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1. Full Text Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance
by Wickström, Malin and Dyberg, Cecilia and Milosevic, Jelena and Einvik, Christer and Calero, Raul and Sveinbjörnsson, Baldur and Sandén, Emma and Darabi, Anna and Siesjö, Peter and Kool, Marcel and Kogner, Per and Baryawno, Ninib and Johnsen, John Inge
Nature communications, ISSN 2041-1723, 11/2015, Volume 6, Issue 1, pp. 8904 - 8904
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Index Medicus | VDP | Klinisk medisinske fag: 750 | Onkologi: 762 | Oncology: 762 | Medisinske Fag: 700 | Clinical medical disciplines: 750 | Medical disciplines: 700 | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
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2. Full Text WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited
by Boulter, L and Guest, R.V and Kendall, T.J and Wilson, D.H and Wojtacha, D and Robson, A.J and Ridgway, R.A and Samuel, K and van Rooijen, N and Barry, S.T and Wigmore, S.J and Sansom, O.J and Forbes, S.J
The Journal of clinical investigation, ISSN 0021-9738, 2015, Volume 125, Issue 3, pp. 1269 - 1285
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Anisoles - pharmacology | Humans | Male | Cholangiocarcinoma - metabolism | Bile Ducts, Intrahepatic - metabolism | Keratins - metabolism | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Benzeneacetamides - pharmacology | Wnt Signaling Pathway | Bile Duct Neoplasms - drug therapy | Cell Survival - drug effects | Aniline Compounds - pharmacology | Bile Duct Neoplasms - metabolism | Pyrimidines - pharmacology | Rats, Sprague-Dawley | beta Catenin - metabolism | Heterocyclic Compounds, 2-Ring - pharmacology | Xenograft Model Antitumor Assays | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Macrophages - metabolism | Animals | Cholangiocarcinoma - drug therapy | Mice, Nude | Tamoxifen - pharmacology | Cell Line, Tumor | Macrophages - drug effects | Cell Proliferation - drug effects | Clodronic Acid - administration & dosage | Pyridines - pharmacology | Liposomes | Physiological aspects | Research | Tumor proteins | Wnt proteins | Oncology, Experimental | Cancer | Heparan sulfate | Medical research | Liver | Gene expression | Cancer therapies | Studies | Councils | Medical prognosis | Cell cycle | Ligands | Mutation | Tumors | Index Medicus | Abridged Index Medicus
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3. Full Text Combined treatment with morphine and Δ9-tetrahydrocannabinol in rhesus monkeys: Antinociceptive tolerance and withdrawal
by Gerak, L.R and France, C.P
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 05/2016, Volume 357, Issue 2, pp. 357 - 366
Analgesics - pharmacology | Opioid-Related Disorders - psychology | Morphine - pharmacology | Drug Tolerance | Analgesics, Opioid - pharmacology | Morpholines - pharmacology | Pain Measurement - drug effects | Macaca mulatta | Cannabinoid Receptor Agonists - pharmacology | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology | Naphthalenes - pharmacology | Dose-Response Relationship, Drug | Heart Rate - drug effects | Animals | Benzoxazines - pharmacology | Cyclohexanols - pharmacology | Dronabinol - pharmacology | Substance Withdrawal Syndrome - psychology | Index Medicus | Behavioral Pharmacology
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4. Full Text Neurokinin B Activates Arcuate Kisspeptin Neurons Through Multiple Tachykinin Receptors in the Male Mouse
by de Croft, Simon and Boehm, Ulrich and Herbison, Allan E
Endocrinology (Philadelphia), ISSN 0013-7227, 08/2013, Volume 154, Issue 8, pp. 2750 - 2760
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Fundamental and applied biological sciences. Psychology | Vertebrates: endocrinology | Biological and medical sciences | Receptors, Neurokinin-2 - antagonists & inhibitors | Receptors, Tachykinin - metabolism | Analgesics, Non-Narcotic - pharmacology | Arcuate Nucleus of Hypothalamus - cytology | Male | Peptide Fragments - pharmacology | Substance P - pharmacology | Green Fluorescent Proteins - genetics | Neurokinin B - pharmacology | Quinolines - pharmacology | Kisspeptins - genetics | Piperidines - pharmacology | Neurons - physiology | Receptors, Neurokinin-3 - metabolism | Neurons - metabolism | Receptors, Neurokinin-2 - metabolism | Dynorphins - metabolism | Neurons - drug effects | Substance P - analogs & derivatives | Receptors, Neurokinin-3 - antagonists & inhibitors | Membrane Potentials - drug effects | Green Fluorescent Proteins - metabolism | Arcuate Nucleus of Hypothalamus - metabolism | Receptors, Opioid, kappa - agonists | Receptors, Neurokinin-3 - agonists | Receptors, Opioid, kappa - metabolism | Mice, Transgenic | Kisspeptins - metabolism | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology | Neurokinin B - metabolism | Patch-Clamp Techniques | Animals | Dynorphins - pharmacology | Kisspeptins - pharmacology | Mice | Oligopeptides - pharmacology | Index Medicus | Abridged Index Medicus
