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Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 626 - 630
The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy. One... 
Enzymes | Cell growth | Glioma | RNA | Neurons | REPORTS | Methylation | Cellular differentiation | Genetic mutation | Heterologous transplantation | Tumors | TRANSFORMATION | GLIOBLASTOMA | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | PHENOTYPE | ACUTE MYELOID-LEUKEMIA | MUTATIONS | ONCOMETABOLITE 2-HYDROXYGLUTARATE | BRAIN | Benzeneacetamides - toxicity | Protein Multimerization | Imidazoles - administration & dosage | Gene Expression Profiling | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - genetics | RNA Interference | Enzyme Inhibitors - toxicity | Glioma - pathology | Imidazoles - toxicity | Gene Expression Regulation, Neoplastic - drug effects | Benzeneacetamides - pharmacology | Mutant Proteins - antagonists & inhibitors | Glioma - enzymology | Enzyme Inhibitors - pharmacology | Isocitrate Dehydrogenase - genetics | Mutant Proteins - metabolism | Imidazoles - pharmacology | Mice, SCID | Benzeneacetamides - administration & dosage | Xenograft Model Antitumor Assays | Animals | Cell Differentiation - drug effects | Cell Transformation, Neoplastic | Isocitrate Dehydrogenase - chemistry | Mutant Proteins - chemistry | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mice | Histones - metabolism | Glioma - drug therapy | Cell proliferation | Gene mutations | Gliomas | Growth | Cancer cells | Physiological aspects | Genetic aspects | Research | Cancer | Genes | Cells | Mutation | Drugs | Binding | Mutations | Inhibitors | Online | Delay
Journal Article
Cell Reports, ISSN 2211-1247, 01/2017, Volume 18, Issue 3, pp. 601 - 610
Cancer cells exhibit increased use of nutrients, including glucose and glutamine, to support the bioenergetic and biosynthetic demands of proliferation. We... 
lung cancer | metabolic crisis | PET imaging | erlotinib | AMPK | glutamine | CB-839 | EGFR | PATHWAYS | GEFITINIB | POSITRON-EMISSION-TOMOGRAPHY | GLUTATHIONE | ADENOCARCINOMA | GROWTH | PROLIFERATION | MUTATIONS | EXPRESSION | ERLOTINIB | CELL BIOLOGY | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | AMP-Activated Protein Kinases - metabolism | Apoptosis - drug effects | Benzeneacetamides - toxicity | Humans | Glutamine - metabolism | Lung Neoplasms - pathology | Transplantation, Heterologous | Autophagy - drug effects | Erlotinib Hydrochloride - toxicity | Carbon Radioisotopes - chemistry | Receptor, Epidermal Growth Factor - metabolism | Benzeneacetamides - therapeutic use | RNA Interference | Thiadiazoles - therapeutic use | Glutamine - chemistry | Carcinoma, Non-Small-Cell Lung - pathology | Radiopharmaceuticals - chemistry | AMP-Activated Protein Kinases - antagonists & inhibitors | Fluorodeoxyglucose F18 - chemistry | Glutaminase - metabolism | Mice, SCID | Glutaminase - antagonists & inhibitors | Thiadiazoles - toxicity | Animals | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Lung Neoplasms - diagnostic imaging | Carcinoma, Non-Small-Cell Lung - diagnostic imaging | Erlotinib Hydrochloride - therapeutic use | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | AMP-Activated Protein Kinases - genetics
Journal Article
Neuropharmacology, ISSN 0028-3908, 02/2016, Volume 101, pp. 320 - 329
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2010, Volume 649, Issue 1, pp. 336 - 341
Pruritus is a common adverse effect of opioid treatment. However, the mechanism by which pruritus is induced by opioid administration is unclear. In this... 
