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Journal Article
Lancet, The, ISSN 0140-6736, 2015, Volume 385, Issue 9971, pp. 857 - 866
Journal Article
Journal Article
JAMA, ISSN 0098-7484, 06/2011, Volume 305, Issue 22, pp. 2327 - 2334
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2009, Volume 119, Issue 5, pp. 1109 - 1123
Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia... 
CHRONIC MYELOGENOUS LEUKEMIA | MEDICINE, RESEARCH & EXPERIMENTAL | MALIGNANT GLIOMA-CELLS | BLAST CRISIS | CLINICAL RESISTANCE | BCR-ABL MUTATIONS | ENDOPLASMIC-RETICULUM | CYTOCHROME-C RELEASE | CASPASE ACTIVATION | IMATINIB RESISTANCE | CHRONIC MYELOID-LEUKEMIA | Transcription Factor CHOP - genetics | Neoplastic Stem Cells - cytology | Gene Expression - drug effects | Calcium - metabolism | Gene Expression - genetics | Microtubule-Associated Proteins - metabolism | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Endoplasmic Reticulum - metabolism | Antineoplastic Agents - therapeutic use | Autophagy - physiology | Thiazoles - therapeutic use | Autophagy - drug effects | Chloroquine - pharmacology | Neoplastic Stem Cells - metabolism | RNA Interference | Endoplasmic Reticulum - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Macrolides - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Dasatinib | Chloroquine - therapeutic use | Piperazines - therapeutic use | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Mice, Inbred C3H | Xenograft Model Antitumor Assays | Fusion Proteins, bcr-abl - genetics | Animals | Cell Death - physiology | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Benzamides | Macrolides - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | Causes of | Physiological aspects | Genetic aspects | Chronic myeloid leukemia | Research | Drug therapy | Phagocytosis | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal Article
Lancet, The, ISSN 0140-6736, 2009, Volume 374, Issue 9691, pp. 695 - 703
Summary Background Patients with chronic obstructive pulmonary disease (COPD) have few options for treatment. The efficacy and safety of the... 
Internal Medicine | PDE4 INHIBITOR ROFLUMILAST | MEDICINE, GENERAL & INTERNAL | IN-VITRO | PHOSPHODIESTERASE-4 INHIBITORS | MANAGEMENT | THERAPY | INFLAMMATION | THEOPHYLLINE | FLUTICASONE | COPD | SALMETEROL | Bronchodilator Agents - therapeutic use | Phosphodiesterase Inhibitors - therapeutic use | Forced Expiratory Volume - drug effects | Humans | Middle Aged | Male | Pulmonary Disease, Chronic Obstructive - etiology | Cyclopropanes - therapeutic use | Vital Capacity - drug effects | Benzamides - therapeutic use | Aminopyridines - therapeutic use | Phosphodiesterase 4 Inhibitors | Female | Drug Therapy, Combination | Scopolamine Derivatives - therapeutic use | Tiotropium Bromide | Severity of Illness Index | Pulmonary Disease, Chronic Obstructive - diagnosis | Salmeterol Xinafoate | Double-Blind Method | Administration, Oral | Administration, Inhalation | Albuterol - analogs & derivatives | Treatment Outcome | Regression Analysis | Analysis of Variance | Smoking - epidemiology | Albuterol - therapeutic use | Aged | Pulmonary Disease, Chronic Obstructive - drug therapy | Lung diseases, Obstructive | Dosage and administration | Enzyme inhibitors | Research | Drug therapy | Bronchodilator agents | Studies | Smoking cessation | Molecular structure | Clinical trials | Chronic obstructive pulmonary disease | Clinical medicine | Headache | Respiratory function | Side effects | Motivation | salmeterol | Lung | Bronchodilators | Diarrhea | Nausea | Index Medicus | Abridged Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 05/2012, Volume 125, Issue 17, pp. 2128 - 2137
Background-The French pulmonary hypertension (PH) registry allows the survey of epidemiological trends. Isolated cases of precapillary PH have been reported in... 
Dasatinib | Chronic myeloid leukemia | Vascular complications | Adverse drug events | Pulmonary hypertension | CHRONIC MYELOGENOUS LEUKEMIA | LONG-TERM | SURVIVAL | CARDIAC & CARDIOVASCULAR SYSTEMS | MYELOPROLIFERATIVE DISORDERS | INHIBITORS IMATINIB | pulmonary hypertension | TYROSINE KINASE | CELL-GROWTH | FAILURE | NILOTINIB | CHRONIC MYELOID-LEUKEMIA | adverse drug events | vascular complications | dasatinib | chronic myeloid leukemia | PERIPHERAL VASCULAR DISEASE | Hypertension, Pulmonary - diagnosis | Follow-Up Studies | Humans | Middle Aged | Calcium Channel Blockers - therapeutic use | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Male | Antineoplastic Agents - therapeutic use | Protein Kinase Inhibitors - adverse effects | Thiazoles - therapeutic use | Hypertension, Pulmonary - chemically induced | Thiazoles - adverse effects | Antineoplastic Agents - adverse effects | Adult | Female | Registries | Antineoplastic Agents - pharmacology | Hypertension, Pulmonary - drug therapy | Drug Utilization - statistics & numerical data | Endothelin Receptor Antagonists | Bone Morphogenetic Protein Receptors, Type II - genetics | Adverse Drug Reaction Reporting Systems | Treatment Outcome | Piperazines - therapeutic use | Hypertension, Pulmonary - epidemiology | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - adverse effects | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Adolescent | Pyrimidines - adverse effects | Hydroxyurea - therapeutic use | Aged | Hemodynamics - drug effects | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Benzamides | Care and treatment | Dosage and administration | Drug therapy | Index Medicus | Abridged Index Medicus | Life Sciences | Biochemistry, Molecular Biology
Journal Article
Blood, ISSN 0006-4971, 10/2011, Volume 118, Issue 17, pp. 4567 - 4576
Journal Article