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1. Full Text Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study
by Swedberg, Karl, Prof and Komajda, Michel, Prof and Böhm, Michael, Prof and Borer, Jeffrey S, Prof and Ford, Ian, Prof and Dubost-Brama, Ariane, MD and Lerebours, Guy, MD and Tavazzi, Luigi, Prof and SHIFT Investigators and Sahlgrenska akademin and Institute of Medicine and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Institutionen för medicin
Lancet, The, ISSN 0140-6736, 2010, Volume 376, Issue 9744, pp. 875 - 885
Summary Background Chronic heart failure is associated with high mortality and morbidity. Raised resting heart rate is a risk factor for adverse outcomes. We... 
Internal Medicine | CARDIAC & CARDIOVASCULAR SYSTEMS | Severity of Illness Index | Heart Failure - complications | Cardiovascular Agents - administration & dosage | Double-Blind Method | Benzazepines - adverse effects | Humans | Middle Aged | Heart Failure - physiopathology | Kaplan-Meier Estimate | Male | Treatment Outcome | Sinoatrial Node - drug effects | Heart Failure - drug therapy | Cardiovascular Agents - therapeutic use | Heart Rate - drug effects | Benzazepines - therapeutic use | Electrocardiography | Adult | Female | Aged | Benzazepines - administration & dosage | Cardiovascular Agents - adverse effects | Chronic Disease | Heart Failure - mortality | Heart failure | Complications and side effects | Heart beat | Patient outcomes | Dosage and administration | Drug therapy | Health aspects | Cardiovascular agents | Heart rate | Cardiovascular disease | use | Sinoatrial Node/drug effects | Heart Failure/complications/drug therapy/mortality/physiopathology | Kardiologi | Cardiac and Cardiovascular Systems | Benzazepines/administration & dosage/adverse effects/therapeutic use | Heart Rate/drug effects | Cardiovascular Agents/administration & dosage/adverse effects/therapeutic | Kaplan-Meiers Estimate
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2. Full Text 9- and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma
by Maiwald, Franziska and Benítez, Diego and Charquero, Diego and Dar, Mahin Abad and Erdmann, Hanna and Preu, Lutz and Koch, Oliver and Hölscher, Christoph and Loaëc, Nadège and Meijer, Laurent and Comini, Marcelo A and Kunick, Conrad
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2014, Volume 83, pp. 274 - 283
Trypanosomes from the “brucei” complex are pathogenic parasites endemic in sub-Saharan Africa and causative agents of severe diseases in humans and livestock.... 
Nagana | Chalcones | Cinnamides | Trypanosoma brucei brucei | Paullones | Human trypanosomiasis | CHEMISTRY, MEDICINAL | VALIDATION | BRUCEI | HUMAN SERUM | SIDE-CHAINS | TRYPANOTHIONE SYNTHETASE | BLOOD-STREAM | AFFINITY-CHROMATOGRAPHY | DRUG TARGET | IMMOBILIZED AXIN | Cell Line | Humans | Trypanocidal Agents - toxicity | Trypanocidal Agents - chemistry | Structure-Activity Relationship | Benzazepines - pharmacology | Benzazepines - chemical synthesis | Trypanosoma brucei brucei - drug effects | Trypanosoma brucei brucei - physiology | Trypanosomiasis, African - parasitology | Animals | Trypanocidal Agents - pharmacology | Drug Design | Trypanocidal Agents - chemical synthesis | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | Benzazepines - toxicity | Benzazepines - chemistry | Substitution reactions | Antiparasitic agents | Livestock | Trypanocidal Agents/chemistry | Trypanocidal Agents/chemical synthesis | Trypanosoma brucei brucei/drug effects | Trypanocidal Agents/pharmacology | Biochemistry, Molecular Biology | Benzazepines/pharmacology | Trypanosomiasis, African/parasitology | Life Sciences | Benzazepines/toxicity | Macrophages/drug effects | Benzazepines/chemistry | Trypanosoma brucei brucei/physiology | Trypanocidal Agents/toxicity | Cell Proliferation/drug effects | Benzazepines/chemical synthesis
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3. Full Text Ivabradine in Stable Coronary Artery Disease without Clinical Heart Failure
by Fox, Kim and Ford, Ian and Steg, Philippe Gabriel and Tardif, Jean-Claude and Tendera, Michal and Ferrari, Roberto and SIGNIFY Investigators
The New England Journal of Medicine, ISSN 0028-4793, 09/2014, Volume 371, Issue 12, pp. 1091 - 1099
In this trial, over 19,000 patients with stable coronary artery disease were assigned to ivabradine (adjusted to achieve a target heart rate) or placebo. At 27... 
