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Journal of Clinical Investigation, ISSN 0021-9738, 03/2015, Volume 125, Issue 3, pp. 1269 - 1285
Cholangiocarcinoma (CC) is typically diagnosed at an advanced stage and is refractory to surgical intervention and chemotherapy. Despite a global increase in... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | INTRAHEPATIC CHOLANGIOCARCINOMA | THIOACETAMIDE | PORCUPINE | LIVER | BILIARY | BETA-CATENIN | RAT CHOLANGIOCARCINOMA | PROGRESSION | CANCER STEM-CELLS | Anisoles - pharmacology | Humans | Male | Cholangiocarcinoma - metabolism | Bile Ducts, Intrahepatic - metabolism | Keratins - metabolism | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Benzeneacetamides - pharmacology | Wnt Signaling Pathway | Bile Duct Neoplasms - drug therapy | Cell Survival - drug effects | Aniline Compounds - pharmacology | Bile Duct Neoplasms - metabolism | Pyrimidines - pharmacology | Rats, Sprague-Dawley | beta Catenin - metabolism | Heterocyclic Compounds, 2-Ring - pharmacology | Xenograft Model Antitumor Assays | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Macrophages - metabolism | Animals | Cholangiocarcinoma - drug therapy | Mice, Nude | Tamoxifen - pharmacology | Cell Line, Tumor | Macrophages - drug effects | Cell Proliferation - drug effects | Clodronic Acid - administration & dosage | Pyridines - pharmacology | Liposomes | Physiological aspects | Research | Tumor proteins | Wnt proteins | Oncology, Experimental | Cancer | Heparan sulfate | Medical research | Liver | Gene expression | Cancer therapies | Studies | Councils | Medical prognosis | Cell cycle | Ligands | Mutation | Tumors
Journal Article
Endocrinology, ISSN 0013-7227, 08/2013, Volume 154, Issue 8, pp. 2750 - 2760
Kisspeptin neurons located in the arcuate nucleus (ARN) coexpress dynorphin and neurokinin B (NKB) and may interact to influence gonadotropin secretion. Using... 
GNRH PULSE-GENERATOR | HORMONE SECRETION | MORPHOLOGIC EVIDENCE | FEMALE MOUSE | IN-VITRO | MESSENGER-RNA EXPRESSION | PHARMACOLOGICAL CHARACTERIZATION | ENDOCRINOLOGY & METABOLISM | MEDIAN-EMINENCE | KAPPA-OPIOID RECEPTOR | SUBSTANCE-P | Receptors, Neurokinin-2 - antagonists & inhibitors | Receptors, Tachykinin - metabolism | Analgesics, Non-Narcotic - pharmacology | Arcuate Nucleus of Hypothalamus - cytology | Male | Peptide Fragments - pharmacology | Substance P - pharmacology | Green Fluorescent Proteins - genetics | Neurokinin B - pharmacology | Quinolines - pharmacology | Kisspeptins - genetics | Piperidines - pharmacology | Neurons - physiology | Receptors, Neurokinin-3 - metabolism | Neurons - metabolism | Receptors, Neurokinin-2 - metabolism | Dynorphins - metabolism | Neurons - drug effects | Substance P - analogs & derivatives | Receptors, Neurokinin-3 - antagonists & inhibitors | Membrane Potentials - drug effects | Green Fluorescent Proteins - metabolism | Arcuate Nucleus of Hypothalamus - metabolism | Receptors, Opioid, kappa - agonists | Receptors, Neurokinin-3 - agonists | Receptors, Opioid, kappa - metabolism | Mice, Transgenic | Kisspeptins - metabolism | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology | Neurokinin B - metabolism | Patch-Clamp Techniques | Animals | Dynorphins - pharmacology | Kisspeptins - pharmacology | Mice | Oligopeptides - pharmacology
Journal Article
Psychopharmacology, ISSN 0033-3158, 9/2015, Volume 232, Issue 17, pp. 3249 - 3258
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 11/2013, Volume 38, Issue 12, pp. 2484 - 2497
Activation of kappa-opioid receptors (KORs) in monoamine circuits results in dysphoria-like behaviors and stress-induced reinstatement of drug seeking in both... 
