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Journal Article
Journal Article
Nature Neuroscience, ISSN 1097-6256, 05/2010, Volume 13, Issue 5, pp. 592 - 600
When chronic alterations in neuronal activity occur, network gain is maintained by global homeostatic scaling of synaptic strength, but the stability of... 
MOUSE-BRAIN | HIPPOCAMPAL SLICE CULTURES | AXON TERMINALS | GAIN-CONTROL | SYNAPTIC-TRANSMISSION | GABA RELEASE | CB1 CANNABINOID RECEPTOR | RAT HIPPOCAMPUS | EXPRESSION | NEUROSCIENCES | PLASTICITY | Cannabinoid Receptor Modulators - metabolism | Cannabinoid Receptor Modulators - pharmacology | Calcium - metabolism | gamma-Aminobutyric Acid - metabolism | Nerve Net - physiology | Patch-Clamp Techniques - methods | Dose-Response Relationship, Drug | Neural Inhibition - physiology | Drug Interactions | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Neurons - physiology | Benzamides - pharmacology | Homeostasis - drug effects | Tetrodotoxin - pharmacology | Neurons - drug effects | Electric Stimulation - methods | Endocannabinoids | Carbamates - pharmacology | Pyrazoles - pharmacology | Synapses - drug effects | Synapses - physiology | Enzyme Inhibitors - pharmacology | Inhibitory Postsynaptic Potentials - physiology | Morpholines - pharmacology | Rats | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Biophysics | Calcium Channel Blockers - pharmacology | Down-Regulation - drug effects | Hippocampus - cytology | Arachidonic Acids - pharmacology | Naphthalenes - pharmacology | Agatoxins | Conotoxins - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Glycerides - pharmacology | Polyamines - pharmacology | Animals | Homeostasis - physiology | Benzoxazines - pharmacology | Polyunsaturated Alkamides - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | In Vitro Techniques | Neural Inhibition - drug effects | Inhibitory Postsynaptic Potentials - drug effects | Brain | Physiological aspects | Homeostasis | Research | Synapses | Injuries | Index Medicus
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 02/2009, Volume 34, Issue 3, pp. 681 - 697
Psychopharmacological studies have implicated the mesolimbic dopamine (DA) system in the mediation of cost/benefit evaluations about delay or effort-related... 
Discounting | Gambling | Amphetamine | Parkinson's disease | D | receptors | D-1 RECEPTOR | PSYCHIATRY | discounting | amphetamine | gambling | NEUROCHEMICAL PROFILE | NORMAL VOLUNTEERS | NEUROSCIENCES | VENTROMEDIAL PREFRONTAL CORTEX | D-2 receptors | IMPULSIVE BEHAVIOR | D-3 receptors | PHARMACOLOGY & PHARMACY | RECEPTOR GENE | D-AMPHETAMINE | PROBABILISTIC REINFORCEMENT | WORKING-MEMORY | PARKINSONS-DISEASE | Receptors, Dopamine D4 - agonists | Rats, Long-Evans | Decision Making - drug effects | Risk | Receptors, Dopamine D4 - antagonists & inhibitors | Pyrrolidines - pharmacology | Conditioning, Operant - drug effects | Receptors, Dopamine D1 - agonists | Behavior, Animal - drug effects | Benzamides - pharmacology | Benzopyrans - pharmacology | Receptors, Dopamine D3 - antagonists & inhibitors | Oxazines - pharmacology | Receptors, Dopamine D1 - antagonists & inhibitors | Dopamine Agonists - pharmacology | Dextroamphetamine - pharmacology | Receptors, Dopamine D2 - agonists | Rats | Behavior, Animal - physiology | Bromocriptine - pharmacology | Benzazepines - pharmacology | Piperazines - pharmacology | Naphthalenes - pharmacology | Receptors, Dopamine D3 - agonists | Reinforcement Schedule | Pyrroles - pharmacology | Animals | Dopamine Antagonists - pharmacology | Decision Making - physiology | Pyridines - pharmacology | Dopamine D2 Receptor Antagonists | Salicylamides - pharmacology | Index Medicus
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, pp. 5712 - 5712
Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway... 