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5. Full Text Locus coeruleus kappa-opioid receptors modulate reinstatement of cocaine place preference through a noradrenergic mechanism
by Al-Hasani, Ream and McCall, Jordan G and Foshage, Audra M and Bruchas, Michael R
Neuropsychopharmacology (New York, N.Y.), ISSN 0893-133X, 11/2013, Volume 38, Issue 12, pp. 2484 - 2497
norepinephrine | kappa-opioid receptor | cocaine | reinstatement | locus coeruleus | b-adrenergic receptors | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer | Psychology. Psychoanalysis. Psychiatry | Psychopharmacology | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Neuropharmacology | Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) | Naltrexone - analogs & derivatives | Adrenergic beta-1 Receptor Antagonists - pharmacology | Locus Coeruleus - drug effects | Male | Adrenergic alpha-2 Receptor Agonists - pharmacology | Adrenergic beta-Antagonists - pharmacology | Drug-Seeking Behavior | Naltrexone - pharmacology | Propranolol - pharmacology | Clonidine - pharmacology | Receptors, Adrenergic, beta - metabolism | Receptors, Adrenergic, alpha - metabolism | Receptors, Opioid, kappa - antagonists & inhibitors | Conditioning (Psychology) - drug effects | Mice, Inbred C57BL | Receptors, Opioid, kappa - agonists | Receptors, Opioid, kappa - metabolism | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology | Cocaine - administration & dosage | Cocaine - pharmacology | Animals | Mice | Betaxolol - pharmacology | Propanolamines - pharmacology | Locus Coeruleus - metabolism | Index Medicus | Adrenergic receptors | beta adrenergic receptors | kappa opioid receptor | Catecholamines | behavioral Science | Original | β-adrenergic receptors | opioids
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6. Full Text Role of 5-HT2C receptors in effects of monoamine releasers on intracranial self-stimulation in rats
by Bauer, Clayton T and Banks, Matthew L and Blough, Bruce E and Negus, S Stevens
Psychopharmacology, ISSN 0033-3158, 9/2015, Volume 232, Issue 17, pp. 3249 - 3258
Neurosciences | Biomedicine | Dopamine | Amphetamine | Serotonin | Methylenedioxymethamphetamine | Fenfluramine | Intracranial self-stimulation | Pharmacology/Toxicology | Psychiatry | 5-HT 2C receptors | receptors | 5-HT | Pharmacology & Pharmacy | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Receptor, Serotonin, 5-HT2C - drug effects | Receptors, Opioid, kappa - agonists | Rats | Male | Serotonin 5-HT2 Receptor Agonists - pharmacology | Electrodes, Implanted | Serotonin 5-HT2 Receptor Antagonists - pharmacology | Fenfluramine - pharmacology | Rats, Sprague-Dawley | Pyrrolidines - pharmacology | Self Stimulation - drug effects | Animals | Conditioning, Operant - drug effects | N-Methyl-3,4-methylenedioxyamphetamine - pharmacology | Aminopyridines - pharmacology | Adrenergic Uptake Inhibitors - pharmacology | Indoles - pharmacology | Biogenic Monoamines - metabolism | Serotonin Uptake Inhibitors - pharmacology | Benzeneacetamides - pharmacology | Index Medicus | serotonin | amphetamine | methylenedioxymethamphetamine | 5-HT2C receptors | dopamine | fenfluramine | intracranial self-stimulation
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7. Full Text Behavioral Pharmacology of Novel Kappa Opioid Receptor Antagonists in Rats
by Page, Sarah and Mavrikaki, Maria M and Lintz, Tania and Puttick, Daniel and Roberts, Edward and Rosen, Hugh and Carroll, F. Ivy and Carlezon, William A and Chartoff, Elena H
The international journal of neuropsychopharmacology, ISSN 1461-1457, 11/2019, Volume 22, Issue 11, pp. 735 - 745