norepinephrine | kappa-opioid receptor | cocaine | reinstatement | locus coeruleus | b-adrenergic receptors | AGONIST SALVINORIN | PRESYNAPTIC INHIBITION | PSYCHIATRY | P38 MAPK | NEUROSCIENCES | BED NUCLEUS | PREFRONTAL CORTEX | CORTICOTROPIN-RELEASING-FACTOR | STRIA TERMINALIS | STRESS-INDUCED REINSTATEMENT | AXON TERMINALS | beta-adrenergic receptors | PHARMACOLOGY & PHARMACY | SALVINORIN-A | Naltrexone - analogs & derivatives | Adrenergic beta-1 Receptor Antagonists - pharmacology | Locus Coeruleus - drug effects | Male | Adrenergic alpha-2 Receptor Agonists - pharmacology | Adrenergic beta-Antagonists - pharmacology | Drug-Seeking Behavior | Naltrexone - pharmacology | Propranolol - pharmacology | Clonidine - pharmacology | Receptors, Adrenergic, beta - metabolism | Receptors, Adrenergic, alpha - metabolism | Receptors, Opioid, kappa - antagonists & inhibitors | Conditioning (Psychology) - drug effects | Mice, Inbred C57BL | Receptors, Opioid, kappa - agonists | Receptors, Opioid, kappa - metabolism | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology | Cocaine - administration & dosage | Cocaine - pharmacology | Animals | Mice | Betaxolol - pharmacology | Propanolamines - pharmacology | Locus Coeruleus - metabolism | Adrenergic receptors | beta adrenergic receptors | kappa opioid receptor | Catecholamines | Neuropharmacology | behavioral Science | Original | β-adrenergic receptors | opioids
Journal Article
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 02/2014, Volume 39, Issue 3, pp. 614 - 624
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 08/2013, Volume 38, Issue 9, pp. 1770 - 1779
Kappa-opioid receptors (KORs) are important for motivation and other medial prefrontal cortex (mPFC)-dependent behaviors. Although KORs are present in the... 
aversion | GABA | kappa-opioid receptors | dopamine | prefrontal cortex | glutamate | IN-VIVO MICRODIALYSIS | RAT | PSYCHIATRY | COCAINE | DYNORPHIN | DOPAMINERGIC-NEURONS | NEUROSCIENCES | EXTRACELLULAR GLUTAMATE | NUCLEUS-ACCUMBENS | CORTEX | PHARMACOLOGY & PHARMACY | GLUTAMATE LEVELS | Naltrexone - analogs & derivatives | Analgesics - pharmacology | Narcotic Antagonists - administration & dosage | Synaptic Transmission - physiology | Neurotransmitter Uptake Inhibitors - antagonists & inhibitors | gamma-Aminobutyric Acid - metabolism | Pyrrolidines - antagonists & inhibitors | Neurotransmitter Uptake Inhibitors - pharmacology | Pyrrolidines - administration & dosage | Male | Dicarboxylic Acids - pharmacology | Miniature Postsynaptic Potentials - drug effects | Excitatory Postsynaptic Potentials - drug effects | Pyrrolidines - pharmacology | Excitatory Postsynaptic Potentials - physiology | Naltrexone - pharmacology | Drug Interactions | Prefrontal Cortex - drug effects | Pyramidal Cells - physiology | Synaptic Transmission - drug effects | Dicarboxylic Acids - antagonists & inhibitors | Pyramidal Cells - drug effects | Benzeneacetamides - pharmacology | Naltrexone - administration & dosage | Dopamine - metabolism | Receptors, Opioid, kappa - genetics | Receptors, Opioid, kappa - antagonists & inhibitors | Glutamic Acid - pharmacology | Microinjections | Receptors, Opioid, kappa - agonists | Analgesics - administration & dosage | Rats | Avoidance Learning - physiology | Benzeneacetamides - administration & dosage | Mice, Knockout | Receptors, Opioid, kappa - physiology | Animals | Narcotic Antagonists - pharmacology | Prefrontal Cortex - metabolism | Avoidance Learning - drug effects | Glutamic Acid - metabolism | Mice | Prefrontal Cortex - physiology | Original | opioids
Journal Article
Blood, ISSN 0006-4971, 09/2015, Volume 126, Issue 11, pp. 1346 - 1356
Journal Article
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 2003, Volume 17, Issue 8, pp. 949 - 951
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 09/2013, Volume 84, Issue 3, pp. 415 - 424
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 534, Issue 7605, pp. 129 - 132
The epidermal growth factor receptor (EGFR)-directed tyrosine kinase inhibitors (TKIs) gefitinib, erlotinib and afatinib are approved treatments for non-small... 
CELL LUNG-CANCER | EGFR KINASE | GROWTH-FACTOR RECEPTOR | TARGETED THERAPIES | GEFITINIB | ACTIVATION | MECHANISM | MULTIDISCIPLINARY SCIENCES | MUTATIONS | AZD9291 | Lung Neoplasms - drug therapy | Drug Resistance, Multiple - drug effects | Protein Conformation - drug effects | ErbB Receptors - genetics | Lung Neoplasms - pathology | Antineoplastic Agents - pharmacology | Benzeneacetamides - pharmacology | Mutant Proteins - antagonists & inhibitors | Disease Models, Animal | Allosteric Regulation - drug effects | Carcinoma, Non-Small-Cell Lung - pathology | Drug Resistance, Multiple - genetics | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Lung Neoplasms - enzymology | Allosteric Site - drug effects | Mutant Proteins - genetics | Cetuximab - pharmacology | Mutant Proteins - metabolism | Drug Synergism | Drug Resistance, Neoplasm - genetics | Animals | ErbB Receptors - chemistry | Mutant Proteins - chemistry | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Protein Multimerization - drug effects | Drug Resistance, Neoplasm - drug effects | Studies | Phosphorylation | Nuclear magnetic resonance--NMR | Epidermal growth factor | Mutation | Kinases | Enzyme kinetics | Tumors
Journal Article