BRAF INHIBITION | TYROSINE KINASE AXL | RAF INHIBITION | CELLS | BREAST-CANCER METASTASIS | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | IMPROVED SURVIVAL | MEK INHIBITORS | UP-REGULATION | CONFERS RESISTANCE | Prognosis | Skin Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Melanoma - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Indoles - pharmacology | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Skin Neoplasms - pathology | Proto-Oncogene Proteins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - metabolism | Signal Transduction | Proto-Oncogene Proteins - genetics | Imidazoles - pharmacology | Melanoma - pathology | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Skin Neoplasms - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Proto-Oncogene Proteins B-raf - genetics | Aminopyridines - pharmacology | Melanoma - drug therapy | Skin Neoplasms - genetics | Cell Line, Tumor | Oximes - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Microphthalmia-Associated Transcription Factor - genetics | Pyridones - pharmacology | Index Medicus
Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 01/2013, Volume 304, Issue 1, pp. R23 - R32
The interaction between adenosine and soluble epoxide hydrolase (sEH) in vascular response is not known. Therefore, we hypothesized that lack of sEH in mice... 
Relaxation | CYP2J5-epoxgenase;ω-hydroxylase | receptor | Soluble epoxide hydrolase | Contraction | Adenosine A | Epoxide Hydrolases - physiology | Adenosine-5'-(N-ethylcarboxamide) - pharmacology | Butyrates - pharmacology | Male | Receptor, Adenosine A2A - physiology | Lauric Acids - pharmacology | Vasodilation - genetics | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Adenosine A2 Receptor Agonists - pharmacology | Urea - analogs & derivatives | Female | Benzamides - pharmacology | Oxygenases - physiology | Vasodilation - physiology | 8,11,14-Eicosatrienoic Acid - pharmacology | Adamantane - analogs & derivatives | NG-Nitroarginine Methyl Ester - pharmacology | Adamantane - pharmacology | Triazines - pharmacology | Phenethylamines - pharmacology | Vasodilator Agents - pharmacology | Enzyme Inhibitors - pharmacology | Gene Silencing | Adenosine - pharmacology | Pyrimidines - pharmacology | Epoxide Hydrolases - genetics | Triazoles - pharmacology | Adenosine A2 Receptor Antagonists - pharmacology | PPAR gamma - physiology | Animals | Adenosine - analogs & derivatives | Benzoates - pharmacology | Mice | Phenylurea Compounds - pharmacology | Pyridines - pharmacology | Vasodilation - drug effects | Urea - pharmacology | Index Medicus | adenosine A2a receptor | CYP2J5-epoxgenase | ω-hydroxylase | relaxation | contraction | Cardiovascular and Renal Integration | soluble epoxide hydrolase | adenosine A1 receptor
Journal Article
Pharmacological Research, ISSN 1043-6618, 09/2012, Volume 66, Issue 3, pp. 251 - 259
Endocannabinoids exhibit vasodilatory properties and reduce blood pressure . However, the influence and mechanism of action of the prominent endocannabinoid,... 
Endocannabinoid | Abnormal cannabidiol | Pulmonary artery | Anandamide | Endothelium | VIRODHAMINE | VASORELAXATION | SMALL MESENTERIC-ARTERY | CANNABINOID RECEPTOR | VESSELS | VASCULATURE | RESISTANCE | PHARMACOLOGY & PHARMACY | CHANNELS | HYPERTENSION | ABNORMAL-CANNABIDIOL | Tetraethylammonium - pharmacology | Endocannabinoids - pharmacology | Rats, Wistar | Capsaicin - pharmacology | Anisoles - pharmacology | Cyclohexanes - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Male | Apamin - pharmacology | Receptors, Cannabinoid - metabolism | TRPV Cation Channels - metabolism | Piperidines - pharmacology | Charybdotoxin - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Potassium Chloride - metabolism | Cannabinoid Receptor Antagonists - pharmacology | Indoles - pharmacology | Benzamides - pharmacology | Potassium Channel Blockers - pharmacology | Carbamates - pharmacology | Pyrazoles - pharmacology | Amidohydrolases - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Receptors, Epoprostenol - metabolism | Rats | Amidohydrolases - antagonists & inhibitors | Capsaicin - analogs & derivatives | Imidazoles - pharmacology | Pulmonary Artery - drug effects | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Receptors, Epoprostenol - antagonists & inhibitors | Animals | Benzyl Compounds - pharmacology | Endothelium, Vascular - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Polyunsaturated Alkamides - pharmacology | Nitric Oxide Synthase - metabolism | Vasodilation - drug effects | Hypertension | Enzymes | Vasodilators | Blood vessels | Glycerol | Fatty acids | Pulmonary hypertension | Glycerin | Cannabinoids | Dilatation | Dimethyl sulfoxide | Hydrolases | Indomethacin | Index Medicus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2007, Volume 572, Issue 1, pp. 12 - 22
Pulmonary fibroblast to myofibroblast conversion is a pathophysiological feature of idiopathic pulmonary fibrosis and COPD. This conversion is induced by... 