Naloxone methiodide | Peripheral opioid receptor | Loperamide | Itch | DAMGO | SYSTEM | INDUCED PRURITUS | ACTIVATION | MORPHINE | DELTA | NALOXONE | RESPONSES | KAPPA | PHARMACOLOGY & PHARMACY | SKIN | Analgesics, Opioid - antagonists & inhibitors | Analgesics, Opioid - toxicity | Opioid-Related Disorders - drug therapy | Loperamide - toxicity | Enkephalin, Ala-MePhe-Gly- - administration & dosage | Antipruritics - therapeutic use | Analgesics, Opioid - pharmacology | Male | Receptors, Opioid, mu - agonists | Antipruritics - pharmacology | Dose-Response Relationship, Drug | Loperamide - antagonists & inhibitors | Pruritus - drug therapy | Behavior, Animal - drug effects | Receptors, Opioid, delta - antagonists & inhibitors | Enkephalin, Ala-MePhe-Gly- - antagonists & inhibitors | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - toxicity | Enkephalin, D-Penicillamine (2,5)- - toxicity | Pruritus - chemically induced | Injections, Intradermal | Receptors, Opioid, kappa - antagonists & inhibitors | Loperamide - administration & dosage | Enkephalin, Ala-MePhe-Gly- - pharmacology | Quaternary Ammonium Compounds - therapeutic use | Receptors, Opioid, kappa - agonists | Loperamide - pharmacology | Antipruritics - administration & dosage | Naloxone - therapeutic use | Receptors, Opioid, mu - antagonists & inhibitors | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology | Mice, Inbred ICR | Naloxone - analogs & derivatives | Animals | Analgesics, Opioid - administration & dosage | Enkephalin, Ala-MePhe-Gly- - toxicity | Naloxone - pharmacology | Quaternary Ammonium Compounds - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - pharmacology | Mice | Naloxone - administration & dosage | Receptors, Opioid, delta - agonists | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - therapeutic use | Skin - drug effects | Quaternary Ammonium Compounds - pharmacology | Receptors, Opioid, mu - physiology | Pruritus | Acetic acid
Journal Article
Homeopathy, ISSN 1475-4916, 2009, Volume 98, Issue 2, pp. 83 - 87
Journal Article
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 07/2015, Volume 6, Issue 10, pp. 1751 - 1758
Selective activation of peripheral κ opioid receptors (KORs) may overcome the dose-limiting adverse effects of conventional opioid analgesics. We recently... 
peripheral | pain | U-50488 | conorphin-1 | analgesia | κ opioid receptor | TETRAPEPTIDE ANALOGS | CHEMISTRY, MEDICINAL | kappa opioid receptor | RAT | MORPHINE | SODIUM-CHANNELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PAIN PATHWAYS | ANTINOCICEPTION | NEUROSCIENCES | SENSORY NEURONS | VISCERAL PAIN | FORMALIN TEST | AGONIST | Inflammation - chemically induced | Inflammation - pathology | Peripheral Nervous System Diseases - chemically induced | Freund's Adjuvant - toxicity | Rats, Wistar | Humans | Male | Nerve Endings - metabolism | Pain - chemically induced | Oligopeptides - therapeutic use | Inflammation - complications | Cisplatin - toxicity | Pain - drug therapy | HEK293 Cells | Carrageenan - toxicity | Disease Models, Animal | Analgesics - therapeutic use | Mice, Inbred C57BL | Receptors, Opioid, kappa - agonists | Receptors, Opioid, kappa - metabolism | Rats | Naloxone - therapeutic use | Analgesics, Non-Narcotic - therapeutic use | Pain - pathology | Peptides - pharmacology | Gene Expression Regulation - drug effects | Animals | Naloxone - pharmacology | Nerve Endings - drug effects | Skin - innervation | Mice | Oligopeptides - pharmacology | Pain Measurement | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - therapeutic use | Peptides - therapeutic use | Peripheral Nervous System Diseases - drug therapy
Journal Article
Neuropharmacology, ISSN 0028-3908, 11/2016, Volume 110, Issue Pt A, pp. 92 - 101
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