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Oncogene, ISSN 1476-5594, 07/2009, Volume 27, Issue S1, pp. S149 - S157
Cancer cells show deviant behavior that induces apoptotic signaling. To survive, cancer cells typically acquire changes enabling evasion of death signals. One... 
Bcl-2 | Drug resistance and ABT-737 | BH3 mimetic | Apoptosis | Cancer | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | Sulfones - therapeutic use | Multigene Family | Proto-Oncogene Proteins c-bcl-2 - physiology | Apoptosis - drug effects | Humans | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Piperazines - chemistry | Structure-Activity Relationship | Nitrophenols - chemistry | Drug Delivery Systems | Benzamides - therapeutic use | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Thionucleotides - chemistry | Sulfones - chemistry | Drug Design | Proto-Oncogene Proteins c-bcl-2 - chemistry | Antineoplastic Agents - pharmacology | Biphenyl Compounds - chemistry | Antineoplastic Agents - classification | Pyrroles - therapeutic use | Dimerization | Benzamides - chemistry | Binding, Competitive | Protein Structure, Tertiary | Sulfonamides - chemistry | Thionucleotides - therapeutic use | Clinical Trials as Topic | Mitochondria - drug effects | Antineoplastic Agents - chemistry | Sulfonamides - pharmacology | Piperazines - pharmacology | Neoplasms - drug therapy | Animals | Sulfonamides - therapeutic use | Pyrroles - chemistry | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Aniline Compounds - chemistry | Aniline Compounds - therapeutic use | Mitochondria - physiology | Drug Screening Assays, Antitumor | Proteins | Signal transduction | Molecular biology | Index Medicus
Journal Article
Accounts of chemical research, ISSN 0001-4842, 08/2009, Volume 42, Issue 8, pp. 1074 - 1086
Journal Article
Macromolecular rapid communications., ISSN 1022-1336, 12/2012, Volume 33, Issue 24, pp. 2062 - 2091
Journal Article
PloS one, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, pp. e29828 - e29828
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Nitriles - pharmacology | Protein-Tyrosine Kinases - metabolism | Escherichia coli | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Drug Resistance, Neoplasm | Piperazines - chemistry | Isomerism | Pyrimidines - chemistry | Quinolines - pharmacology | Protein Kinase Inhibitors - chemistry | Spectrophotometry, Infrared | X-Ray Diffraction | Protein-Tyrosine Kinases - chemistry | Binding Sites | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Dasatinib | Recombinant Proteins - antagonists & inhibitors | Aniline Compounds - pharmacology | Quinolines - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Pyrimidines - pharmacology | Static Electricity | Imatinib Mesylate | Piperazines - pharmacology | Fusion Proteins, bcr-abl - antagonists & inhibitors | Nitriles - chemistry | Thiazoles - chemistry | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Aniline Compounds - chemistry | Benzamides | Mutation | Fusion Proteins, bcr-abl - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Phenols | Phosphotransferases | BCR protein | Phosphorylation | Peptides | Leukemia | Clinical trials | Fluorescence | Infrared absorption | Spectroscopic analysis | Biochemistry | Kinases | Cancer therapies | Proteins | Sulfur | Fusion protein | Growth factors | Electric fields | Protein-tyrosine kinase | Crystal structure | Medical research | Enzymes | Imatinib | Chlorine | Myeloid leukemia | Abl protein | Chronic myeloid leukemia | Chemical compounds | Mutants | Gene amplification | Inhibitors | Resistant mutant | Binding sites | Index Medicus
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 12/2012, Volume 51, Issue 52, pp. 13001 - 13005
Journal Article