VENTRICULAR SYSTOLIC DYSFUNCTION | RATE REDUCTION | MEDICINE, GENERAL & INTERNAL | RISK-FACTOR | ANGINA | I-F INHIBITOR | DOUBLE-BLIND | BEAUTIFUL | PLACEBO-CONTROLLED TRIAL | SUBGROUP ANALYSIS | OUTCOMES | Double-Blind Method | Benzazepines - adverse effects | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Risk | Benzazepines - pharmacology | Coronary Artery Disease - drug therapy | Heart Rate - drug effects | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Coronary Artery Disease - physiopathology | Benzazepines - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Intention to Treat Analysis | Cardiovascular Diseases - mortality | Heart Failure | Female | Aged | Angina, Stable - drug therapy | Drug Therapy, Combination | Adrenergic beta-Antagonists - therapeutic use | Myocardial infarction | Heart attacks | Physical activity | Coronary artery | Clinical trials | Cardiovascular disease | Angina | Angina pectoris | Coronary artery disease | Cholesterol | Heart rate | Bradycardia | Coronary vessels | Ventricle | Cardiovascular diseases | Cardiology | Drug therapy | Heart diseases | Life Sciences | Human health and pathology | Cardiology and cardiovascular system
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4. Full Text Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial
by Böhm, Michael, Prof and Swedberg, Karl, Prof and Komajda, Michel, Prof and Borer, Jeffrey S, Prof and Ford, Ian, Prof and Dubost-Brama, Ariane, MD and Lerebours, Guy, MD and Tavazzi, Luigi, Prof and SHIFT Investigators and Sahlgrenska akademin and Institute of Medicine and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Institutionen för medicin
Lancet, The, ISSN 0140-6736, 2010, Volume 376, Issue 9744, pp. 886 - 894
Summary Background Raised resting heart rate is a marker of cardiovascular risk. We postulated that heart rate is also a risk factor for cardiovascular events... 
Internal Medicine | RATE REDUCTION | HUMAN MYOCARDIUM | MEDICINE, GENERAL & INTERNAL | SYSTOLIC DYSFUNCTION BEAUTIFUL | CARDIOVASCULAR-DISEASE | DOUBLE-BLIND | ATHEROSCLEROSIS | CORONARY-ARTERY-DISEASE | BETA-BLOCKER | IVABRADINE | LEFT-VENTRICULAR FUNCTION | Benzazepines - adverse effects | Humans | Middle Aged | Heart Failure - physiopathology | Male | Sinoatrial Node - drug effects | Heart Rate - drug effects | Electrocardiography | Adult | Female | Heart Failure - mortality | Severity of Illness Index | Heart Failure - complications | Cardiovascular Agents - administration & dosage | Double-Blind Method | Risk Factors | Kaplan-Meier Estimate | Treatment Outcome | Heart Failure - drug therapy | Cardiovascular Agents - therapeutic use | Benzazepines - therapeutic use | Aged | Benzazepines - administration & dosage | Cardiovascular Agents - adverse effects | Chronic Disease | Heart failure | Prevention | Heart beat | Dosage and administration | Drug therapy | Health aspects | Risk factors | Cardiovascular agents | Studies | Heart rate | Cardiovascular disease | Mortality | Cardiovascular diseases | use | Sinoatrial Node/drug effects | Heart Failure/complications/drug therapy/mortality/physiopathology | Kardiologi | Cardiac and Cardiovascular Systems | Benzazepines/administration & dosage/adverse effects/therapeutic use | Heart Rate/drug effects | Cardiovascular Agents/administration & dosage/adverse effects/therapeutic | Kaplan-Meiers Estimate
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5. Full Text Nicotine receptor partial agonists for smoking cessation
by Cahill, Kate and Lindson-Hawley, Nicola and Thomas, Kyla H and Fanshawe, Thomas R and Lancaster, Tim
Cochrane Database of Systematic Reviews, ISSN 1469-493X, 05/2016, Volume 2016, Issue 5, p. CD006103
Background Nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract... 
Smoking [drug therapy] | Varenicline | Humans | RANDOMIZED CONTROLLED-TRIAL | Quinolizines [therapeutic use] | PSYCHIATRIC ADVERSE EVENTS | TOBACCO-DEPENDENCE TREATMENT | Quinoxalines [therapeutic use] | MEDICINE, GENERAL & INTERNAL | Bupropion [therapeutic use] | Nicotine [adverse effects; antagonists & inhibitors] | REPLACEMENT THERAPY | SUSTAINED-RELEASE BUPROPION | Smoking Cessation [methods] | Counseling [methods] | VARENICLINE TREATMENT | METHADONE-MAINTAINED SMOKERS | Randomized Controlled Trials as Topic | Azepines [therapeutic use] | DOUBLE-BLIND PLACEBO | Alkaloids [therapeutic use] | Nicotinic Agonists [adverse effects; therapeutic use] | Azocines [therapeutic use] | LONG-TERM SAFETY | Benzazepines [therapeutic use] | PLACEBO-CONTROLLED TRIAL | Substance Withdrawal Syndrome [prevention & control] | Heterocyclic Compounds with 4 or More Rings [therapeutic use] | Quinolizines - therapeutic use | Azepines - adverse effects | Azocines - therapeutic use | Azocines - adverse effects | Substance Withdrawal Syndrome - prevention & control | Alkaloids - adverse effects | Benzazepines - adverse effects | Smoking - drug therapy | Heterocyclic Compounds, 4 or More Rings - adverse effects | Nicotinic Agonists - therapeutic use | Nicotine - antagonists & inhibitors | Smoking Cessation - methods | Azepines - therapeutic use | Nicotine - adverse effects | Nicotinic Agonists - adverse effects | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Benzazepines - therapeutic use | Counseling - methods | Alkaloids - therapeutic use | Quinolizines - adverse effects | Varenicline - therapeutic use | Bupropion - therapeutic use
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