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The Journal of biological chemistry, ISSN 1083-351X, 2012, Volume 287, Issue 28, pp. 23283 - 23293
Smoking cessation is an important aim in public health worldwide as tobacco smoking causes many preventable deaths. Addiction to tobacco smoking results from... 
GATED ION-CHANNEL | CYS-LOOP RECEPTOR | DETERMINANTS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | X-RAY-STRUCTURE | RESOLUTION | HOMOLOG ACHBP | AGONISTS | SELECTIVITY | 10-SUBSTITUTED CYTISINE DERIVATIVES | Nicotinic Agonists - metabolism | Humans | Varenicline | Aplysia - metabolism | Acetylcholine - metabolism | Quinolizines - metabolism | Azocines - metabolism | Nicotinic Agonists - chemistry | Receptors, Nicotinic - chemistry | HEK293 Cells | Carrier Proteins - chemistry | Alkaloids - metabolism | Azocines - chemistry | Binding, Competitive | Protein Structure, Tertiary | Cell Line | Receptors, Nicotinic - metabolism | Protein Structure, Secondary | Models, Molecular | Quinoxalines - chemistry | Quinoxalines - metabolism | Binding Sites - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Nicotine - metabolism | Nicotine - chemistry | Protein Binding | Ligands | Benzazepines - metabolism | Kinetics | Mutation | Benzazepines - chemistry | Receptors, Nicotinic - genetics | Alkaloids - chemistry | Quinolizines - chemistry | Smoking Cessation | alpha7 Nicotinic Acetylcholine Receptor | Acetylcholine-binding Protein | Protein Structure and Folding | Crystal Structure | Ligand-binding Protein | Cys-loop Receptors | Ion Channels | Nicotinic Acetylcholine Receptors | Cytisine | α4β2-selective Ligands
Journal Article
Journal of biological inorganic chemistry, ISSN 0949-8257, 2010, Volume 15, Issue 6, pp. 903 - 918
The synthesis of ruthenium(II) and osmium(II) arene complexes with the closely related indolo[3,2-c]quinolines... 
Life Sciences | Biochemistry, general | Ruthenium | Microbiology | Indolo[3,2- c ]quinolines | Indolo[3,2- d ]benzazepines | Osmium | 2-d]benzazepines | Indolo | 2-c]quinolines | 2-OXOQUINOLINE DERIVATIVES | RUTHENIUM(II) ARENE COMPLEXES | BIOCHEMISTRY & MOLECULAR BIOLOGY | HL-60 CELLS | OSMIUM(II) | CHEMISTRY, INORGANIC & NUCLEAR | IN-VITRO | CDK INHIBITORS | CARDIAC STIMULANT ACTIVITY | PAULLONES | Indolo[3,2-c]quinolines | ANTICANCER COMPLEXES | Indolo[3,2-d]benzazepines | PLATELET AGGREGATION INHIBITORS | Antineoplastic Agents - chemical synthesis | Humans | Crystallography, X-Ray | Benzazepines - chemical synthesis | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Cyclin-Dependent Kinases - antagonists & inhibitors | Intercalating Agents - chemical synthesis | Spectrum Analysis | Quinolines - chemistry | Intercalating Agents - pharmacology | Benzazepines - pharmacology | DNA - metabolism | Antineoplastic Agents - chemistry | Intercalating Agents - chemistry | Quinolines - chemical synthesis | Quinolines - metabolism | Intercalating Agents - metabolism | Animals | Organometallic Compounds - metabolism | Organometallic Compounds - chemical synthesis | Cell Line, Tumor | Ligands | Organometallic Compounds - chemistry | Benzazepines - metabolism | Cell Cycle - drug effects | Benzazepines - chemistry | Organometallic Compounds - pharmacology | Ionization | Analysis | Oncology, Experimental | DNA | Chemical properties | Research | Mass spectrometry | Cancer | Original Paper
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2017, Volume 60, Issue 4, pp. 1247 - 1261
Journal Article
Neuropharmacology, ISSN 0028-3908, 2014, Volume 87, pp. 206 - 213
There has been a dramatic rise in the abuse of synthetic cathinones known as “bath salts,” including 3,4-methylenedioxypyrovalerone (MDPV), an analog linked to... 
3,4-Methylenedioxypyrovalerone | Synthetic cathinones | α-PVP | Locomotor activity | Functional observational battery | Monoamine transporter | ANALOGS | RATS | LOCOMOTOR-ACTIVITY | MEPHEDRONE | CATHINONE DERIVATIVES | MONOAMINE TRANSPORTERS | NEUROSCIENCES | INTOXICATION | alpha-PVP | IN-VITRO | DOPAMINE | PHARMACOLOGY & PHARMACY | 2ND-GENERATION LEGAL HIGHS | Dopamine Plasma Membrane Transport Proteins - metabolism | Synaptosomes - drug effects | Central Nervous System Stimulants - pharmacology | Motor Activity - drug effects | Male | Synaptosomes - metabolism | Pyrrolidines - pharmacology | Dose-Response Relationship, Drug | Benzodioxoles - chemistry | Locomotion - drug effects | Designer Drugs - pharmacology | Catecholamine Plasma Membrane Transport Proteins - metabolism | Brain - physiopathology | Catecholamine Plasma Membrane Transport Proteins - antagonists & inhibitors | Benzazepines - pharmacology | Random Allocation | Pyrrolidines - chemistry | Rats, Sprague-Dawley | Mice, Inbred ICR | Brain - drug effects | Designer Drugs - chemistry | Animals | Dopamine Antagonists - pharmacology | Central Nervous System Stimulants - chemistry | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Street Drugs - pharmacology | Benzodioxoles - pharmacology | RNA-Binding Proteins - metabolism | Street Drugs - chemistry | Bath products | Resveratrol | monoamine transporter | locomotor activity | 3,4-methylenedioxypyrovalerone | functional observational battery | synthetic cathinones
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 3/2015, Volume 112, Issue 13, pp. E1652 - E1658
Journal Article
Cell Stem Cell, ISSN 1934-5909, 06/2013, Volume 12, Issue 6, pp. 713 - 726
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease, characterized by motor neuron (MN) death, for which there are no truly... 
SURVIVAL | MATRIX METALLOPROTEINASES | PROTEIN-KINASE | TDP-43 | MOUSE MODEL | DEATH | AMYOTROPHIC-LATERAL-SCLEROSIS | FRONTOTEMPORAL LOBAR DEGENERATION | C-JUN | DISEASE PROGRESSION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Superoxide Dismutase - genetics | Embryonic Stem Cells - cytology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Structure-Activity Relationship | Amyotrophic Lateral Sclerosis - drug therapy | Protein Kinase Inhibitors - chemistry | Protein Kinase Inhibitors - analysis | Motor Neurons - cytology | Cholestenones - chemistry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Indoles - pharmacology | Amyotrophic Lateral Sclerosis - enzymology | Induced Pluripotent Stem Cells - cytology | Motor Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Superoxide Dismutase - metabolism | Cell Survival - drug effects | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Cells, Cultured | Mice, Transgenic | Benzazepines - pharmacology | Motor Neurons - enzymology | Glycogen Synthase Kinase 3 - metabolism | Amyotrophic Lateral Sclerosis - pathology | Animals | Cell Differentiation - drug effects | Cholestenones - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Mutation | Superoxide Dismutase-1 | Benzazepines - chemistry | Indoles - chemistry
Journal Article