Neurosciences | Clinical Neurology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Neurosciences & Neurology | Psychiatry | Science & Technology | Anti-Anxiety Agents - administration & dosage | Narcotic Antagonists - administration & dosage | Analgesics, Non-Narcotic - pharmacology | Pyrrolidines - administration & dosage | Male | Pyrrolidines - pharmacology | Benzamides - administration & dosage | Piperidines - pharmacology | Behavior, Animal - drug effects | Antidepressive Agents - pharmacology | Benzamides - pharmacology | Drug Evaluation, Preclinical | Tetrahydroisoquinolines - pharmacology | Piperidines - administration & dosage | Receptors, Opioid, kappa - antagonists & inhibitors | Receptors, Opioid, kappa - agonists | Anti-Anxiety Agents - pharmacology | Rats | Analgesics, Non-Narcotic - administration & dosage | Tetrahydroisoquinolines - administration & dosage | Rats, Sprague-Dawley | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology | Animals | Narcotic Antagonists - pharmacology | Antidepressive Agents - administration & dosage | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - administration & dosage | Drug Development | Index Medicus | U50 | 488 | Regular s | JDTic | LY-2456302 | analgesia | ICSS
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8. Full Text Differential expression and sensitivity of presynaptic and postsynaptic opioid receptors regulating hypothalamic proopiomelanocortin neurons
by Pennock, Reagan L and Hentges, Shane T
The Journal of neuroscience, ISSN 0270-6474, 01/2011, Volume 31, Issue 1, pp. 281 - 288
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Naltrexone - analogs & derivatives | Analgesics - pharmacology | Receptors, Opioid - agonists | Analgesics, Opioid - pharmacology | Neurons - cytology | Peptide Fragments - pharmacology | Patch-Clamp Techniques - methods | Somatostatin - pharmacology | Pyrrolidines - pharmacology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Naltrexone - pharmacology | Synapses - metabolism | Gene Expression - physiology | Neurons - physiology | Neurons - drug effects | Benzeneacetamides - pharmacology | Receptors, Opioid - metabolism | Membrane Potentials - drug effects | Synapses - drug effects | Enkephalin, Ala-MePhe-Gly- - pharmacology | Mice, Inbred C57BL | Mice, Transgenic | Pro-Opiomelanocortin - metabolism | Animals | Analysis of Variance | Hypothalamus - cytology | Narcotic Antagonists - pharmacology | Luminescent Proteins - genetics | Mice | Dizocilpine Maleate - pharmacology | In Vitro Techniques | Neural Inhibition - drug effects | Inhibitory Postsynaptic Potentials - drug effects | Index Medicus
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9. Full Text Prefrontal cortical kappa-opioid receptor modulation of local neurotransmission and conditioned place aversion
by Tejeda, Hugo A and Counotte, Danielle S and Oh, Eric and Ramamoorthy, Sammanda and Schultz-Kuszak, Kristin N and Bäckman, Cristina M and Chefer, Vladmir and O'Donnell, Patricio and Shippenberg, Toni S
Neuropsychopharmacology (New York, N.Y.), ISSN 0893-133X, 08/2013, Volume 38, Issue 9, pp. 1770 - 1779
aversion | GABA | kappa-opioid receptors | dopamine | prefrontal cortex | glutamate | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Biological and medical sciences | Medical sciences | Naltrexone - analogs & derivatives | Analgesics - pharmacology | Narcotic Antagonists - administration & dosage | Synaptic Transmission - physiology | Neurotransmitter Uptake Inhibitors - antagonists & inhibitors | gamma-Aminobutyric Acid - metabolism | Pyrrolidines - antagonists & inhibitors | Neurotransmitter Uptake Inhibitors - pharmacology | Pyrrolidines - administration & dosage | Male | Dicarboxylic Acids - pharmacology | Miniature Postsynaptic Potentials - drug effects | Excitatory Postsynaptic Potentials - drug effects | Pyrrolidines - pharmacology | Excitatory Postsynaptic Potentials - physiology | Naltrexone - pharmacology | Drug Interactions | Prefrontal Cortex - drug effects | Pyramidal Cells - physiology | Synaptic Transmission - drug effects | Dicarboxylic Acids - antagonists & inhibitors | Pyramidal Cells - drug effects | Benzeneacetamides - pharmacology | Naltrexone - administration & dosage | Dopamine - metabolism | Receptors, Opioid, kappa - genetics | Receptors, Opioid, kappa - antagonists & inhibitors | Glutamic Acid - pharmacology | Microinjections | Receptors, Opioid, kappa - agonists | Analgesics - administration & dosage | Rats | Avoidance Learning - physiology | Benzeneacetamides - administration & dosage | Mice, Knockout | Receptors, Opioid, kappa - physiology | Animals | Narcotic Antagonists - pharmacology | Prefrontal Cortex - metabolism | Avoidance Learning - drug effects | Glutamic Acid - metabolism | Mice | Prefrontal Cortex - physiology | Index Medicus | Original | opioids
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10. Full Text Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition
by Jacque, Nathalie and Ronchetti, Anne Marie and Larrue, Clément and