1 Protein - genetics | Pyrazoles - administration & dosage | Indazoles - pharmacokinetics | Receptor Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - genetics | Melanoma - drug therapy | Adolescent | Receptor, trkA - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Indazoles - adverse effects | Colorectal Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Psychopharmacology, ISSN 0033-3158, 10/2002, Volume 163, Issue 3, pp. 412 - 419
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e37097
We have previously shown that peroxisome proliferator activating receptor beta/delta (PPAR beta/delta is overexpressed in psoriasis. PPAR beta/delta is not... 
DELTA ANTAGONIST | GAMMA AGONISTS | CELLS | ACID | MULTIDISCIPLINARY SCIENCES | GSK3787 | IDENTIFICATION | EXPRESSION | Benzamides - pharmacokinetics | Skin - metabolism | Humans | Thiophenes - administration & dosage | PPAR gamma - metabolism | Benzamides - administration & dosage | Psoriasis - genetics | Psoriasis - pathology | Psoriasis - metabolism | Ointments | Skin - pathology | Disease Models, Animal | PPAR gamma - genetics | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Psoriasis - drug therapy | PPAR-beta - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Skin Absorption | Recombinant Proteins - genetics | Sulfones - pharmacokinetics | PPAR-beta - genetics | Thiophenes - pharmacokinetics | Animals | PPAR gamma - antagonists & inhibitors | PPAR-beta - antagonists & inhibitors | Mice | Administration, Topical | Skin - drug effects | Sulfones - administration & dosage | Animal models | Pathogenesis | Multiple myeloma | Antagonists | Arthritis | Activation | Metastasis | Stomach cancer | Vehicles | Signal transduction | Atherosclerosis | Skin diseases | Life sciences | Inhibition | Growth factors | Medical research | Psoriasis | Dermatology | Research & development--R&D | Rheumatology | Transgenic mice | Exploration | Mass spectroscopy | Epidermis | Data processing | Inflammation | Liquid chromatography | Dentistry | Metabolism | High-performance liquid chromatography | Medicine | Signaling | Chemistry | Nursing | Acids | Ligands | Skin | Peroxisome proliferator-activated receptors | Topical application | Mass spectrometry | High performance liquid chromatography | Research & development | R&D
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2018, Volume 28, Issue 8, pp. 1392 - 1396
Journal Article
Drugs, ISSN 0012-6667, 2007, Volume 67, Issue 6, pp. 847 - 858
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2013, Volume 23, Issue 22, pp. 6118 - 6122
A new series of 2-(benzyloxy)benzamides are presented that are potent functional antagonists of TRPM8 and possess improved LipE and LE compared to the original... 
Library design | Multi-dimensional scaling | Lead hopping | TRPM8 | 1,3-Diamino cyclohexane | REAGENT | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | MEDICINAL CHEMISTRY | AFFINITY | AMINES | PROSTATE-CANCER | MENTHOL | CHANNELS | EFFICIENCY | Animals | TRPM Cation Channels - antagonists & inhibitors | Humans | Drug Design | Rats | Benzamides - pharmacology | Structure-Activity Relationship | Drug Discovery | Antagonists
Journal Article