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Journal Article
British Journal of Cancer, ISSN 0007-0920, 11/2014, Volume 111, Issue 10, pp. 1932 - 1944
Background: Two strategies to interrogate the insulin growth factor 1 receptor (IGF-1R) pathway were investigated: vertical inhibition with dalotuzumab and... 
dalotuzumab | MK-2206 | colorectal cancer | ovarian cancer | ridaforolimus | MK-0752 | MAMMALIAN TARGET | ADVANCED MALIGNANCIES | GENE-EXPRESSION SIGNATURE | PROSTATE-CANCER RISK | MONOCLONAL-ANTIBODY | INSULIN | ONCOLOGY | CLINICAL-TRIALS | IGF-1 RECEPTOR | T-ALL | GROWTH-FACTOR-I | Neoplasms - metabolism | Sulfones - therapeutic use | Receptor, IGF Type 1 - antagonists & inhibitors | Prognosis | Follow-Up Studies | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | TOR Serine-Threonine Kinases - antagonists & inhibitors | Tissue Distribution | Clinical Trials, Phase III as Topic | Receptors, Notch - antagonists & inhibitors | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Heterocyclic Compounds, 3-Ring - pharmacokinetics | Sirolimus - analogs & derivatives | Sirolimus - therapeutic use | Benzene Derivatives - therapeutic use | Propionates - therapeutic use | Antibodies, Monoclonal - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols | Propionates - pharmacokinetics | Sirolimus - pharmacokinetics | Sulfones - pharmacokinetics | Neoplasms - drug therapy | Randomized Controlled Trials as Topic | Benzene Derivatives - pharmacokinetics | Heterocyclic Compounds, 3-Ring - therapeutic use | Aged | Neoplasm Staging | Neoplasms - pathology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Clinical Trials, Phase II as Topic | Cohort Studies | Index Medicus | Clinical Study
Journal Article
BRITISH JOURNAL OF CANCER, ISSN 0007-0920, 03/2018, Volume 118, Issue 6, pp. 793 - 801
Background: The Notch pathway is frequently activated in cancer. Pathway inhibition by gamma-secretase inhibitors has been shown to be effective in... 
SURVIVAL | pancreatic cancer | notch pathway | ADVANCED SOLID TUMORS | THERAPY | ONCOLOGY | gamma-secretase | gemcitabine | NOTCH SIGNALING PATHWAY | CANCER | RO4929097 | PROGRESSION | Clinical Study | γ-secretase
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2012, Volume 55, Issue 10, pp. 4700 - 4713
Journal Article
British journal of cancer, ISSN 0007-0920, 03/2018, Volume 118, Issue 6, p. 793
Journal Article
Journal of Toxicology and Environmental Health, Part A, ISSN 1528-7394, 12/2014, Volume 77, Issue 22-24, pp. 1502 - 1521
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2015, Volume 58, Issue 23, pp. 9154 - 9170
Journal Article
Toxicology Letters, ISSN 0378-4274, 07/2016, Volume 255, pp. 11 - 23
The MetaMap -Tox database contains plasma-metabolome and toxicity data of rats obtained from oral administration of 550 reference compounds following a... 
Rat | Oral versus inhalative exposure | Plasma metabolome | RESONANCE-BASED METABONOMICS | SAFETY ASSESSMENT | TOXICITY | METABOLOMICS | PATTERN-RECOGNITION | PLASMA | LIVER | MAGNETIC-RESONANCE | MICE | TOXICOLOGY | DIURNAL-VARIATION | Metabolomics | Rats, Wistar | Male | Ethylene Glycols - pharmacokinetics | Dimethylformamide - pharmacokinetics | Dose-Response Relationship, Drug | Furans - pharmacokinetics | Dimethylformamide - administration & dosage | Inhalation Exposure | Female | Benzene Derivatives - administration & dosage | Furans - toxicity | Principal Component Analysis | Aniline Compounds - administration & dosage | Databases, Factual | Chloroform - toxicity | Drug Administration Schedule | Risk Assessment | Administration, Oral | Administration, Inhalation | Chloroform - administration & dosage | Metabolome | Aniline Compounds - pharmacokinetics | Aniline Compounds - toxicity | Chloroform - pharmacokinetics | Animals | Benzene Derivatives - pharmacokinetics | Dimethylformamide - toxicity | Ethylene Glycols - administration & dosage | Toxicity Tests | Benzene Derivatives - toxicity | Ethylene Glycols - toxicity | Furans - administration & dosage | Aniline | Metabolites | Cytokinins | Dimethylformamide | Index Medicus | Ethylbenzene | Databases | Target recognition | Toxicity | Rats | Yield strength | Exposure
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2013, Volume 23, Issue 21, pp. 5870 - 5873
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2015, Volume 23, Issue 17, pp. 5419 - 5432
Journal Article