TGF-β | Sildenafil | Lung fibroblast | Fibrosis | Phosphodiesterase | lung fibroblast | CELLS | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | PROLIFERATION | sildenafil | CARDIAC FIBROBLASTS | TGF-beta | GROWTH-FACTOR-BETA | DISEASE | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | fibrosis | phosphodiesterase | DIFFERENTIATION | IDIOPATHIC PULMONARY-FIBROSIS | EXPRESSION | Enzyme Activators - pharmacology | Immunohistochemistry | Cyclic GMP - pharmacology | Humans | Actins - metabolism | Lung - cytology | Natriuretic Peptide, Brain - pharmacology | Sulfones - pharmacology | Quinoxalines - pharmacology | Sildenafil Citrate | Nitroso Compounds - pharmacology | Isoenzymes - metabolism | Oxadiazoles - pharmacology | Benzamides - pharmacology | Nitric Oxide Donors - pharmacology | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Fibroblasts - metabolism | Dinoprostone - pharmacology | Purines - pharmacology | Cells, Cultured | Transforming Growth Factor beta - physiology | Phosphodiesterase Inhibitors - pharmacology | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Piperazines - pharmacology | Blotting, Western | Drug Synergism | Transforming Growth Factor beta - pharmacology | Cell Differentiation - drug effects | Fibroblasts - drug effects | Benzoates - pharmacology | Fibroblasts - cytology | Pyridines - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2007, Volume 152, Issue 5, pp. 699 - 708
Background and purpose: Studies in isolated preparations of vascular tissue (mainly resistance vessels) provide evidence that anandamide exerts vasorelaxation.... 
vasorelaxation | anandamide | rat aorta | Rat aorta | Vasorelaxation | Anandamide | PHARMACOLOGICAL CHARACTERIZATION | SENSORY NERVES MEDIATE | OXIDATIVE-METABOLISM | PROSTANOID RECEPTORS | CANNABINOID RECEPTOR | ISOLATED MESENTERIC-ARTERY | HYPERPOLARIZING FACTOR | PROSTAGLANDIN E-2 ETHANOLAMIDE | VANILLOID RECEPTORS | CARDIOVASCULAR FUNCTION | PHARMACOLOGY & PHARMACY | Cannabinoid Receptor Modulators - pharmacology | Rats, Wistar | Capsaicin - pharmacology | Bornanes - pharmacology | Endothelium, Vascular - drug effects | Male | Peptide Fragments - pharmacology | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Apamin - pharmacology | Aorta, Abdominal - drug effects | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Piperidines - pharmacology | Charybdotoxin - pharmacology | Benzamides - pharmacology | Vasodilation - physiology | Isoindoles - pharmacology | Endocannabinoids | Carbamates - pharmacology | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - biosynthesis | Calcitonin Gene-Related Peptide - pharmacology | Nitric Oxide - antagonists & inhibitors | Rats | Capsaicin - analogs & derivatives | Aorta, Abdominal - physiology | Sulfonamides - pharmacology | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Pyrazoles - administration & dosage | Animals | Polyunsaturated Alkamides - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Vasodilation - drug effects | In Vitro Techniques | Index Medicus | Research Papers
Journal Article